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Conserved domains on  [gi|1054302639|ref|NP_001317105|]
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coordinator of PRMT5 and differentiation stimulator isoform 2 [Homo sapiens]

Protein Classification

COPR5 domain-containing protein( domain architecture ID 10634009)

COPR5 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COPR5 pfam15340
Cooperator of PRMT5 family; COPR5 is a family of histone H4-binding proteins expressed in the ...
 22-172 1.04e-89

Cooperator of PRMT5 family; COPR5 is a family of histone H4-binding proteins expressed in the nucleus. It interacts with the N-terminus of histone H4 thereby mediating the association between histone H4 and PRMT5, PRMT5, the Janus kinase-binding protein 1 that catalyzes the formation of symmetric dimethyl-arginine residues in proteins. COPR5 is specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. This family of proteins is found in eukaryotes.


:

Pssm-ID: 434649  Cd Length: 150  Bit Score: 258.28  E-value: 1.04e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054302639  22 AGFATADHSSQERETEKAMDRLARGTQSIPNDSPARGEGTHSEEEGFAMdEEDSDGELNTWELSEGTNCPPKEQPGDLFN 101
Cdd:pfam15340   1 AGLATADHSGPERETEKATDRLANGAQSVPSDVPAHGEGSHFEEEGFAL-EEESDGEPNAWELPEGTRCLPKEPTAELFN 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1054302639 102 EDWDSELKADQGNPYDADDIQESISQELKPWVCCAPQGDMIYDPSWHHPPPLIPYYSKMVFETGQFDDAED 172
Cdd:pfam15340  80 EDWDLELKADQGNPYDADDIQGSISQEVKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED 150
 
Name Accession Description Interval E-value
COPR5 pfam15340
Cooperator of PRMT5 family; COPR5 is a family of histone H4-binding proteins expressed in the ...
 22-172 1.04e-89

Cooperator of PRMT5 family; COPR5 is a family of histone H4-binding proteins expressed in the nucleus. It interacts with the N-terminus of histone H4 thereby mediating the association between histone H4 and PRMT5, PRMT5, the Janus kinase-binding protein 1 that catalyzes the formation of symmetric dimethyl-arginine residues in proteins. COPR5 is specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. This family of proteins is found in eukaryotes.


Pssm-ID: 434649  Cd Length: 150  Bit Score: 258.28  E-value: 1.04e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054302639  22 AGFATADHSSQERETEKAMDRLARGTQSIPNDSPARGEGTHSEEEGFAMdEEDSDGELNTWELSEGTNCPPKEQPGDLFN 101
Cdd:pfam15340   1 AGLATADHSGPERETEKATDRLANGAQSVPSDVPAHGEGSHFEEEGFAL-EEESDGEPNAWELPEGTRCLPKEPTAELFN 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1054302639 102 EDWDSELKADQGNPYDADDIQESISQELKPWVCCAPQGDMIYDPSWHHPPPLIPYYSKMVFETGQFDDAED 172
Cdd:pfam15340  80 EDWDLELKADQGNPYDADDIQGSISQEVKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED 150
 
Name Accession Description Interval E-value
COPR5 pfam15340
Cooperator of PRMT5 family; COPR5 is a family of histone H4-binding proteins expressed in the ...
 22-172 1.04e-89

Cooperator of PRMT5 family; COPR5 is a family of histone H4-binding proteins expressed in the nucleus. It interacts with the N-terminus of histone H4 thereby mediating the association between histone H4 and PRMT5, PRMT5, the Janus kinase-binding protein 1 that catalyzes the formation of symmetric dimethyl-arginine residues in proteins. COPR5 is specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. This family of proteins is found in eukaryotes.


Pssm-ID: 434649  Cd Length: 150  Bit Score: 258.28  E-value: 1.04e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054302639  22 AGFATADHSSQERETEKAMDRLARGTQSIPNDSPARGEGTHSEEEGFAMdEEDSDGELNTWELSEGTNCPPKEQPGDLFN 101
Cdd:pfam15340   1 AGLATADHSGPERETEKATDRLANGAQSVPSDVPAHGEGSHFEEEGFAL-EEESDGEPNAWELPEGTRCLPKEPTAELFN 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1054302639 102 EDWDSELKADQGNPYDADDIQESISQELKPWVCCAPQGDMIYDPSWHHPPPLIPYYSKMVFETGQFDDAED 172
Cdd:pfam15340  80 EDWDLELKADQGNPYDADDIQGSISQEVKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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