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Conserved domains on  [gi|1150273469|ref|NP_001335880|]
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WD repeat-containing protein 49 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
427-844 1.10e-29

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 1.10e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  427 LRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVIS 506
Cdd:COG2319     16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  507 SDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQi 583
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTLTG-HTGA-VRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGAvtSVAFSP- 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  584 lilKKKILVTG-WERAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNSTENAHHVL 661
Cdd:COG2319    173 ---DGKLLASGsDDGTVRLWDLATGKLLR----TLTG---HTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTL 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  662 ------------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFLKarkntavtG 729
Cdd:COG2319    243 tghsgsvrsvafSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHS--------------GGVNSVAFSP--------D 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  730 GANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIEeyclnssknkitkAPTL 808
Cdd:COG2319    300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPD--GKTLASGSDDGTVRLWDLA-------------TGEL 364

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1150273469  809 IRSFQPHEDRISSLEMCePGGQLLiISSSADCSICV 844
Cdd:COG2319    365 LRTLTGHTGAVTSVAFS-PDGRTL-ASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
246-564 6.95e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 6.95e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319    107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319    172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319    246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319    320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397


                   ....*.
gi 1150273469  559 IWDFNG 564
Cdd:COG2319    398 LWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
427-844 1.10e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 1.10e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  427 LRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVIS 506
Cdd:COG2319     16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  507 SDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQi 583
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTLTG-HTGA-VRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGAvtSVAFSP- 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  584 lilKKKILVTG-WERAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNSTENAHHVL 661
Cdd:COG2319    173 ---DGKLLASGsDDGTVRLWDLATGKLLR----TLTG---HTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTL 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  662 ------------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFLKarkntavtG 729
Cdd:COG2319    243 tghsgsvrsvafSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHS--------------GGVNSVAFSP--------D 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  730 GANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIEeyclnssknkitkAPTL 808
Cdd:COG2319    300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPD--GKTLASGSDDGTVRLWDLA-------------TGEL 364

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1150273469  809 IRSFQPHEDRISSLEMCePGGQLLiISSSADCSICV 844
Cdd:COG2319    365 LRTLTGHTGAVTSVAFS-PDGRTL-ASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 482-842 4.57e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 4.57e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  482 SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  562 FN-GYCHHTLnVGQDGAV---DISQililKKKILVT-GWERAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPPQ 636
Cdd:cd00200     80 LEtGECVRTL-TGHTSYVssvAFSP----DGRILSSsSRDKTIKVWDVETGKCLT----TLRG---HTDWVNSVAFSPDG 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  637 TLVT-GSYDGEIVLWNNSTEnahhvlhpdyqrllkskldtKPQKLLSAgrsqpshpmadHsttgvrnfeidtegKNAVMR 715
Cdd:cd00200    148 TFVAsSSQDGTIKLWDLRTG--------------------KCVATLTG-----------H--------------TGEVNS 182

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  716 LCFLKarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHS-GVGSIIMSTDkmNRYLTTGDLDGWLKIWNieeyc 794
Cdd:cd00200    183 VAFSP--------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPD--GYLLASGSEDGTIRVWD----- 247

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1150273469  795 lnssknkiTKAPTLIRSFQPHEDRISSLeMCEPGGQLLiISSSADCSI 842
Cdd:cd00200    248 --------LRTGECVQTLSGHTNSVTSL-AWSPDGKRL-ASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
246-564 6.95e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 6.95e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319    107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319    172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319    246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319    320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397


                   ....*.
gi 1150273469  559 IWDFNG 564
Cdd:COG2319    398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-431 1.06e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  139 HKDTIQKVIFLKNSSHYLTISKEGLLAIWgehlKLQETFPITSDatKLKHLWVTSLVSLENVNKIAVAFTSKEVCFYDLl 218
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW----DLETGELLRTL--KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  219 skEEFACQYKLQGLKGTPICMDY-----------------WYDpLDANESILSFGDITGKVQAIAF--TAALIslferpA 279
Cdd:cd00200     81 --ETGECVRTLTGHTSYVSSVAFspdgrilssssrdktikVWD-VETGKCLTTLRGHTDWVNSVAFspDGTFV------A 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  280 SACEDGeaTMTInWaELLSGchKCCHILEHklHQGdWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLN-MTSFN 358
Cdd:cd00200    152 SSSQDG--TIKL-W-DLRTG--KCVATLTG--HTG-EVNSVAFSPDGEKLLSSSSDGT---IKLWDLSTGKCLGtLRGHE 219

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1150273469  359 iaQGIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:cd00200    220 --NGVNSVAFSPDGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 520-561 5.71e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1150273469   520 TGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:smart00320    1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
521-561 2.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.82e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1150273469  521 GQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:pfam00400    1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 394-431 8.79e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.79e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1150273469   394 KPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
393-431 3.21e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1150273469  393 SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
427-844 1.10e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 1.10e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  427 LRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVIS 506
Cdd:COG2319     16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  507 SDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQi 583
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTLTG-HTGA-VRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGAvtSVAFSP- 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  584 lilKKKILVTG-WERAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNSTENAHHVL 661
Cdd:COG2319    173 ---DGKLLASGsDDGTVRLWDLATGKLLR----TLTG---HTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTL 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  662 ------------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFLKarkntavtG 729
Cdd:COG2319    243 tghsgsvrsvafSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHS--------------GGVNSVAFSP--------D 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  730 GANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIEeyclnssknkitkAPTL 808
Cdd:COG2319    300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPD--GKTLASGSDDGTVRLWDLA-------------TGEL 364

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1150273469  809 IRSFQPHEDRISSLEMCePGGQLLiISSSADCSICV 844
Cdd:COG2319    365 LRTLTGHTGAVTSVAFS-PDGRTL-ASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 482-842 4.57e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 4.57e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  482 SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  562 FN-GYCHHTLnVGQDGAV---DISQililKKKILVT-GWERAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPPQ 636
Cdd:cd00200     80 LEtGECVRTL-TGHTSYVssvAFSP----DGRILSSsSRDKTIKVWDVETGKCLT----TLRG---HTDWVNSVAFSPDG 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  637 TLVT-GSYDGEIVLWNNSTEnahhvlhpdyqrllkskldtKPQKLLSAgrsqpshpmadHsttgvrnfeidtegKNAVMR 715
Cdd:cd00200    148 TFVAsSSQDGTIKLWDLRTG--------------------KCVATLTG-----------H--------------TGEVNS 182

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  716 LCFLKarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHS-GVGSIIMSTDkmNRYLTTGDLDGWLKIWNieeyc 794
Cdd:cd00200    183 VAFSP--------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPD--GYLLASGSEDGTIRVWD----- 247

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1150273469  795 lnssknkiTKAPTLIRSFQPHEDRISSLeMCEPGGQLLiISSSADCSI 842
Cdd:cd00200    248 --------LRTGECVQTLSGHTNSVTSL-AWSPDGKRL-ASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
365-791 3.78e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 3.78e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  365 AFDYHSRLNLIATAGINNKVCLWNPYVvSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIacs 444
Cdd:COG2319     41 SLAASPDGARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL--- 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  445 fpksqdfrclfhfdeahgrlfisfnnqlallamkseaskrvKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKI 524
Cdd:COG2319    117 -----------------------------------------TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  525 KQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQililKKKILVTG-WERAIT 600
Cdd:COG2319    156 RTLTG-HSGA-VTSVAFSPDGKLLASGSDDGTVRLWDLaTGKLLRTLTGHTGAvrSVAFSP----DGKLLASGsADGTVR 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  601 VFRPQNFNQffiqPEEWKGgiqHHDDILCAAFLP-PQTLVTGSYDGEIVLWNNSTENAHHVL------------HPDYQR 667
Cdd:COG2319    230 LWDLATGKL----LRTLTG---HSGSVRSVAFSPdGRLLASGSADGTVRLWDLATGELLRTLtghsggvnsvafSPDGKL 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  668 LLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFlkarkntaVTGGANLVSCGGSGYVRFWDI 747
Cdd:COG2319    303 LASGSDDGTV-RLWDLATGKLLRTLTGHT--------------GAVRSVAF--------SPDGKTLASGSDDGTVRLWDL 359

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 1150273469  748 YKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIE 791
Cdd:COG2319    360 ATGELLRTLTGHTGaVTSVAFSPD--GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 362-651 7.32e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.58  E-value: 7.32e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  362 GIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRI 441
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  442 ACSfpkSQDFRCLfHFDeAHGRLFI--SFNNQLALLAMKSEASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMI 518
Cdd:cd00200     90 TGH---TSYVSSV-AFS-PDGRILSssSRDKTIKVWDVETGKCLTTlRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  519 DTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDG--AVDISQililKKKILVTG- 594
Cdd:cd00200    165 RTGKCVATLTG-H-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGvnSVAFSP----DGYLLASGs 238

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1150273469  595 WERAITVFRPQNFnqffiqpEEWKGGIQHHDDILCAAFLP-PQTLVTGSYDGEIVLWN 651
Cdd:cd00200    239 EDGTIRVWDLRTG-------ECVQTLSGHTNSVTSLAWSPdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
311-654 1.35e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 1.35e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  311 LHQGDWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLNmTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPy 390
Cdd:COG2319     75 LGHTAAVLSVAFSPDGRLLASASADGT---VRLWDLATGLLLR-TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL- 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  391 VVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQ----------HQLSIQRIACSfpksqdfrclfhfdeA 460
Cdd:COG2319    150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtgkllrtltgHTGAVRSVAFS---------------P 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  461 HGRLFIS--FNNQLALLAMKS-EASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGnaEIS 537
Cdd:COG2319    215 DGKLLASgsADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVN 292

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  538 TMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLN--VGQDGAVDISQililKKKILVTG-WERAITVFRPQNFNQffiq 613
Cdd:COG2319    293 SVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTghTGAVRSVAFSP----DGKTLASGsDDGTVRLWDLATGEL---- 364

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 1150273469  614 PEEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNST 654
Cdd:COG2319    365 LRTLTG---HTGAVTSVAFSPDgRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
246-564 6.95e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 6.95e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319    107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319    172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319    246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319    320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397


                   ....*.
gi 1150273469  559 IWDFNG 564
Cdd:COG2319    398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-431 1.06e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  139 HKDTIQKVIFLKNSSHYLTISKEGLLAIWgehlKLQETFPITSDatKLKHLWVTSLVSLENVNKIAVAFTSKEVCFYDLl 218
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW----DLETGELLRTL--KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  219 skEEFACQYKLQGLKGTPICMDY-----------------WYDpLDANESILSFGDITGKVQAIAF--TAALIslferpA 279
Cdd:cd00200     81 --ETGECVRTLTGHTSYVSSVAFspdgrilssssrdktikVWD-VETGKCLTTLRGHTDWVNSVAFspDGTFV------A 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  280 SACEDGeaTMTInWaELLSGchKCCHILEHklHQGdWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLN-MTSFN 358
Cdd:cd00200    152 SSSQDG--TIKL-W-DLRTG--KCVATLTG--HTG-EVNSVAFSPDGEKLLSSSSDGT---IKLWDLSTGKCLGtLRGHE 219

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1150273469  359 iaQGIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:cd00200    220 --NGVNSVAFSPDGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 733-848 3.81e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 3.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469  733 LVSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKMNRYLTTGDlDGWLKIWNIEeyclnssknkitkAPTLIRSF 812
Cdd:cd00200     24 LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS-DKTIRLWDLE-------------TGECVRTL 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1150273469  813 QPHEDRISSLeMCEPGGQlLIISSSADCSICV----TGVC 848
Cdd:cd00200     90 TGHTSYVSSV-AFSPDGR-ILSSSSRDKTIKVwdveTGKC 127
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 520-561 5.71e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1150273469   520 TGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:smart00320    1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
521-561 2.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.82e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1150273469  521 GQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:pfam00400    1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 394-431 8.79e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.79e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1150273469   394 KPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
393-431 3.21e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1150273469  393 SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 623-651 8.99e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 8.99e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1150273469   623 HHDDILCAAFLP-PQTLVTGSYDGEIVLWN 651
Cdd:smart00320   11 HTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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