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Conserved domains on  [gi|1063696728|ref|NP_001322358|]
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AGAMOUS-like 67 [Arabidopsis thaliana]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 734)

MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor)-box domain-containing protein functions as a transcription factor and may be involved in various important aspects of development and differentiation

CATH:  3.40.1810.10
Gene Ontology:  GO:0003700|GO:0046983
PubMed:  8875863|29802068|12949148
SCOP:  4001594

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS super family cl00109
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 2-75 4.55e-28

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


The actual alignment was detected with superfamily member cd00265:

Pssm-ID: 469617 [Multi-domain]  Cd Length: 77  Bit Score: 102.25  E-value: 4.55e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063696728   2 GRVKLELKRIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLFSGqTRIEDVLARYINLPD 75
Cdd:cd00265     1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSS-PSMEKIIERYQKTSG 73
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-75 4.55e-28

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 102.25  E-value: 4.55e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063696728   2 GRVKLELKRIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLFSGqTRIEDVLARYINLPD 75
Cdd:cd00265     1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSS-PSMEKIIERYQKTSG 73
MADS smart00432
MADS domain;
2-58 6.88e-27

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 98.40  E-value: 6.88e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063696728    2 GRVKLELKRIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLFS 58
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFA 57
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
10-57 7.07e-24

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 90.56  E-value: 7.07e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063696728  10 RIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLF 57
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-58 3.66e-05

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 44.24  E-value: 3.66e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063696728   1 MGRVKLELKRIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLFS 58
Cdd:COG5068    81 VTGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFT 138
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-75 4.55e-28

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 102.25  E-value: 4.55e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063696728   2 GRVKLELKRIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLFSGqTRIEDVLARYINLPD 75
Cdd:cd00265     1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSS-PSMEKIIERYQKTSG 73
MADS smart00432
MADS domain;
2-58 6.88e-27

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 98.40  E-value: 6.88e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063696728    2 GRVKLELKRIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLFS 58
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFA 57
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 2-54 2.28e-26

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 97.20  E-value: 2.28e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063696728   2 GRVKLELKRIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRL 54
Cdd:cd00120     1 GRGKIEIKRIENKTSRQVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKL 53
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 2-79 9.14e-25

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 93.86  E-value: 9.14e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063696728   2 GRVKLELKRIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLFSGQTRIEDVLARYINLPDQERE 79
Cdd:cd00266     1 GRKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSEVEGVISRFEVLSALERK 78
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
10-57 7.07e-24

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 90.56  E-value: 7.07e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063696728  10 RIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLF 57
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-58 3.66e-05

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 44.24  E-value: 3.66e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063696728   1 MGRVKLELKRIEKSTNRQITFSKRKKGLIKKAYELSTLCDIDLALLMFSPSDRLCLFS 58
Cdd:COG5068    81 VTGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFT 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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