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Conserved domains on  [gi|1168720174|ref|NP_001336713|]
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inactive cell surface hyaluronidase CEMIP2 isoform c [Homo sapiens]

Protein Classification

ILEI domain-containing protein( domain architecture ID 11238926)

ILEI domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 606-690 9.47e-13

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


:

Pssm-ID: 464817  Cd Length: 89  Bit Score: 64.20  E-value: 9.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1168720174 606 GVLLLVVDPCSvpFRLTEKTVF---PLADVSRIEEYLKtGIPPRSIVLLSTRGEI---KQLNISHLLVPLGLAKPAHLYD 679
Cdd:pfam15711   2 GINVVVVDACT--GKVLDSKSFdtySYSDSSRLANFLK-SIPDGSIVLIATKDEAsskLSDEARKALESLGSSKIDNLGF 78

                          90
                  ....*....|.
gi 1168720174 680 KGSTIFLGFSG 690
Cdd:pfam15711  79 RDSWAFIGFKG 89
 
Name Accession Description Interval E-value
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 606-690 9.47e-13

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 64.20  E-value: 9.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1168720174 606 GVLLLVVDPCSvpFRLTEKTVF---PLADVSRIEEYLKtGIPPRSIVLLSTRGEI---KQLNISHLLVPLGLAKPAHLYD 679
Cdd:pfam15711   2 GINVVVVDACT--GKVLDSKSFdtySYSDSSRLANFLK-SIPDGSIVLIATKDEAsskLSDEARKALESLGSSKIDNLGF 78

                          90
                  ....*....|.
gi 1168720174 680 KGSTIFLGFSG 690
Cdd:pfam15711  79 RDSWAFIGFKG 89
PANDER_like_KIAA1199 cd13941
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ...
 587-701 3.18e-05

PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized.


Pssm-ID: 260115  Cd Length: 157  Bit Score: 44.80  E-value: 3.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1168720174 587 RGDPSVISVNGTDFTFRSAGVLLLVVDPCSvpFRLTEKTVFPLADV----SRIEEYLkTGIPPRSIVLLSTRGE-IKQLN 661
Cdd:cd13941    22 KDDFAYIEVDGKKFFLSEDGIQVVVIDGHS--GKVVDTTSFRNSILqgipAQLENYV-TNIKDNSIVLITSKGRlVSRGP 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1168720174 662 ISHLLVPLGLAKPAHLYDKGStiFLGFSGNFKPSWTKLFT 701
Cdd:cd13941    99 WTKVLEKLGADQGFKLKEKMA--FVGFKGSFRPVWVKLVT 136
 
Name Accession Description Interval E-value
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 606-690 9.47e-13

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 64.20  E-value: 9.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1168720174 606 GVLLLVVDPCSvpFRLTEKTVF---PLADVSRIEEYLKtGIPPRSIVLLSTRGEI---KQLNISHLLVPLGLAKPAHLYD 679
Cdd:pfam15711   2 GINVVVVDACT--GKVLDSKSFdtySYSDSSRLANFLK-SIPDGSIVLIATKDEAsskLSDEARKALESLGSSKIDNLGF 78

                          90
                  ....*....|.
gi 1168720174 680 KGSTIFLGFSG 690
Cdd:pfam15711  79 RDSWAFIGFKG 89
PANDER_like_KIAA1199 cd13941
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ...
 587-701 3.18e-05

PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized.


Pssm-ID: 260115  Cd Length: 157  Bit Score: 44.80  E-value: 3.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1168720174 587 RGDPSVISVNGTDFTFRSAGVLLLVVDPCSvpFRLTEKTVFPLADV----SRIEEYLkTGIPPRSIVLLSTRGE-IKQLN 661
Cdd:cd13941    22 KDDFAYIEVDGKKFFLSEDGIQVVVIDGHS--GKVVDTTSFRNSILqgipAQLENYV-TNIKDNSIVLITSKGRlVSRGP 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1168720174 662 ISHLLVPLGLAKPAHLYDKGStiFLGFSGNFKPSWTKLFT 701
Cdd:cd13941    99 WTKVLEKLGADQGFKLKEKMA--FVGFKGSFRPVWVKLVT 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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