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Conserved domains on  [gi|1182945148|ref|NP_001337531|]
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E3 ubiquitin-protein ligase E3D isoform 2 [Homo sapiens]

Protein Classification

HECT-type E3 ubiquitin transferase( domain architecture ID 10561263)

HECT-type E3 ubiquitin transferase such as mammalian E3 ubiquitin-protein ligase E3D that accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 2-352 5.94e-89

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


:

Pssm-ID: 462911  Cd Length: 362  Bit Score: 271.64  E-value: 5.94e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148   2 PMNISIMPS---SLQMKTPEGCTEIQLPAEVRLVPSSCRGLQFVVGDGLHLRLQTQAKLGTKLISMFNQSSQTQEC---- 74
Cdd:pfam09814  19 LKSTRVSLSddgLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLPGDELSFRLPLADSSSKFGSFDLESSLSAQKElevp 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148  75 ---------CTFYCQSCGEVIIKDRKLLRVLPLPSENWGALVGEWCCHPDPF----------ANKSLHPQENDCFIGDSF 135
Cdd:pfam09814  99 wsakdlspgFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDhdhlatkgygANSKLVPQEGDGLVGLTF 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 136 FLVNLRTSLWQQRpelspvemccvssdnhCKLEPKANTKVICKRCKVMLGETVSSETTKFYMTEIIIQSSERSFPiIPRS 215
Cdd:pfam09814 179 FLLNESDCQGLKL----------------SSKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQPSEGSDS-IPRS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 216 WFVQSVIAQCLVQLSSARSTFRFTIQGQDD-KVYILLWLLNSDSLVIESLRNskyikkfpllentfkaDSSSAWSAVKVL 294
Cdd:pfam09814 242 FPPESIVAALLLELISRSSTRKFLIQPEDGeTHYLLLWVFNPDLLVSSSSSS----------------NSLIAKRAMKVL 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1182945148 295 YQPCIKSrNEKLVSLWESDISVHPLTLPSATCLELLLILSKSNANLPSSLRRVNSFQV 352
Cdd:pfam09814 306 YKDCIDS-EEANSLLDENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKFNEWKV 362
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 2-352 5.94e-89

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 271.64  E-value: 5.94e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148   2 PMNISIMPS---SLQMKTPEGCTEIQLPAEVRLVPSSCRGLQFVVGDGLHLRLQTQAKLGTKLISMFNQSSQTQEC---- 74
Cdd:pfam09814  19 LKSTRVSLSddgLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLPGDELSFRLPLADSSSKFGSFDLESSLSAQKElevp 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148  75 ---------CTFYCQSCGEVIIKDRKLLRVLPLPSENWGALVGEWCCHPDPF----------ANKSLHPQENDCFIGDSF 135
Cdd:pfam09814  99 wsakdlspgFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDhdhlatkgygANSKLVPQEGDGLVGLTF 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 136 FLVNLRTSLWQQRpelspvemccvssdnhCKLEPKANTKVICKRCKVMLGETVSSETTKFYMTEIIIQSSERSFPiIPRS 215
Cdd:pfam09814 179 FLLNESDCQGLKL----------------SSKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQPSEGSDS-IPRS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 216 WFVQSVIAQCLVQLSSARSTFRFTIQGQDD-KVYILLWLLNSDSLVIESLRNskyikkfpllentfkaDSSSAWSAVKVL 294
Cdd:pfam09814 242 FPPESIVAALLLELISRSSTRKFLIQPEDGeTHYLLLWVFNPDLLVSSSSSS----------------NSLIAKRAMKVL 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1182945148 295 YQPCIKSrNEKLVSLWESDISVHPLTLPSATCLELLLILSKSNANLPSSLRRVNSFQV 352
Cdd:pfam09814 306 YKDCIDS-EEANSLLDENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKFNEWKV 362
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
76-357 9.76e-07

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 50.03  E-value: 9.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148  76 TFYCQSCGEVIIKDRKLLRvlpLPSENWGALVGEWCCHPDPFANKS-------LHPQENDCFIGDSFFLVNLrtslwqqr 148
Cdd:COG5629    87 GFRCKQGNEILHSIRSMND---LPSEGWEELIDCWSCHNDYCEFKSmlggpltPRPREGGLLLGDSYLLIND-------- 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 149 pelspvemccvsSDNHCKLEPKANTKVICKRCKVMLGETVSSETTK-FYMTEIIIQSSERSFPiiprswfVQSVIAQCLV 227
Cdd:COG5629   156 ------------ADLEGKVAYGPNFKLHCSFCNARLGLPNDSSIRKlFRYNKEVIPNGCTKIH-------PHEDLAYSYL 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 228 QLSSARSTFRFTIQGQDDKvyILLWLLNSDSLVIESLRNSKYIKKFPLlentfkadsssawSAVKVLY-QPCIKSRNEKL 306
Cdd:COG5629   217 NAYFRDKNVLLLEANQARS--YEIWHFYRAILITVEPNRSLSRAEAMK-------------VTIKNTDvPPKITKSTESS 281

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1182945148 307 VSLWESDISvhpltlpsatclELLLILSKSNANLPSSLRRVNSFQVAFLKM 357
Cdd:COG5629   282 EDIPVSSFN------------EFYSKLIYDNVMSPTSDIKAGGWKISFVTE 320
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 2-352 5.94e-89

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 271.64  E-value: 5.94e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148   2 PMNISIMPS---SLQMKTPEGCTEIQLPAEVRLVPSSCRGLQFVVGDGLHLRLQTQAKLGTKLISMFNQSSQTQEC---- 74
Cdd:pfam09814  19 LKSTRVSLSddgLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLPGDELSFRLPLADSSSKFGSFDLESSLSAQKElevp 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148  75 ---------CTFYCQSCGEVIIKDRKLLRVLPLPSENWGALVGEWCCHPDPF----------ANKSLHPQENDCFIGDSF 135
Cdd:pfam09814  99 wsakdlspgFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDhdhlatkgygANSKLVPQEGDGLVGLTF 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 136 FLVNLRTSLWQQRpelspvemccvssdnhCKLEPKANTKVICKRCKVMLGETVSSETTKFYMTEIIIQSSERSFPiIPRS 215
Cdd:pfam09814 179 FLLNESDCQGLKL----------------SSKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQPSEGSDS-IPRS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 216 WFVQSVIAQCLVQLSSARSTFRFTIQGQDD-KVYILLWLLNSDSLVIESLRNskyikkfpllentfkaDSSSAWSAVKVL 294
Cdd:pfam09814 242 FPPESIVAALLLELISRSSTRKFLIQPEDGeTHYLLLWVFNPDLLVSSSSSS----------------NSLIAKRAMKVL 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1182945148 295 YQPCIKSrNEKLVSLWESDISVHPLTLPSATCLELLLILSKSNANLPSSLRRVNSFQV 352
Cdd:pfam09814 306 YKDCIDS-EEANSLLDENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKFNEWKV 362
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
76-357 9.76e-07

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 50.03  E-value: 9.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148  76 TFYCQSCGEVIIKDRKLLRvlpLPSENWGALVGEWCCHPDPFANKS-------LHPQENDCFIGDSFFLVNLrtslwqqr 148
Cdd:COG5629    87 GFRCKQGNEILHSIRSMND---LPSEGWEELIDCWSCHNDYCEFKSmlggpltPRPREGGLLLGDSYLLIND-------- 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 149 pelspvemccvsSDNHCKLEPKANTKVICKRCKVMLGETVSSETTK-FYMTEIIIQSSERSFPiiprswfVQSVIAQCLV 227
Cdd:COG5629   156 ------------ADLEGKVAYGPNFKLHCSFCNARLGLPNDSSIRKlFRYNKEVIPNGCTKIH-------PHEDLAYSYL 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182945148 228 QLSSARSTFRFTIQGQDDKvyILLWLLNSDSLVIESLRNSKYIKKFPLlentfkadsssawSAVKVLY-QPCIKSRNEKL 306
Cdd:COG5629   217 NAYFRDKNVLLLEANQARS--YEIWHFYRAILITVEPNRSLSRAEAMK-------------VTIKNTDvPPKITKSTESS 281

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1182945148 307 VSLWESDISvhpltlpsatclELLLILSKSNANLPSSLRRVNSFQVAFLKM 357
Cdd:COG5629   282 EDIPVSSFN------------EFYSKLIYDNVMSPTSDIKAGGWKISFVTE 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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