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Conserved domains on  [gi|1062594099|ref|NP_001318063|]
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zinc finger protein 253 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-421 1.56e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099  94 NLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRC--EECGKAFNQSANLTTHKRIHTGEKPYRCEecgkafkQSSNLTTHK 171
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS-------KSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 172 KIHtgekpYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEECGK--AFKHPSHVTTHKKIHTRG-----KPYNCEECGKS 244
Cdd:COG5048   105 ASS-----SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQsnslhPPLPANSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 245 FKHCSNLTIHKRIHTGEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYRCRECGKAFNHS------TTLFSHEKIHTGEK 318
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 319 PYKCDECGKTFTWPSILSKHKRTHTG-EKPYKCEECGKSFTASSTLTTHKR--IHTGE--KPYKCEE--CGKAFNWSSDL 391
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350
                  ....*....|....*....|....*....|
gi 1062594099 392 NKHKKIHIERKPYIVKNVTDLLNVPPLLIS 421
Cdd:COG5048   340 KRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-421 1.56e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099  94 NLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRC--EECGKAFNQSANLTTHKRIHTGEKPYRCEecgkafkQSSNLTTHK 171
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS-------KSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 172 KIHtgekpYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEECGK--AFKHPSHVTTHKKIHTRG-----KPYNCEECGKS 244
Cdd:COG5048   105 ASS-----SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQsnslhPPLPANSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 245 FKHCSNLTIHKRIHTGEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYRCRECGKAFNHS------TTLFSHEKIHTGEK 318
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 319 PYKCDECGKTFTWPSILSKHKRTHTG-EKPYKCEECGKSFTASSTLTTHKR--IHTGE--KPYKCEE--CGKAFNWSSDL 391
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350
                  ....*....|....*....|....*....|
gi 1062594099 392 NKHKKIHIERKPYIVKNVTDLLNVPPLLIS 421
Cdd:COG5048   340 KRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
zf-H2C2_2 pfam13465
Zinc-finger double domain;
138-163 2.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.04e-04
                          10        20
                  ....*....|....*....|....*.
gi 1062594099 138 NLTTHKRIHTGEKPYRCEECGKAFKQ 163
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-421 1.56e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099  94 NLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRC--EECGKAFNQSANLTTHKRIHTGEKPYRCEecgkafkQSSNLTTHK 171
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS-------KSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 172 KIHtgekpYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEECGK--AFKHPSHVTTHKKIHTRG-----KPYNCEECGKS 244
Cdd:COG5048   105 ASS-----SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQsnslhPPLPANSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 245 FKHCSNLTIHKRIHTGEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYRCRECGKAFNHS------TTLFSHEKIHTGEK 318
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 319 PYKCDECGKTFTWPSILSKHKRTHTG-EKPYKCEECGKSFTASSTLTTHKR--IHTGE--KPYKCEE--CGKAFNWSSDL 391
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350
                  ....*....|....*....|....*....|
gi 1062594099 392 NKHKKIHIERKPYIVKNVTDLLNVPPLLIS 421
Cdd:COG5048   340 KRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-279 6.68e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 6.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 122 KPYRCEECGKAFNQSANLTTHKR--IHTGE--KPYRCEE--CGKAFKQSSNLTTHKKIHTGEKPYKC--EECGKAFNRST 193
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 194 D----LTTHKIVHTGEKPYKC---EECGKAFKHPSHVTTHKKIHTRGKPYNCE--ECGKSFKHCSNLTIHKRIHTGEKPY 264
Cdd:COG5048   368 NneppQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*...
gi 1062594099 265 KCEECGK---AFHLSSHL 279
Cdd:COG5048   448 LCSILKSfrrDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-396 1.01e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 234 KPYNCEECGKSFKHCSNLTIHKR--IHTGE--KPYKCEE--CGKAFHLSSHLTTHKILHTGEKPYRC--RECGKAFNHST 305
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 306 T-----LFSHEKIHTGEKPYKCD--ECGKTFTWPSILSKHKRTHTGEKP--YKCEECGKSFTASSTLTTHKRIHTGEKPY 376
Cdd:COG5048   368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 1062594099 377 KCEECGKaFNWSSDLNKHKK 396
Cdd:COG5048   448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-329 2.12e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 178 KPYKCEECGKAFNRSTDLTTHK--IVHTGE--KPYKCEE--CGKAFKHPSHVTTHKKIHTRGKPYNC--EECGKSFKHCS 249
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 250 N-----LTIHKRIHTGEKPYKCE--ECGKAFHLSSHLTTHKILHTGEKPYRCR--ECGKAFNHSTTLFSHEKIHTGEKPY 320
Cdd:COG5048   368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ....*....
gi 1062594099 321 KCDECGKTF 329
Cdd:COG5048   448 LCSILKSFR 456
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 148-228 2.80e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 148 GEKPYRCE--ECGKAFKQSSNLTTHKKiHTgekpykceECGKAFNRSTDLTTHKIVHTGEKPYKCEECGKAFKHPSHVTT 225
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1062594099 226 HKK 228
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 176-255 2.03e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 176 GEKPYKCE--ECGKAFNRSTDLTTHKIvhTGEKPYKCEECGKAFKHPSHVTthkkihtRGKPYNCEECGKSFKHCSNLTI 253
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQKLHENPSPEKMNIFSA-------KDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1062594099 254 HK 255
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
138-163 2.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.04e-04
                          10        20
                  ....*....|....*....|....*.
gi 1062594099 138 NLTTHKRIHTGEKPYRCEECGKAFKQ 163
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
166-191 3.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 1062594099 166 NLTTHKKIHTGEKPYKCEECGKAFNR 191
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-358 4.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.61e-04
                          10        20
                  ....*....|....*....|....
gi 1062594099 335 LSKHKRTHTGEKPYKCEECGKSFT 358
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 120-172 5.61e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 5.61e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1062594099 120 GEKPYRCE--ECGKAFNQSANLTTHKR-------------------IHTGEKPYRCEECGKAFKQSSNLTTHKK 172
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-273 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....
gi 1062594099 250 NLTIHKRIHTGEKPYKCEECGKAF 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-386 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....
gi 1062594099 363 LTTHKRIHTGEKPYKCEECGKAFN 386
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
111-135 1.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*
gi 1062594099 111 LTTHKKIHTGEKPYRCEECGKAFNQ 135
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-330 1.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.88e-03
                          10        20
                  ....*....|....*....|....
gi 1062594099 307 LFSHEKIHTGEKPYKCDECGKTFT 330
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
194-219 2.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 1062594099 194 DLTTHKIVHTGEKPYKCEECGKAFKH 219
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 221-312 3.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062594099 221 SHVTTHKKIHTRGKPYNCEECGKSFKHCSNLTIH---KRIHT-GEKPYKCE--ECGKAF-------------HLSSHLT- 280
Cdd:COG5189   303 GGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYknqnglkyhmlhgHQNQKLHe 382

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1062594099 281 -----THKILHTGEKPYRCRECGKAFNHSTTLFSHEK 312
Cdd:COG5189   383 npspeKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
278-303 5.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 1062594099 278 HLTTHKILHTGEKPYRCRECGKAFNH 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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