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Conserved domains on  [gi|1178431697|ref|NP_001337265|]
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cilia- and flagella-associated protein 298 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CFAP298 super family cl12631
Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which ...
 189-251 3.55e-28

Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).


The actual alignment was detected with superfamily member pfam11069:

Pssm-ID: 463214  Cd Length: 95  Bit Score: 103.12  E-value: 3.55e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178431697 189 AQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQR--------------------------------LEENDDDAYLNSP 236
Cdd:pfam11069   1 AQLWWAGKEMQRGKKLSDYIGKNEKTKIIVKLQKKgsgapgrepvvseeeqkammayyyrkqeelkkLEEDDDDSYLNSE 80

                          90
                  ....*....|....*
gi 1178431697 237 WADNTALKRHFHGVK 251
Cdd:pfam11069  81 WADPRGLKRQLHGLN 95
 
Name Accession Description Interval E-value
CFAP298 pfam11069
Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which ...
 189-251 3.55e-28

Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).


Pssm-ID: 463214  Cd Length: 95  Bit Score: 103.12  E-value: 3.55e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178431697 189 AQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQR--------------------------------LEENDDDAYLNSP 236
Cdd:pfam11069   1 AQLWWAGKEMQRGKKLSDYIGKNEKTKIIVKLQKKgsgapgrepvvseeeqkammayyyrkqeelkkLEEDDDDSYLNSE 80

                          90
                  ....*....|....*
gi 1178431697 237 WADNTALKRHFHGVK 251
Cdd:pfam11069  81 WADPRGLKRQLHGLN 95
 
Name Accession Description Interval E-value
CFAP298 pfam11069
Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which ...
 189-251 3.55e-28

Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).


Pssm-ID: 463214  Cd Length: 95  Bit Score: 103.12  E-value: 3.55e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178431697 189 AQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQR--------------------------------LEENDDDAYLNSP 236
Cdd:pfam11069   1 AQLWWAGKEMQRGKKLSDYIGKNEKTKIIVKLQKKgsgapgrepvvseeeqkammayyyrkqeelkkLEEDDDDSYLNSE 80

                          90
                  ....*....|....*
gi 1178431697 237 WADNTALKRHFHGVK 251
Cdd:pfam11069  81 WADPRGLKRQLHGLN 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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