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Conserved domains on  [gi|1200742298|ref|NP_001338977|]
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N-acetylgalactosamine kinase isoform 4 [Homo sapiens]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 1-319 3.42e-116

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 344.77  E-value: 3.42e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSP 80
Cdd:PLN02521  150 LDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  81 LRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE-- 152
Cdd:PLN02521  230 VRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGsh 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 153 ----MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE-- 222
Cdd:PLN02521  309 gssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSsl 386

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 223 APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ- 301
Cdd:PLN02521  387 SEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKs 466

                         330       340
                  ....*....|....*....|.
gi 1200742298 302 RSD-GSLAPEKQSL--FATKP 319
Cdd:PLN02521  467 RIEkGVIKEEDLGLyvFASKP 487
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 1-319 3.42e-116

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 344.77  E-value: 3.42e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSP 80
Cdd:PLN02521  150 LDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  81 LRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE-- 152
Cdd:PLN02521  230 VRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGsh 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 153 ----MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE-- 222
Cdd:PLN02521  309 gssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSsl 386

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 223 APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ- 301
Cdd:PLN02521  387 SEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKs 466

                         330       340
                  ....*....|....*....|.
gi 1200742298 302 RSD-GSLAPEKQSL--FATKP 319
Cdd:PLN02521  467 RIEkGVIKEEDLGLyvFASKP 487
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
1-321 6.49e-60

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 196.53  E-value: 6.49e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFS 79
Cdd:COG0153   109 FDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCR 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  80 PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslqwdKVLRleEVqaklgiSLEEmllvte 158
Cdd:COG0153   189 SLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV-------KSLR--DV------TLED------ 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 159 dalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAKHVYSEAARVLQFKKICEEapeNMVQLLGELMNQS 238
Cdd:COG0153   247 --------------------LEAARARLGDE--------VLRRRARHVVTENQRVLEAVEALRA---GDLEAFGKLMNAS 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 239 HMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQRsdGSLAPEkqsLFAT 317
Cdd:COG0153   296 HASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEK--TGLEPD---FYVV 370


                  ....
gi 1200742298 318 KPGA 321
Cdd:COG0153   371 KPSD 374
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-323 3.83e-48

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 166.15  E-value: 3.83e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298   2 NCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFS 79
Cdd:TIGR00131 112 DIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  80 PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslqwdkvlrleevqaKLGISLEEMLlvte 158
Cdd:TIGR00131 191 SLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA-----------------TDKGALRDFM---- 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 159 dalhPEPYNPEEIcrclgisleelRTQILSPNTQdvlifklyQRAKHVYSEAARVLQFKKICEEapENMVQLlGELMNQS 238
Cdd:TIGR00131 249 ----NEYFARYIA-----------RLTKMLPLVE--------ERAKHVVSENLRVLKAVKAMKD--NDFKQF-GALMNES 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 239 HMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDgslAPEKQSLFAT 317
Cdd:TIGR00131 303 HASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTG---LELTFYVIVS 379


                  ....*.
gi 1200742298 318 KPGASE 323
Cdd:TIGR00131 380 KPGAGS 385
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 221-301 2.76e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 50.55  E-value: 2.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 221 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSMVP-ADKLPSFLANVHK 297
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 1200742298 298 AYYQ 301
Cdd:pfam08544  82 AGKK 85
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 1-319 3.42e-116

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 344.77  E-value: 3.42e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSP 80
Cdd:PLN02521  150 LDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  81 LRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE-- 152
Cdd:PLN02521  230 VRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGsh 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 153 ----MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE-- 222
Cdd:PLN02521  309 gssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSsl 386

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 223 APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ- 301
Cdd:PLN02521  387 SEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKs 466

                         330       340
                  ....*....|....*....|.
gi 1200742298 302 RSD-GSLAPEKQSL--FATKP 319
Cdd:PLN02521  467 RIEkGVIKEEDLGLyvFASKP 487
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
1-321 6.49e-60

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 196.53  E-value: 6.49e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFS 79
Cdd:COG0153   109 FDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCR 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  80 PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslqwdKVLRleEVqaklgiSLEEmllvte 158
Cdd:COG0153   189 SLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV-------KSLR--DV------TLED------ 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 159 dalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAKHVYSEAARVLQFKKICEEapeNMVQLLGELMNQS 238
Cdd:COG0153   247 --------------------LEAARARLGDE--------VLRRRARHVVTENQRVLEAVEALRA---GDLEAFGKLMNAS 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 239 HMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQRsdGSLAPEkqsLFAT 317
Cdd:COG0153   296 HASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEK--TGLEPD---FYVV 370


                  ....
gi 1200742298 318 KPGA 321
Cdd:COG0153   371 KPSD 374
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-323 3.83e-48

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 166.15  E-value: 3.83e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298   2 NCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFS 79
Cdd:TIGR00131 112 DIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  80 PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslqwdkvlrleevqaKLGISLEEMLlvte 158
Cdd:TIGR00131 191 SLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA-----------------TDKGALRDFM---- 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 159 dalhPEPYNPEEIcrclgisleelRTQILSPNTQdvlifklyQRAKHVYSEAARVLQFKKICEEapENMVQLlGELMNQS 238
Cdd:TIGR00131 249 ----NEYFARYIA-----------RLTKMLPLVE--------ERAKHVVSENLRVLKAVKAMKD--NDFKQF-GALMNES 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 239 HMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDgslAPEKQSLFAT 317
Cdd:TIGR00131 303 HASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTG---LELTFYVIVS 379


                  ....*.
gi 1200742298 318 KPGASE 323
Cdd:TIGR00131 380 KPGAGS 385
PRK05322 PRK05322
galactokinase; Provisional
 1-299 7.01e-33

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 125.36  E-value: 7.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYIGTEGGGMDQSISFLAEEGTAKLI--- 76
Cdd:PRK05322  113 FDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTEnEFIGVNSGIMDQFAIGMGKKDHAILLdcn 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  77 ----EFSPLRATDVKLpsgavfVIANScvemNKA---ATSHFNIRVMECRLAakllakykslqwdkvlrLEEVQAKLGI- 148
Cdd:PRK05322  193 tleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERRAECEKA-----------------LEELQKKLDIk 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 149 SLEEmllVTEDALhpepynpeeicrclgislEELRTQILSPNtqdvlifkLYQRAKHVYSEAARVLQFKKICEEapeNMV 228
Cdd:PRK05322  246 SLGE---LTEEEF------------------DEYSYLIKDET--------LLKRARHAVTENQRTLKAVKALKA---GDL 293

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1200742298 229 QLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAY 299
Cdd:PRK05322  294 EKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 37-303 3.46e-30

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 118.10  E-value: 3.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  37 LSKVELAEICAKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNkAATSHFNIRV 115
Cdd:PRK05101  149 LSGAEIALNGQEAEnQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRR 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 116 MECRLAAKLLAKykslqwdKVLR---LEEVQAKlgisleemllvtEDALHPEpynpeeicrclgisleelrtqilspntq 192
Cdd:PRK05101  228 QQCETAARFFGV-------KALRdvtLEQFNAV------------AAELDPV---------------------------- 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 193 dvlifkLYQRAKHVYSEAARVLQFKKICEEapENMVqLLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGS-RL 270
Cdd:PRK05101  261 ------VAKRARHVITENARTLEAASALAA--GDLK-RMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRM 331

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1200742298 271 TGAGWGGCTVSMVPADKLPSFLANVHKAYYQRS 303
Cdd:PRK05101  332 TGGGFGGCIVALVPEELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 5-302 3.30e-27

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 109.32  E-value: 3.30e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298   5 VDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRA 83
Cdd:PRK03817   91 VSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENeFVGVPCGIMDQFAVAFGKKDHAIFLDTMTLEY 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  84 TDVKLPSGAVFVIANSCVEmNKAATSHFNIRVMECRLAAKLLAKYKSLQwdkvlrleevqaklgisleemllVTEDALHp 163
Cdd:PRK03817  171 EYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKSSKE-----------------------VTEEDLS- 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 164 epynpeeicrclgiSLEELrtqilspntqdvlifkLYQRAKHVYSEAARVLQFKKICEEapeNMVQLLGELMNQSHMSCR 243
Cdd:PRK03817  226 --------------KLPPL----------------LRKRAGYVLRENERVLKVRDALKE---GDIETLGELLTESHWDLA 272

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1200742298 244 DMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 302
Cdd:PRK03817  273 DNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
PRK00555 PRK00555
galactokinase; Provisional
 20-298 6.47e-20

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 89.15  E-value: 6.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  20 ALVCCAGLVTLTVL-GRNLSKVELAEICAKSER-YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGA--VFV 95
Cdd:PRK00555  110 AALECAVLGAVGAAtGTRIDRLEQARLAQRAENeYVGAPTGLLDQLAALFGAPKTALLIDFRDLTVRPVAFDPDAagVVL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  96 IANSCVEMNKAATSHFNIRVMECRLAAKLLAkykslqwdkVLRLEEVQAKLGISLeemllvtedalhpepynpeeicrcl 175
Cdd:PRK00555  190 LLMDSRARHRHAGGEYAARRASCERAAADLG---------VSSLRAVQDRGLAAL------------------------- 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 176 gisleelrTQILSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEEAPenmVQLLGELMNQSHMSCRDMYECSCPELDQ 255
Cdd:PRK00555  236 --------GAIADPID--------ARRARHVLTENQRVLDFAAALADSD---FTAAGQLLTASHASMRDDFEITTERIDL 296

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1200742298 256 LVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKA 298
Cdd:PRK00555  297 IADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRA 339
PLN02865 PLN02865
galactokinase
 52-324 8.24e-13

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 68.67  E-value: 8.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  52 YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAV-------FVIANSCVEMNKAATSHFNIRVMECRLAAKL 124
Cdd:PLN02865  184 YLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfkILLAFSGLRHALTNKPGYNLRVSECQEAARF 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 125 LAKYKSLqwdkvlrlEEVQAKLGisleemllvtedALHPEPYnpeeicrclgisleELRTQILSPNtqdvlifkLYQRAK 204
Cdd:PLN02865  264 LLEASGN--------DELEPLLC------------NVEPEVY--------------EAHKCKLEAV--------LARRAE 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 205 HVYSEAARVLqfkKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMV 283
Cdd:PLN02865  302 HYFSENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFV 378

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1200742298 284 PADKLPSFLANVhKAYYQRSDGSLA---PEKQSLFATKPGASER 324
Cdd:PLN02865  379 DAEMAEEAASFV-RDEYEKAQPELAsniNGDKPVLICEAGDCAR 421
PTZ00290 PTZ00290
galactokinase; Provisional
 38-302 9.07e-12

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 65.61  E-value: 9.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  38 SKVELAEIcAKSERYIGTEGGG-----MDQSISFLAEEG----------TAKLIEFSPLratdvkLPSGAVFVIANSCVE 102
Cdd:PTZ00290  189 SKEELIEL-AKQARRIETEFCGvnvgiMDQFISAFAEEDkfmfldckslTFESHDMTPL------LGDGACFLLIDSMIK 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 103 MNkaatshfnirvmecrLAAKLLAKYKSLQWDkvlrLEEVQAKLG--ISLEEMLLVTEDALHPEPY----NPEEIcrclg 176
Cdd:PTZ00290  262 HD---------------LLGGTAGMYNTVRSD----QEGAQKKIGkhRYRGKPFTFSDLVRNPKKYtfdgDVVAF----- 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 177 isLEELRTQiLSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEEA----PENMVQLLGELMNQSHMSCRDMYECSCPE 252
Cdd:PTZ00290  318 --MESCKPL-MTPGE--------FERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPE 386

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1200742298 253 LDQLVD-ICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 302
Cdd:PTZ00290  387 LDFIHElINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKAR 437
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 198-282 1.92e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.10  E-value: 1.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 198 KLYQRAKHVYSEAARVLQfkkiceeapENMVQLLGELMNQSHMSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 277
Cdd:PTZ00298  218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                  ....*
gi 1200742298 278 CTVSM 282
Cdd:PTZ00298  288 LVVAL 292
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 33-278 2.14e-10

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 60.24  E-value: 2.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298  33 LGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLaeEGtakLIEF-SPLRATDVKLPSGAVFVIANSCVemnKAATSHf 111
Cdd:COG1577   114 YGVELSKEELFKLALEAEKIVHGNPSGLDTAASTY--GG---PIYYqRGDRAEPLELPKNLPLVVGDTGV---PASTKE- 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 112 nirvmecrLAAKLLAKYKSlqwdkvlrleevqaklgisleemllvtedalHPEPYNPeeicrclgisleelrtqilspnt 191
Cdd:COG1577   185 --------LVAKVRKLKER-------------------------------NPELYEA----------------------- 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 192 qdvlifkLYQRAKHVYSEAARVLQfkkiceeapENMVQLLGELMNQSHmscRDMYE--CSCPELDQLVDICRKFGAQGSR 269
Cdd:COG1577   203 -------FLEEIGDLVEEAIEALE---------EGDLEALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAK 263


                  ....*....
gi 1200742298 270 LTGAGWGGC 278
Cdd:COG1577   264 LTGAGGGGC 272
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 228-280 3.18e-09

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 56.92  E-value: 3.18e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1200742298 228 VQLLGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTV 280
Cdd:TIGR00549 220 VESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
PRK03926 PRK03926
mevalonate kinase; Provisional
 231-287 1.02e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 55.44  E-value: 1.02e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1200742298 231 LGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADK 287
Cdd:PRK03926  216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 221-301 2.76e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 50.55  E-value: 2.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 221 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSMVP-ADKLPSFLANVHK 297
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 1200742298 298 AYYQ 301
Cdd:pfam08544  82 AGKK 85
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 201-310 6.25e-06

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 47.10  E-value: 6.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200742298 201 QRAKHVYSEAARVLQFKKICEEApENMVQLL--------GELMNQSHMSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 271
Cdd:COG2605   205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1200742298 272 GAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDGSLAPE 310
Cdd:COG2605   284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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