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Conserved domains on  [gi|1145994705|ref|NP_001335652|]
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zinc finger protein 439 isoform e [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
277-437 3.61e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 277 KLYECKQCGKALSSLTSFQTHIRM--HSGE--RPYEC--KTCGKGFYSAKSFQRHEKTHSGEKPYKCK--QCGKAFT--- 345
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 346 --RSGSFRYHERTHTGEKPYEC--KQCGKAFRSAPNLQLHGRTHTGEKPYQCK--ECGKAFRSASQLRIHRRIHTGEKPY 419
Cdd:COG5048   368 nnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*...
gi 1145994705 420 ECKKCGKaFRYVQNFRFH 437
Cdd:COG5048   448 LCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-326 6.31e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 6.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 149 IYHSSIQRHMVVHSGDG-PYKCKFCGKAFHCLSLYLIHERT--HTGE--KPYEC--KQCGKSFSYSATHRIHERTHIGEK 221
Cdd:COG5048   271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 222 PYEC--QECGKAFHS-----PRSCHRHERSHMGEKAYQC--KECGKAFMCPRYVRRHERTHSRKKLYECK--QCGKALSS 290
Cdd:COG5048   351 PAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1145994705 291 LTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHE 326
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
277-437 3.61e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 277 KLYECKQCGKALSSLTSFQTHIRM--HSGE--RPYEC--KTCGKGFYSAKSFQRHEKTHSGEKPYKCK--QCGKAFT--- 345
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 346 --RSGSFRYHERTHTGEKPYEC--KQCGKAFRSAPNLQLHGRTHTGEKPYQCK--ECGKAFRSASQLRIHRRIHTGEKPY 419
Cdd:COG5048   368 nnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*...
gi 1145994705 420 ECKKCGKaFRYVQNFRFH 437
Cdd:COG5048   448 LCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-326 6.31e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 6.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 149 IYHSSIQRHMVVHSGDG-PYKCKFCGKAFHCLSLYLIHERT--HTGE--KPYEC--KQCGKSFSYSATHRIHERTHIGEK 221
Cdd:COG5048   271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 222 PYEC--QECGKAFHS-----PRSCHRHERSHMGEKAYQC--KECGKAFMCPRYVRRHERTHSRKKLYECK--QCGKALSS 290
Cdd:COG5048   351 PAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1145994705 291 LTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHE 326
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 5.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 1145994705 321 SFQRHEKTHSGEKPYKCKQCGKAFTR 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-206 2.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.04e-03
                          10        20
                  ....*....|....*....|..
gi 1145994705 185 HERTHTGEKPYECKQCGKSFSY 206
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
277-437 3.61e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 277 KLYECKQCGKALSSLTSFQTHIRM--HSGE--RPYEC--KTCGKGFYSAKSFQRHEKTHSGEKPYKCK--QCGKAFT--- 345
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 346 --RSGSFRYHERTHTGEKPYEC--KQCGKAFRSAPNLQLHGRTHTGEKPYQCK--ECGKAFRSASQLRIHRRIHTGEKPY 419
Cdd:COG5048   368 nnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*...
gi 1145994705 420 ECKKCGKaFRYVQNFRFH 437
Cdd:COG5048   448 LCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-326 6.31e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 6.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 149 IYHSSIQRHMVVHSGDG-PYKCKFCGKAFHCLSLYLIHERT--HTGE--KPYEC--KQCGKSFSYSATHRIHERTHIGEK 221
Cdd:COG5048   271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 222 PYEC--QECGKAFHS-----PRSCHRHERSHMGEKAYQC--KECGKAFMCPRYVRRHERTHSRKKLYECK--QCGKALSS 290
Cdd:COG5048   351 PAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1145994705 291 LTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHE 326
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 331-410 8.90e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 8.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 331 GEKPYKCK--QCGKAFTRSGSFRYHeRTHtgekpyecKQCGKAFRSAPNLQLHGRTHTGEKPYQCKECGKAFRSASQLRI 408
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1145994705 409 HR 410
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-426 2.25e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1145994705 361 KPYECKQCGKAFRSAPNLQLHGRTHTGEKPYQC--KECGKAFRSASQLRIHRRIHTGEKPYECKKCGK 426
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-445 2.89e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 166 PYKCKFCGKAFHCLSLYLIHERTHTGEKPYECKQCGKSFSYSATH--RIHERTHIGEKPYEC-QECGKAFHSPRSCHRHE 242
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLelSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 243 RSHMGEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECKQC----------------------GKALSSLTSFQTHIRM 300
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 301 HSGERPYECKTCGKGFYSAKSFQRHEKTHSGEKPYKCKQCGKAFTRSGSFRYHERTHTGEKPYECKQCGKAFRSAPNLQL 380
Cdd:COG5048   193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1145994705 381 HGRTHTGE-------KPYQCKECGKAFRSASQLRIHRR--IHTGE--KPYECKK--CGKAFRYVQNFRFHERTQTHKN 445
Cdd:COG5048   273 SSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 5.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 1145994705 321 SFQRHEKTHSGEKPYKCKQCGKAFTR 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
314-394 6.73e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 6.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994705 314 KGFYSAKSFQRHEKTHSG-EKPYKCKQCGKAFTRSGSFRYHERT--HTGE--KPYEC--KQCGKAFRSAPNLQLHGRTHT 386
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347


                  ....*...
gi 1145994705 387 GEKPYQCK 394
Cdd:COG5048   348 SISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-374 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1145994705 349 SFRYHERTHTGEKPYECKQCGKAFRS 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-430 1.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|....*
gi 1145994705 406 LRIHRRIHTGEKPYECKKCGKAFRY 430
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-206 2.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.04e-03
                          10        20
                  ....*....|....*....|..
gi 1145994705 185 HERTHTGEKPYECKQCGKSFSY 206
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-402 3.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 1145994705 377 NLQLHGRTHTGEKPYQCKECGKAFRS 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 391-413 6.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 6.80e-03
                          10        20
                  ....*....|....*....|...
gi 1145994705 391 YQCKECGKAFRSASQLRIHRRIH 413
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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