NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1150763495|ref|NP_001335976|]
View 

coiled-coil domain-containing protein 74A isoform 11 [Homo sapiens]

Protein Classification

Mplasa_alph_rch and CCDC92 domain-containing protein( domain architecture ID 10633014)

Mplasa_alph_rch and CCDC92 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CCDC92 pfam14916
Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is ...
 47-100 3.75e-18

Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.


:

Pssm-ID: 464372 [Multi-domain]  Cd Length: 57  Bit Score: 75.40  E-value: 3.75e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1150763495  47 QKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKDLHYKLIMNQTSQKKDS 100
Cdd:pfam14916   1 EQRLQSLEKSILFLQQQHAATLKGLHKEIERLQKENKDLTFKLVMSEGESSQQG 54
 
Name Accession Description Interval E-value
CCDC92 pfam14916
Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is ...
 47-100 3.75e-18

Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.


Pssm-ID: 464372 [Multi-domain]  Cd Length: 57  Bit Score: 75.40  E-value: 3.75e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1150763495  47 QKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKDLHYKLIMNQTSQKKDS 100
Cdd:pfam14916   1 EQRLQSLEKSILFLQQQHAATLKGLHKEIERLQKENKDLTFKLVMSEGESSQQG 54
geminin_CC cd22589
central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil ...
 48-92 3.94e-03

central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil domain-containing protein 1 (GemC1) and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. Geminin is an inhibitor of Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC) that function in the duplication of chromosomal DNA. Pre-RC assembly culminates in the recruitment of the hexameric mini-chromosome maintenance complex (MCM) onto chromatin. Geminin tightly binds and sequesters Cdt1 in a complex that is unable to recruit MCM to origins, inhibiting DNA replication. It belongs to the geminin family of proteins that also includes GemC1 and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of geminin.


Pssm-ID: 439143 [Multi-domain]  Cd Length: 65  Bit Score: 34.89  E-value: 3.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1150763495  48 KRNLDLEKSLQFLQQQHSEmLAKLHEEIEHLKRENKDL-----HYKLIMN 92
Cdd:cd22589    10 ERRKALYEALQENEKLHKE-IEQLDEEIARLKEENDELeelaeHVQYLAE 58
 
Name Accession Description Interval E-value
CCDC92 pfam14916
Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is ...
 47-100 3.75e-18

Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.


Pssm-ID: 464372 [Multi-domain]  Cd Length: 57  Bit Score: 75.40  E-value: 3.75e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1150763495  47 QKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKDLHYKLIMNQTSQKKDS 100
Cdd:pfam14916   1 EQRLQSLEKSILFLQQQHAATLKGLHKEIERLQKENKDLTFKLVMSEGESSQQG 54
geminin_CC cd22589
central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil ...
 48-92 3.94e-03

central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil domain-containing protein 1 (GemC1) and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. Geminin is an inhibitor of Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC) that function in the duplication of chromosomal DNA. Pre-RC assembly culminates in the recruitment of the hexameric mini-chromosome maintenance complex (MCM) onto chromatin. Geminin tightly binds and sequesters Cdt1 in a complex that is unable to recruit MCM to origins, inhibiting DNA replication. It belongs to the geminin family of proteins that also includes GemC1 and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of geminin.


Pssm-ID: 439143 [Multi-domain]  Cd Length: 65  Bit Score: 34.89  E-value: 3.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1150763495  48 KRNLDLEKSLQFLQQQHSEmLAKLHEEIEHLKRENKDL-----HYKLIMN 92
Cdd:cd22589    10 ERRKALYEALQENEKLHKE-IEQLDEEIARLKEENDELeelaeHVQYLAE 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH