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Conserved domains on  [gi|1061899969|ref|NP_001317919|]
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ATP-dependent RNA helicase DHX30 isoform 4 [Homo sapiens]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
398-930 7.17e-137

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 436.05  E-value: 7.17e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  398 PVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 477
Cdd:COG1643      2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  478 ELGPSLRRNVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLNPA 556
Cdd:COG1643     78 ELGEPVGETVGYRVRFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  557 LRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqylhrhrhheSEDECALdLDLVTDLVLHIdA 636
Cdd:COG1643    157 LKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA-L 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  637 RGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIV 716
Cdd:COG1643    217 AEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIR 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  717 HVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ-A 795
Cdd:COG1643    294 YVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILElA 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  796 KIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVV 875
Cdd:COG1643    374 AWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILA 449

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061899969  876 SCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRSSR 930
Cdd:COG1643    450 ALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 987-1074 5.06e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  987 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1064
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 1061899969 1065 QVHPLAVLLL 1074
Cdd:pfam07717   69 AISPEWLLLF 78
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
398-930 7.17e-137

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 436.05  E-value: 7.17e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  398 PVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 477
Cdd:COG1643      2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  478 ELGPSLRRNVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLNPA 556
Cdd:COG1643     78 ELGEPVGETVGYRVRFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  557 LRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqylhrhrhheSEDECALdLDLVTDLVLHIdA 636
Cdd:COG1643    157 LKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA-L 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  637 RGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIV 716
Cdd:COG1643    217 AEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIR 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  717 HVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ-A 795
Cdd:COG1643    294 YVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILElA 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  796 KIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVV 875
Cdd:COG1643    374 AWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILA 449

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061899969  876 SCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRSSR 930
Cdd:COG1643    450 ALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 406-583 6.24e-121

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 369.89  E-value: 6.24e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17976      1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 565
Cdd:cd17976     81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                          170
                   ....*....|....*...
gi 1061899969  566 GDNERFSRYFGGCPVIKV 583
Cdd:cd17976    161 GDNQRLSRYFGGCPVVRV 178
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 404-863 8.22e-84

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 291.06  E-value: 8.22e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  404 PQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcnVIITQPRRISAVSVAQRVSHELGPSL 483
Cdd:PRK11664     2 SSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK-----IIMLEPRRLAARNVAQRLAEQLGEKP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  484 RRNVGFQVRLESK--PPSRggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQR-LNPALRLV 560
Cdd:PRK11664    77 GETVGYRMRAESKvgPNTR---LEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQgLRDDLKLL 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  561 LMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilAKLGKHQYLhrhrhhesEDECAldlDLVTDLVlhidaRGEP 640
Cdd:PRK11664   154 IMSATLDNDRLQQLLPDAPVIVSEGRSFPVERRY-----QPLPAHQRF--------DEAVA---RATAELL-----RQES 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  641 GGILCFLPGWQEIKGVQQRLQEALGmheSKYLILPVHSNIPMMDQ-KAIfQQPPVGVRKIVLATNIAETSITINDIVHVV 719
Cdd:PRK11664   213 GSLLLFLPGVGEIQRVQEQLASRVA---SDVLLCPLYGALSLAEQqKAI-LPAPAGRRKVVLATNIAETSLTIEGIRLVV 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  720 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLV---LQAK 796
Cdd:PRK11664   289 DSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLlelLQWG 368

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1061899969  797 IHMPEKTaveflsKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAkAIVLAA 863
Cdd:PRK11664   369 CHDPAQL------SWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLA-AMLVAA 428
DEXDc smart00487
DEAD-like helicases superfamily;
410-589 7.39e-25

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 103.34  E-value: 7.39e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969   410 PHRDTILNAIEQHP-VVVISGDTGCGKTTRIPQLLLERYvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVG 488
Cdd:smart00487   11 PYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAL---KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVG 87

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969   489 FQVRLESKPP-----SRGGALLFCTVGILLRKLQSNP-SLEGVSHVIVDEVHERDvNTDFLLILLKGLQRLNPALRLVLM 562
Cdd:smart00487   88 LYGGDSKREQlrkleSGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLLL 166

                           170       180
                    ....*....|....*....|....*....
gi 1061899969   563 SAT--GDNERFSRYFGGCPVIKVPGFMYP 589
Cdd:smart00487  167 SATppEEIENLLELFLNDPVFIDVGFTPL 195
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 823-911 3.61e-17

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 78.05  E-value: 3.61e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  823 AVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQ------------- 888
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSvRDPFVQPNFldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 1061899969  889 NRAEVDKVKALLSH-DSGSDHLAF 911
Cdd:pfam04408   81 RRAADEKARAKFARlDLEGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 987-1074 5.06e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  987 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1064
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 1061899969 1065 QVHPLAVLLL 1074
Cdd:pfam07717   69 AISPEWLLLF 78
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
398-930 7.17e-137

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 436.05  E-value: 7.17e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  398 PVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 477
Cdd:COG1643      2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  478 ELGPSLRRNVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLNPA 556
Cdd:COG1643     78 ELGEPVGETVGYRVRFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  557 LRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqylhrhrhheSEDECALdLDLVTDLVLHIdA 636
Cdd:COG1643    157 LKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA-L 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  637 RGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIV 716
Cdd:COG1643    217 AEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIR 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  717 HVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ-A 795
Cdd:COG1643    294 YVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILElA 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  796 KIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVV 875
Cdd:COG1643    374 AWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILA 449

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061899969  876 SCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRSSR 930
Cdd:COG1643    450 ALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 406-583 6.24e-121

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 369.89  E-value: 6.24e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17976      1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 565
Cdd:cd17976     81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                          170
                   ....*....|....*...
gi 1061899969  566 GDNERFSRYFGGCPVIKV 583
Cdd:cd17976    161 GDNQRLSRYFGGCPVVRV 178
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 404-863 8.22e-84

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 291.06  E-value: 8.22e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  404 PQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcnVIITQPRRISAVSVAQRVSHELGPSL 483
Cdd:PRK11664     2 SSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK-----IIMLEPRRLAARNVAQRLAEQLGEKP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  484 RRNVGFQVRLESK--PPSRggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQR-LNPALRLV 560
Cdd:PRK11664    77 GETVGYRMRAESKvgPNTR---LEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQgLRDDLKLL 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  561 LMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilAKLGKHQYLhrhrhhesEDECAldlDLVTDLVlhidaRGEP 640
Cdd:PRK11664   154 IMSATLDNDRLQQLLPDAPVIVSEGRSFPVERRY-----QPLPAHQRF--------DEAVA---RATAELL-----RQES 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  641 GGILCFLPGWQEIKGVQQRLQEALGmheSKYLILPVHSNIPMMDQ-KAIfQQPPVGVRKIVLATNIAETSITINDIVHVV 719
Cdd:PRK11664   213 GSLLLFLPGVGEIQRVQEQLASRVA---SDVLLCPLYGALSLAEQqKAI-LPAPAGRRKVVLATNIAETSLTIEGIRLVV 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  720 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLV---LQAK 796
Cdd:PRK11664   289 DSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLlelLQWG 368

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1061899969  797 IHMPEKTaveflsKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAkAIVLAA 863
Cdd:PRK11664   369 CHDPAQL------SWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLA-AMLVAA 428
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 380-912 1.02e-83

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 298.51  E-value: 1.02e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  380 AEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVI 459
Cdd:PRK11131    47 AKEIAQAAQRVLLREAARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLEL----GRGVKGLIG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  460 ITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN 539
Cdd:PRK11131   123 HTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLM-TDGILLAEIQQDRLLMQYDTIIIDEAHERSLN 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  540 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilaklgkhqylhRHRHHESEDE 619
Cdd:PRK11131   202 IDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY---------------RPIVEEADDT 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  620 CALDLDLVTDLVLHIDARGePGGILCFLPGWQEIKGVQQRLQEALGMHESkylILPVHSNIPMMDQKAIFQqpPVGVRKI 699
Cdd:PRK11131   267 ERDQLQAIFDAVDELGREG-PGDILIFMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRI 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  700 VLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ 779
Cdd:PRK11131   341 VLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFT 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  780 VPEILRTPLENLVLQ-AKIHMPEKTAVEFlskaVDSPNIKAVDEAVILLQEIGVLDQRE-----YLTTLGQRLAHISTDP 853
Cdd:PRK11131   421 DPEILRTNLASVILQmTALGLGDIAAFPF----VEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDP 496

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  854 RLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQNRAEVDKvKALLSHDSGSDHLAFV 912
Cdd:PRK11131   497 RLARMVLEAQKHGCVREVMIITSALSiQDPRERPMDKQQASDE-KHRRFADKESDFLAFV 555
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 422-583 2.91e-81

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 262.01  E-value: 2.91e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  422 HPVVVISGDTGCGKTTRIPQLLLERYVTegRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPpSRG 501
Cdd:cd17917      1 NQVVVIVGETGSGKTTQVPQFLLEDGLA--KGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKT-SSK 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  502 GALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVI 581
Cdd:cd17917     78 TRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVI 157


                   ..
gi 1061899969  582 KV 583
Cdd:cd17917    158 HI 159
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 588-767 4.81e-79

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 256.69  E-value: 4.81e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  588 YPVKEHYLEDILAKLGKHqylhrhrhheSEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRL-QEALGM 666
Cdd:cd18791      1 FPVEVYYLEDILELLGIS----------SEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLrEELLSP 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  667 HESKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRA 746
Cdd:cd18791     71 DLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKA 150

                          170       180
                   ....*....|....*....|.
gi 1061899969  747 NVIQRRGRAGRCQSGFAYHLF 767
Cdd:cd18791    151 SAEQRAGRAGRTRPGKCYRLY 171
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 376-583 8.78e-72

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 238.97  E-value: 8.78e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  376 PLLEAEEVRLSQSLL-ELWRRRG------PVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYV 448
Cdd:cd17972     22 PLAFATPEQISMDLKnELMYQREqdhnlqQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFI 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  449 TEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSnpSLEGVSHV 528
Cdd:cd17972    102 QNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFCTVGVLLRKLEA--GIRGISHV 179

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1061899969  529 IVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKV 583
Cdd:cd17972    180 IVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 406-583 1.70e-63

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 213.55  E-value: 1.70e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPS--L 483
Cdd:cd17981      1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAEScgL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  484 RRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMS 563
Cdd:cd17981     81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160

                          170       180
                   ....*....|....*....|
gi 1061899969  564 ATGDNERFSRYFGGCPVIKV 583
Cdd:cd17981    161 ATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 398-583 8.77e-62

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 208.54  E-value: 8.77e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  398 PVWQEapqlpvdphRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSH 477
Cdd:cd17985      2 PAWQE---------RETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQ 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  478 ELGPSLRRNVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPAL 557
Cdd:cd17985     73 ERAERVGQSVGYQIRLESVK-SSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDL 151

                          170       180
                   ....*....|....*....|....*.
gi 1061899969  558 RLVLMSATGDNERFSRYFGGCPVIKV 583
Cdd:cd17985    152 KVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 406-583 1.14e-59

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 202.45  E-value: 1.14e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYV-TEGRGARCNVIITQPRRISAVSVAQRVSHELG---- 480
Cdd:cd17975      1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLlNGGTAQKCNIVCTQPRRISAMSLATRVCEELGcesg 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  481 PSLRRNV-GFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRL 559
Cdd:cd17975     81 PGGKNSLcGYQIRMESRT-GEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159

                          170       180
                   ....*....|....*....|....
gi 1061899969  560 VLMSATGDNERFSRYFGGCPVIKV 583
Cdd:cd17975    160 ILMSATVDCEKFSSYFTHCPILRI 183
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 406-583 5.49e-53

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 183.11  E-value: 5.49e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERyvTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17987      1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDD--CYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPS-LEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSA 564
Cdd:cd17987     79 TVGYQIRLESRV-SPKTLLTFCTNGVLLRTLMAGDSaLSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157

                          170
                   ....*....|....*....
gi 1061899969  565 TGDNERFSRYFGGCPVIKV 583
Cdd:cd17987    158 ALDVNLFIRYFGSCPVIYI 176
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 406-590 3.96e-51

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 178.08  E-value: 3.96e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTegRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17988      1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYK--RGKYCNIVVTQPRRIAAISIARRVSQEREWTLGS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLEsKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPA-LRLVLMSA 564
Cdd:cd17988     79 LVGYQVGLE-RPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSA 157

                          170       180
                   ....*....|....*....|....*.
gi 1061899969  565 TGDNERFSRYFGgcpVIKVPGFMYPV 590
Cdd:cd17988    158 TISCKEFADYFT---TPNNPAYVFEV 180
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 406-581 2.59e-50

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 175.62  E-value: 2.59e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcnVI-ITQPRRISAVSVAQRVSHELGPSLR 484
Cdd:cd17978      1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGG-----MIgITQPRRVAAVSVAKRVAEEMGVELG 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  485 RNVGFQVRLESKpPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLN-----PALRL 559
Cdd:cd17978     76 QLVGYSVRFDDV-TSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKV 154

                          170       180
                   ....*....|....*....|..
gi 1061899969  560 VLMSATGDNERFSRYFGGCPVI 581
Cdd:cd17978    155 IIMSATLDADLFSEYFNGAPVL 176
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 406-583 5.27e-49

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 171.47  E-value: 5.27e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTegrgarcNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17979      1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFR-------HIACTQPRRIACISLAKRVAFESLNQYGS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESkppSRGGA--LLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMS 563
Cdd:cd17979     74 KVAYQIRFER---TRTLAtkLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMS 150

                          170       180
                   ....*....|....*....|
gi 1061899969  564 ATGDNERFSRYFGGCPVIKV 583
Cdd:cd17979    151 ATINIELFSGYFEGAPVVQV 170
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 406-583 3.16e-46

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 163.83  E-value: 3.16e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCnviITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17974      1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIG---CTQPRRVAAMSVAARVAEEMGVKLGN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESKPPSRGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 565
Cdd:cd17974     78 EVGYSIRFEDCTSEKT-VLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSAT 156

                          170
                   ....*....|....*...
gi 1061899969  566 GDNERFSRYFGGCPVIKV 583
Cdd:cd17974    157 MDAEKFSAFFDDAPIFRI 174
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 399-583 8.83e-46

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 162.97  E-value: 8.83e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  399 VWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARcnVIITQPRRISAVSVAQRVSHE 478
Cdd:cd17973      6 ILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--VACTQPRRVAAMSVAQRVAEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  479 LGPSLRRNVGFQVRLESKPPSRGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALR 558
Cdd:cd17973     84 MDVKLGEEVGYSIRFEDCSSAKT-ILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLK 162

                          170       180
                   ....*....|....*....|....*
gi 1061899969  559 LVLMSATGDNERFSRYFGGCPVIKV 583
Cdd:cd17973    163 LIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 406-583 9.00e-46

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 162.50  E-value: 9.00e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17990      1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG----KIIVLEPRRVAARAAARRLATLLGEAPGE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQR-LNPALRLVLMSA 564
Cdd:cd17990     77 TVGYRVRGESRV-GRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSA 155

                          170
                   ....*....|....*....
gi 1061899969  565 TGDNERFSRYFGGCPVIKV 583
Cdd:cd17990    156 TLDGDGLAALLPEAPVVES 174
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 406-583 1.62e-45

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 161.85  E-value: 1.62e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17989      1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLEL----GRGIRGLIGHTQPRRLAARSVAERIAEELKTELGG 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESKPPSRGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 565
Cdd:cd17989     77 AVGYKVRFTDQTSDETCVKLM-TDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSAT 155

                          170
                   ....*....|....*...
gi 1061899969  566 GDNERFSRYFGGCPVIKV 583
Cdd:cd17989    156 IDAERFSRHFNNAPIIEV 173
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 406-575 3.21e-44

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 158.40  E-value: 3.21e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLER-YVTEGRgarcNVIITQPRRISAVSVAQRVSHELGPSLR 484
Cdd:cd17980      1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAgWTAGGR----VVGCTQPRRVAAVTVAGRVAEEMGAVLG 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  485 RNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSA 564
Cdd:cd17980     77 HEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASA 156

                          170
                   ....*....|.
gi 1061899969  565 TGDNERFSRYF 575
Cdd:cd17980    157 TLDAEKFRDFF 167
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 406-583 5.08e-44

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 158.29  E-value: 5.08e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVI-ITQPRRISAVSVAQRVSHELGpSLR 484
Cdd:cd17982      1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIgITQPRRVAAVSMAKRVAEELN-VFG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  485 RNVGFQVRLESKpPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILL-----------KGLQRL 553
Cdd:cd17982     80 KEVSYQIRYDST-VSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLsrivplraklyLQDQTV 158

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1061899969  554 NPaLRLVLMSATGDNERFS---RYFGGCP-VIKV 583
Cdd:cd17982    159 KP-LKLVIMSATLRVEDFTenkLLFPRPPpVIKV 191
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 406-584 1.18e-42

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 153.79  E-value: 1.18e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17971      6 LPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAE----AGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQ 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 565
Cdd:cd17971     82 EVGYTIRFEDCT-SPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSAT 160

                          170
                   ....*....|....*....
gi 1061899969  566 GDNERFSRYFGGCPVIKVP 584
Cdd:cd17971    161 LDAVKFSQYFYEAPIFTIP 179
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 406-583 2.24e-39

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 144.14  E-value: 2.24e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17983      1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHE----DGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 565
Cdd:cd17983     77 EVGYAIRFEDCT-SENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSAT 155

                          170
                   ....*....|....*...
gi 1061899969  566 GDNERFSRYFGGCPVIKV 583
Cdd:cd17983    156 MDADKFADFFGNVPIFTI 173
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 406-583 1.30e-38

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 142.30  E-value: 1.30e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17984      1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYE----AGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESkPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPA-----LRLV 560
Cdd:cd17984     77 KVGYQVRFDD-CSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPnrkehLKVV 155

                          170       180
                   ....*....|....*....|...
gi 1061899969  561 LMSATGDNERFSRYFGGCPVIKV 583
Cdd:cd17984    156 VMSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 406-583 1.12e-27

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 110.69  E-value: 1.12e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLErYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 485
Cdd:cd17977      1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAE-YCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGH 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  486 NVGFQVRLESKPPSRGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 565
Cdd:cd17977     80 EVGYVIPFENCCTNET-ILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCP 158

                          170
                   ....*....|....*...
gi 1061899969  566 GDNERFSRYFGGCPVIKV 583
Cdd:cd17977    159 HLSSKLLSYYGNVPLIEV 176
DEXDc smart00487
DEAD-like helicases superfamily;
410-589 7.39e-25

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 103.34  E-value: 7.39e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969   410 PHRDTILNAIEQHP-VVVISGDTGCGKTTRIPQLLLERYvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVG 488
Cdd:smart00487   11 PYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAL---KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVG 87

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969   489 FQVRLESKPP-----SRGGALLFCTVGILLRKLQSNP-SLEGVSHVIVDEVHERDvNTDFLLILLKGLQRLNPALRLVLM 562
Cdd:smart00487   88 LYGGDSKREQlrkleSGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLLL 166

                           170       180
                    ....*....|....*....|....*....
gi 1061899969   563 SAT--GDNERFSRYFGGCPVIKVPGFMYP 589
Cdd:smart00487  167 SATppEEIENLLELFLNDPVFIDVGFTPL 195
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 406-583 8.81e-22

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 93.81  E-value: 8.81e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  406 LPVDPHRDTILNAIEQHP-VVVISGDTGCGKTTRIPQLLLErYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLR 484
Cdd:cd17986      1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAE-FALSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  485 RNVGFQVRLES-KPPSRggALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMS 563
Cdd:cd17986     80 HEVGYSIPQEDcTGPNT--ILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVT 157

                          170       180
                   ....*....|....*....|
gi 1061899969  564 ATGDNERFSRYFGGCPVIKV 583
Cdd:cd17986    158 SPALEPKLRAFWGNPPVVHV 177
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 415-761 6.25e-19

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 92.35  E-value: 6.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  415 ILNAIEQHPVVVISGDTGCGKTTRIPQLLLE-RYV---TEGRGARCNVIITQPRRISAVSVAQRVSHelGPSLRRNVGFQ 490
Cdd:PHA02653   172 IFEAWISRKPVVLTGGTGVGKTSQVPKLLLWfNYLfggFDNLDKIDPNFIERPIVLSLPRVALVRLH--SITLLKSLGFD 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  491 VrLESKP----------------PSRGGaLLFCTvgillRKLQSNpSLEGVSHVIVDEVHERDVNTDFLL-ILLKGLQRL 553
Cdd:PHA02653   250 E-IDGSPislkygsipdelintnPKPYG-LVFST-----HKLTLN-KLFDYGTVIIDEVHEHDQIGDIIIaVARKHIDKI 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  554 NpalRLVLMSAT--GDNERFSRYFGGCPVIKVPGF-MYPVKEHYLEDilaklgKHQYLHRHRHHESEDecaldldlvtDL 630
Cdd:PHA02653   322 R---SLFLMTATleDDRDRIKEFFPNPAFVHIPGGtLFPISEVYVKN------KYNPKNKRAYIEEEK----------KN 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  631 VLHI--DARGEPG--GILcFLPGWQEIKGVQQRLQEALgmheSKYLILPVHSNIPMMDQ--KAIFQQPPVgvrKIVLATN 704
Cdd:PHA02653   383 IVTAlkKYTPPKGssGIV-FVASVSQCEEYKKYLEKRL----PIYDFYIIHGKVPNIDEilEKVYSSKNP---SIIISTP 454

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1061899969  705 IAETSITINDIVHVVDSG-LHKEERYDLKtkvscleTVWVSRANVIQRRGRAGRCQSG 761
Cdd:PHA02653   455 YLESSVTIRNATHVYDTGrVYVPEPFGGK-------EMFISKSMRTQRKGRVGRVSPG 505
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 823-911 3.61e-17

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 78.05  E-value: 3.61e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  823 AVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQ------------- 888
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSvRDPFVQPNFldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 1061899969  889 NRAEVDKVKALLSH-DSGSDHLAF 911
Cdd:pfam04408   81 RRAADEKARAKFARlDLEGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 829-912 6.01e-17

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 76.54  E-value: 6.01e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969   829 EIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSlQNRAEVDKVKALLSHDsGSDH 908
Cdd:smart00847    1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK-EKREDADAARRRFADP-ESDH 78


                    ....
gi 1061899969   909 LAFV 912
Cdd:smart00847   79 LTLL 82
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 422-565 1.47e-16

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 77.83  E-value: 1.47e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  422 HPVVVISGDTGCGKTTRIPQLLLERYVTegrgARCNVIITQPRRISAVSVAQRVSHELGPSLRrnVGFQVRLESKPPSRG 501
Cdd:cd00046      1 GENVLITAPTGSGKTLAALLAALLLLLK----KGKKVLVLVPTKALALQTAERLRELFGPGIR--VAVLVGGSSAEEREK 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1061899969  502 GA-----LLFCTVGILLRKLQSN--PSLEGVSHVIVDEVHERDVNTDFLLIL-LKGLQRLNPALRLVLMSAT 565
Cdd:cd00046     75 NKlgdadIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILdLAVRKAGLKNAQVILLSAT 146
HELICc smart00490
helicase superfamily c-terminal domain;
658-757 4.62e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 65.70  E-value: 4.62e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969   658 QRLQEALGMHesKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLhkeerydlktkvsc 737
Cdd:smart00490    1 EELAELLKEL--GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL-------------- 64

                            90       100
                    ....*....|....*....|
gi 1061899969   738 letvWVSRANVIQRRGRAGR 757
Cdd:smart00490   65 ----PWSPASYIQRIGRAGR 80
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 425-565 1.07e-10

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 61.49  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  425 VVISGDTGCGKTT--RIPqlLLERYVTEGRGARcnVIITQPRRISA---VSVAQRVSHELGPSLRRNVGFQVRLESKPPS 499
Cdd:pfam00270   17 VLVQAPTGSGKTLafLLP--ALEALDKLDNGPQ--ALVLAPTRELAeqiYEELKKLGKGLGLKVASLLGGDSRKEQLEKL 92

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061899969  500 RGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNtDFLLILLKGLQRLNPALRLVLMSAT 565
Cdd:pfam00270   93 KGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDM-GFGPDLEEILRRLPKKRQILLLSAT 157
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 629-757 1.16e-10

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 59.53  E-value: 1.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  629 DLVLHIDARGEPGGILCFLPGWQEIKGvqQRLQEALGmheskYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAET 708
Cdd:pfam00271    4 EALLELLKKERGGKVLIFSQTKKTLEA--ELLLEKEG-----IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1061899969  709 SITINDIVHVVDSGLHKeerydlktkvscletvwvSRANVIQRRGRAGR 757
Cdd:pfam00271   77 GLDLPDVDLVINYDLPW------------------NPASYIQRIGRAGR 107
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 987-1074 5.06e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  987 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1064
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 1061899969 1065 QVHPLAVLLL 1074
Cdd:pfam07717   69 AISPEWLLLF 78
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 425-582 6.45e-05

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 44.95  E-value: 6.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  425 VVISGDTGCGKTTrIPQLLLERYVTEGRGarcNVIITQPRRisAVS--VAQRVSHELGPSlrrnvGFQVRL------ESK 496
Cdd:cd17921     20 VLVSAPTSSGKTL-IAELAILRALATSGG---KAVYIAPTR--ALVnqKEADLRERFGPL-----GKNVGLltgdpsVNK 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  497 PPSRGGALLFCT---VGILLRKLqSNPSLEGVSHVIVDEVH-----ERDVntdFLLILLKGLQRLNPALRLVLMSATGDN 568
Cdd:cd17921     89 LLLAEADILVATpekLDLLLRNG-GERLIQDVRLVVVDEAHligdgERGV---VLELLLSRLLRINKNARFVGLSATLPN 164

                          170
                   ....*....|....*
gi 1061899969  569 -ERFSRYFGGCPVIK 582
Cdd:cd17921    165 aEDLAEWLGVEDLIR 179
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 698-768 4.64e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 36.91  E-value: 4.64e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1061899969  698 KIVLATNIAETSITINDIVHVVdsglhkeerydlktkvscLETVWVSRANVIQRRGRAGR-CQSGFAYHLFP 768
Cdd:cd18785     24 EILVATNVLGEGIDVPSLDTVI------------------FFDPPSSAASYIQRVGRAGRgGKDEGEVILFV 77
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
413-691 7.81e-03

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 40.39  E-value: 7.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  413 DTILNAIEQ-HPVVVISGDTGCGKTtRIPQLLLERYVTEGRgarcnVIITQPRRISAVSVAQRVSHELGPSLRRnvgfqv 491
Cdd:COG1061     90 EALLAALERgGGRGLVVAPTGTGKT-VLALALAAELLRGKR-----VLVLVPRRELLEQWAEELRRFLGDPLAG------ 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  492 rleSKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHErdVNTDFlliLLKGLQRLNPALRLvLMSAT-----G 566
Cdd:COG1061    158 ---GGKKDSDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHH--AGAPS---YRRILEAFPAAYRL-GLTATpfrsdG 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  567 DNERFSRYFGgcPVIKVP-------GFmypVKEHYLEDILAKLGKHQYLHRHRHHESEDECALDLDLVTDLVLHI-DARG 638
Cdd:COG1061    229 REILLFLFDG--IVYEYSlkeaiedGY---LAPPEYYGIRVDLTDERAEYDALSERLREALAADAERKDKILRELlREHP 303

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1061899969  639 EPGGILCFLPGWQEIKGVQQRLQEAlgmhesKYLILPVHSNIPMMDQKAIFQQ 691
Cdd:COG1061    304 DDRKTLVFCSSVDHAEALAELLNEA------GIRAAVVTGDTPKKEREEILEA 350
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 409-561 8.27e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 38.64  E-value: 8.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  409 DPHRDTILNAIEQH-----PVVVISGDTGCGKTT---RIPQLLLER--YVTEGRGARCNVIITQPRRISAVSVAQRVSHE 478
Cdd:pfam13191    6 EEELEQLLDALDRVrsgrpPSVLLTGEAGTGKTTllrELLRALERDggYFLRGKCDENLPYSPLLEALTREGLLRQLLDE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899969  479 LGPSLRRNVGFQVRLESKP-PSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTdflLILLKGLQRLNPAL 557
Cdd:pfam13191   86 LESSLLEAWRAALLEALAPvPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEAS---LQLLAALLRLLESL 162


                   ....
gi 1061899969  558 RLVL 561
Cdd:pfam13191  163 PLLV 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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