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Conserved domains on  [gi|1198817809|ref|NP_001338719|]
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caspase recruitment domain-containing protein 8 isoform i [Homo sapiens]

Protein Classification

FIIND domain-containing protein( domain architecture ID 10611523)

FIIND domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FIIND pfam13553
Function to find; The function to find (FIIND) was initially discovered in two proteins, NLRP1 ...
 103-306 2.84e-112

Function to find; The function to find (FIIND) was initially discovered in two proteins, NLRP1 (aka NALP1, CARD7, NAC, DEFCAP) and CARD8 (aka TUCAN, Cardinal). NLRP1 is a member of the Nod-like receptor (NLR) protein superfamily and is involved in apoptosis and inflammation. To date, it is the only NLR protein known to have a FIIND domain. The FIIND domain is also present in the CARD8 protein where, like in NLRP1, it is followed by a C-terminal CARD domain. Both proteins are described to form an "inflammasome", a macro-molecular complex able to process caspase 1 and activate pro-IL1beta. The FIIND domain is present in only a very small subset of the kingdom of life, comprising primates, rodents (mouse, rat), carnivores (dog) and a few more, such as horse. The function of this domain is yet to be determined. Publications describing the newly discovered NLRP1 protein failed to identify it as a separate domain; for example, it was taken as part of the adjacent leucine rich repeat domain (LRR). Upon discovery of CARD8 it was noted that the N-terminal region shared significant sequence identity with an undescribed region in NLRP1. Before getting its final name, FIIND, this domain was termed NALP1-associated domain (NAD).


:

Pssm-ID: 463919  Cd Length: 252  Bit Score: 325.38  E-value: 2.84e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198817809 103 FPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLalDLQHHEQWLVGGPLFDVTAEPEeAVAEIHLPHFISLQAGEVDV 182
Cdd:pfam13553   3 LPGAGSYQCSVTGLVFVVRRAVTIEYEFLSWSQFL--DLLPPQHWMVAGPLFDIKAEPG-AVTAIHLPHFICLQAGHVDT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198817809 183 SWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIaSGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALL 262
Cdd:pfam13553  80 SLFQVAHFKDEGMLLEPPARVEPSHVVLEVPSFSPVGVLLRI-HATSPPIPIHGVVLLYYHLHPEDVTFHLYLIPNDCSI 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1198817809 263 TKAIDDEEDR-FHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPK 306
Cdd:pfam13553 159 IKAIDDEEKKsFQFVRIDKPPPCQSLYFGSRYRLSSSPELEITPK 203
 
Name Accession Description Interval E-value
FIIND pfam13553
Function to find; The function to find (FIIND) was initially discovered in two proteins, NLRP1 ...
 103-306 2.84e-112

Function to find; The function to find (FIIND) was initially discovered in two proteins, NLRP1 (aka NALP1, CARD7, NAC, DEFCAP) and CARD8 (aka TUCAN, Cardinal). NLRP1 is a member of the Nod-like receptor (NLR) protein superfamily and is involved in apoptosis and inflammation. To date, it is the only NLR protein known to have a FIIND domain. The FIIND domain is also present in the CARD8 protein where, like in NLRP1, it is followed by a C-terminal CARD domain. Both proteins are described to form an "inflammasome", a macro-molecular complex able to process caspase 1 and activate pro-IL1beta. The FIIND domain is present in only a very small subset of the kingdom of life, comprising primates, rodents (mouse, rat), carnivores (dog) and a few more, such as horse. The function of this domain is yet to be determined. Publications describing the newly discovered NLRP1 protein failed to identify it as a separate domain; for example, it was taken as part of the adjacent leucine rich repeat domain (LRR). Upon discovery of CARD8 it was noted that the N-terminal region shared significant sequence identity with an undescribed region in NLRP1. Before getting its final name, FIIND, this domain was termed NALP1-associated domain (NAD).


Pssm-ID: 463919  Cd Length: 252  Bit Score: 325.38  E-value: 2.84e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198817809 103 FPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLalDLQHHEQWLVGGPLFDVTAEPEeAVAEIHLPHFISLQAGEVDV 182
Cdd:pfam13553   3 LPGAGSYQCSVTGLVFVVRRAVTIEYEFLSWSQFL--DLLPPQHWMVAGPLFDIKAEPG-AVTAIHLPHFICLQAGHVDT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198817809 183 SWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIaSGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALL 262
Cdd:pfam13553  80 SLFQVAHFKDEGMLLEPPARVEPSHVVLEVPSFSPVGVLLRI-HATSPPIPIHGVVLLYYHLHPEDVTFHLYLIPNDCSI 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1198817809 263 TKAIDDEEDR-FHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPK 306
Cdd:pfam13553 159 IKAIDDEEKKsFQFVRIDKPPPCQSLYFGSRYRLSSSPELEITPK 203
 
Name Accession Description Interval E-value
FIIND pfam13553
Function to find; The function to find (FIIND) was initially discovered in two proteins, NLRP1 ...
 103-306 2.84e-112

Function to find; The function to find (FIIND) was initially discovered in two proteins, NLRP1 (aka NALP1, CARD7, NAC, DEFCAP) and CARD8 (aka TUCAN, Cardinal). NLRP1 is a member of the Nod-like receptor (NLR) protein superfamily and is involved in apoptosis and inflammation. To date, it is the only NLR protein known to have a FIIND domain. The FIIND domain is also present in the CARD8 protein where, like in NLRP1, it is followed by a C-terminal CARD domain. Both proteins are described to form an "inflammasome", a macro-molecular complex able to process caspase 1 and activate pro-IL1beta. The FIIND domain is present in only a very small subset of the kingdom of life, comprising primates, rodents (mouse, rat), carnivores (dog) and a few more, such as horse. The function of this domain is yet to be determined. Publications describing the newly discovered NLRP1 protein failed to identify it as a separate domain; for example, it was taken as part of the adjacent leucine rich repeat domain (LRR). Upon discovery of CARD8 it was noted that the N-terminal region shared significant sequence identity with an undescribed region in NLRP1. Before getting its final name, FIIND, this domain was termed NALP1-associated domain (NAD).


Pssm-ID: 463919  Cd Length: 252  Bit Score: 325.38  E-value: 2.84e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198817809 103 FPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLalDLQHHEQWLVGGPLFDVTAEPEeAVAEIHLPHFISLQAGEVDV 182
Cdd:pfam13553   3 LPGAGSYQCSVTGLVFVVRRAVTIEYEFLSWSQFL--DLLPPQHWMVAGPLFDIKAEPG-AVTAIHLPHFICLQAGHVDT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1198817809 183 SWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIaSGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALL 262
Cdd:pfam13553  80 SLFQVAHFKDEGMLLEPPARVEPSHVVLEVPSFSPVGVLLRI-HATSPPIPIHGVVLLYYHLHPEDVTFHLYLIPNDCSI 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1198817809 263 TKAIDDEEDR-FHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPK 306
Cdd:pfam13553 159 IKAIDDEEKKsFQFVRIDKPPPCQSLYFGSRYRLSSSPELEITPK 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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