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Conserved domains on  [gi|1069561729|ref|NP_001333025|]
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tetratricopeptide repeat protein 36 isoform b [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 1008599)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NlpI super family cl34822
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
3-104 9.55e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG4785:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.45  E-value: 9.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   3 AEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDD 82
Cdd:COG4785    84 DSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA----YLNRGIALYYLGRYEL 159

                          90       100
                  ....*....|....*....|..
gi 1069561729  83 ARRDFERAARLGSPFARRQLVL 104
Cdd:COG4785   160 AIADLEKALELDPNDPERALWL 181
 
Name Accession Description Interval E-value
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
3-104 9.55e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.45  E-value: 9.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   3 AEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDD 82
Cdd:COG4785    84 DSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA----YLNRGIALYYLGRYEL 159

                          90       100
                  ....*....|....*....|..
gi 1069561729  83 ARRDFERAARLGSPFARRQLVL 104
Cdd:COG4785   160 AIADLEKALELDPNDPERALWL 181
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 21-95 8.07e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 43.82  E-value: 8.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1069561729  21 LLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGrgraARQSFVQRGLLARLQGRDDDARRDFERAARLGS 95
Cdd:TIGR00990 326 LGEKEAIALNLRGTFKCLKGKHLEALADLSKSIELDPR----VTQSYIKRASMNLELGDPDKAEEDFDKALKLNS 396
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 7-99 1.72e-04

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 39.77  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   7 DLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDDARRD 86
Cdd:PLN03088   17 DFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKA----YLRKGTACMKLEEYQTAKAA 92

                          90
                  ....*....|...
gi 1069561729  87 FERAARLGSPFAR 99
Cdd:PLN03088   93 LEKGASLAPGDSR 105
TPR_1 pfam00515
Tetratricopeptide repeat;
26-55 1.32e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.32  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1069561729  26 ASAYNNRAQARRLQGDVAGALEDLERAVEL 55
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALEL 30
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 4-56 6.68e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 34.91  E-value: 6.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1069561729   4 EAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELS 56
Cdd:cd24142    12 DQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELD 64
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 26-55 9.40e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 32.03  E-value: 9.40e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1069561729   26 ASAYNNRAQARRLQGDVAGALEDLERAVEL 55
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
 
Name Accession Description Interval E-value
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
3-104 9.55e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.45  E-value: 9.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   3 AEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDD 82
Cdd:COG4785    84 DSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA----YLNRGIALYYLGRYEL 159

                          90       100
                  ....*....|....*....|..
gi 1069561729  83 ARRDFERAARLGSPFARRQLVL 104
Cdd:COG4785   160 AIADLEKALELDPNDPERALWL 181
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1-93 1.15e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.84  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   1 MAAEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRD 80
Cdd:COG3914   121 LLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEA----LNNLGNALQDLGRL 196

                          90
                  ....*....|...
gi 1069561729  81 DDARRDFERAARL 93
Cdd:COG3914   197 EEAIAAYRRALEL 209
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-93 2.84e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.68  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   2 AAEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDD 81
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEA----YLNLGEALRRLGRLE 163

                          90
                  ....*....|..
gi 1069561729  82 DARRDFERAARL 93
Cdd:COG3914   164 EAIAALRRALEL 175
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
3-93 3.91e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 3.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   3 AEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDD 82
Cdd:COG0457    19 RRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA----LNNLGLALQALGRYEE 94

                          90
                  ....*....|.
gi 1069561729  83 ARRDFERAARL 93
Cdd:COG0457    95 ALEDYDKALEL 105
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 21-95 8.07e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 43.82  E-value: 8.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1069561729  21 LLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGrgraARQSFVQRGLLARLQGRDDDARRDFERAARLGS 95
Cdd:TIGR00990 326 LGEKEAIALNLRGTFKCLKGKHLEALADLSKSIELDPR----VTQSYIKRASMNLELGDPDKAEEDFDKALKLNS 396
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 3-103 1.35e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.53  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   3 AEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAARqsfvQRGLLARLQGRDDD 82
Cdd:COG4235    28 LRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALY----LLGLAAFQQGDYAE 103

                          90       100
                  ....*....|....*....|.
gi 1069561729  83 ARRDFERAARLGSPFARRQLV 103
Cdd:COG4235   104 AIAAWQKLLALLPADAPARLL 124
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
3-128 8.13e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 8.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   3 AEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDD 82
Cdd:COG0457    87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADA----LYNLGIALEKLGRYEE 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1069561729  83 ARRDFERAARLGSPFARRQLVLLNPYAALCNRMLADMMGQLRRPRD 128
Cdd:COG0457   163 ALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALR 208
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
21-93 9.72e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.28  E-value: 9.72e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1069561729  21 LLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDDARRDFERAARL 93
Cdd:COG4785    68 ALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEA----YNNRGLAYLLLGDYDAALEDFDRALEL 136
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
2-93 1.47e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   2 AAEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEdLERAVELSGGRGRAarqsFVQRGLLARLQGRDD 81
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEA----LLNLAELLLELGDYD 76

                          90
                  ....*....|..
gi 1069561729  82 DARRDFERAARL 93
Cdd:COG3063    77 EALAYLERALEL 88
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 7-99 1.72e-04

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 39.77  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   7 DLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDDARRD 86
Cdd:PLN03088   17 DFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKA----YLRKGTACMKLEEYQTAKAA 92

                          90
                  ....*....|...
gi 1069561729  87 FERAARLGSPFAR 99
Cdd:PLN03088   93 LEKGASLAPGDSR 105
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1-111 2.40e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 2.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   1 MAAEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAArqsfVQRGLLARLQGRD 80
Cdd:COG4783    13 ALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEAR----LNLGLALLKAGDY 88

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1069561729  81 DDARRDFERAARLGSPFARRQLVLLNPYAAL 111
Cdd:COG4783    89 DEALALLEKALKLDPEHPEAYLRLARAYRAL 119
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 4-62 4.46e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 4.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1069561729   4 EAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRA 62
Cdd:TIGR02917 375 ALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRA 433
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1-93 6.16e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.48  E-value: 6.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   1 MAAEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAARQsfvqRGLLARLQGRD 80
Cdd:COG4783    47 ILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLR----LARAYRALGRP 122

                          90
                  ....*....|...
gi 1069561729  81 DDARRDFERAARL 93
Cdd:COG4783   123 DEAIAALEKALEL 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
23-99 9.10e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 37.68  E-value: 9.10e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1069561729  23 PERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDDARRDFERAARLGSPFAR 99
Cdd:COG0457     5 PDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEA----LYNLGLAYLRLGRYEEALADYEQALELDPDDAE 77
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 5-92 1.15e-03

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 37.59  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   5 AGDLSTALERFGQAICLLPeRASAYNNRAQARRLQGDVAGALEDLERAVELsggrgrAARQSFVQRGLLARLQGRDDDA- 83
Cdd:PRK09782  589 PGQPELALNDLTRSLNIAP-SANAYVARATIYRQRHNVPAAVSDLRAALEL------EPNNSNYQAALGYALWDSGDIAq 661

                          90
                  ....*....|
gi 1069561729  84 -RRDFERAAR 92
Cdd:PRK09782  662 sREMLERAHK 671
TPR_1 pfam00515
Tetratricopeptide repeat;
26-55 1.32e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.32  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1069561729  26 ASAYNNRAQARRLQGDVAGALEDLERAVEL 55
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALEL 30
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-111 1.76e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 36.89  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   2 AAEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDD 81
Cdd:COG3914    54 AAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEA----LFNLGNLLLALGRLE 129

                          90       100       110
                  ....*....|....*....|....*....|
gi 1069561729  82 DARRDFERAARLGSPFARRQLVLLNPYAAL 111
Cdd:COG3914   130 EALAALRRALALNPDFAEAYLNLGEALRRL 159
TPR_12 pfam13424
Tetratricopeptide repeat;
24-93 3.37e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 34.29  E-value: 3.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1069561729  24 ERASAYNNRAQARRLQGDVAGALEDLERAVELS----GGRGRAARQSFVQRGLLARLQGRDDDARRDFERAARL 93
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIArrllGPDHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 3-111 3.38e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 35.86  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   3 AEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDD 82
Cdd:COG2956   121 EQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARA----LLLLAELYLEQGDYEE 196

                          90       100
                  ....*....|....*....|....*....
gi 1069561729  83 ARRDFERAARLGSPFARRQLVLLNPYAAL 111
Cdd:COG2956   197 AIAALERALEQDPDYLPALPRLAELYEKL 225
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
3-114 6.59e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 34.98  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   3 AEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAARQSFVQRGLLARLQGRDDD 82
Cdd:COG0457   121 LELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALL 200

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1069561729  83 ARRDFERAARLGSPFARRQLVLLNPYAALCNR 114
Cdd:COG0457   201 LALEQALRKKLAILTLAALAELLLLALALLLA 232
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 4-56 6.68e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 34.91  E-value: 6.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1069561729   4 EAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELS 56
Cdd:cd24142    12 DQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELD 64
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 4-104 8.98e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 34.70  E-value: 8.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069561729   4 EAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAarqsFVQRGLLARLQGRDDDA 83
Cdd:COG2956    88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA----YCELAELYLEQGDYDEA 163

                          90       100
                  ....*....|....*....|.
gi 1069561729  84 RRDFERAARLGSPFARRQLVL 104
Cdd:COG2956   164 IEALEKALKLDPDCARALLLL 184
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 26-55 9.40e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 32.03  E-value: 9.40e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1069561729   26 ASAYNNRAQARRLQGDVAGALEDLERAVEL 55
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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