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Conserved domains on  [gi|1189398067|ref|NP_001338093|]
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ubiquitin carboxyl-terminal hydrolase 15 isoform 8 [Homo sapiens]

Protein Classification

ubiquitin carboxyl-terminal hydrolase( domain architecture ID 1000871)

ubiquitin carboxyl-terminal hydrolase is a C19 family peptidase that deubiquitinates polyubiquitinated target proteins

CATH:  3.90.70.10
EC:  3.4.19.12
Gene Ontology:  GO:0016579|GO:0046872|GO:0003723

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UBP12 super family cl35019
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
1-599 8.17e-111

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5560:

Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 352.26  E-value: 8.17e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067   1 MRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQ---LKDA 77
Cdd:COG5560   311 MHGSVASAYADLIKQLYDGNLHAFTPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGLHEDLNRIIKKPYTSkpdLSPG 390
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  78 DGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPM 157
Cdd:COG5560   391 DDVVVKKKAKECWWEHLKRNDSIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLPLPVSMVWKHTIVVFPESGRRQPL 470
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 158 QYKVVV-PKIGNILDLCTALSALSGIpaDKMIVTDIYNHRFHRIF--AMDENLSSIMERDDIYVFEININrtedteHVII 234
Cdd:COG5560   471 KIELDAsSTIRGLKKLVDAEYGKLGC--FEIKVMCIYYGGNYNMLepADKVLLQDIPQTDFVYLYETNDN------GIEV 542
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 235 PVclrekFRHSSYTHHTGSSLFGQPFLM--AVPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCckdqNINGNGPN 312
Cdd:COG5560   543 PV-----VHLRIEKGYKSKRLFGDPFLQlnVLIKASIYDKLVKEFEELLVLVEMKKTDVDLVSEQVRL----LREESSPS 613
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 313 GIHeegsPSEMETDEPDDESSQDQELPSENENsqsedsvggdndsenglcTEDTCkgqLTGHKKRLFTFQFNNLGNtdin 392
Cdd:COG5560   614 SWL----KLETEIDTKREEQVEEEGQMNFNDA------------------VVISC---EWEEKRYLSLFSYDPLWT---- 664
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 393 yikddtrhirfdDRQLRLDERSflaldwdpdlkkryfdenaaedfekhesveykppkkpfVKLKDCIELFTTKEKLGAED 472
Cdd:COG5560   665 ------------IREIGAAERT--------------------------------------ITLQDCLNEFSKPEQLGLSD 694
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 473 PWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYG 552
Cdd:COG5560   695 SWYCPGCKEFRQASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPIDDLDLSGVEYMVDDPRLIYDLYAVDNHYG 774
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 1189398067 553 GMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQR 599
Cdd:COG5560   775 GLSGGHYTAYARNFANNGWYLFDDSRITEVDPEDSVTSSAYVLFYRR 821
 
Name Accession Description Interval E-value
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
1-599 8.17e-111

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 352.26  E-value: 8.17e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067   1 MRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQ---LKDA 77
Cdd:COG5560   311 MHGSVASAYADLIKQLYDGNLHAFTPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGLHEDLNRIIKKPYTSkpdLSPG 390
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  78 DGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPM 157
Cdd:COG5560   391 DDVVVKKKAKECWWEHLKRNDSIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLPLPVSMVWKHTIVVFPESGRRQPL 470
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 158 QYKVVV-PKIGNILDLCTALSALSGIpaDKMIVTDIYNHRFHRIF--AMDENLSSIMERDDIYVFEININrtedteHVII 234
Cdd:COG5560   471 KIELDAsSTIRGLKKLVDAEYGKLGC--FEIKVMCIYYGGNYNMLepADKVLLQDIPQTDFVYLYETNDN------GIEV 542
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 235 PVclrekFRHSSYTHHTGSSLFGQPFLM--AVPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCckdqNINGNGPN 312
Cdd:COG5560   543 PV-----VHLRIEKGYKSKRLFGDPFLQlnVLIKASIYDKLVKEFEELLVLVEMKKTDVDLVSEQVRL----LREESSPS 613
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 313 GIHeegsPSEMETDEPDDESSQDQELPSENENsqsedsvggdndsenglcTEDTCkgqLTGHKKRLFTFQFNNLGNtdin 392
Cdd:COG5560   614 SWL----KLETEIDTKREEQVEEEGQMNFNDA------------------VVISC---EWEEKRYLSLFSYDPLWT---- 664
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 393 yikddtrhirfdDRQLRLDERSflaldwdpdlkkryfdenaaedfekhesveykppkkpfVKLKDCIELFTTKEKLGAED 472
Cdd:COG5560   665 ------------IREIGAAERT--------------------------------------ITLQDCLNEFSKPEQLGLSD 694
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 473 PWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYG 552
Cdd:COG5560   695 SWYCPGCKEFRQASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPIDDLDLSGVEYMVDDPRLIYDLYAVDNHYG 774
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 1189398067 553 GMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQR 599
Cdd:COG5560   775 GLSGGHYTAYARNFANNGWYLFDDSRITEVDPEDSVTSSAYVLFYRR 821
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
451-598 4.15e-61

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 203.29  E-value: 4.15e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 451 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSE 530
Cdd:cd02674    82 PKVTLEDCLRLFTKEETLDGDNAWKCPKCKKKRKATKKLTISRLPKVLIIHLKRFSFSRGSTRKLTTPVTFPLNDLDLTP 161
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1189398067 531 FLINPN-AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQ 598
Cdd:cd02674   162 YVDTRSfTGPFKYDLYAVVNHYGSLNGGHYTAYCKNNETNDWYKFDDSRVTKVSESSVVSSSAYILFYE 230
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
442-597 1.65e-50

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 177.63  E-value: 1.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 442 SVEYKPPKK--PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLV 519
Cdd:pfam00443 149 SLPIPGDSAelKTASLQICFLQFSKLEELDDEEKYYCDKCGCKQDAIKQLKISRLPPVLIIHLKRFSYNRSTWEKLNTEV 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 520 DFPInDLDMSEFLINPNAGP----CRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASED-QIVSKAAYV 594
Cdd:pfam00443 229 EFPL-ELDLSRYLAEELKPKtnnlQDYRLVAVVVHSGSLSSGHYIAYIKAYENNRWYKFDDEKVTEVDEEtAVLSSSAYI 307

                  ...
gi 1189398067 595 LFY 597
Cdd:pfam00443 308 LFY 310
 
Name Accession Description Interval E-value
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
1-599 8.17e-111

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 352.26  E-value: 8.17e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067   1 MRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQ---LKDA 77
Cdd:COG5560   311 MHGSVASAYADLIKQLYDGNLHAFTPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGLHEDLNRIIKKPYTSkpdLSPG 390
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  78 DGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPM 157
Cdd:COG5560   391 DDVVVKKKAKECWWEHLKRNDSIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLPLPVSMVWKHTIVVFPESGRRQPL 470
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 158 QYKVVV-PKIGNILDLCTALSALSGIpaDKMIVTDIYNHRFHRIF--AMDENLSSIMERDDIYVFEININrtedteHVII 234
Cdd:COG5560   471 KIELDAsSTIRGLKKLVDAEYGKLGC--FEIKVMCIYYGGNYNMLepADKVLLQDIPQTDFVYLYETNDN------GIEV 542
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 235 PVclrekFRHSSYTHHTGSSLFGQPFLM--AVPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCckdqNINGNGPN 312
Cdd:COG5560   543 PV-----VHLRIEKGYKSKRLFGDPFLQlnVLIKASIYDKLVKEFEELLVLVEMKKTDVDLVSEQVRL----LREESSPS 613
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 313 GIHeegsPSEMETDEPDDESSQDQELPSENENsqsedsvggdndsenglcTEDTCkgqLTGHKKRLFTFQFNNLGNtdin 392
Cdd:COG5560   614 SWL----KLETEIDTKREEQVEEEGQMNFNDA------------------VVISC---EWEEKRYLSLFSYDPLWT---- 664
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 393 yikddtrhirfdDRQLRLDERSflaldwdpdlkkryfdenaaedfekhesveykppkkpfVKLKDCIELFTTKEKLGAED 472
Cdd:COG5560   665 ------------IREIGAAERT--------------------------------------ITLQDCLNEFSKPEQLGLSD 694
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 473 PWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYG 552
Cdd:COG5560   695 SWYCPGCKEFRQASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPIDDLDLSGVEYMVDDPRLIYDLYAVDNHYG 774
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 1189398067 553 GMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQR 599
Cdd:COG5560   775 GLSGGHYTAYARNFANNGWYLFDDSRITEVDPEDSVTSSAYVLFYRR 821
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
451-598 4.15e-61

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 203.29  E-value: 4.15e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 451 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSE 530
Cdd:cd02674    82 PKVTLEDCLRLFTKEETLDGDNAWKCPKCKKKRKATKKLTISRLPKVLIIHLKRFSFSRGSTRKLTTPVTFPLNDLDLTP 161
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1189398067 531 FLINPN-AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQ 598
Cdd:cd02674   162 YVDTRSfTGPFKYDLYAVVNHYGSLNGGHYTAYCKNNETNDWYKFDDSRVTKVSESSVVSSSAYILFYE 230
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
442-597 1.65e-50

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 177.63  E-value: 1.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 442 SVEYKPPKK--PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLV 519
Cdd:pfam00443 149 SLPIPGDSAelKTASLQICFLQFSKLEELDDEEKYYCDKCGCKQDAIKQLKISRLPPVLIIHLKRFSYNRSTWEKLNTEV 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 520 DFPInDLDMSEFLINPNAGP----CRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASED-QIVSKAAYV 594
Cdd:pfam00443 229 EFPL-ELDLSRYLAEELKPKtnnlQDYRLVAVVVHSGSLSSGHYIAYIKAYENNRWYKFDDEKVTEVDEEtAVLSSSAYI 307

                  ...
gi 1189398067 595 LFY 597
Cdd:pfam00443 308 LFY 310
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
442-598 2.51e-37

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 139.54  E-value: 2.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 442 SVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCpNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMR-DKLDTLVD 520
Cdd:cd02257    88 SLPLPVKGLPQVSLEDCLEKFFKEEILEGDNCYKC-EKKKKQEATKRLKIKKLPPVLIIHLKRFSFNEDGTkEKLNTKVS 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 521 FPINdLDMSEFLI------NPNAGPCRYNLIAVSNHYGGMGGG-HYTAFAKNKDDGKWYYFDDSSVSTASEDQIV----- 588
Cdd:cd02257   167 FPLE-LDLSPYLSegekdsDSDNGSYKYELVAVVVHSGTSADSgHYVAYVKDPSDGKWYKFNDDKVTEVSEEEVLefgsl 245
                         170
                  ....*....|
gi 1189398067 589 SKAAYVLFYQ 598
Cdd:cd02257   246 SSSAYILFYE 255
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
3-147 1.31e-33

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 130.64  E-value: 1.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067   3 GEIAKSYAELIKQMWSG-KFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRirkkpyiqlkdadgrp 81
Cdd:pfam00443  45 INLLCALRDLFKALQKNsKSSSVSPKMFKKSLGKLNPDFSGYKQQDAQEFLLFLLDGLHEDLNG---------------- 108
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1189398067  82 dkvvaeeaweNHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYL 147
Cdd:pfam00443 109 ----------NHSTENESLITDLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPGDSAELKTASL 164
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
455-597 3.31e-33

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 129.32  E-value: 3.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 455 LKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYmrDKLDTLVDFPiNDLDMSEFLIN 534
Cdd:cd02661   164 LEDALEQFTKPEQLDGENKYKCERCKKKVKASKQLTIHRAPNVLTIHLKRFSNFRG--GKINKQISFP-ETLDLSPYMSQ 240
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1189398067 535 PNAGPCRYNLIAVSNHYGGMGGG-HYTAFAKNkDDGKWYYFDDSSVSTASEDQIVSKAAYVLFY 597
Cdd:cd02661   241 PNDGPLKYKLYAVLVHSGFSPHSgHYYCYVKS-SNGKWYNMDDSKVSPVSIETVLSQKAYILFY 303
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
454-597 5.96e-32

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 126.33  E-value: 5.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 454 KLKDCIELFTTKEKLGaEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY-MRDKLDTLVDFPInDLDMSEFL 532
Cdd:cd02660   177 TLSDCLDRFTRPEKLG-DFAYKCSGCGSTQEATKQLSIKKLPPVLCFQLKRFEHSLNkTSRKIDTYVQFPL-ELNMTPYT 254
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1189398067 533 I---------NPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDgKWYYFDDSSVSTASEDQIVSKAAYVLFY 597
Cdd:cd02660   255 SssigdtqdsNSLDPDYTYDLFAVVVHKGTLDTGHYTAYCRQGDG-QWFKFDDAMITRVSEEEVLKSQAYLLFY 327
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
450-597 7.89e-23

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 99.80  E-value: 7.89e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 450 KPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYM--RDKLDTLVDFPiNDLD 527
Cdd:cd02668   153 KGHKTLEECIDEFLKEEQLTGDNQYFCESCNSKTDATRRIRLTTLPPTLNFQLLRFVFDRKTgaKKKLNASISFP-EILD 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 528 MSEFLINPNAGPCRYNLIAVSNHY-GGMGGGHYTAFAKNKDDGKWYYFDDSSVS--------------TASEDQ------ 586
Cdd:cd02668   232 MGEYLAESDEGSYVYELSGVLIHQgVSAYSGHYIAHIKDEQTGEWYKFNDEDVEempgkplklgnsedPAKPRKseikkg 311
                         170
                  ....*....|..
gi 1189398067 587 -IVSKAAYVLFY 597
Cdd:cd02668   312 tHSSRTAYMLVY 323
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
446-598 7.45e-22

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 95.92  E-value: 7.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 446 KPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCkehQQATKKLDLWSLPPVLVVHLKRFSYSRYMRD-KLDTLVDFPiN 524
Cdd:cd02667   104 SDEIKSECSIESCLKQFTEVEILEGNNKFACENC---TKAKKQYLISKLPPVLVIHLKRFQQPRSANLrKVSRHVSFP-E 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 525 DLDMSEFLiNPNAGPC------RYNLIAVSNHYGGMGGGHYTAFAK---------------------NKDDGKWYYFDDS 577
Cdd:cd02667   180 ILDLAPFC-DPKCNSSedkssvLYRLYGVVEHSGTMRSGHYVAYVKvrppqqrlsdltkskpaadeaGPGSGQWYYISDS 258
                         170       180
                  ....*....|....*....|.
gi 1189398067 578 SVSTASEDQIVSKAAYVLFYQ 598
Cdd:cd02667   259 DVREVSLEEVLKSEAYLLFYE 279
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
450-602 1.09e-21

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 96.56  E-value: 1.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 450 KPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYS--RYMRDKLDTLVDFPInDLD 527
Cdd:cd02659   148 KGKKNLEESLDAYVQGETLEGDNKYFCEKCGKKVDAEKGVCFKKLPPVLTLQLKRFEFDfeTMMRIKINDRFEFPL-ELD 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 528 MSEFLINPNA-----------GPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSK------ 590
Cdd:cd02659   227 MEPYTEKGLAkkegdsekkdsESYIYELHGVLVHSGDAHGGHYYSYIKDRDDGKWYKFNDDVVTPFDPNDAEEEcfggee 306
                         170       180
                  ....*....|....*....|....*...
gi 1189398067 591 ----------------AAYVLFYQRQDT 602
Cdd:cd02659   307 tqktydsgprafkrttNAYMLFYERKSP 334
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
44-147 1.93e-16

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 78.87  E-value: 1.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  44 QQQDCQELLAFLLDGLHedlnrirkkpyiqlkdadgrpdkvvaeeawenhlkrndSIIVDIFHGLFKSTLVCPECAKISV 123
Cdd:cd02674    21 DQQDAQEFLLFLLDGLH--------------------------------------SIIVDLFQGQLKSRLTCLTCGKTST 62
                          90       100
                  ....*....|....*....|....
gi 1189398067 124 TFDPFCYLTLPLPMKKERTLEVYL 147
Cdd:cd02674    63 TFEPFTYLSLPIPSGSGDAPKVTL 86
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
43-146 7.86e-16

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 77.91  E-value: 7.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  43 YQQQDCQELLAFLLDGLHEDLNRIRKKpyiqlkdadgrpdkvvaeeawENHLKRNDSIIVDIFHGLFKSTLVCPECAKIS 122
Cdd:cd02257    20 SEQQDAHEFLLFLLDKLHEELKKSSKR---------------------TSDSSSLKSLIHDLFGGKLESTIVCLECGHES 78
                          90       100
                  ....*....|....*....|....
gi 1189398067 123 VTFDPFCYLTLPLPMKKERTLEVY 146
Cdd:cd02257    79 VSTEPELFLSLPLPVKGLPQVSLE 102
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
455-598 8.92e-16

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 78.51  E-value: 8.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 455 LKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYS-RYMR-DKLDTLVDFPindLDMSEFL 532
Cdd:cd02663   149 ITSCLRQFSATETLCGRNKFYCDECCSLQEAEKRMKIKKLPKILALHLKRFKYDeQLNRyIKLFYRVVFP---LELRLFN 225
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1189398067 533 INPNA-GPCR-YNLIAVSNHY-GGMGGGHYTAFAKNKddGKWYYFDDSSVSTASEDQIV--------SKAAYVLFYQ 598
Cdd:cd02663   226 TTDDAeNPDRlYELVAVVVHIgGGPNHGHYVSIVKSH--GGWLLFDDETVEKIDENAVEeffgdspnQATAYVLFYQ 300
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
435-598 1.15e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 78.13  E-value: 1.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 435 EDFEKHESVEYKPPKKPfVKLKDCIELFTTKEKLgaEDpwYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRD- 513
Cdd:cd02658   161 PKDEATEKEEGELVYEP-VPLEDCLKAYFAPETI--ED--FCSTCKEKTTATKTTGFKTFPDYLVINMKRFQLLENWVPk 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 514 KLDTLVDFPindldmsEFLinpnaGPCRYNLIAVSNHY-GGMGGGHYTAFAKNKDD--GKWYYFDDSSVSTASEDQIVSK 590
Cdd:cd02658   236 KLDVPIDVP-------EEL-----GPGKYELIAFISHKgTSVHSGHYVAHIKKEIDgeGKWVLFNDEKVVASQDPPEMKK 303

                  ....*...
gi 1189398067 591 AAYVLFYQ 598
Cdd:cd02658   304 LGYIYFYQ 311
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
493-597 8.89e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 75.45  E-value: 8.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 493 SLPPVLVVHLKRFSYSRYMRDKLDTL--VDFPINdLDMSEFLinpnAGPCRYNLIAVSNHYGGMGGG-HYTAFAKNKDDG 569
Cdd:cd02657   195 RLPKYLTVQFVRFFWKRDIQKKAKILrkVKFPFE-LDLYELC----TPSGYYELVAVITHQGRSADSgHYVAWVRRKNDG 269
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1189398067 570 KWYYFDDSSVSTASEDQIVSKA-------AYVLFY 597
Cdd:cd02657   270 KWIKFDDDKVSEVTEEDILKLSgggdwhiAYILLY 304
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
25-144 1.73e-11

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 65.10  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  25 TPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLhedlnrirkKPYIqlkdadgrpdkvvaeeawenhlkrnDSiivdI 104
Cdd:cd02667    31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGL---------RTFI-------------------------DS----I 72
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1189398067 105 FHGLFKSTLVCPECAKISVTFDPFCYLTLPL--PMKKERTLE 144
Cdd:cd02667    73 FGGELTSTIMCESCGTVSLVYEPFLDLSLPRsdEIKSECSIE 114
Peptidase_C19M cd02669
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
447-598 2.91e-11

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239134 [Multi-domain]  Cd Length: 440  Bit Score: 65.80  E-value: 2.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 447 PPKKPF--VKLKDCIELFTTKEKLGAEDPwycPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPIN 524
Cdd:cd02669   286 PPPPLFkdGNEENIIPQVPLKQLLKKYDG---KTETELKDSLKRYLISRLPKYLIFHIKRFSKNNFFKEKNPTIVNFPIK 362
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1189398067 525 DLDMSEFLINPNAGPCR---YNLIA-VSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQ 598
Cdd:cd02669   363 NLDLSDYVHFDKPSLNLstkYNLVAnIVHEGTPQEDGTWRVQLRHKSTNKWFEIQDLNVKEVLPQLIFLSESYIQIWE 440
Peptidase_C19F cd02662
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
455-598 1.58e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239127 [Multi-domain]  Cd Length: 240  Bit Score: 61.61  E-value: 1.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 455 LKDCIELFTTKEKLgaEDPwYCPNCkehQQATKKLdlwslPPVLVVHLKRFSYS-RYMRDKLDTLVDFPindldmsEFLi 533
Cdd:cd02662    98 LEHCLDDFLSTEII--DDY-KCDRC---QTVIVRL-----PQILCIHLSRSVFDgRGTSTKNSCKVSFP-------ERL- 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 534 npnaGPCRYNLIAVSNHYGGMGGGHYTAF--------------------AKNKDDGKWYYFDDSSVSTASEDQIV-SKAA 592
Cdd:cd02662   159 ----PKVLYRLRAVVVHYGSHSSGHYVCYrrkplfskdkepgsfvrmreGPSSTSHPWWRISDTTVKEVSESEVLeQKSA 234

                  ....*.
gi 1189398067 593 YVLFYQ 598
Cdd:cd02662   235 YMLFYE 240
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
435-597 1.72e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 62.99  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 435 EDFEKHESVEYKP-PKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRD 513
Cdd:cd02671   161 ELSKSEESSEISPdPKTEMKTLKWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKLPEVITIHLKCFAANGSEFD 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 514 ------KLDTLVDFPInDLDMSEFLINPNAGpcRYNLIAVSNHY-GGMGGGHYTAFAknkddgKWYYFDDSSVSTASEDQ 586
Cdd:cd02671   241 cygglsKVNTPLLTPL-KLSLEEWSTKPKND--VYRLFAVVMHSgATISSGHYTAYV------RWLLFDDSEVKVTEEKD 311
                         170       180
                  ....*....|....*....|
gi 1189398067 587 IV---------SKAAYVLFY 597
Cdd:cd02671   312 FLealspntssTSTPYLLFY 331
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
37-141 2.86e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 62.00  E-value: 2.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  37 APQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPyiqlkdadgrpdkvvaeeaweNHLKRNDSIIVDIFHGLFKSTLVCP 116
Cdd:cd02660    80 SRNLAGYSQQDAHEFFQFLLDQLHTHYGGDKNEA---------------------NDESHCNCIIHQTFSGSLQSSVTCQ 138
                          90       100
                  ....*....|....*....|....*
gi 1189398067 117 ECAKISVTFDPFCYLTLPLPMKKER 141
Cdd:cd02660   139 RCGGVSTTVDPFLDLSLDIPNKSTP 163
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
476-587 3.59e-10

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 63.35  E-value: 3.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  476 CPNCKEH--QQATKKLDLWSLPPVLVVHLKRFSYS--RYMRDKLDTLVDFPInDLDMSEFLiNPNA-----GPCRYNLIA 546
Cdd:COG5077    358 RYNAEKHglQDAKKGVIFESLPPVLHLQLKRFEYDfeRDMMVKINDRYEFPL-EIDLLPFL-DRDAdksenSDAVYVLYG 435
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1189398067  547 VSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQI 587
Cdd:COG5077    436 VLVHSGDLHEGHYYALLKPEKDGRWYKFDDTRVTRATEKEV 476
Peptidase_C19H cd02664
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
452-598 4.34e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239129 [Multi-domain]  Cd Length: 327  Bit Score: 61.74  E-value: 4.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 452 FVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSR--YMRDKL------DTLVDFPI 523
Cdd:cd02664   133 FPSVQDLLNYFLSPEKLTGDNQYYCEKCASLQDAEKEMKVTGAPEYLILTLLRFSYDQktHVREKImdnvsiNEVLSLPV 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 524 ND-LDMSEFLINPNAGPCR-----------YNLIAV---------SNHY-----------GGMGGGHYTAFAKNKDDGK- 570
Cdd:cd02664   213 RVeSKSSESPLEKKEEESGddgelvtrqvhYRLYAVvvhsgysseSGHYftyardqtdadSTGQECPEPKDAEENDESKn 292
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1189398067 571 WYYFDDSSVS--TASEDQIV-----SKAAYVLFYQ 598
Cdd:cd02664   293 WYLFNDSRVTfsSFESVQNVtsrfpKDTPYILFYE 327
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
13-144 2.79e-08

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 55.74  E-value: 2.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  13 IKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIqlkdadgrpdkvvaeeawEN 92
Cdd:cd02661    54 VERALASSGPGSAPRIFSSNLKQISKHFRIGRQEDAHEFLRYLLDAMQKACLDRFKKLKA------------------VD 115
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1189398067  93 HLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFcyLTLPLPMKKERTLE 144
Cdd:cd02661   116 PSSQETTLVQQIFGGYLRSQVKCLNCKHVSNTYDPF--LDLSLDIKGADSLE 165
USP7_C2 pfam14533
Ubiquitin-specific protease C-terminal; This C-terminal domain on many long ubiquitin-specific ...
127-264 6.47e-06

Ubiquitin-specific protease C-terminal; This C-terminal domain on many long ubiquitin-specific proteases has no known function.


Pssm-ID: 464201  Cd Length: 204  Bit Score: 47.48  E-value: 6.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 127 PFCYLTLPLPMK---KERTLEVYLVrMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIP---ADKMIVTDIYNHRFHRI 200
Cdd:pfam14533   1 ALYYEVLDISLSeleNKKSIKVTWL-SPGLKKEEELELLVPKNGTVADLLEELQKKVKLSeegSGKIRLYEVSNHKIYKE 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1189398067 201 FAMDENLSSIMERDDIYVFEI---NINRTEDTehVIIPVClrekfrHssYtHHTGSSLFGQPFLMAV 264
Cdd:pfam14533  80 LSEDEPIDSLNDYLTLYAEEIpeeELNLDEGE--RLIPVF------H--F-QKEPSRTHGIPFLFVL 135
Peptidase_C19Q cd02673
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
476-597 1.33e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239138 [Multi-domain]  Cd Length: 245  Bit Score: 44.06  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 476 CPNCKeHQQATKKLDLWSLPPVLVVHLKRFsYSRYMrdkldTLVDFPINDLDMSEFLINPNagpcRYNLIAVSNHY-GGM 554
Cdd:cd02673   129 CSSCK-CESAISSERIMTFPECLSINLKRY-KLRIA-----TSDYLKKNEEIMKKYCGTDA----KYSLVAVICHLgESP 197
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1189398067 555 GGGHYTAFAKNKDDG-KWYYFDDSSVSTASEDQI---VSKAAYVLFY 597
Cdd:cd02673   198 YDGHYIAYTKELYNGsSWLYCSDDEIRPVSKNDVstnARSSGYLIFY 244
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
10-137 5.23e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 42.70  E-value: 5.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067  10 AELIKQMWSGKFSY--------------VTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDglhedlnRIRKKPYIQLK 75
Cdd:cd02658    51 IKLADGLLSGRYSKpaslksendpyqvgIKPSMFKALIGKGHPEFSTMRQQDALEFLLHLID-------KLDRESFKNLG 123
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1189398067  76 DADGRPDKVVAEEawenhlkrndsiivdifhglfksTLVCPECAKISVTFDPFCYLTLPLPM 137
Cdd:cd02658   124 LNPNDLFKFMIED-----------------------RLECLSCKKVKYTSELSEILSLPVPK 162
Peptidase_C19I cd02665
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
494-597 4.12e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239130 [Multi-domain]  Cd Length: 228  Bit Score: 39.46  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 494 LPPVLVVHLKRFSYSRYMRDKLDTLVDFPindldmSEFLINPnagpcrYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYY 573
Cdd:cd02665   128 LPPVLTFELSRFEFNQGRPEKIHDKLEFP------QIIQQVP------YELHAVLVHEGQANAGHYWAYIYKQSRQEWEK 195
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1189398067 574 FDDSSVSTASEDQIVSKA--------AYVLFY 597
Cdd:cd02665   196 YNDISVTESSWEEVERDSfgggrnpsAYCLMY 227
Peptidase_C19P cd02672
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
458-598 5.25e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239137 [Multi-domain]  Cd Length: 268  Bit Score: 39.03  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067 458 CIELFTTKEKlgaEDPWYCPNCKEHQQATKKLDLWSLPP----VLVVHLKRFSYSRYMR-------DKLDTLVDFPINDL 526
Cdd:cd02672   122 LLKRSLDLEK---VTKAWCDTCCKYQPLEQTTSIRHLPDilllVLVINLSVTNGEFDDInvvlpsgKVMQNKVSPKAIDH 198
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1189398067 527 DmSEFLINPNAGPCRYNLIA-VSNHYGGMGGGHYTAF----AKNKDDGKWYYFDDSSVSTasedqiVSKAAYVLFYQ 598
Cdd:cd02672   199 D-KLVKNRGQESIYKYELVGyVCEINDSSRGQHNVVFvikvNEESTHGRWYLFNDFLVTP------VSELAYILLYQ 268
Peptidase_C19M cd02669
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
3-136 5.78e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239134 [Multi-domain]  Cd Length: 440  Bit Score: 39.61  E-value: 5.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189398067   3 GEIAKSYAELIKQMWSgkfsyvtPRAFKTQVG----------RFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKpyi 72
Cdd:cd02669   162 SELVKRLSELIRKIWN-------PRNFKGHVSphellqavskVSKKKFSITEQSDPVEFLSWLLNTLHKDLGGSKKP--- 231
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1189398067  73 qlkdadgrpdkvvaeeawenhlkrNDSIIVDIFHGLFK---------------STLVCPECAKISVTFDPFCYLTLPLP 136
Cdd:cd02669   232 ------------------------NSSIIHDCFQGKVQietqkikphaeeegsKDKFFKDSRVKKTSVSPFLLLTLDLP 286
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
5-70 6.93e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 38.85  E-value: 6.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1189398067   5 IAKSYAELIKQMwSGKFSYVTPRAFKTQVGRFAPQFS------GYQQQDCQELLAFLLDGLHEDLNRIRKKP 70
Cdd:cd02657    45 LTNALRDLFDTM-DKKQEPVPPIEFLQLLRMAFPQFAekqnqgGYAQQDAEECWSQLLSVLSQKLPGAGSKG 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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