|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-570 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1144.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLE 80
Cdd:PLN02437 223 MKDDSIEGIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLE 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK 160
Cdd:PLN02437 303 PWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKK 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSE---- 236
Cdd:PLN02437 383 VVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKgvpl 462
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 237 ---------------HTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAE 301
Cdd:PLN02437 463 eshpsklvgslgsknRYFDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPE 542
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 302 AQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMP 381
Cdd:PLN02437 543 AQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMP 622
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 382 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTV 461
Cdd:PLN02437 623 TASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTV 702
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 462 WEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKV 541
Cdd:PLN02437 703 WEIKQRTLVDMAADRGCYIDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATG 782
|
570 580 590
....*....|....*....|....*....|.
gi 1057503148 542 SKEEEEKERNT--AAMVCSLENRDECLMCGS 570
Cdd:PLN02437 783 VAAPEEEDVETkmAQMVCSLDNREECLACGS 813
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
1-516 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 744.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLE 80
Cdd:pfam02867 7 SVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRGAAAVYLE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKL-YASYEKQGRVR 159
Cdd:pfam02867 86 VWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYEREENEGIRK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 160 KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTY 239
Cdd:pfam02867 166 KTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKFVEFGGTF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 240 DFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALE 319
Cdd:pfam02867 246 DFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFETMYYYALK 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 320 ASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTD------LWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNE 393
Cdd:pfam02867 326 ASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATE 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 394 SIEPYTSNIYTRRVLSgefqivnphllkdlterglwheemknqiiacngsiqsipeipDDLKQLYKTVWEISQKTVLKMA 473
Cdd:pfam02867 406 SIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQKAHIDMA 443
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 1057503148 474 AERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 516
Cdd:pfam02867 444 AARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
3-532 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 738.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:COG0209 136 EDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVW 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVV 162
Cdd:COG0209 215 HPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTI 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTsEHTYDFK 242
Cdd:COG0209 295 KARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-DGEFDWE 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 243 KLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASC 322
Cdd:COG0209 374 KLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASA 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 323 DLAKEQGPYETYEGSPVSKGILQYDMW--NVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTS 400
Cdd:COG0209 454 ELAKERGAFPAFEGSKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFS 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 401 NIYTRRVLS-GEFQIVNPHLLKDLTERGLWHEEMKNQIIAcNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAF 479
Cdd:COG0209 534 LVYVRKVLDgGEFTVVNPYLVRALKELGLWDEELVEKIKE-DGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKH 612
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1057503148 480 IDQSQSLNIHIA-EPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNK 532
Cdd:COG0209 613 VDQAISKTLNLPnDATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
3-519 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 672.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:cd01679 58 DDSLESIYDTIKECAQLSKIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIW 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVEtnqdwslmcpnecpgldevwgeefeklyasyekqgrvrkvv 162
Cdd:cd01679 137 HPDIEEFLDLKKNNGDERRRARDLFYGVWIPDLFMERVE----------------------------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 kaQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSK-----DEVAVCNLASLALNMYVTseh 237
Cdd:cd01679 176 --RDLWRKILESQFETGYPYILFKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT--- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 238 tydFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGA 317
Cdd:cd01679 251 ---FEKLEEVVKLAVRALDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 318 LEASCDLAKEQGpyetyegspvskgilqydmwnvtptdlwdwkvlkekiakyGIRNSLLIAPMPTASTAQILGNNESIEP 397
Cdd:cd01679 328 LKASCELAKERG----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEP 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 398 YTSNIYTRRVLSGEFQIVNPHLLKDLTERGlwheemknqiiacngsiqsipeipddlkqLYKTVWEISQKTVLKMAAERG 477
Cdd:cd01679 368 ITSNIYVRRVLSGEFPVVNPHLEKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQ 418
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1057503148 478 AFIDQSQSLNIHIAEP-NYGKLTSMHFYGWKQGLKTGmYYLRT 519
Cdd:cd01679 419 KHIDQGQSLNLFLTPPaTTRDLNSLYFYAWKKGLKTL-YYLRT 460
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
3-520 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 658.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:TIGR02506 88 DDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAAAVYLEVW 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK-- 160
Cdd:TIGR02506 167 HPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKDVEARKki 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 -VVKAQQLWYAIIESQTETGTPYMLYKDSCNRK-SNQQNLGTIKCSNLCTEIVEYTSKD---EVAVCNLASLALNMYVTS 235
Cdd:TIGR02506 247 rKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVNLANFVME 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 236 EhTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYY 315
Cdd:TIGR02506 327 D-KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDRIFEAIYY 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 316 GALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLW-------DWKVLKEKIAKYGIRNSLLIAPMPTASTAQI 388
Cdd:TIGR02506 406 YAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMPTASSSQL 485
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 389 LGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKT 468
Cdd:TIGR02506 486 TGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTAYELDQEA 565
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1057503148 469 VLKMAAERGAFIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTR 520
Cdd:TIGR02506 566 LIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-570 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1144.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLE 80
Cdd:PLN02437 223 MKDDSIEGIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLE 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK 160
Cdd:PLN02437 303 PWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKK 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSE---- 236
Cdd:PLN02437 383 VVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKgvpl 462
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 237 ---------------HTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAE 301
Cdd:PLN02437 463 eshpsklvgslgsknRYFDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPE 542
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 302 AQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMP 381
Cdd:PLN02437 543 AQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMP 622
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 382 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTV 461
Cdd:PLN02437 623 TASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTV 702
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 462 WEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKV 541
Cdd:PLN02437 703 WEIKQRTLVDMAADRGCYIDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATG 782
|
570 580 590
....*....|....*....|....*....|.
gi 1057503148 542 SKEEEEKERNT--AAMVCSLENRDECLMCGS 570
Cdd:PLN02437 783 VAAPEEEDVETkmAQMVCSLDNREECLACGS 813
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
1-516 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 744.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLE 80
Cdd:pfam02867 7 SVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRGAAAVYLE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKL-YASYEKQGRVR 159
Cdd:pfam02867 86 VWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYEREENEGIRK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 160 KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTY 239
Cdd:pfam02867 166 KTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKFVEFGGTF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 240 DFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALE 319
Cdd:pfam02867 246 DFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFETMYYYALK 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 320 ASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTD------LWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNE 393
Cdd:pfam02867 326 ASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATE 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 394 SIEPYTSNIYTRRVLSgefqivnphllkdlterglwheemknqiiacngsiqsipeipDDLKQLYKTVWEISQKTVLKMA 473
Cdd:pfam02867 406 SIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQKAHIDMA 443
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 1057503148 474 AERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 516
Cdd:pfam02867 444 AARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
3-532 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 738.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:COG0209 136 EDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVW 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVV 162
Cdd:COG0209 215 HPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTI 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTsEHTYDFK 242
Cdd:COG0209 295 KARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-DGEFDWE 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 243 KLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASC 322
Cdd:COG0209 374 KLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASA 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 323 DLAKEQGPYETYEGSPVSKGILQYDMW--NVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTS 400
Cdd:COG0209 454 ELAKERGAFPAFEGSKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFS 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 401 NIYTRRVLS-GEFQIVNPHLLKDLTERGLWHEEMKNQIIAcNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAF 479
Cdd:COG0209 534 LVYVRKVLDgGEFTVVNPYLVRALKELGLWDEELVEKIKE-DGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKH 612
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1057503148 480 IDQSQSLNIHIA-EPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNK 532
Cdd:COG0209 613 VDQAISKTLNLPnDATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
3-519 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 672.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:cd01679 58 DDSLESIYDTIKECAQLSKIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIW 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVEtnqdwslmcpnecpgldevwgeefeklyasyekqgrvrkvv 162
Cdd:cd01679 137 HPDIEEFLDLKKNNGDERRRARDLFYGVWIPDLFMERVE----------------------------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 kaQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSK-----DEVAVCNLASLALNMYVTseh 237
Cdd:cd01679 176 --RDLWRKILESQFETGYPYILFKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT--- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 238 tydFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGA 317
Cdd:cd01679 251 ---FEKLEEVVKLAVRALDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 318 LEASCDLAKEQGpyetyegspvskgilqydmwnvtptdlwdwkvlkekiakyGIRNSLLIAPMPTASTAQILGNNESIEP 397
Cdd:cd01679 328 LKASCELAKERG----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEP 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 398 YTSNIYTRRVLSGEFQIVNPHLLKDLTERGlwheemknqiiacngsiqsipeipddlkqLYKTVWEISQKTVLKMAAERG 477
Cdd:cd01679 368 ITSNIYVRRVLSGEFPVVNPHLEKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQ 418
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1057503148 478 AFIDQSQSLNIHIAEP-NYGKLTSMHFYGWKQGLKTGmYYLRT 519
Cdd:cd01679 419 KHIDQGQSLNLFLTPPaTTRDLNSLYFYAWKKGLKTL-YYLRT 460
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
3-520 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 658.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:TIGR02506 88 DDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAAAVYLEVW 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK-- 160
Cdd:TIGR02506 167 HPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKDVEARKki 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 -VVKAQQLWYAIIESQTETGTPYMLYKDSCNRK-SNQQNLGTIKCSNLCTEIVEYTSKD---EVAVCNLASLALNMYVTS 235
Cdd:TIGR02506 247 rKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVNLANFVME 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 236 EhTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYY 315
Cdd:TIGR02506 327 D-KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDRIFEAIYY 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 316 GALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLW-------DWKVLKEKIAKYGIRNSLLIAPMPTASTAQI 388
Cdd:TIGR02506 406 YAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMPTASSSQL 485
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 389 LGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKT 468
Cdd:TIGR02506 486 TGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTAYELDQEA 565
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1057503148 469 VLKMAAERGAFIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTR 520
Cdd:TIGR02506 566 LIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-568 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 558.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWH 83
Cdd:PRK07207 381 DDLDGIYEAIKDNALLSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGG-KRKGAVCAYLETWH 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 84 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQG-----RV 158
Cdd:PRK07207 460 LDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLFGKAFEEAYTAYEAKAargeiKL 539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 159 RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHT 238
Cdd:PRK07207 540 FKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVGVVHSSNLCTEITLNTSDDEIAVCNLGSVNLVAHIKDGAK 619
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 239 YDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL 318
Cdd:PRK07207 620 LDHEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAI 699
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 319 EASCDLAKEQGPYETYEGSPVSKGILQYD-----------MWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQ 387
Cdd:PRK07207 700 WASTELAEERGRYSSYEGSLWSRGILPIDslkllaearggYLEVDRSSTLDWDALRARIKKHGMRNSNCMAIAPTATISN 779
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 388 ILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQK 467
Cdd:PRK07207 780 IIGVSQSIEPTYQNLYVKSNLSGEFTVVNPYLVRDLKARGLWDEVMVNDLKYFDGSLQRIDRIPADLKALYATAFEVDPR 859
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 468 TVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNKEKL------KDKEKV 541
Cdd:PRK07207 860 WLVEAASRRQKWIDQAQSLNLYMAGASGKKLDETYKLAWLRGLKT-TYYLRTLGATHVEKSTVNTGALnavssgGGGAGG 938
|
570 580
....*....|....*....|....*..
gi 1057503148 542 SKEEEEKERNTAAMVCSLENRDeCLMC 568
Cdd:PRK07207 939 AAAAAAAPPAADPKACSIDDPD-CEAC 964
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-522 |
3.14e-155 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 471.35 E-value: 3.14e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWH 83
Cdd:PRK12365 464 DDLVHIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGG-KRKGAVCVYLEVWH 542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 84 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQ---GRVR- 159
Cdd:PRK12365 543 LDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAYGEEFEKLYEEYERKvdtGEIRl 622
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 160 -KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHT 238
Cdd:PRK12365 623 yKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSETETAVCNLGSINLVEHIVNDGL 702
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 239 yDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL 318
Cdd:PRK12365 703 -DEEKLSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAI 781
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 319 EASCDLAKEQGPYETYEGSPVSKGILQYDMWN------------VTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTA 386
Cdd:PRK12365 782 LASSLLAKERGTYSSYKGSKWDRGYLPIDTIEllkeyrgeanllMDTSSRKDWEPVRSLIKEYGMRNSQLMAIAPTATIS 861
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 387 QILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQ 466
Cdd:PRK12365 862 NIIGVTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERIPDHLKKIFLTAFEIEP 941
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 1057503148 467 KTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPA 522
Cdd:PRK12365 942 EWIIECASRRQKWIDMGQSLNLYLAEPDGKKLSNMYLTAWKKGLKT-TYYLRSSAA 996
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-534 |
6.34e-135 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 412.39 E-value: 6.34e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 1 MKDDsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLE 80
Cdd:PRK06539 232 MQDD-IEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGG-KKFGALCFYME 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQ---GR 157
Cdd:PRK06539 310 NWHMDFPEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKAFSKRYAQYVEQaeaGR 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 158 VR--KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTS 235
Cdd:PRK06539 390 IRmfKRITAREQFRAILMSLQTTSHPWLTWKDTINNRALNNNTGTIHLSNLCTEICLPQDRDNVSVCNLASINLSRHLAD 469
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 236 EHTyDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYY 315
Cdd:PRK06539 470 GEL-DWAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISY 548
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 316 GALEASCDLAKEQGPYETYEGSPVSKGILQYDMW-----------NVTPTDLWDWKVLKEKIaKYGIRNSLLIAPMPTAS 384
Cdd:PRK06539 549 AAIDESADLAAERGAYPNFEGSRWSRGMVPVDSIalleadrgvpvDVNRTTRLDWDALRAKV-RGGMRNATLMAIAPTAS 627
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 385 TAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWhEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEI 464
Cdd:PRK06539 628 IGLVAGTTPGLDPQFSQIFSRSTSSGKFLEVNRNLVADLKELGLW-ETVREEILRSQGDIQEIAAIPDEIKALYRTSFQL 706
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 465 SQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNKEK 534
Cdd:PRK06539 707 SPYAFLEVAARAQKWVDQAISRNMYLESRDIGDMMDIYTAAWEMGVKT-TYYLHMKPRHTAEQSTVKVNK 775
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-519 |
6.10e-123 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 380.23 E-value: 6.10e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNkRPGAFAIYLEPWH 83
Cdd:PRK08447 223 DNIEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGT-RKGAIAVYLEPWH 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 84 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK-VV 162
Cdd:PRK08447 302 MDISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYGEEFEKRYLEYEKDEKIIKeYI 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI------------VEYTSKDEV----------- 219
Cdd:PRK08447 382 NAKELWKKILTNYFETGLPFLCFKDNANRANPNAHAGIIRSSNLCTEIfqntapnhykikIEFEDGSIEffeeeelvtvd 461
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 220 ---------------------------------AVCNLASLALNMYVTSEhtydfkKLAEVTKVVVRNLNKIIDINYYPV 266
Cdd:PRK08447 462 sgitkkakkitsldslkgkkiyivekekkdgktAVCNLASINLSKINTKE------DIERVVPIAIRMLDNVIDLNFYPN 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 267 PEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQY 346
Cdd:PRK08447 536 RKVKATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFPI 615
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 347 DMWN------VTPTDLW----DWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPytsnIYTRRvlsgefqivn 416
Cdd:PRK08447 616 DKANeeakklVERGGLFdsacDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEP----VYKRK---------- 681
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 417 phllkdlterglWHEEMKNQIIACngsiqSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA-EPNY 495
Cdd:PRK08447 682 ------------WFEENLSGLIPV-----VVPNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSlDKAS 744
|
570 580
....*....|....*....|....*
gi 1057503148 496 GK-LTSMHFYGWKQGLKTgMYYLRT 519
Cdd:PRK08447 745 GKyLNEIYTLAWKLGLKS-TYYLRS 768
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-520 |
8.81e-117 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 363.66 E-value: 8.81e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:PRK09209 243 DDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLG-QRKGAIAVYLDVW 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECP-----GLDEVWGEE-----FEKLYASY 152
Cdd:PRK09209 322 HKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKkvmgwYLEDFYDEKkgdgsFREKYEEC 401
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 153 EKQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIV----------EYTSKDEV-- 219
Cdd:PRK09209 402 VADERLsRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGMIYSSNLCTEIMqnmsptvmiqEIISGGQIvi 481
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 220 -------AVCNLASLALNMYVTSEhtydfkKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFIL 292
Cdd:PRK09209 482 tkqpgdfVVCNLSSINLGRAVTAD------VLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLAL 555
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 293 MRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGilQY-DMWNVTPTdlwDWKVLKEKIAKYGI 371
Cdd:PRK09209 556 KGIAWESEEAVQYADELYERINYLTIQASMELAKEKGAYPVFKGSDWQTG--EYfERRGYNSP---QWDELAAQVAENGV 630
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 372 RNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPhllkDLTERGLWHEEmknqiiacngsiqsipeip 451
Cdd:PRK09209 631 RNAYLMAVAPNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVTAP----DLSLDTWPYYE------------------- 687
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1057503148 452 ddlkqlyKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIaePN---YGKLTSMHFYGWKQGLKTgMYYLRTR 520
Cdd:PRK09209 688 -------KGAYKVDQFWSIRQNAARQRHVDQSISFNFYV--PStirASELLDLHMTAWKEGLKT-TYYVRST 749
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-523 |
1.07e-110 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 343.09 E-value: 1.07e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIaGTNGNSNGLVPMLRVYNNTARYVDQGGNKRpGAFAIYLEPW 82
Cdd:PRK09102 97 EDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPI-RNNGKSSGIIPFIKVMDSLTLAISQGSLRR-GSFAVYLDIE 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPnecpgldevwgeefeklyasyeKQGRVRKVV 162
Cdd:PRK09102 175 HPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISP----------------------KDKSVIRTV 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRK--SNQQNLG-TIKCSNLCTEI-----VEYTSKDEVAVCNLASLALNMYVT 234
Cdd:PRK09102 233 KARDLWAKILETRIETGEPYLLFIDNVNRAlpEVYKDLGlKVKASNLCSEItlptgIDHLGEDRTAVCCLSSLNLEYYDE 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 235 SEHTYDFkklaevTKVVVRNLNKIID--INYYP--VPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIF 310
Cdd:PRK09102 313 WKDTDAF------IEDLMRFLDNVLQdfIDKAPdeMERAKYSAMRERSVGLGVMGFHSYLQSKMIPFESVMAKQWNKKIF 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 311 ETIYYGALEASCDLAKEQGPyetyegspvskgilqydmwnvtPTDLwdwkvlkekiAKYGI--RNSLLIAPMPTASTAQI 388
Cdd:PRK09102 387 KHIREQADKASKELAKEKGE----------------------CPDA----------AGYGVmrRFSTKMAIAPTASISII 434
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 389 LGN-NESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQK 467
Cdd:PRK09102 435 LGNtSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKGKDTDEVWSSILTNEGSVQHLDFLSEEEKDVFKTAFEIDQR 514
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 1057503148 468 TVLKMAAERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAA 523
Cdd:PRK09102 515 WIIELAADRQKYIDQAQSLNLFLpANVPKRDLNKLHFEAWKKGVKS-LYYQRSKSVQ 570
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-520 |
1.56e-108 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 344.04 E-value: 1.56e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWH 83
Cdd:PRK12364 323 DSLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLG-MRQGAVAVYLDVWH 401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 84 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVE--TNQDWSLMCPNECP-----GLDEVWGEEFEKLYASYEKQG 156
Cdd:PRK12364 402 KDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKMVRddINQSWYLFCPHEILtvkgyALEDYYGEEWEKRYLDCVNDA 481
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 157 RV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI-----------------------VE 212
Cdd:PRK12364 482 RIsKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANPNKHKGMIYCSNLCTEIaqnmsaietvsteietedgdtvvVT 561
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 213 YTSKDEVAVCNLASLAL-NMYVTSEHtydfkKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFI 291
Cdd:PRK12364 562 TTRPGDFVVCNLASLSLgNIDLEDEE-----ELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRYRSIGLGVSGYHHALA 636
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 292 LMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILqYDMWNVTPTdlwDWKVLKEKIAKYGI 371
Cdd:PRK12364 637 KNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTGAY-FRKRGYTSE---EWQRLAREVAENGM 712
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 372 RNSLLIAPMPTASTAQILGNNESIEPytsniytrrvlsgefqIVNPHLLkdlterglwhEEMKNQIIAcngsiQSIPEIP 451
Cdd:PRK12364 713 RNAYLLAVAPTSSTSIIAGTTAGVDP----------------VMKRYFL----------EEKKGALMP-----RVAPELS 761
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 452 DDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA-EPNYGKLTSMHFYGWKQGLKTgMYYLRTR 520
Cdd:PRK12364 762 DKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITnEFTMRQVLDLYLLAWEEGVKT-IYYVRSK 830
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-520 |
7.67e-104 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 329.85 E-value: 7.67e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:PRK07088 245 DDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLG-KRKGGAAITLDIW 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGL---------DEVWGEEFEKLYASYE 153
Cdd:PRK07088 324 HKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHEIKKVkgysledyyDEEDRKEFTKKYLECE 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 154 KQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVA------------ 220
Cdd:PRK07088 404 EDTNIpRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCHEIAQNMSESELLeeeiidengyye 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 221 -----------VCNLASLALNmyvtsehTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADA 289
Cdd:PRK07088 484 vvqkikagdmvTCNLNSIVLG-------NVDDEELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGLGTSGYHHM 556
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 290 FILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGilqyDMWNVTPTDLWDWKVLKEKIAKY 369
Cdd:PRK07088 557 LANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG----KYFERRGYNSERWKKLKEEIKKY 632
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 370 GIRNSLLIAPMPTASTAQILGNNESIEPytsnIYTRrvlsgefqivnphllkdltergLWHEEMKnqiiacnGSIqsIPE 449
Cdd:PRK07088 633 GMRNGYITAVAPTGSTSNIANTTAGIDP----VFKR----------------------FFMEEKK-------GSF--TPK 677
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1057503148 450 IPDDLKQ----LYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAePNYGKLTSMHFY--GWKQGLKTgMYYLRTR 520
Cdd:PRK07088 678 TAPDLNEenfwYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYIT-PEYKAKQILNLYieAWKQGVKT-IYYVRNK 752
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
3-511 |
4.50e-89 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 286.14 E-value: 4.50e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:TIGR02504 85 EDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGG-TRRGAQMGILDVW 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKEEQrardlF-FALWIPDLFMKRVETNQDWSLMCPNEcpgldevwgeefeklyasyekqgRVRKV 161
Cdd:TIGR02504 164 HPDIEEFIEAKAKEGKLQN-----FnISVGVTDEFMEAVENDEEYELRNPRT-----------------------GEYKE 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 162 VKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI--VEYTSkdevavCNLASLALNMYV----TS 235
Cdd:TIGR02504 216 VDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQplLPYES------CNLGSINLAKFVkndfGD 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 236 EHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYY 315
Cdd:TIGR02504 290 EASFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEVMEFIAD 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 316 GALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVT-PTDLWDWkvlkekIAKYGIRNSLLIAPMPTASTAQILGNNES 394
Cdd:TIGR02504 370 AAYRASAELAKERGAFPLYDASKYPMGRAMGARIPSAlPAEIREA------IRKYGIRNAQLTTIAPTGTISLIAGTSSG 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 395 IEPYTSNIYTRRVL-SGEFQIVNPHLLKDLTERGLWHEEmKNQIIACNGSIQSIPEiPDDLKQLYKTVWEISQKTVLKMA 473
Cdd:TIGR02504 444 IEPVFALVYFRNVTvGGELLEVNPLVELALRELGYYSDE-IVKYVDEKGTVEGAPG-PEELPKVFVTAMDISPEDHVLMQ 521
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 1057503148 474 AERGAFIDQSQSLNIHIaePN----------YgkltsmhFYGWKQGLK 511
Cdd:TIGR02504 522 AAIQPWVDSSISKTINM--PSdatvedvkavY-------LEAWKLGLK 560
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
1-398 |
2.67e-86 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 275.27 E-value: 2.67e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLE 80
Cdd:cd02888 39 VEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTGGVASGPVSFMRVFDAATGVIKQGG-TRRGANMGVLD 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 81 PWHLDIFEFLDLKKntgKEEQRARDLFFAL--WIPDLFMKRVETNQDWSLMCPNECPGldevwgeefeklyasyekqGRV 158
Cdd:cd02888 118 VDHPDIEEFIDAKM---KEEKTVVLQNFNIsvAVTDAFMEAVENDEPWELRNPREPDT-------------------GKV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 159 RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIV--EYTSkdevavCNLASLALNMYV--- 233
Cdd:cd02888 176 YRTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPGLGRINATNPCGEQPllPYES------CNLGSINLSKFVknp 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 234 TSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETI 313
Cdd:cd02888 250 FGGASFDFERLREAVRLAVRFLDNVIDVNRYPLPEIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFI 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 314 YYGALEASCDLAKEQGPYETYEGSpvskgilQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNE 393
Cdd:cd02888 330 RDAAYRASAELAKERGPFPLFDAS-------RYLMLKVIVNAKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSS 402
|
....*
gi 1057503148 394 SIEPY 398
Cdd:cd02888 403 GIEPI 407
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
3-534 |
1.42e-75 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 254.64 E-value: 1.42e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCA-LISKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEP 81
Cdd:PHA02572 229 GDSLDSINKTAMAIVkYISKRAG-IGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGG-IRGGAATAYYPI 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 82 WHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGldEVWG------EEFEKLYASYEKQ 155
Cdd:PHA02572 307 WHLEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGG--ELYDayfadqDRFRELYEALEKD 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 156 GRVR-KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNqqNLGTIKCSNLCTEIVEYTS-------KDEVAVCNLASL 227
Cdd:PHA02572 385 PSVRkKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHSP--FKDPIRQSNLCCEIALPTKplnhidgEGEIALCTLSAI 462
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 228 ALNMYVtsehtyDFKKLAEVTKVVVRNLNKIIDINYYPVPEAcLSNKRHRPIGIGVQGLAdAFILMRY-PFESAEAQLLN 306
Cdd:PHA02572 463 VLGNFE------DQDEIEELAEVAVRALDNLLDYQDYPVPAA-LKAKKRRSLGVGVTNYA-HYLAKNFaSYEDANADLVH 534
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 307 KqIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWN------VTPTDLWDWKVLKEKIAKYGIRNSLLIAPM 380
Cdd:PHA02572 535 E-LFERLQYYLIKASNKLAKEKGACEYFSDTKYSRGELPIDWYKkkvdelVAPKYNCDWESLREDLKKYGIRNSTLSALM 613
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 381 PTASTAQILGNNESIEPYTSNIYTRRVLSGEFqivnphllkdlterglwheemkNQIiacngsiqsIPEIpDDLKQLYKT 460
Cdd:PHA02572 614 PCESSSQVSNSTNGIEPPRGPVSIKKSKEGPF----------------------NQV---------VPNV-ETLKDLYDL 661
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 461 VWEISQKT---VLKMAAERGAFIDQSQSLNIHIAEPNY--GKL-TSMHF----YGWKQGLKTgMYYLRTRPAANPIQFTL 530
Cdd:PHA02572 662 LWDLAKKGnkgYLTQVAIMQKFVDQAISANTSYDPENYpnGKVpMSVMLddllYFYYYGGKT-LYYHNTRDGKGTEDYEI 740
|
....
gi 1057503148 531 NKEK 534
Cdd:PHA02572 741 ETPK 744
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
3-479 |
1.90e-65 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 227.12 E-value: 1.90e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPW 82
Cdd:PRK08665 103 GDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGI-LRVD 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNTGKeeqrARDLFFALWIPDLFMKRVETNQDWSLMCPNEcpgldevwgeefeklyasyekqGRVRKVV 162
Cdd:PRK08665 182 HPDIMEFITCKEDNGE----LTNFNISVAITEAFMEAVEADEEYDLINPRT----------------------GEVVGRL 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVTsEHTYD 240
Cdd:PRK08665 236 NAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEqpLLPYES------CNLGSINLSKMVK-NGDVD 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 241 FKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEA 320
Cdd:PRK08665 309 WEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQDEAHAA 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 321 SCDLAKEQGPYETYEGSpvskgilqydmwnvtptdLWDwkvlKEKIAKYgiRNSLL--IAPMPTAStaqILGNNES-IEP 397
Cdd:PRK08665 389 SRELAEERGPFPNYEGS------------------IYD----KDGLGPM--RNATVttIAPTGTIS---IIAGCSSgIEP 441
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 398 YTSNIYTRRVLSGEFQI-VNPHLLKDLTERGLWHEE-MKNqiIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAe 475
Cdd:PRK08665 442 LFALSFTRNVMDGERLVeVNPVFEAAAKEEGFYSEElMEK--IAEKGSIQDIDEVPEDVRRVFVTAHDISPEWHVRMQA- 518
|
....
gi 1057503148 476 rgAF 479
Cdd:PRK08665 519 --AF 520
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
3-490 |
2.73e-64 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 224.34 E-value: 2.73e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:PRK06406 258 PDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVASGPLSFMRIFDVTTDVIKQGG-KRRGANMGILSYH 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKKNtgkEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPnecpgldevwgeefeklyasyeKQGRVRKVV 162
Cdd:PRK06406 337 HPDIMEFITSKDS---ENKVLSNFNISVAVTDEFFDKLDNDDYYPLRNP----------------------RNGKEVKRI 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVTsEHTYD 240
Cdd:PRK06406 392 KARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNLGEIESTNPCGEqpLLPYES------CNLGSINLSKFVE-NGKID 464
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 241 FKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEA 320
Cdd:PRK06406 465 WDRLRETVHIATRFLDNVIDANKFPVPQIKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRA 544
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 321 SCDLAKEQGPYETYEGSpvskgilqydmwnvtptdlwDWKvlKEKIAkygIRNSLLIAPMPTASTAQILGNNESIEPYTS 400
Cdd:PRK06406 545 SQKLAEERGVFPAWYGS--------------------EWE--KKGIK---MRNSTTTTIAPTGTISIIAGCSSSIEPLFA 599
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 401 NIYTRRVLSGEFQI-VNPHLLKDLTERGLWHEEMKNQiIACNGSIQSIpEIPDDLKQLYKTVWEISQKTVLKMAAERGAF 479
Cdd:PRK06406 600 IAFVRHVLNGQELLeVNPLFEEITRKRGLYSEELMRK-VAETGNLQNI-DVPEDIKRIFVTAHEIDPQWHVLMQATFQRY 677
|
490
....*....|.
gi 1057503148 480 IDQSQSLNIHI 490
Cdd:PRK06406 678 CDSGVSKTINL 688
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-527 |
1.55e-59 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 211.00 E-value: 1.55e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTlkQCALI---SKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYL 79
Cdd:PRK09103 228 GDSLDSINAT--SSAIVkyvSQRAG-IGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-VRGGAATLFY 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 80 EPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVW---GEEFEKLYASYEKQG 156
Cdd:PRK09103 304 PIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFfadQDEFERLYTKYEQDD 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 157 RVRK-VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSN-QQNLGTIKCSNLCTEIVEYT--------SKDEVAVCNLAS 226
Cdd:PRK09103 384 SIRKkRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPKVAPVRQSNLCLEIALPTkplndvndENGEIALCTLSA 463
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 227 LALNmyvTSEHTYDFKKLAEvtkVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLadAFIL----MRYPFESAEA 302
Cdd:PRK09103 464 FNLG---AINSLDELEELAD---LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINF--AYYLakngVRYSDGSANN 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 303 qlLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMW-----NVTPTDL-WDWKVLKEKIAKYGIRNSLL 376
Cdd:PRK09103 536 --LTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAQGILPIDTYkkdldAICNEPLhYDWETLREEIKTHGLRNSTL 613
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 377 IAPMPTASTAQILGNNESIEPytsniytrrvlsgefqivnPhllkdlteRGLWH-EEMKNQIIAcngsiQSIPEIpDDLK 455
Cdd:PRK09103 614 SALMPSETSSQISNATNGIEP-------------------P--------RGYVSiKASKDGILK-----QVVPDY-ERLK 660
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 456 QLYKTVWEI-SQKTVLKMAAERGAFIDQSQSLNIHIaEPN---YGKLTSMHF-----YGWKQGLKTgMYYLRTRPAANPI 526
Cdd:PRK09103 661 DAYELLWEMpNNDGYLQLVGIMQKFVDQSISANTNY-DPSrfpSGKVPMKQLlkdllTAYKFGVKT-LYYHNTRDGAEDA 738
|
.
gi 1057503148 527 Q 527
Cdd:PRK09103 739 Q 739
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
4-432 |
9.93e-42 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 161.16 E-value: 9.93e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRpGAFAIYLEPWH 83
Cdd:PRK08115 197 DSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGKSSGSVSWLDDIAKLTHLVEQGGSRR-GAQMIMLADWH 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 84 LDIFEFLD-----------LKKNTGKEE------------------------------------------QRARDLF--- 107
Cdd:PRK08115 276 PDILEFIIskmqnprilryLLENTEDEQikrlvkeklkftplseveeamyqaivnykniegqggfdtkviKEAENKLrtg 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 108 --FALWIPDL-------------FMKRVETNQDWSLMCPN-------ECPGLDEVWGE-----EFEKLyaSYEKqgRVRK 160
Cdd:PRK08115 356 gtYTVNNPEFltganisvcltkeFMEAVENDEEYELRFPDvenyteeEMEIYNEEWHEvgdvrEWEKM--GYPV--RTYR 431
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLG-TIKCSNLCTE--IVEYTskdevaVCNLASLAL-NMYVTSE 236
Cdd:PRK08115 432 KIKAKELWNLINICATYSAEPGIFFIDNANEMTNAKAYGqKVVATNPCGEqpLAPYS------VCNLAAINLaNMADKET 505
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 237 HTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYG 316
Cdd:PRK08115 506 KTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATT 585
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 317 ALEASCDLAKEQGPYETYEGSP------VSKGILQYDMWNVTPTDlwdwkvLKEKIAKYGIRNSLLIAPMPTASTAQILG 390
Cdd:PRK08115 586 AYRTSIELAKEKGSFPFLVGQTeeetakLREAFINTGYMKKMPED------IREDILKYGIRNSHLLTVAPTGSTGTMVG 659
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1057503148 391 NNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEE 432
Cdd:PRK08115 660 VSTGLEPYFSFSYYRSGRLGKFIEVKADIVQEYLDKHPEADE 701
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
204-464 |
4.49e-41 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 159.93 E-value: 4.49e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 204 SNLCTE--IVEYTSkdevavCNLASLALNMYVTSEHT----YDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHR 277
Cdd:PRK08332 1294 SHNCGEepLYEYES------CNLASINLAKFVKYDENgkpyFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTR 1367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 278 PIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGIL------QYDMWNV 351
Cdd:PRK08332 1368 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELpvegfyHPEIWNL 1447
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 352 TptdlwdWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHE 431
Cdd:PRK08332 1448 P------WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSE 1521
|
250 260 270
....*....|....*....|....*....|...
gi 1057503148 432 EMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEI 464
Cdd:PRK08332 1522 ELLKKISDNYGSVQGLEEIPEDMQRVFVTALDI 1554
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
3-453 |
2.71e-30 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 126.62 E-value: 2.71e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGtNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPW 82
Cdd:PRK06556 158 DDSMESILNWYKEEGMLFKGGSGTGTNLSRIRSSKELLSG-GGTASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVD 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 83 HLDIFEFLDLKkntGKEEQRARDLFFALWIPDL----------------------FMKRVETNQDWSLMCpnecpgldev 140
Cdd:PRK06556 237 HPDIEEFIETK---AKEEDKIRALRDAGYDMDLggeayssvqyqnannsvrvsdeFMRAVENDGEFGLRA---------- 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 141 wgeefeklyasyEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEiveYTSKDEVA 220
Cdd:PRK06556 304 ------------RTDGEVIETVDAKELFRKIAEAAWECADPGIQYDDTINDWHTCPESGRINASNPCSE---YMFLDNSS 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 221 vCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESA 300
Cdd:PRK06556 369 -CNLASLNLMKFLRDDGTFDVESFRHAVELVITAMEISICFADFPTEKIARNTRAFRQLGLGYANLGALLMATGLPYDSD 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 301 EAQLLNKQIFETIYYGALEASCDLAKEQGPYETYE-----------------GSPVSKGILQYDMWNVTpTDLWDwKVLK 363
Cdd:PRK06556 448 GGRALAAAITSLMTGEAYRRSAELAGVVGPFEGYArnaephlrvmrkhaaanDAIRPLGEVDAALLEAA-KEAWD-DALE 525
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 364 EKiAKYGIRNS--LLIAP-------MPTASTaqilgnneSIEPYTSNI-YTRRVLSGEFQIVNPHLLKDLTERGlWHEEM 433
Cdd:PRK06556 526 LG-EKNGYRNAqaSVLAPtgtigfmMDCDTT--------GIEPDFALVkYKKLVGGGSMKIVNQTVPRALKKLG-YSEEQ 595
|
490 500
....*....|....*....|...
gi 1057503148 434 KNQI---IACNGSIQSIPEIPDD 453
Cdd:PRK06556 596 IEAIveyIAEHGHIEGAPGLKPE 618
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
24-414 |
3.77e-30 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 124.91 E-value: 3.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 24 GGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPWHLDIFEFLDLKKNtgkeeqRA 103
Cdd:PRK06948 121 GGIGYDFSAIPPADARPDADHPDSPGVCAALDRFDRICAALPFRDGRRGAQMAV-LRCDHPDLLAFVAAKRG------RA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 104 RDLFF--ALWIPDLFMKRVETNQDWSLMCPNE--------CPGLDEVWgeefekLYASyekqgrvrkvVKAQQLWYAIIE 173
Cdd:PRK06948 194 RWTTFnlSVAVTDAFMQAVAQDLPWALRHRAPprraaggaLRGADGAW------TYAT----------VPARHLWREIVS 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 174 SQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVT------SEHTYDFKKLA 245
Cdd:PRK06948 258 AARDSAEPGLLFVDTIDAANPLREHERIDATNPCGEqpLPPYGS------CVLGPIDLSRFVRhpfgvgGEPRFDFAALA 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 246 EVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLA 325
Cdd:PRK06948 332 TAVRIQVRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALA 411
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 326 KEQGPY-----ETYEGSPVSKGILQydmwnvtptdlwdwKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNES--IEPY 398
Cdd:PRK06948 412 AERGAYplcdpAAHLDALRAGPPLP--------------HAVCHAIARHGLRNSHLLSFAPVGSVSLAFGDNCSpgIEPA 477
|
410
....*....|....*.
gi 1057503148 399 TSNIYTRRVLSGEFQI 414
Cdd:PRK06948 478 RAWIEHRPVRAGAGGA 493
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
17-343 |
2.50e-05 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 46.76 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 17 ALISKSAGGIGVAV--SCIRATGSYIAG-TNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY----LEPWHLDIFEF 89
Cdd:cd00576 62 AASNQNGGGVSFARasSILSPYGSRDYAkGSGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIggvhKGKGDKISQEF 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 90 LDLKKNTGKEEQRardlffaLWIPDLFMKrvetnqdwslmcpnecpgldeVWGEEFEKLYASYEKQGRvrkvvkaqqlwy 169
Cdd:cd00576 142 LNLALANGGEGIP-------LNFPNLSVR---------------------VSSDKPGILVKAVELKQL------------ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 170 aIIESQTETGTPYMLYKDSCNrksnqqnLGTIkcsnlcteiveytskdevavcNLASLALNMYVTSEHTYDfKKLAEVTK 249
Cdd:cd00576 182 -IAEEARKTGSPGIFNDELCN-------LVSL---------------------NLARIMEKAINGSMDVVL-EELEELAF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 250 VVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPF-ESAEAQLLNKQIFETIYYGALEASCDL--AK 326
Cdd:cd00576 232 LAVRALDCVIDSHDERIPTIELGGDERRTVGLGIAGVADLLIKLGLEKvGDPEADDLAAELVDQLKKHLVKATNERgfNF 311
|
330 340
....*....|....*....|
gi 1057503148 327 EQG--PYETY-EGSPVSKGI 343
Cdd:cd00576 312 LLGlsPSESNsSGAPATNGV 331
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
27-207 |
2.46e-04 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 44.37 E-value: 2.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 27 GVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPWHLDIFEFLDLK-KNTGKEEQRARD 105
Cdd:PRK08332 757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGI-LEIWHPDIEKFIHAKeKNIGTNVLSNFN 835
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 106 LFFALWipDLFMKRVETNQDWSLMCPnecpgldevwgeefeklyasyeKQGRVRKVVKAQQLWYAIIESQTETGTPYMLY 185
Cdd:PRK08332 836 ISVGIW--EDFWEALKEGKKYPLINP----------------------RTGEVVKEIDPKSLFEELAYMAWAKADPGVIF 891
|
170 180
....*....|....*....|....
gi 1057503148 186 KDSCNRKS--NQQNLGTIKCSNLC 207
Cdd:PRK08332 892 FDVINRRNvlKEAKGGPIRATNPC 915
|
|
|