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Conserved domains on  [gi|1093794680|ref|NP_001333621|]
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protein RIC-3 isoform j [Homo sapiens]

Protein Classification

RIC3 domain-containing protein( domain architecture ID 10634033)

RIC3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RIC3 pfam15361
Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with ...
 1-116 5.55e-33

Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.


:

Pssm-ID: 464671  Cd Length: 142  Bit Score: 119.00  E-value: 5.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093794680   1 MMHHHQAPS--DGQTPGARFQRSHLAEAFAKAKGSGGGAGgggsgRGLMGQIIPIYGFGIFLYILYILFKL-SKG-KTTA 76
Cdd:pfam15361  27 SSHSFKHPEsaQQRAAGHPFMRSHMEEAIAKTKGKGQGGS-----KGLMGQLMPIYGIGILLYILYILFKIkSKKdKTKS 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1093794680  77 EDGKCYTAMPGNTHRKITS-FELAQLQEKLKETEAAMEKLI 116
Cdd:pfam15361 102 KESKFKPKRTEGAKKKIETeNELNQLQERLAQTERAMEKIL 142
 
Name Accession Description Interval E-value
RIC3 pfam15361
Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with ...
 1-116 5.55e-33

Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.


Pssm-ID: 464671  Cd Length: 142  Bit Score: 119.00  E-value: 5.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093794680   1 MMHHHQAPS--DGQTPGARFQRSHLAEAFAKAKGSGGGAGgggsgRGLMGQIIPIYGFGIFLYILYILFKL-SKG-KTTA 76
Cdd:pfam15361  27 SSHSFKHPEsaQQRAAGHPFMRSHMEEAIAKTKGKGQGGS-----KGLMGQLMPIYGIGILLYILYILFKIkSKKdKTKS 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1093794680  77 EDGKCYTAMPGNTHRKITS-FELAQLQEKLKETEAAMEKLI 116
Cdd:pfam15361 102 KESKFKPKRTEGAKKKIETeNELNQLQERLAQTERAMEKIL 142
 
Name Accession Description Interval E-value
RIC3 pfam15361
Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with ...
 1-116 5.55e-33

Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.


Pssm-ID: 464671  Cd Length: 142  Bit Score: 119.00  E-value: 5.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093794680   1 MMHHHQAPS--DGQTPGARFQRSHLAEAFAKAKGSGGGAGgggsgRGLMGQIIPIYGFGIFLYILYILFKL-SKG-KTTA 76
Cdd:pfam15361  27 SSHSFKHPEsaQQRAAGHPFMRSHMEEAIAKTKGKGQGGS-----KGLMGQLMPIYGIGILLYILYILFKIkSKKdKTKS 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1093794680  77 EDGKCYTAMPGNTHRKITS-FELAQLQEKLKETEAAMEKLI 116
Cdd:pfam15361 102 KESKFKPKRTEGAKKKIETeNELNQLQERLAQTERAMEKIL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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