Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 377 ILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRAAAVGIYEQYLSEKASP 456
Cdd:cd08719     1 ILVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYRVSAEQQLSELHLRQRGGEHQRSDVYEMLRAAALNIYDQYLSEKASP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1186128418 457 RVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVR 511
Cdd:cd08719    81 RVPLDDSLVKKLLNRLRNDTPSDLWFDDIQQKVFDIMQEDERFYPAFKKSPAYVK 135

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 377 ILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRAAAVGIYEQYLSEKASP 456
Cdd:cd08719     1 ILVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYRVSAEQQLSELHLRQRGGEHQRSDVYEMLRAAALNIYDQYLSEKASP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1186128418 457 RVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVR 511
Cdd:cd08719    81 RVPLDDSLVKKLLNRLRNDTPSDLWFDDIQQKVFDIMQEDERFYPAFKKSPAYVK 135

PXA domain; This domain is associated with PX domains pfam00787.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418  98 NIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLRVFRKAQQ 177
Cdd:pfam02194   2 PEVDAALDELIDLIIRDFVQSWYSKISSDPEFPNEVRQTLRHALRELSQRLRKVDLASLLLSRLLPLLTSHLEDYRKAEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 178 KITEKDDQvkGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARG 257
Cdd:pfam02194  82 AVRGKKLN--ELDLALASKYLALKPHPALSPVLLSSSQSREAEQKYLRLLVDGLLPLLLPPEDLESRPVRVLVREILACL 159

                         170       180
                  ....*....|....*....|..
gi 1186128418 258 ILLPLINQLSDPDYINQYVIWM 279
Cdd:pfam02194 160 VLLPVINKLSDPDFINELIVKL 181

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 374 LDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQlevllsrqrdgkhqtnqtkgLLRAAAVGIYEQYLSEK 453
Cdd:pfam00615   2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDE--------------------ERLKKAKEIYNEFLAPG 61

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1186128418 454 ASPRVTVDDYLVAKLADTLNHEdPTPEIFDDIQRKVYELMLRDErfYPSFRQNALYVRM 512
Cdd:pfam00615  62 SPKEINLDSDLREEIRENLEKE-PTRDLFDEAQAEVYELMEKDS--YPRFLKSPLYLRL 117

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 377 ILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRAAAVGIYEQYLSEKASP 456
Cdd:cd08719     1 ILVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYRVSAEQQLSELHLRQRGGEHQRSDVYEMLRAAALNIYDQYLSEKASP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1186128418 457 RVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVR 511
Cdd:cd08719    81 RVPLDDSLVKKLLNRLRNDTPSDLWFDDIQQKVFDIMQEDERFYPAFKKSPAYVK 135

PXA domain; This domain is associated with PX domains pfam00787.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418  98 NIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLRVFRKAQQ 177
Cdd:pfam02194   2 PEVDAALDELIDLIIRDFVQSWYSKISSDPEFPNEVRQTLRHALRELSQRLRKVDLASLLLSRLLPLLTSHLEDYRKAEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 178 KITEKDDQvkGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARG 257
Cdd:pfam02194  82 AVRGKKLN--ELDLALASKYLALKPHPALSPVLLSSSQSREAEQKYLRLLVDGLLPLLLPPEDLESRPVRVLVREILACL 159

                         170       180
                  ....*....|....*....|..
gi 1186128418 258 ILLPLINQLSDPDYINQYVIWM 279
Cdd:pfam02194 160 VLLPVINKLSDPDFINELIVKL 181

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 378 LVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEvllsrqrdgkhqtnqtkglLRAAAVGIYEQYLSEKASPR 457
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDEE-------------------LKSKAKEIYDKYISKDAPKE 61

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1186128418 458 VTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDerFYPSFRQNALYVR 511
Cdd:cd07440    62 INIPESIREEIEENLEEPYPDPDCFDEAQEHILNLLEKD--SYPRFLKSDLYLK 113

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 377 ILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYrvtaQQQLEvLLSRQRDGKHQTNQtkgllraaAVGIYEQYLSEKASP 456
Cdd:cd08721     1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNF----QSQLA-AKEGQYDGQQAQND--------AMIIYDKYFSLQATE 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1186128418 457 RVTVDDYLVAKLADTLNHED-PTPEIFDDIQRKVYELMlrDERFYPSFRQNALYVR 511
Cdd:cd08721    68 PLGFDDKTRLEVESNICREGgPLPSCFEAPLLQALTTL--EQHYLPGFLSSQLYYK 121

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 374 LDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTA-------------QQQLEVLLSRQRDGKHQTNQTKGLLRA 440
Cdd:cd08735     5 LEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAwsrirahslntvkHSSLEEPVSPSLDRKVLESKSTDSLSQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 441 A----------------AVGIYEQYLSEKASPRVTVDD----YLVAKLADTLNHEDPTpeIFDDIQRKVYELMLRDerFY 500
Cdd:cd08735    85 RltddddeksmksierdAVSIYTKYISPDAAKPIPITEeirnDIVAKICGEDGQVDPN--CFVEAQSFVFSAMEQD--HF 160

                  ....*....
gi 1186128418 501 PSFRQNALY 509
Cdd:cd08735   161 TEFLRSHFF 169

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 374 LDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQqlevllsrqrdgkhqtnqtkgLLRAAAVGIYEQYLSEK 453
Cdd:cd08715     1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYKKTESD---------------------LLPCKAEEIYKEFVQSD 59

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1186128418 454 ASPRVTVDDYLVAKLADTLnhEDPTPEIFDDIQRKVYELMLRDErfYPSFRQNALYVRM 512
Cdd:cd08715    60 AAKQINIDFRTRESTAKKI--KAPTPTCFDEAQKVIYILMERDS--YPRFLKSDIYLNL 114

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 363 AANFGKLCTVPldsilvdnVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLevllsrqRDGKHQTnqtkgllraaa 442
Cdd:cd08745     2 AQSFDKLMKSP--------AGRNVFREFLRTEYSEENMLFWLACEELKAEANKHV-------IDEKARL----------- 55

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1186128418 443 vgIYEQYLSEKASPRVTVDdylvAKLADTLNH--EDPTPEIFDDIQRKVYELMLRDErfYPSFRQNALY 509
Cdd:cd08745    56 --IYEDYISILSPKEVSLD----SRVREGINRkmQEPSSHTFDDAQLQIYTLMHRDS--YPRFLNSPIY 116

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 374 LDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQleVLLSRQRDgkhqtnqtkgllraaavgIYEQYLSEK 453
Cdd:cd08713     1 LEKLLLHKYGLAVFRAFLQTEFSEENLEFWLACEEYKKIKSQS--KMASRAKK------------------IFAEYIAIQ 60

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1186128418 454 ASPRVTVDDYLVAKLADTLnhEDPTPEIFDDIQRKVYELMLRDErfYPSFRQNALY 509
Cdd:cd08713    61 SCKEVNLDSYTREHTKENL--QNPTRGCFDLAQKRIYGLMEKDS--YPRFLRSDLY 112

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 363 AANFGKLCTVPldsilvdnVALQFFMDYMQQTGGQAHLFFWMTVEGYRvtaqqqlevllsrqrdgkhqTNQTKGLLRAAA 442
Cdd:cd08744     2 SQNFDKMMKTP--------AGRNLFREFLRTEYSEENLLFWLACEDLK--------------------KEQNKKVIEEKA 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1186128418 443 VGIYEQYLSEKASPRVTVDdylvAKLADTLNHE--DPTPEIFDDIQRKVYELMLRDErfYPSFRQNALY 509
Cdd:cd08744    54 RLIYEDYISILSPKEVSLD----SRVREVINRNllDPNPHMYEDAQLQIYTLMHRDS--FPRFLNSQIY 116

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1186128418 445 IYEQYLSeKASPRVTVDDYLVAKLADTlNHEDPTPEIFDDIQRKVYELMLRDErfYPSFRQNALY 509
Cdd:cd08718    56 IYEDYIS-ILSPKEVSLDSRVREVINR-NMLEPSPHTFDDAQLQIYTLMHRDS--YPRFLNSAIY 116

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS18 protein. RGS18 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS18 is a member of the R4/RGS subfamily and is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 374 LDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRvtaqqqlevllsrqrdgKHQTNQtkgLLRAAAVGIYEQYLSEK 453
Cdd:cd08712     1 FDKLLSHKDGLEAFTRFLKTEFSEENIEFWIACEDYK-----------------KSKTPQ---QIHLKAKAIYEKFIQTD 60

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1186128418 454 ASPRVTVDdyLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDErfYPSFRQNALY 509
Cdd:cd08712    61 APKEVNLD--FHTKEVTTNSIEQPTLTSFDAAQSRVYQLMEQDS--YPRFLKSDIY 112

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 390 YMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQrdgkhqtnqtkgllraaavgIYEQYLSEKASPRVTVDDylVAKLA 469
Cdd:cd08716    17 YLKTEHSDENIEFWLACETYKKIASQRKRISMARK--------------------LFASYIQPQAPREINIDS--PTRKA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1186128418 470 DTLNHEDPTPEIFDDIQRKVYELMLRDErfYPSFRQNALY 509
Cdd:cd08716    75 IIRNIQEPTQSCFDEAQRIVYMHMERDS--YPRFLESKFY 112

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 374 LDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLevllsrqrdgkhqtnqtkglLRAAAVGIYEQYLSEK 453
Cdd:cd08709     1 FDELLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTKSPQK--------------------LTSKAKKIYTDFIEKE 60

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1186128418 454 ASPRVTVDDYLVAKLADTLnhEDPTPEIFDDIQRKVYELMlrDERFYPSFRQNALY 509
Cdd:cd08709    61 APKEINIDFQTKTLIAQNI--QEATSGCFTAAQKRVYSLM--ENNSYPRFLESEFY 112

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 374 LDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTaqqqlevllsrqrdgkhqtnQTKGLLRAAAVGIYEQYLSEK 453
Cdd:cd08711    12 FDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKT--------------------RSTAKLVSKAHRIFEEFVDVQ 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1186128418 454 AsPRVTVDDYLVAKLADTlNHEDPTPEIFDDIQRKVYELMLRDErfYPSFRQNALY 509
Cdd:cd08711    72 A-PREVNIDFQTREATRK-NLQEPSLTCFDQAQGKVHSLMEKDS--YPRFLRSKMY 123

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 378 LVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRvtaqQQLEVLLSRQRDGKHQTNQTKGLLRAAAVGIYEQYLSeKASPR 457
Cdd:cd08729     1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGFK----NPLEDTENDYSLDSSQSRSWIDSDKEDIAMIYETYFS-DPSPS 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1186128418 458 VTVDDYLVAKLADTLN---HEDPTPEIFD------DIQRKVYELMlrDERFYPSFRQNALYVR 511
Cdd:cd08729    76 LNVPKASRDPIRLFLNagvNASPNEQYRKarravlMAQRAVYEEM--EEEDFPEFKKSELFYK 136

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186128418 374 LDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLevllsrqrdgkhqtnqtkgllRAAAVGIYEQYLSEK 453
Cdd:cd08705     9 FSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKYGPQSQV---------------------PEKVQEIYQEFLAPG 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1186128418 454 ASPRVTVDDYLVAKLADTLnhEDPTPEIFDDIQRKVYELMLRDErfYPSFRQNALY 509
Cdd:cd08705    68 APSWINIDSKTMEITLKNL--KDPHRYTFDAAQEHIYMLMKKDS--YPRFLRSDIY 119