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Conserved domains on  [gi|1209601058|ref|NP_001339758|]
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suppression of tumorigenicity 18 protein isoform a [Homo sapiens]

Protein Classification

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List of domain hits

Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
479-715 2.91e-108

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


:

Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 336.34  E-value: 2.91e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  479 PSQAITSPRATVSKEQEKFGKVPFDYASFDAQVFGKRPLIQTVQGRKTPP--FPESKHFPNPVKFPNRLPSAGAHTQSPG 556
Cdd:pfam08474    3 NNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPkgFDAKKYFCKPSSPSSSLTSSYAPSSSSS 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  557 RASSYSYGQCSEDTHIAAAAAiLNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRILDksapLTSSNTS 636
Cdd:pfam08474   83 SSSSYDYTHDMEAAHMAATAI-LNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRG----VTSGSVL 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  637 IPTPSSSPFKTSSILvNAAFYQALCDQEGWDTPINYSKTHGKTEEEKE--KDPVSSLENLEEKKFPGEASIPSPKPKLHA 714
Cdd:pfam08474  158 TPLPPMSPQRQASLL-NSRCYQALCAQDCWDLPVDYTKIKRIDEEEKEepEDLDPFQELLEERKYPGEVTIPSPKPKYPP 236

                   .
gi 1209601058  715 R 715
Cdd:pfam08474  237 C 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
767-795 4.74e-17

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 75.26  E-value: 4.74e-17
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  767 KCPTPGCDGSGHVTGNYASHRSLSGCPRA 795
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
723-751 2.87e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 72.95  E-value: 2.87e-16
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  723 TCPTPGCDGSGHVTGNYASHRSVSGCPLA 751
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
411-439 2.18e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.56  E-value: 2.18e-14
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  411 KCPTPGCTGRGHVNSNRNTHRSLSGCPIA 439
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
815-843 2.40e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.56  E-value: 2.40e-14
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  815 KCPVIGCDGQGHISGKYTSHRTASGCPLA 843
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
367-393 3.10e-13

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 64.48  E-value: 3.10e-13
                           10        20
                   ....*....|....*....|....*..
gi 1209601058  367 KCPIPGCDGTGHVTGLYPHHRSLSGCP 393
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
869-895 2.48e-11

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 59.08  E-value: 2.48e-11
                           10        20
                   ....*....|....*....|....*..
gi 1209601058  869 CPLPGCNGLGHVNNVFVTHRSLSGCPL 895
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPY 28
Com_YlbF super family cl42071
Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and ...
921-1006 1.63e-04

Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and archaeal proteins that includes both YlbF and YmcA which may interact synergistically. The family is necessary for correct biofilm formation, as null mutants of ymcA and ylbF fail to form pellicles at air-liquid interfaces and grow on solid media as smooth, undifferentiated colonies. During development, YmcA, YlbF and YaaT, family PSPI, pfam04468, interact directly with one another forming a stable ternary complex, in vitro. All three proteins are required for competence, sporulation and the formation of biofilms. The YmcA-YlbF-YaaT complex affects the phosphotransfer between Spo0F and Spo0B, thus accelerating the production of Spo0A~P. The three processes of biofilm formation, mature spore formation and competence all require the active, phosphorylated form of Spo0A, as Spo0A-P.


The actual alignment was detected with superfamily member PRK13676:

Pssm-ID: 455416 [Multi-domain]  Cd Length: 114  Bit Score: 42.23  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  921 ESDEEIRHLDE--EIKEL------NESNLKIEADMMKLQTQITSMESNLKTIEEE--------NKLIEQNneSLLKELAG 984
Cdd:PRK13676    11 ELERALRELPEykALKEAkeavkaDEEAKKLFDEFRALQLEIQQKQMTGQEITEEeqqkaqelGQKIQQN--ELLSKLME 88
                           90       100
                   ....*....|....*....|..
gi 1209601058  985 LSQALISSLADIQLPQMGPISE 1006
Cdd:PRK13676    89 AEQRLSVYINDINKIIFKPLEE 110
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
479-715 2.91e-108

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 336.34  E-value: 2.91e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  479 PSQAITSPRATVSKEQEKFGKVPFDYASFDAQVFGKRPLIQTVQGRKTPP--FPESKHFPNPVKFPNRLPSAGAHTQSPG 556
Cdd:pfam08474    3 NNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPkgFDAKKYFCKPSSPSSSLTSSYAPSSSSS 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  557 RASSYSYGQCSEDTHIAAAAAiLNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRILDksapLTSSNTS 636
Cdd:pfam08474   83 SSSSYDYTHDMEAAHMAATAI-LNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRG----VTSGSVL 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  637 IPTPSSSPFKTSSILvNAAFYQALCDQEGWDTPINYSKTHGKTEEEKE--KDPVSSLENLEEKKFPGEASIPSPKPKLHA 714
Cdd:pfam08474  158 TPLPPMSPQRQASLL-NSRCYQALCAQDCWDLPVDYTKIKRIDEEEKEepEDLDPFQELLEERKYPGEVTIPSPKPKYPP 236

                   .
gi 1209601058  715 R 715
Cdd:pfam08474  237 C 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
767-795 4.74e-17

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 75.26  E-value: 4.74e-17
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  767 KCPTPGCDGSGHVTGNYASHRSLSGCPRA 795
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
723-751 2.87e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 72.95  E-value: 2.87e-16
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  723 TCPTPGCDGSGHVTGNYASHRSVSGCPLA 751
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
411-439 2.18e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.56  E-value: 2.18e-14
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  411 KCPTPGCTGRGHVNSNRNTHRSLSGCPIA 439
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
815-843 2.40e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.56  E-value: 2.40e-14
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  815 KCPVIGCDGQGHISGKYTSHRTASGCPLA 843
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
367-393 3.10e-13

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 64.48  E-value: 3.10e-13
                           10        20
                   ....*....|....*....|....*..
gi 1209601058  367 KCPIPGCDGTGHVTGLYPHHRSLSGCP 393
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
869-895 2.48e-11

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 59.08  E-value: 2.48e-11
                           10        20
                   ....*....|....*....|....*..
gi 1209601058  869 CPLPGCNGLGHVNNVFVTHRSLSGCPL 895
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPY 28
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
921-1006 1.63e-04

YlbF/YmcA family competence regulator;


Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 42.23  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  921 ESDEEIRHLDE--EIKEL------NESNLKIEADMMKLQTQITSMESNLKTIEEE--------NKLIEQNneSLLKELAG 984
Cdd:PRK13676    11 ELERALRELPEykALKEAkeavkaDEEAKKLFDEFRALQLEIQQKQMTGQEITEEeqqkaqelGQKIQQN--ELLSKLME 88
                           90       100
                   ....*....|....*....|..
gi 1209601058  985 LSQALISSLADIQLPQMGPISE 1006
Cdd:PRK13676    89 AEQRLSVYINDINKIIFKPLEE 110
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
923-972 3.40e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 40.63  E-value: 3.40e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1209601058  923 DEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEEN-KLIE 972
Cdd:cd22887     24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
890-1045 3.66e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 3.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  890 LSGCPLNAQVIKKGKVSEELMTIKlkatggiesdEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENK 969
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQ----------QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELA 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  970 LIEQNNESLLKELAGLSQALISSLADIQ-----LPQMGPISEQNFEAYVNTLTDMYSNLE--RDYSPECKALLESIKQAV 1042
Cdd:COG4942     80 ALEAELAELEKEIAELRAELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADL 159

                   ...
gi 1209601058 1043 KGI 1045
Cdd:COG4942    160 AEL 162
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
479-715 2.91e-108

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 336.34  E-value: 2.91e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  479 PSQAITSPRATVSKEQEKFGKVPFDYASFDAQVFGKRPLIQTVQGRKTPP--FPESKHFPNPVKFPNRLPSAGAHTQSPG 556
Cdd:pfam08474    3 NNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPkgFDAKKYFCKPSSPSSSLTSSYAPSSSSS 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  557 RASSYSYGQCSEDTHIAAAAAiLNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRILDksapLTSSNTS 636
Cdd:pfam08474   83 SSSSYDYTHDMEAAHMAATAI-LNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRG----VTSGSVL 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  637 IPTPSSSPFKTSSILvNAAFYQALCDQEGWDTPINYSKTHGKTEEEKE--KDPVSSLENLEEKKFPGEASIPSPKPKLHA 714
Cdd:pfam08474  158 TPLPPMSPQRQASLL-NSRCYQALCAQDCWDLPVDYTKIKRIDEEEKEepEDLDPFQELLEERKYPGEVTIPSPKPKYPP 236

                   .
gi 1209601058  715 R 715
Cdd:pfam08474  237 C 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
767-795 4.74e-17

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 75.26  E-value: 4.74e-17
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  767 KCPTPGCDGSGHVTGNYASHRSLSGCPRA 795
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
723-751 2.87e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 72.95  E-value: 2.87e-16
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  723 TCPTPGCDGSGHVTGNYASHRSVSGCPLA 751
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
411-439 2.18e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.56  E-value: 2.18e-14
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  411 KCPTPGCTGRGHVNSNRNTHRSLSGCPIA 439
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
815-843 2.40e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.56  E-value: 2.40e-14
                           10        20
                   ....*....|....*....|....*....
gi 1209601058  815 KCPVIGCDGQGHISGKYTSHRTASGCPLA 843
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
367-393 3.10e-13

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 64.48  E-value: 3.10e-13
                           10        20
                   ....*....|....*....|....*..
gi 1209601058  367 KCPIPGCDGTGHVTGLYPHHRSLSGCP 393
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
869-895 2.48e-11

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 59.08  E-value: 2.48e-11
                           10        20
                   ....*....|....*....|....*..
gi 1209601058  869 CPLPGCNGLGHVNNVFVTHRSLSGCPL 895
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPY 28
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
921-1006 1.63e-04

YlbF/YmcA family competence regulator;


Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 42.23  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  921 ESDEEIRHLDE--EIKEL------NESNLKIEADMMKLQTQITSMESNLKTIEEE--------NKLIEQNneSLLKELAG 984
Cdd:PRK13676    11 ELERALRELPEykALKEAkeavkaDEEAKKLFDEFRALQLEIQQKQMTGQEITEEeqqkaqelGQKIQQN--ELLSKLME 88
                           90       100
                   ....*....|....*....|..
gi 1209601058  985 LSQALISSLADIQLPQMGPISE 1006
Cdd:PRK13676    89 AEQRLSVYINDINKIIFKPLEE 110
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
923-972 3.40e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 40.63  E-value: 3.40e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1209601058  923 DEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEEN-KLIE 972
Cdd:cd22887     24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
890-1045 3.66e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 3.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  890 LSGCPLNAQVIKKGKVSEELMTIKlkatggiesdEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENK 969
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQ----------QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELA 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  970 LIEQNNESLLKELAGLSQALISSLADIQ-----LPQMGPISEQNFEAYVNTLTDMYSNLE--RDYSPECKALLESIKQAV 1042
Cdd:COG4942     80 ALEAELAELEKEIAELRAELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADL 159

                   ...
gi 1209601058 1043 KGI 1045
Cdd:COG4942    160 AEL 162
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
895-1000 1.06e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601058  895 LNAQVIKKGKVSEELMTIKLKATggiESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQN 974
Cdd:COG4372     89 LQAAQAELAQAQEELESLQEEAE---ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165
                           90       100
                   ....*....|....*....|....*.
gi 1209601058  975 NESLLKELAGLSQALISSLADIQLPQ 1000
Cdd:COG4372    166 LAALEQELQALSEAEAEQALDELLKE 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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