BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related complex subunit 5 (BORCS5), which is also called loss of heterozygosity 12 chromosomal region 1 (LOH12CR1), myristoylated lysosomal protein, or myrlysin. BORCS5 is a component of BLOC-1 related complex (BORC), a multisubunit complex that also contains Lyspersin/C17orf59, Diaskedin/C10orf32, KxDL1, MEF2BNB, BLOS1, BLOS2, and Snapin subunits. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm. LOH12CR1 may function as a tumor suppressor by inhibiting tumor growth through deregulation of the G1/S checkpoint in human colorectal carcinoma. It has been shown to bind to LKB1, a well-known tumor suppressor gene in colorectal cancer; its expression level could be used as a promising biomarker in patients. This domain has also been found in many hypothetical proteins involved in loss of heterozygosity and thus tumor suppression.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099203  20 GLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQ 99
Cdd:pfam10158   8 GVISKRTNRTNETLEKLSSQHFINLCTRLQEHFNVCAKAVASDQNKIVARIKEVDASIITLFAETVAHQKQYASYAEQFS 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1060099203 100 KVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPD 143
Cdd:pfam10158  88 KVNQISDQLCRIQIILEQNVPSMETLNNILDPDERLEPFVWKPE 131

Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved region of hypothetical proteins involved in loss of heterozygosity and thus tumour suppression. The exact function of family members is not known. This region is also found in subunit 5 of the BLOC-1-related complex, which is also found in the BORC complex. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099203  20 GLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQ 99
Cdd:pfam10158   8 GVISKRTNRTNETLEKLSSQHFINLCTRLQEHFNVCAKAVASDQNKIVARIKEVDASIITLFAETVAHQKQYASYAEQFS 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1060099203 100 KVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPD 143
Cdd:pfam10158  88 KVNQISDQLCRIQIILEQNVPSMETLNNILDPDERLEPFVWKPE 131

Type IV pilus assembly protein PilN [Cell motility, Extracellular structures];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1060099203  84 MQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPDR 144
Cdd:COG3166    64 LDKQIAEIKELKKQKAELLARLQVIEQLQQSRPPWVHLLDELARLLPEGVWLTSLSQQGGT 124

Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved region of hypothetical proteins involved in loss of heterozygosity and thus tumour suppression. The exact function of family members is not known. This region is also found in subunit 5 of the BLOC-1-related complex, which is also found in the BORC complex. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099203  20 GLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQ 99
Cdd:pfam10158   8 GVISKRTNRTNETLEKLSSQHFINLCTRLQEHFNVCAKAVASDQNKIVARIKEVDASIITLFAETVAHQKQYASYAEQFS 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1060099203 100 KVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPD 143
Cdd:pfam10158  88 KVNQISDQLCRIQIILEQNVPSMETLNNILDPDERLEPFVWKPE 131

MEKK4 N-terminal; This domain represents the regulatory N-terminal non-catalytic region of Mitogen-activated protein kinase kinase kinase 4 (MEKK4) which contains a putative PH-domain. This N-terminal region acts as an autoinhibitory domain that must be dissociated from the catalytic domain to allow the activation of these kinases.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1060099203  48 YQDHLHQcaEAVAFDQnalVKRIKEMDLSVETLFSFMQERQKRYAKYAEQ 97
Cdd:pfam19431 290 CREHLQR--QRVAFEQ---VKRVMELLEYVEALYPSLQALQKDYEKYAAK 334