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Conserved domains on  [gi|1145994718|ref|NP_001335649|]
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zinc finger protein 439 isoform d [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 3.10e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 3.10e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1145994718   5 PVAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSIG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-471 1.37e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 300 VRRHERTHSRKKL-YECKQCGKALSSLTSFQTHIRM--HSGE--RPYEC--KTCGKGFYSAKSFQRHEKTHSGEKPYKCK 372
Cdd:COG5048   276 NESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEK 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 373 --QCGKAFT-----RSGSFRYHERTHTGEKPYEC--KQCGKAFRSAPNLQLHGRTHTGEKPYQCK--ECGKAFRSASQLR 441
Cdd:COG5048   356 llNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                         170       180       190
                  ....*....|....*....|....*....|
gi 1145994718 442 IHRRIHTGEKPYECKKCGKaFRYVQNFRFH 471
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-360 2.36e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 183 IYHSSIQRHMVVHSGDG-PYKCKFCGKAFHCLSLYLIHERT--HTGE--KPYEC--KQCGKSFSYSATHRIHERTHIGEK 255
Cdd:COG5048   271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 256 PYEC--QECGKAFHS-----PRSCHRHERSHMGEKAYQC--KECGKAFMCPRYVRRHERTHSRKKLYECK--QCGKALSS 324
Cdd:COG5048   351 PAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1145994718 325 LTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHE 360
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 3.10e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 3.10e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1145994718   5 PVAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSIG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-48 1.50e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 82.26  E-value: 1.50e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1145994718    6 VAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSIGKK 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 4.43e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 4.43e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1145994718   6 VAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSI 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-471 1.37e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 300 VRRHERTHSRKKL-YECKQCGKALSSLTSFQTHIRM--HSGE--RPYEC--KTCGKGFYSAKSFQRHEKTHSGEKPYKCK 372
Cdd:COG5048   276 NESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEK 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 373 --QCGKAFT-----RSGSFRYHERTHTGEKPYEC--KQCGKAFRSAPNLQLHGRTHTGEKPYQCK--ECGKAFRSASQLR 441
Cdd:COG5048   356 llNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                         170       180       190
                  ....*....|....*....|....*....|
gi 1145994718 442 IHRRIHTGEKPYECKKCGKaFRYVQNFRFH 471
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-360 2.36e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 183 IYHSSIQRHMVVHSGDG-PYKCKFCGKAFHCLSLYLIHERT--HTGE--KPYEC--KQCGKSFSYSATHRIHERTHIGEK 255
Cdd:COG5048   271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 256 PYEC--QECGKAFHS-----PRSCHRHERSHMGEKAYQC--KECGKAFMCPRYVRRHERTHSRKKLYECK--QCGKALSS 324
Cdd:COG5048   351 PAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1145994718 325 LTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHE 360
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
355-380 2.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 1145994718 355 SFQRHEKTHSGEKPYKCKQCGKAFTR 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-240 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|..
gi 1145994718 219 HERTHTGEKPYECKQCGKSFSY 240
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 3.10e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 3.10e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1145994718   5 PVAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSIG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-48 1.50e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 82.26  E-value: 1.50e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1145994718    6 VAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSIGKK 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 4.43e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 4.43e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1145994718   6 VAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSI 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-471 1.37e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 300 VRRHERTHSRKKL-YECKQCGKALSSLTSFQTHIRM--HSGE--RPYEC--KTCGKGFYSAKSFQRHEKTHSGEKPYKCK 372
Cdd:COG5048   276 NESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEK 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 373 --QCGKAFT-----RSGSFRYHERTHTGEKPYEC--KQCGKAFRSAPNLQLHGRTHTGEKPYQCK--ECGKAFRSASQLR 441
Cdd:COG5048   356 llNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                         170       180       190
                  ....*....|....*....|....*....|
gi 1145994718 442 IHRRIHTGEKPYECKKCGKaFRYVQNFRFH 471
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-360 2.36e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 183 IYHSSIQRHMVVHSGDG-PYKCKFCGKAFHCLSLYLIHERT--HTGE--KPYEC--KQCGKSFSYSATHRIHERTHIGEK 255
Cdd:COG5048   271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 256 PYEC--QECGKAFHS-----PRSCHRHERSHMGEKAYQC--KECGKAFMCPRYVRRHERTHSRKKLYECK--QCGKALSS 324
Cdd:COG5048   351 PAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1145994718 325 LTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHE 360
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 365-444 7.64e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 7.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 365 GEKPYKCK--QCGKAFTRSGSFRYHeRTHtgekpyecKQCGKAFRSAPNLQLHGRTHTGEKPYQCKECGKAFRSASQLRI 442
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1145994718 443 HR 444
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-479 1.19e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 200 PYKCKFCGKAFHCLSLYLIHERTHTGEKPYECKQCGKSFSYSATH--RIHERTHIGEKPYEC-QECGKAFHSPRSCHRHE 276
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLelSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 277 RSHMGEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECKQC----------------------GKALSSLTSFQTHIRM 334
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 335 HSGERPYECKTCGKGFYSAKSFQRHEKTHSGEKPYKCKQCGKAFTRSGSFRYHERTHTGEKPYECKQCGKAFRSAPNLQL 414
Cdd:COG5048   193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1145994718 415 HGRTHTGE-------KPYQCKECGKAFRSASQLRIHRR--IHTGE--KPYECKK--CGKAFRYVQNFRFHERTQTHKN 479
Cdd:COG5048   273 SSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
395-460 1.42e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1145994718 395 KPYECKQCGKAFRSAPNLQLHGRTHTGEKPYQC--KECGKAFRSASQLRIHRRIHTGEKPYECKKCGK 460
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
355-380 2.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 1145994718 355 SFQRHEKTHSGEKPYKCKQCGKAFTR 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-428 3.77e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145994718 348 KGFYSAKSFQRHEKTHSG-EKPYKCKQCGKAFTRSGSFRYHERT--HTGE--KPYEC--KQCGKAFRSAPNLQLHGRTHT 420
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347


                  ....*...
gi 1145994718 421 GEKPYQCK 428
Cdd:COG5048   348 SISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 6.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 1145994718 383 SFRYHERTHTGEKPYECKQCGKAFRS 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
440-464 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*
gi 1145994718 440 LRIHRRIHTGEKPYECKKCGKAFRY 464
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-240 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|..
gi 1145994718 219 HERTHTGEKPYECKQCGKSFSY 240
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-436 2.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 1145994718 411 NLQLHGRTHTGEKPYQCKECGKAFRS 436
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 425-447 3.93e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.93e-03
                          10        20
                  ....*....|....*....|...
gi 1145994718 425 YQCKECGKAFRSASQLRIHRRIH 447
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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