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Conserved domains on  [gi|1060099369|ref|NP_001317221|]
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metastasis-associated protein MTA2 isoform 2 [Homo sapiens]

Protein Classification

GATA-type transcription factor( domain architecture ID 13656971)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MTA_R1 pfam17226
MTA R1 domain; The R1 domain is found in the MTA1 protein and its homologs. The domain is ...
 276-351 1.23e-31

MTA R1 domain; The R1 domain is found in the MTA1 protein and its homologs. The domain is composed of 4 alpha helices. It has been shown to bind to the RBBP4 protein. The MTA proteins contain a second partial copy of this domain called R2. The R2 domain is matched by this model for some proteins.


:

Pssm-ID: 465388  Cd Length: 78  Bit Score: 116.16  E-value: 1.23e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1060099369 276 KNRQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDL 351
Cdd:pfam17226   3 KTRQAFYLQTTPLTRLARRLCRDILRPRHAARRPFVPINIAAIKAECQARLPEKSKNPLKLKPKVRGPLTSIANRL 78
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 94-139 3.88e-26

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


:

Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 100.38  E-value: 3.88e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1060099369  94 EWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKT 139
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
190-241 1.54e-16

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


:

Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 73.61  E-value: 1.54e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1060099369  190 KGLTCESCHTTQSAQWYAWGPPNmqCRLCASCWIYWKKYGGLKTPTQLEGAT 241
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGN--KTLCNACGLYYKKHGGLKRPLSLKKDG 51
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 1-25 5.97e-07

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


:

Pssm-ID: 460214  Cd Length: 53  Bit Score: 46.07  E-value: 5.97e-07
                          10        20
                  ....*....|....*....|....*
gi 1060099369   1 MEMKVWDPDNPLTDRQIDQFLVVAR 25
Cdd:pfam01448  28 DELLVWDPNHNLPDRKLDEYLVVAR 52
 
Name Accession Description Interval E-value
MTA_R1 pfam17226
MTA R1 domain; The R1 domain is found in the MTA1 protein and its homologs. The domain is ...
 276-351 1.23e-31

MTA R1 domain; The R1 domain is found in the MTA1 protein and its homologs. The domain is composed of 4 alpha helices. It has been shown to bind to the RBBP4 protein. The MTA proteins contain a second partial copy of this domain called R2. The R2 domain is matched by this model for some proteins.


Pssm-ID: 465388  Cd Length: 78  Bit Score: 116.16  E-value: 1.23e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1060099369 276 KNRQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDL 351
Cdd:pfam17226   3 KTRQAFYLQTTPLTRLARRLCRDILRPRHAARRPFVPINIAAIKAECQARLPEKSKNPLKLKPKVRGPLTSIANRL 78
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 94-139 3.88e-26

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 100.38  E-value: 3.88e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1060099369  94 EWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKT 139
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
190-241 1.54e-16

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 73.61  E-value: 1.54e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1060099369  190 KGLTCESCHTTQSAQWYAWGPPNmqCRLCASCWIYWKKYGGLKTPTQLEGAT 241
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGN--KTLCNACGLYYKKHGGLKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 194-231 9.23e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.34  E-value: 9.23e-13
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1060099369 194 CESCHTTQSAQWYAWgpPNMQCRLCASCWIYWKKYGGL 231
Cdd:pfam00320   1 CSNCGTTKTPLWRRG--PNGNRTLCNACGLYYKKKGLK 36
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 193-229 4.24e-11

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 58.15  E-value: 4.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1060099369 193 TCESCHTTQSAQWYAWgpPNMQCRLCASCWIYWKKYG 229
Cdd:cd00202     1 ACSNCGTTTTPLWRRG--PSGGSTLCNACGLYWKKHG 35
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 1-25 5.97e-07

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 46.07  E-value: 5.97e-07
                          10        20
                  ....*....|....*....|....*
gi 1060099369   1 MEMKVWDPDNPLTDRQIDQFLVVAR 25
Cdd:pfam01448  28 DELLVWDPNHNLPDRKLDEYLVVAR 52
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 94-138 1.51e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 44.80  E-value: 1.51e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1060099369  94 EWSASEAMLFEEALEKYGKDFNDIrQDFLPWKSLASIVQFYYMWK 138
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKI-AKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
93-140 1.98e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 41.83  E-value: 1.98e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1060099369   93 EEWSASEAMLFEEALEKYG-KDFNDIRQdFLPWKSLASIVQFYYMWKTT 140
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAK-ELPGRTAEQCRERWRNLLKP 49
 
Name Accession Description Interval E-value
MTA_R1 pfam17226
MTA R1 domain; The R1 domain is found in the MTA1 protein and its homologs. The domain is ...
 276-351 1.23e-31

MTA R1 domain; The R1 domain is found in the MTA1 protein and its homologs. The domain is composed of 4 alpha helices. It has been shown to bind to the RBBP4 protein. The MTA proteins contain a second partial copy of this domain called R2. The R2 domain is matched by this model for some proteins.


Pssm-ID: 465388  Cd Length: 78  Bit Score: 116.16  E-value: 1.23e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1060099369 276 KNRQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDL 351
Cdd:pfam17226   3 KTRQAFYLQTTPLTRLARRLCRDILRPRHAARRPFVPINIAAIKAECQARLPEKSKNPLKLKPKVRGPLTSIANRL 78
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 94-139 3.88e-26

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 100.38  E-value: 3.88e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1060099369  94 EWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKT 139
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
190-241 1.54e-16

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 73.61  E-value: 1.54e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1060099369  190 KGLTCESCHTTQSAQWYAWGPPNmqCRLCASCWIYWKKYGGLKTPTQLEGAT 241
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGN--KTLCNACGLYYKKHGGLKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 194-231 9.23e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.34  E-value: 9.23e-13
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1060099369 194 CESCHTTQSAQWYAWgpPNMQCRLCASCWIYWKKYGGL 231
Cdd:pfam00320   1 CSNCGTTKTPLWRRG--PNGNRTLCNACGLYYKKKGLK 36
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 193-229 4.24e-11

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 58.15  E-value: 4.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1060099369 193 TCESCHTTQSAQWYAWgpPNMQCRLCASCWIYWKKYG 229
Cdd:cd00202     1 ACSNCGTTTTPLWRRG--PSGGSTLCNACGLYWKKHG 35
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 1-25 5.97e-07

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 46.07  E-value: 5.97e-07
                          10        20
                  ....*....|....*....|....*
gi 1060099369   1 MEMKVWDPDNPLTDRQIDQFLVVAR 25
Cdd:pfam01448  28 DELLVWDPNHNLPDRKLDEYLVVAR 52
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 94-138 1.51e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 44.80  E-value: 1.51e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1060099369  94 EWSASEAMLFEEALEKYGKDFNDIrQDFLPWKSLASIVQFYYMWK 138
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKI-AKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
93-140 1.98e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 41.83  E-value: 1.98e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1060099369   93 EEWSASEAMLFEEALEKYG-KDFNDIRQdFLPWKSLASIVQFYYMWKTT 140
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAK-ELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 94-138 2.62e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 2.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1060099369  94 EWSASEAMLFEEALEKYG-KDFNDIRQdFLPWKSLASIVQFYYMWK 138
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAK-ELPGRTPKQCRERWRNLL 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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