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Conserved domains on  [gi|1194445927|ref|NP_001338598|]
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zinc finger protein 100 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
35-95 3.23e-33

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 3.23e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1194445927   35 LTFRDVAIEFSLEEWQCLDSAQQGLYRKVMLENYRNLVFLGIALTKPDLITCLEQGKEPWN 95
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-525 6.58e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 258 KPYKCEECGKAFNRSSHLTTHKIIHTGEKPYRC--EECGKAFNRSSHLTTHKRIHTGVKPYKCT-ECGKAFNRSSHLTTH 334
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 335 RIIHTGEKPYKCEECGKAFNQSSTLT--THKITHAGEKPYK---------------------CEECGKAFYRFSYLTKHK 391
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 392 TSHTGEKFYKCEECGK------------GFNWSSALTKHKRIHTGEKPYKCE---------------ECGKAFNESSNLT 444
Cdd:COG5048   192 VSTSIPSSSENSPLSSsysipssssdqnLENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 445 THKMIHTGE-------KPYKCDECGKAFNRSSQLTAHK--MIHTGE--KPYKCEE--CGKAFNRSSTLTKHKITHTG--E 509
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSisP 351

                         330
                  ....*....|....*.
gi 1194445927 510 KSYKWEECGKDFNQSL 525
Cdd:COG5048   352 AKEKLLNSSSKFSPLL 367
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
35-95 3.23e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 3.23e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1194445927   35 LTFRDVAIEFSLEEWQCLDSAQQGLYRKVMLENYRNLVFLGIALTKPDLITCLEQGKEPWN 95
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-75 7.58e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 7.58e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1194445927  34 PLTFRDVAIEFSLEEWQCLDSAQQGLYRKVMLENYRNLVFLG 75
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-74 8.35e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.35e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1194445927  35 LTFRDVAIEFSLEEWQCLDSAQQGLYRKVMLENYRNLVFL 74
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-525 6.58e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 258 KPYKCEECGKAFNRSSHLTTHKIIHTGEKPYRC--EECGKAFNRSSHLTTHKRIHTGVKPYKCT-ECGKAFNRSSHLTTH 334
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 335 RIIHTGEKPYKCEECGKAFNQSSTLT--THKITHAGEKPYK---------------------CEECGKAFYRFSYLTKHK 391
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 392 TSHTGEKFYKCEECGK------------GFNWSSALTKHKRIHTGEKPYKCE---------------ECGKAFNESSNLT 444
Cdd:COG5048   192 VSTSIPSSSENSPLSSsysipssssdqnLENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 445 THKMIHTGE-------KPYKCDECGKAFNRSSQLTAHK--MIHTGE--KPYKCEE--CGKAFNRSSTLTKHKITHTG--E 509
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSisP 351

                         330
                  ....*....|....*.
gi 1194445927 510 KSYKWEECGKDFNQSL 525
Cdd:COG5048   352 AKEKLLNSSSKFSPLL 367
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-438 1.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.67e-04
                          10        20
                  ....*....|....*....|....*
gi 1194445927 414 ALTKHKRIHTGEKPYKCEECGKAFN 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
35-95 3.23e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 3.23e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1194445927   35 LTFRDVAIEFSLEEWQCLDSAQQGLYRKVMLENYRNLVFLGIALTKPDLITCLEQGKEPWN 95
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-75 7.58e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 7.58e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1194445927  34 PLTFRDVAIEFSLEEWQCLDSAQQGLYRKVMLENYRNLVFLG 75
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-74 8.35e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.35e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1194445927  35 LTFRDVAIEFSLEEWQCLDSAQQGLYRKVMLENYRNLVFL 74
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-525 6.58e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 258 KPYKCEECGKAFNRSSHLTTHKIIHTGEKPYRC--EECGKAFNRSSHLTTHKRIHTGVKPYKCT-ECGKAFNRSSHLTTH 334
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 335 RIIHTGEKPYKCEECGKAFNQSSTLT--THKITHAGEKPYK---------------------CEECGKAFYRFSYLTKHK 391
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 392 TSHTGEKFYKCEECGK------------GFNWSSALTKHKRIHTGEKPYKCE---------------ECGKAFNESSNLT 444
Cdd:COG5048   192 VSTSIPSSSENSPLSSsysipssssdqnLENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 445 THKMIHTGE-------KPYKCDECGKAFNRSSQLTAHK--MIHTGE--KPYKCEE--CGKAFNRSSTLTKHKITHTG--E 509
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSisP 351

                         330
                  ....*....|....*.
gi 1194445927 510 KSYKWEECGKDFNQSL 525
Cdd:COG5048   352 AKEKLLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-533 5.58e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 5.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 149 KSVDECKVHKEHDNKLNQCLITTQSNIFQCDPSAKVFHTFSNSNRHKIRHTRKKPFKC--KKCEKSFCMLLHLTQHKRFH 226
Cdd:COG5048     7 QSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 227 ITENSY-QCKDCGKAFNWFSTLTTHRRIHTGEKPYKCEECGKAF--NRSSHLTTHKIIHTGEKP----YRCEECGKAFNR 299
Cdd:COG5048    87 HNNPSDlNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPssRDPQLPDLLSISNLRNNPlpgnNSSSVNTPQSNS 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 300 SSH----------------LTTHKRIHTGVKPYKCTECGKAFNRSSHLTTHRIIHTGEKPYKCEECGKAF-------NQS 356
Cdd:COG5048   167 LHPplpanslskdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPS 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 357 STLTTHKITHAGEKPYKCeECGKAFYRFSYLTKHKTSHTG-EKFYKCEECGKGFNWSSALTKHKR--IHTGE--KPYKCE 431
Cdd:COG5048   247 SLSSSDSSSSASESPRSS-LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCP 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 432 E--CGKAFNESSNLTTHKMIHTGEKPYKCDEC-------GKAFNRSSQLTAHKMIHTGEKPYKCE--ECGKAFNRSSTLT 500
Cdd:COG5048   326 YslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1194445927 501 KHKITHTGEKS--YKWEECGKDFNQSLSLIKQNNS 533
Cdd:COG5048   406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKI 440
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-395 7.25e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 7.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 258 KPYKCEECGKAFNRSSHLTTHK--IIHTGE--KPYRCEE--CGKAFNRSSHLTTHKRIHTGVKPYKC--TECGKAFNRSS 329
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1194445927 330 H-----LTTHRIIHTGEKPYKCE--ECGKAFNQSSTLTTHKITHAGEKP--YKCEECGKAFYRFSYLTKHKTSHT 395
Cdd:COG5048   368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-503 3.26e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 269 FNRSSHLTTHKIIHTGEKPYRCEECG--KAFNRSSHLTTHKRIHTG-VKPYKCTECGKAFNRSSHLTTHR--IIHTGE-- 341
Cdd:COG5048   240 LLSQSPSSLSSSDSSSSASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEsl 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 342 KPYKCEE--CGKAFNQSSTLTTHKITHAGEKPYKCeecgkafyrfsyltkhKTSHTGEKFYKCEEcgkgfNWSSALTKHK 419
Cdd:COG5048   320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE----------------KLLNSSSKFSPLLN-----NEPPQSLQQY 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 420 RIHTGEKPYKCE--ECGKAFNESSNLTTHKMIHTGEKP--YKCDECGKAFNRSSQLTAHKMIHTGEKPYKCEECGKAFNR 495
Cdd:COG5048   379 KDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458


                  ....*...
gi 1194445927 496 SSTLTKHK 503
Cdd:COG5048   459 LDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
454-535 5.23e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 454 KPYKCDECGKAFNRSSQLTAHKMIHTGEKPYKC--EECGKAFNRSSTLTKHKITHTGEKSYKWEECGKDFNQSLSLIKQN 531
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111


                  ....
gi 1194445927 532 NSYW 535
Cdd:COG5048   112 SSSS 115
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-438 1.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.67e-04
                          10        20
                  ....*....|....*....|....*
gi 1194445927 414 ALTKHKRIHTGEKPYKCEECGKAFN 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
442-467 2.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 1194445927 442 NLTTHKMIHTGEKPYKCDECGKAFNR 467
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
302-327 2.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.54e-04
                          10        20
                  ....*....|....*....|....*.
gi 1194445927 302 HLTTHKRIHTGVKPYKCTECGKAFNR 327
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-271 3.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.69e-04
                          10        20
                  ....*....|....*....|....*
gi 1194445927 247 LTTHRRIHTGEKPYKCEECGKAFNR 271
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 368-447 3.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 368 GEKPYKCE--ECGKAFyrfsyltkhkTSHTGEKFYKCE-ECGKGFNWSSALTKHKRIHTGEKPYKCEECGKAFNESSNLT 444
Cdd:COG5189   346 DGKPYKCPveGCNKKY----------KNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1194445927 445 THK 447
Cdd:COG5189   416 YHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 424-507 4.75e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 424 GEKPYKCE--ECGKAFNESSNLTTHKmihtgekpyKCDECGKAFNRSSQLTAHKMIHTGEKPYKCEECGKAFNRSSTLtK 501
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                  ....*.
gi 1194445927 502 HKITHT 507
Cdd:COG5189   416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-299 5.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.80e-04
                          10        20
                  ....*....|....*....|....*.
gi 1194445927 274 HLTTHKIIHTGEKPYRCEECGKAFNR 299
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-355 7.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 1194445927 330 HLTTHRIIHTGEKPYKCEECGKAFNQ 355
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 340-395 1.23e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1194445927 340 GEKPYKCE--ECGKAFNQSSTLTTHK-------ITH------------AGEKPYKCEECGKAFYRFSYLTKHKTSHT 395
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 284-366 1.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 284 GEKPYRCE--ECGKAFNRSSHLTTHKrihtgvkpyKCTECGKAFNRSSHLTTHRIIHTGEKPYKCEECGKAFNQSSTLTT 361
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 1194445927 362 HkITH 366
Cdd:COG5189   417 H-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 248-307 1.36e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194445927 248 TTHRRIHT-GEKPYKCE--ECGKAFNRSSHLTTHK-------------------IIHTGEKPYRCEECGKAFNRSSHLTT 305
Cdd:COG5189   337 TPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1194445927 306 HK 307
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
471-495 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*
gi 1194445927 471 LTAHKMIHTGEKPYKCEECGKAFNR 495
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 288-310 4.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.37e-03
                          10        20
                  ....*....|....*....|...
gi 1194445927 288 YRCEECGKAFNRSSHLTTHKRIH 310
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 316-338 7.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.87e-03
                          10        20
                  ....*....|....*....|...
gi 1194445927 316 YKCTECGKAFNRSSHLTTHRIIH 338
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 484-506 9.39e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.39e-03
                          10        20
                  ....*....|....*....|...
gi 1194445927 484 YKCEECGKAFNRSSTLTKHKITH 506
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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