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Conserved domains on  [gi|1102041705|ref|NP_001333909|]
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stress-associated endoplasmic reticulum protein 2 [Homo sapiens]

Protein Classification

RAMP4 family protein( domain architecture ID 10535141)

RAMP4 family protein similar to human stress-associated endoplasmic reticulum protein 1 (SERP1), also called ribosome-attached membrane protein 4 (RAMP4), that interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum, and protects unfolded target proteins against degradation during ER stress

Gene Ontology:  GO:0005783|GO:0030968

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RAMP4 pfam06624
Ribosome associated membrane protein RAMP4; This family consists of several ribosome ...
 3-58 2.76e-30

Ribosome associated membrane protein RAMP4; This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. stabilization of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER.


:

Pssm-ID: 461965  Cd Length: 57  Bit Score: 100.29  E-value: 2.76e-30
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 1102041705  3 AKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQII 58
Cdd:pfam06624  2 QTRRMRRANEKFAKNITKRGKVPKSLKKKEKKSPVGPWLLGLFIFVVCGSAIFQII 57
 
Name Accession Description Interval E-value
RAMP4 pfam06624
Ribosome associated membrane protein RAMP4; This family consists of several ribosome ...
 3-58 2.76e-30

Ribosome associated membrane protein RAMP4; This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. stabilization of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER.


Pssm-ID: 461965  Cd Length: 57  Bit Score: 100.29  E-value: 2.76e-30
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 1102041705  3 AKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQII 58
Cdd:pfam06624  2 QTRRMRRANEKFAKNITKRGKVPKSLKKKEKKSPVGPWLLGLFIFVVCGSAIFQII 57
 
Name Accession Description Interval E-value
RAMP4 pfam06624
Ribosome associated membrane protein RAMP4; This family consists of several ribosome ...
 3-58 2.76e-30

Ribosome associated membrane protein RAMP4; This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. stabilization of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER.


Pssm-ID: 461965  Cd Length: 57  Bit Score: 100.29  E-value: 2.76e-30
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 1102041705  3 AKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQII 58
Cdd:pfam06624  2 QTRRMRRANEKFAKNITKRGKVPKSLKKKEKKSPVGPWLLGLFIFVVCGSAIFQII 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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