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Conserved domains on  [gi|1194445944|ref|NP_001338601|]
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zinc finger protein 100 isoform 5 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
44-311 1.18e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944  44 KPYKCEECGKAFNRSSHLTTHKIIHTGEKPYRC--EECGKAFNRSSHLTTHKRIHTGVKPYKCT-ECGKAFNRSSHLTTH 120
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 121 RIIHTGEKPYKCEECGKAFNQSSTLT--THKITHAGEKPYK---------------------CEECGKAFYRFSYLTKHK 177
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 178 TSHTGEKFYKCEECGK------------GFNWSSALTKHKRIHTGEKPYKCE---------------ECGKAFNESSNLT 230
Cdd:COG5048   192 VSTSIPSSSENSPLSSsysipssssdqnLENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 231 THKMIHTGE-------KPYKCDECGKAFNRSSQLTAHK--MIHTGE--KPYKCEE--CGKAFNRSSTLTKHKITHTG--E 295
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSisP 351

                         330
                  ....*....|....*.
gi 1194445944 296 KSYKWEECGKDFNQSL 311
Cdd:COG5048   352 AKEKLLNSSSKFSPLL 367
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
44-311 1.18e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944  44 KPYKCEECGKAFNRSSHLTTHKIIHTGEKPYRC--EECGKAFNRSSHLTTHKRIHTGVKPYKCT-ECGKAFNRSSHLTTH 120
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 121 RIIHTGEKPYKCEECGKAFNQSSTLT--THKITHAGEKPYK---------------------CEECGKAFYRFSYLTKHK 177
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 178 TSHTGEKFYKCEECGK------------GFNWSSALTKHKRIHTGEKPYKCE---------------ECGKAFNESSNLT 230
Cdd:COG5048   192 VSTSIPSSSENSPLSSsysipssssdqnLENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 231 THKMIHTGE-------KPYKCDECGKAFNRSSQLTAHK--MIHTGE--KPYKCEE--CGKAFNRSSTLTKHKITHTG--E 295
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSisP 351

                         330
                  ....*....|....*.
gi 1194445944 296 KSYKWEECGKDFNQSL 311
Cdd:COG5048   352 AKEKLLNSSSKFSPLL 367
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-224 5.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 5.87e-04
                          10        20
                  ....*....|....*....|....*
gi 1194445944 200 ALTKHKRIHTGEKPYKCEECGKAFN 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
44-311 1.18e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944  44 KPYKCEECGKAFNRSSHLTTHKIIHTGEKPYRC--EECGKAFNRSSHLTTHKRIHTGVKPYKCT-ECGKAFNRSSHLTTH 120
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 121 RIIHTGEKPYKCEECGKAFNQSSTLT--THKITHAGEKPYK---------------------CEECGKAFYRFSYLTKHK 177
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 178 TSHTGEKFYKCEECGK------------GFNWSSALTKHKRIHTGEKPYKCE---------------ECGKAFNESSNLT 230
Cdd:COG5048   192 VSTSIPSSSENSPLSSsysipssssdqnLENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 231 THKMIHTGE-------KPYKCDECGKAFNRSSQLTAHK--MIHTGE--KPYKCEE--CGKAFNRSSTLTKHKITHTG--E 295
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSisP 351

                         330
                  ....*....|....*.
gi 1194445944 296 KSYKWEECGKDFNQSL 311
Cdd:COG5048   352 AKEKLLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
44-181 3.87e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944  44 KPYKCEECGKAFNRSSHLTTHK--IIHTGE--KPYRCEE--CGKAFNRSSHLTTHKRIHTGVKPYKC--TECGKAFNRSS 115
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1194445944 116 H-----LTTHRIIHTGEKPYKCE--ECGKAFNQSSTLTTHKITHAGEKP--YKCEECGKAFYRFSYLTKHKTSHT 181
Cdd:COG5048   368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
55-289 2.60e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 2.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944  55 FNRSSHLTTHKIIHTGEKPYRCEECG--KAFNRSSHLTTHKRIHTG-VKPYKCTECGKAFNRSSHLTTHR--IIHTGE-- 127
Cdd:COG5048   240 LLSQSPSSLSSSDSSSSASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEsl 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 128 KPYKCEE--CGKAFNQSSTLTTHKITHAGEKPYKCeecgkafyrfsyltkhKTSHTGEKFYKCEEcgkgfNWSSALTKHK 205
Cdd:COG5048   320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE----------------KLLNSSSKFSPLLN-----NEPPQSLQQY 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 206 RIHTGEKPYKCE--ECGKAFNESSNLTTHKMIHTGEKP--YKCDECGKAFNRSSQLTAHKMIHTGEKPYKCEECGKAFNR 281
Cdd:COG5048   379 KDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458


                  ....*...
gi 1194445944 282 SSTLTKHK 289
Cdd:COG5048   459 LDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-293 1.46e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 156 KPYKCEECGKAFYRFSYLTKHK--TSHTGEKFYKCEE----CGKGFNWSSALTKHKRIHTGEKPYKC--EECGKAFNESS 227
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1194445944 228 NLTTHKMIH-----TGEKPYKCD--ECGKAFNRSSQLTAHKMIHTGEKP--YKCEECGKAFNRSSTLTKHKITHT 293
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
240-321 9.79e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 9.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 240 KPYKCDECGKAFNRSSQLTAHKMIHTGEKPYKC--EECGKAFNRSSTLTKHKITHTGEKSYKWEECGKDFNQSLSLIKQN 317
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111


                  ....
gi 1194445944 318 NSYW 321
Cdd:COG5048   112 SSSS 115
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 154-233 3.83e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 154 GEKPYKCE--ECGKAFyrfsyltkhkTSHTGEKFYKCE-ECGKGFNWSSALTKHKRIHTGEKPYKCEECGKAFNESSNLT 230
Cdd:COG5189   346 DGKPYKCPveGCNKKY----------KNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1194445944 231 THK 233
Cdd:COG5189   416 YHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 210-293 4.78e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 4.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944 210 GEKPYKCE--ECGKAFNESSNLTTHKmihtgekpyKCDECGKAFNRSSQLTAHKMIHTGEKPYKCEECGKAFNRSSTLtK 287
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                  ....*.
gi 1194445944 288 HKITHT 293
Cdd:COG5189   416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-224 5.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 5.87e-04
                          10        20
                  ....*....|....*....|....*
gi 1194445944 200 ALTKHKRIHTGEKPYKCEECGKAFN 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-253 8.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 8.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 1194445944 228 NLTTHKMIHTGEKPYKCDECGKAFNR 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
88-113 8.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 8.69e-04
                          10        20
                  ....*....|....*....|....*.
gi 1194445944  88 HLTTHKRIHTGVKPYKCTECGKAFNR 113
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
33-57 1.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|....*
gi 1194445944  33 LTTHRRIHTGEKPYKCEECGKAFNR 57
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 126-181 1.29e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1194445944 126 GEKPYKCE--ECGKAFNQSSTLTTHK-------ITH------------AGEKPYKCEECGKAFYRFSYLTKHKTSHT 181
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 70-152 1.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944  70 GEKPYRCE--ECGKAFNRSSHLTTHKrihtgvkpyKCTECGKAFNRSSHLTTHRIIHTGEKPYKCEECGKAFNQSSTLTT 147
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 1194445944 148 HkITH 152
Cdd:COG5189   417 H-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 34-93 1.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445944  34 TTHRRIHT-GEKPYKCE--ECGKAFNRSSHLTTHK-------------------IIHTGEKPYRCEECGKAFNRSSHLTT 91
Cdd:COG5189   337 TPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1194445944  92 HK 93
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
60-85 1.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 1194445944  60 HLTTHKIIHTGEKPYRCEECGKAFNR 85
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
116-141 2.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 1194445944 116 HLTTHRIIHTGEKPYKCEECGKAFNQ 141
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-281 5.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.67e-03
                          10        20
                  ....*....|....*....|....*
gi 1194445944 257 LTAHKMIHTGEKPYKCEECGKAFNR 281
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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