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Conserved domains on  [gi|1169292786|ref|NP_001336833|]
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BLOC-3 complex member HPS4 isoform e [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Intu_longin_1 pfam19031
First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain ...
 15-121 1.67e-31

First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 436911  Cd Length: 112  Bit Score: 118.49  E-value: 1.67e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169292786  15 WNYFFLYDGSKVKEEgDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISD---SPPTLVRLRKLKFAIKVDGDYL 91
Cdd:pfam19031   1 LPFFFVYNPTEGKKE-GEEEKKILYYHPEETSLNEKLSLRGIFEALVSFTETFSPtqsSPCLLIELQKYHVAYREVEDDL 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1169292786  92 WVLGCAVE---LPDVSCKRFLDQLVGFFNFYNG 121
Cdd:pfam19031  80 WLIGSVSNpdnIPDPYYSSVLEQLYRFFKLFYG 112
Intu_longin_3 super family cl41027
Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and ...
 598-655 3.33e-10

Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and related proteins.


The actual alignment was detected with superfamily member pfam19033:

Pssm-ID: 436913  Cd Length: 98  Bit Score: 57.34  E-value: 3.33e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169292786 598 TSSTYNFTHYDRIQSLLMANLPQ----VATPQDRRFLQAVSLMHSEFAQ-LPALYEMTVSCTS 655
Cdd:pfam19033   1 ENSLYSYVYFDPMNLALKSPLHQekrqVNGPLDPDFLRLVLDIHSDFSQsLPELKEHIVKTLN 63
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
414-531 5.97e-03

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member PRK14086:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169292786 414 PTPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHPGHSSQAPIPRADPlPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDED 493
Cdd:PRK14086  174 FPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDR-PRRDRTDRPEPPPGAGHVHRGGPGPPERDDAP 252

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1169292786 494 VdgVCESHAAPGLECSSGSANCQGAGPSAdgissRLTP 531
Cdd:PRK14086  253 V--VPIRPSAPGPLAAQPAPAPGPGEPTA-----RLNP 283
 
Name Accession Description Interval E-value
Intu_longin_1 pfam19031
First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain ...
 15-121 1.67e-31

First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 436911  Cd Length: 112  Bit Score: 118.49  E-value: 1.67e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169292786  15 WNYFFLYDGSKVKEEgDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISD---SPPTLVRLRKLKFAIKVDGDYL 91
Cdd:pfam19031   1 LPFFFVYNPTEGKKE-GEEEKKILYYHPEETSLNEKLSLRGIFEALVSFTETFSPtqsSPCLLIELQKYHVAYREVEDDL 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1169292786  92 WVLGCAVE---LPDVSCKRFLDQLVGFFNFYNG 121
Cdd:pfam19031  80 WLIGSVSNpdnIPDPYYSSVLEQLYRFFKLFYG 112
Intu_longin_3 pfam19033
Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and ...
 598-655 3.33e-10

Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 436913  Cd Length: 98  Bit Score: 57.34  E-value: 3.33e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169292786 598 TSSTYNFTHYDRIQSLLMANLPQ----VATPQDRRFLQAVSLMHSEFAQ-LPALYEMTVSCTS 655
Cdd:pfam19033   1 ENSLYSYVYFDPMNLALKSPLHQekrqVNGPLDPDFLRLVLDIHSDFSQsLPELKEHIVKTLN 63
dnaA PRK14086
chromosomal replication initiator protein DnaA;
414-531 5.97e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169292786 414 PTPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHPGHSSQAPIPRADPlPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDED 493
Cdd:PRK14086  174 FPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDR-PRRDRTDRPEPPPGAGHVHRGGPGPPERDDAP 252

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1169292786 494 VdgVCESHAAPGLECSSGSANCQGAGPSAdgissRLTP 531
Cdd:PRK14086  253 V--VPIRPSAPGPLAAQPAPAPGPGEPTA-----RLNP 283
 
Name Accession Description Interval E-value
Intu_longin_1 pfam19031
First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain ...
 15-121 1.67e-31

First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 436911  Cd Length: 112  Bit Score: 118.49  E-value: 1.67e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169292786  15 WNYFFLYDGSKVKEEgDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISD---SPPTLVRLRKLKFAIKVDGDYL 91
Cdd:pfam19031   1 LPFFFVYNPTEGKKE-GEEEKKILYYHPEETSLNEKLSLRGIFEALVSFTETFSPtqsSPCLLIELQKYHVAYREVEDDL 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1169292786  92 WVLGCAVE---LPDVSCKRFLDQLVGFFNFYNG 121
Cdd:pfam19031  80 WLIGSVSNpdnIPDPYYSSVLEQLYRFFKLFYG 112
Intu_longin_3 pfam19033
Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and ...
 598-655 3.33e-10

Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 436913  Cd Length: 98  Bit Score: 57.34  E-value: 3.33e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169292786 598 TSSTYNFTHYDRIQSLLMANLPQ----VATPQDRRFLQAVSLMHSEFAQ-LPALYEMTVSCTS 655
Cdd:pfam19033   1 ENSLYSYVYFDPMNLALKSPLHQekrqVNGPLDPDFLRLVLDIHSDFSQsLPELKEHIVKTLN 63
dnaA PRK14086
chromosomal replication initiator protein DnaA;
414-531 5.97e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169292786 414 PTPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHPGHSSQAPIPRADPlPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDED 493
Cdd:PRK14086  174 FPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDR-PRRDRTDRPEPPPGAGHVHRGGPGPPERDDAP 252

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1169292786 494 VdgVCESHAAPGLECSSGSANCQGAGPSAdgissRLTP 531
Cdd:PRK14086  253 V--VPIRPSAPGPLAAQPAPAPGPGEPTA-----RLNP 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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