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Conserved domains on  [gi|1052798154|ref|NP_001317030|]
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cell division cycle protein 16 homolog isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-93 1.38e-20

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


:

Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 86.15  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  15 DQQQYQSALFWADKV-ASLSREPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD 93
Cdd:pfam12895   1 DQHQYKNAIFLAERLlAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
372-521 5.62e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 77.74  E-value: 5.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 372 YIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEkIKAignevtvdKWEPLLNNLG 451
Cdd:COG0457    13 NLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE-LDP--------DDAEALNNLG 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 452 HVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 521
Cdd:COG0457    84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 274-439 4.10e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.15  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 274 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 353
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 354 AAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKwFLDALEKIKA 433
Cdd:COG3914   167 AALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR-FEELLAALAR 245


                  ....*.
gi 1052798154 434 IGNEVT 439
Cdd:COG3914   246 GPSELS 251
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-93 1.38e-20

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 86.15  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  15 DQQQYQSALFWADKV-ASLSREPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD 93
Cdd:pfam12895   1 DQHQYKNAIFLAERLlAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
372-521 5.62e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 77.74  E-value: 5.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 372 YIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEkIKAignevtvdKWEPLLNNLG 451
Cdd:COG0457    13 NLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE-LDP--------DDAEALNNLG 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 452 HVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 521
Cdd:COG0457    84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 274-439 4.10e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.15  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 274 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 353
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 354 AAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKwFLDALEKIKA 433
Cdd:COG3914   167 AALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR-FEELLAALAR 245


                  ....*.
gi 1052798154 434 IGNEVT 439
Cdd:COG3914   246 GPSELS 251
TPR_12 pfam13424
Tetratricopeptide repeat;
446-510 4.84e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.46  E-value: 4.84e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052798154 446 LLNNLGHVCRKLKKYAEALDYHRQALVLI--------PQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 510
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 10-501 2.23e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.85  E-value: 2.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  10 VRQYLDQQQYQSALFWADKVASLSREPQdiywlaqclyltAQYH--RAAHALRSRKLD---KLYEACRYLAARCHYAake 84
Cdd:TIGR02917  97 ARAYLLQGKFQQVLDELPGKTLLDDEGA------------AELLalRGLAYLGLGQLElaqKSYEQALAIDPRSLYA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  85 hQQALDVLDMEEpiNK-----RLFEKYLKDESGFKDPssdWemsqssikssicLLRGKIYDALDNRTLATYSYKEALKLD 159
Cdd:TIGR02917 162 -KLGLAQLALAE--NRfdearALIDEVLTADPGNVDA---L------------LLKGDLLLSLGNIELALAAYRKAIALR 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 160 -----VYCFEAFDLLTSHHMLTAQEEKE-LLESLPLSKLCNEEQELLRFlfenKLKKYNKPSETVIpESVDGLQENLDVV 233
Cdd:TIGR02917 224 pnniaVLLALATILIEAGEFEEAEKHADaLLKKAPNSPLAHYLKALVDF----QKKNYEDARETLQ-DALKSAPEYLPAL 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 234 VSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGh 313
Cdd:TIGR02917 299 LLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALG- 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 314 KNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQL------------------------------- 362
Cdd:TIGR02917 378 DFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLdpelgradlllilsylrsgqfdkalaaakkl 457

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 363 ---MKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDAL----EKIKAI- 434
Cdd:TIGR02917 458 ekkQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLtidpKNLRAIl 537

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 435 ---------GNEVTVDKW------------EPLLnNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGN 493
Cdd:TIGR02917 538 alaglylrtGNEEEAVAWlekaaelnpqeiEPAL-ALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGD 616


                  ....*...
gi 1052798154 494 FENAVDYF 501
Cdd:TIGR02917 617 LNKAVSSF 624
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 3-128 2.72e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.92  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154   3 LERLRKRVRQ--------------YLDQQQYQSALFWADKVASLSRE-PQDIYWLAQCLYLTAQYHRAAHAL-RSRKLDK 66
Cdd:COG4235     3 IARLRQALAAnpndaegwlllgraYLRLGRYDEALAAYEKALRLDPDnADALLDLAEALLAAGDTEEAEELLeRALALDP 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1052798154  67 LYEACRYLAARCHYAAKEHQQALDvldmeepinkrLFEKYLKDEsgfkDPSSDWEMSQSSIK 128
Cdd:COG4235    83 DNPEALYLLGLAAFQQGDYAEAIA-----------AWQKLLALL----PADAPARLLEASIA 129
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 340-507 4.39e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.08  E-value: 4.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 340 GHSFAVESEHDQAMAAYFTAAQLMKGCHLPMlYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT 419
Cdd:TIGR02917 710 GDLYLRQKDYPAAIQAYRKALKRAPSSQNAI-KLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDK 788

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 420 AEKWFLDALEKikAIGNEVTvdkweplLNNLGHVCRKLKKyAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVD 499
Cdd:TIGR02917 789 AIKHYQTVVKK--APDNAVV-------LNNLAWLYLELKD-PRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALP 858


                  ....*...
gi 1052798154 500 YFHTALGL 507
Cdd:TIGR02917 859 LLRKAVNI 866
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 447-477 5.11e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.51  E-value: 5.11e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1052798154  447 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN 477
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 460-507 7.60e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 37.73  E-value: 7.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1052798154 460 YAEALDYHRQALVLiPQNASTYSAI----GYIHSLMGNFENAVDYFHTALGL 507
Cdd:PRK02603   51 YAEALENYEEALKL-EEDPNDRSYIlynmGIIYASNGEHDKALEYYHQALEL 101
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-93 1.38e-20

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 86.15  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  15 DQQQYQSALFWADKV-ASLSREPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD 93
Cdd:pfam12895   1 DQHQYKNAIFLAERLlAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
372-521 5.62e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 77.74  E-value: 5.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 372 YIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEkIKAignevtvdKWEPLLNNLG 451
Cdd:COG0457    13 NLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE-LDP--------DDAEALNNLG 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 452 HVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 521
Cdd:COG0457    84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
328-511 5.95e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 77.74  E-value: 5.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 328 LEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEV 407
Cdd:COG0457     3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 408 GVVAFQNGEWKTAEKWFLDALEkikaIGNEVtvdkwEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYI 487
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALE----LDPDD-----AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153

                         170       180
                  ....*....|....*....|....
gi 1052798154 488 HSLMGNFENAVDYFHTALGLRRDD 511
Cdd:COG0457   154 LEKLGRYEEALELLEKLEAAALAA 177
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 365-511 8.07e-15

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 71.76  E-value: 8.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 365 GCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEkikaignevtVDKWE 444
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALE----------LDPDE 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1052798154 445 P-LLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDD 511
Cdd:COG4783    72 PeARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 300-521 3.86e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 73.22  E-value: 3.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 300 SWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGL 379
Cdd:COG2956    10 GWYFKGLNYLLNG-QPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLK 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 380 TNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAekwfLDALEKIKAIGnevtvDKWEPLLNNLGHVCRKLKK 459
Cdd:COG2956    89 AGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKA----IEVLERLLKLG-----PENAHAYCELAELYLEQGD 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1052798154 460 YAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 521
Cdd:COG2956   160 YDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 276-531 7.55e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 72.07  E-value: 7.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 276 ELNKANELFylsHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAA 355
Cdd:COG2956    23 QPDKAIDLL---EEALELDPETVEAHLALGNLYRRRGEYDR-AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEEL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 356 YFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKaig 435
Cdd:COG2956    99 LEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDP--- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 436 nevtvdKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFsV 515
Cdd:COG2956   176 ------DCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL-L 248

                         250
                  ....*....|....*.
gi 1052798154 516 TMLGHCIEMYIGDSEA 531
Cdd:COG2956   249 LALADLLERKEGLEAA 264
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
394-521 8.83e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.58  E-value: 8.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 394 LSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEkikaignevtVDKWEP-LLNNLGHVCRKLKKYAEALDYHRQALV 472
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE----------LDPDDAeALYNLGLAYLRLGRYEEALADYEQALE 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1052798154 473 LIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 521
Cdd:COG0457    71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 301-532 2.11e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 73.10  E-value: 2.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 301 WFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQlmkgCHLPMLYIGLEygLT 380
Cdd:COG3914    18 LAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLA----ALLELAALLLQ--AL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 381 NNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKikaignevtVDKWEPLLNNLGHVCRKLKKY 460
Cdd:COG3914    92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALAL---------NPDFAEAYLNLGEALRRLGRL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1052798154 461 AEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIeMYIGDSEAY 532
Cdd:COG3914   163 EEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL-RQACDWEVY 233
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 289-505 5.91e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.68  E-value: 5.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 289 KLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHL 368
Cdd:COG2956    67 KLLERDPDRAEALLELAQDYLKAGLLDR-AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 369 PMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKikaignevtVDKWEPLLN 448
Cdd:COG2956   146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ---------DPDYLPALP 216

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1052798154 449 NLGHVCRKLKKYAEALDYHRQALVLIPQNASTYsAIGYIHSLMGNFENAVDYFHTAL 505
Cdd:COG2956   217 RLAELYEKLGDPEEALELLRKALELDPSDDLLL-ALADLLERKEGLEAALALLERQL 272
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 368-519 6.44e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 6.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 368 LPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKikaignevtVDKWEPLL 447
Cdd:COG2956     9 LGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLER---------DPDRAEAL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1052798154 448 NNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 519
Cdd:COG2956    80 LELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELA 151
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
410-510 5.34e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 53.64  E-value: 5.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 410 VAFQNGEWKTAEKWFLDALEKIKAIGNevtvdkwepLLNNLGHVCRKLKKYAEALDYhRQALVLIPQNASTYSAIGYIHS 489
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNAD---------ALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLL 70

                          90       100
                  ....*....|....*....|.
gi 1052798154 490 LMGNFENAVDYFHTALGLRRD 510
Cdd:COG3063    71 ELGDYDEALAYLERALELDPS 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
289-478 8.23e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.55  E-value: 8.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 289 KLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHL 368
Cdd:COG0457    33 KALELDPDDAEALYNLGLAYLRLGRYEE-ALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAE 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 369 PMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLN 448
Cdd:COG0457   112 ALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALA 191

                         170       180       190
                  ....*....|....*....|....*....|
gi 1052798154 449 NLGHVCRKLKKYAEALDYHRQALVLIPQNA 478
Cdd:COG0457   192 AAEVLLALLLALEQALRKKLAILTLAALAE 221
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 403-521 3.14e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.89  E-value: 3.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 403 VMHEVGVVAFQNGEWKTAEKWFLDALEKikaignevtVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYS 482
Cdd:COG4783     6 ALYALAQALLLAGDYDEAEALLEKALEL---------DPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARL 76

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1052798154 483 AIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 521
Cdd:COG4783    77 NLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA 115
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 274-439 4.10e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.15  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 274 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 353
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 354 AAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKwFLDALEKIKA 433
Cdd:COG3914   167 AALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR-FEELLAALAR 245


                  ....*.
gi 1052798154 434 IGNEVT 439
Cdd:COG3914   246 GPSELS 251
TPR_12 pfam13424
Tetratricopeptide repeat;
446-510 4.84e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.46  E-value: 4.84e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052798154 446 LLNNLGHVCRKLKKYAEALDYHRQALVLI--------PQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 510
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 377-475 6.61e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.27  E-value: 6.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 377 YGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAignevtvdkWEPLLNNLGHVCRK 456
Cdd:COG5010    64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPD---------NPNAYSNLAALLLS 134

                          90
                  ....*....|....*....
gi 1052798154 457 LKKYAEALDYHRQALVLIP 475
Cdd:COG5010   135 LGQDDEAKAALQRALGTSP 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 301-430 8.07e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.73  E-value: 8.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 301 WFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLT 380
Cdd:COG4783     7 LYALAQALLLAGDYDE-AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1052798154 381 NNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEK 430
Cdd:COG4783    86 GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 409-507 2.72e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.73  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 409 VVAFQNGEWKTAEKWFLDALEKIKaignevtvdKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIH 488
Cdd:COG5010    62 NLYNKLGDFEESLALLEQALQLDP---------NNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALL 132

                          90
                  ....*....|....*....
gi 1052798154 489 SLMGNFENAVDYFHTALGL 507
Cdd:COG5010   133 LSLGQDDEAKAALQRALGT 151
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 453-519 4.19e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.96  E-value: 4.19e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052798154 453 VCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 519
Cdd:COG5010    63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLA 129
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 335-429 9.25e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.46  E-value: 9.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 335 AWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQN 414
Cdd:COG4235    19 GWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQ 98

                          90
                  ....*....|....*
gi 1052798154 415 GEWKTAEKWFLDALE 429
Cdd:COG4235    99 GDYAEAIAAWQKLLA 113
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 392-511 9.52e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.46  E-value: 9.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 392 QALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEkikaignevtVDKWEP-LLNNLGHVCRKLKKYAEALDYHRQA 470
Cdd:COG4235     8 QALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALR----------LDPDNAdALLDLAEALLAAGDTEEAEELLERA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1052798154 471 LVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDD 511
Cdd:COG4235    78 LALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 10-501 2.23e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.85  E-value: 2.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  10 VRQYLDQQQYQSALFWADKVASLSREPQdiywlaqclyltAQYH--RAAHALRSRKLD---KLYEACRYLAARCHYAake 84
Cdd:TIGR02917  97 ARAYLLQGKFQQVLDELPGKTLLDDEGA------------AELLalRGLAYLGLGQLElaqKSYEQALAIDPRSLYA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  85 hQQALDVLDMEEpiNK-----RLFEKYLKDESGFKDPssdWemsqssikssicLLRGKIYDALDNRTLATYSYKEALKLD 159
Cdd:TIGR02917 162 -KLGLAQLALAE--NRfdearALIDEVLTADPGNVDA---L------------LLKGDLLLSLGNIELALAAYRKAIALR 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 160 -----VYCFEAFDLLTSHHMLTAQEEKE-LLESLPLSKLCNEEQELLRFlfenKLKKYNKPSETVIpESVDGLQENLDVV 233
Cdd:TIGR02917 224 pnniaVLLALATILIEAGEFEEAEKHADaLLKKAPNSPLAHYLKALVDF----QKKNYEDARETLQ-DALKSAPEYLPAL 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 234 VSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGh 313
Cdd:TIGR02917 299 LLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALG- 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 314 KNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQL------------------------------- 362
Cdd:TIGR02917 378 DFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLdpelgradlllilsylrsgqfdkalaaakkl 457

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 363 ---MKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDAL----EKIKAI- 434
Cdd:TIGR02917 458 ekkQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLtidpKNLRAIl 537

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 435 ---------GNEVTVDKW------------EPLLnNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGN 493
Cdd:TIGR02917 538 alaglylrtGNEEEAVAWlekaaelnpqeiEPAL-ALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGD 616


                  ....*...
gi 1052798154 494 FENAVDYF 501
Cdd:TIGR02917 617 LNKAVSSF 624
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 3-128 2.72e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.92  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154   3 LERLRKRVRQ--------------YLDQQQYQSALFWADKVASLSRE-PQDIYWLAQCLYLTAQYHRAAHAL-RSRKLDK 66
Cdd:COG4235     3 IARLRQALAAnpndaegwlllgraYLRLGRYDEALAAYEKALRLDPDnADALLDLAEALLAAGDTEEAEELLeRALALDP 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1052798154  67 LYEACRYLAARCHYAAKEHQQALDvldmeepinkrLFEKYLKDEsgfkDPSSDWEMSQSSIK 128
Cdd:COG4235    83 DNPEALYLLGLAAFQQGDYAEAIA-----------AWQKLLALL----PADAPARLLEASIA 129
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 340-507 4.39e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.08  E-value: 4.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 340 GHSFAVESEHDQAMAAYFTAAQLMKGCHLPMlYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT 419
Cdd:TIGR02917 710 GDLYLRQKDYPAAIQAYRKALKRAPSSQNAI-KLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDK 788

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 420 AEKWFLDALEKikAIGNEVTvdkweplLNNLGHVCRKLKKyAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVD 499
Cdd:TIGR02917 789 AIKHYQTVVKK--APDNAVV-------LNNLAWLYLELKD-PRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALP 858


                  ....*...
gi 1052798154 500 YFHTALGL 507
Cdd:TIGR02917 859 LLRKAVNI 866
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 307-429 4.73e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.88  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 307 YYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLA 386
Cdd:COG5010    28 EAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEA 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1052798154 387 ERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALE 429
Cdd:COG5010   108 KEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALG 150
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 374-519 5.44e-06

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 48.10  E-value: 5.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 374 GLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALekikAIGNEVTvdkwePLLNNLGHV 453
Cdd:TIGR02521  38 ALGYLEQGDLEVAKENLDKALEHDPDDYLAYLALALYYQQLGELEKAEDSFRRAL----TLNPNNG-----DVLNNYGTF 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1052798154 454 CRKLKKYAEALDYHRQALV--LIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDdtFSVTMLG 519
Cdd:TIGR02521 109 LCQQGKYEQAMQQFEQAIEdpLYPQPARSLENAGLCALKAGDFDKAEKYLTRALQIDPQ--RPESLLE 174
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 276-400 6.05e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 6.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 276 ELNKANELFylsHKLVDLYPSNPVSWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAA 355
Cdd:COG4783    19 DYDEAEALL---EKALELDPDNPEAFALLGEILLQLG-DLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALAL 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1052798154 356 YFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPED 400
Cdd:COG4783    95 LEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
348-505 8.88e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.22  E-value: 8.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 348 EHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDA 427
Cdd:COG4785    88 DYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKA 167

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1052798154 428 LEKikaignevtvDKWEPLLNNLGHVCRKLKKYAEALDYHRQAlvlipqnastysaIGYIHSLMGNFENAVDYFHTAL 505
Cdd:COG4785   168 LEL----------DPNDPERALWLYLAERKLDPEKALALLLED-------------WATAYLLQGDTEEARELFKLAL 222
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 371-478 1.11e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.38  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 371 LYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEkikaignevtVDKWEP-LLNN 449
Cdd:COG4235    21 LLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALA----------LDPDNPeALYL 90

                          90       100
                  ....*....|....*....|....*....
gi 1052798154 450 LGHVCRKLKKYAEALDYHRQALVLIPQNA 478
Cdd:COG4235    91 LGLAAFQQGDYAEAIAAWQKLLALLPADA 119
TPR_12 pfam13424
Tetratricopeptide repeat;
403-471 1.20e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.53  E-value: 1.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1052798154 403 VMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEpLLNNLGHVCRKLKKYAEALDYHRQAL 471
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTAT-TLLNLGRLYLELGRYEEALELLERAL 72
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 295-401 1.62e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 44.61  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 295 PSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIG 374
Cdd:COG4235    14 PNDAEGWLLLGRAYLRLGRYDE-ALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92

                          90       100
                  ....*....|....*....|....*..
gi 1052798154 375 LEYGLTNNSKLAERFFSQALSIAPEDP 401
Cdd:COG4235    93 LAAFQQGDYAEAIAAWQKLLALLPADA 119
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
446-514 2.75e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 2.75e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 446 LLNNLGHVCRKLKKYAEAL-DYhRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFS 514
Cdd:COG4785    75 LYYERGVAYDSLGDYDLAIaDF-DQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 372-505 3.04e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.39  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 372 YIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEkiKAIGNevtVDKWepllNNLG 451
Cdd:TIGR02917 130 LRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLT--ADPGN---VDAL----LLKG 200

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1052798154 452 HVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTAL 505
Cdd:TIGR02917 201 DLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALL 254
COG3899 COG3899
Predicted ATPase [General function prediction only];
317-510 4.29e-05

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 46.78  E-value: 4.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  317 HAR--RYLSKATTLEKTYGPAWIAYgHsFAVESEHDQAMAAYFTAAQLMKGCHLPmlyigleygltnnsKLAERFFSQAL 394
Cdd:COG3899    669 HRRiaRALEARGPEPLEERLFELAH-H-LNRAGERDRAARLLLRAARRALARGAY--------------AEALRYLERAL 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  395 SIAPEDPF------VMHEVGVVAFQNGEWKTAEKWFLDALEK--IKAIGNEVTVDKWEPL--LNNLGHVCRklKKYAEAL 464
Cdd:COG3899    733 ELLPPDPEeeyrlaLLLELAEALYLAGRFEEAEALLERALAAraLAALAALRHGNPPASAraYANLGLLLL--GDYEEAY 810

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1052798154  465 DYHRQALVLI------PQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 510
Cdd:COG3899    811 EFGELALALAerlgdrRLEARALFNLGFILHWLGPLREALELLREALEAGLE 862
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 447-477 5.11e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.51  E-value: 5.11e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1052798154  447 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN 477
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
447-477 6.71e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 6.71e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1052798154 447 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN 477
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 449-519 8.00e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 8.00e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1052798154 449 NLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 519
Cdd:COG4235    22 LLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 308-398 2.00e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.25  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 308 YLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAE 387
Cdd:COG5010    64 YNKLGDFEE-SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAK 142

                          90
                  ....*....|.
gi 1052798154 388 RFFSQALSIAP 398
Cdd:COG5010   143 AALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
453-520 2.38e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.54  E-value: 2.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1052798154 453 VCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDyFHTALGLRRDDTFSVTMLGH 520
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAE 67
TPR_11 pfam13414
TPR repeat;
451-492 8.54e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 37.45  E-value: 8.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1052798154 451 GHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMG 492
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 307-519 2.32e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 307 YYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLA 386
Cdd:TIGR02917 167 QLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 387 ERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAekwfLDALEKIKAIGNEvtvdkWEPLLNNLGHVCRKLKKYAEALDY 466
Cdd:TIGR02917 247 EKHADALLKKAPNSPLAHYLKALVDFQKKNYEDA----RETLQDALKSAPE-----YLPALLLAGASEYQLGNLEQAYQY 317

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1052798154 467 HRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 519
Cdd:TIGR02917 318 LNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLG 370
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 164-507 2.42e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 164 EAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQELLRFLFENKLKKynKPSetvipesvdglqeNLDVVVSLAERHYYN 243
Cdd:TIGR02917 108 QVLDELPGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAI--DPR-------------SLYAKLGLAQLALAE 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 244 CDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHArrylS 323
Cdd:TIGR02917 173 NRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAE----K 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 324 KATTLEKtygpawIAYGHSFAvesEHDQAMAAY-----------FTAAQLMKGCHLPMLYIG--LEYGLtNNSKLAERFF 390
Cdd:TIGR02917 249 HADALLK------KAPNSPLA---HYLKALVDFqkknyedaretLQDALKSAPEYLPALLLAgaSEYQL-GNLEQAYQYL 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 391 SQALSIAPEDPFVMHEVGVVAFQNGEwktaekwFLDALEKIKAIGNEVTVDKwePLLNNLGHVCRKLKKYAEALDYHRQA 470
Cdd:TIGR02917 319 NQILKYAPNSHQARRLLASIQLRLGR-------VDEAIATLSPALGLDPDDP--AALSLLGEAYLALGDFEKAAEYLAKA 389

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1052798154 471 LVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL 507
Cdd:TIGR02917 390 TELDPENAAARTQLGISKLSQGDPSEAIADLETAAQL 426
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
338-511 2.46e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.90  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 338 AYGHSFAVESEHDQAMAAYFTAAQLMKGC-HLPMLYIGLE---YGLTNNSKLAERFFSQALSI-----APEDPFVMHEVG 408
Cdd:COG4785     1 LYALALALLLALALAAAAASKAAILLAALlFAAVLALAIAladLALALAAAALAAAALAAERIdralaLPDLAQLYYERG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 409 VVAFQNGEWKTAEKWFLDALEkikaignevTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIH 488
Cdd:COG4785    81 VAYDSLGDYDLAIADFDQALE---------LDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIAL 151

                         170       180
                  ....*....|....*....|...
gi 1052798154 489 SLMGNFENAVDYFHTALGLRRDD 511
Cdd:COG4785   152 YYLGRYELAIADLEKALELDPND 174
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-159 2.62e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154   2 NLERLRKRVRQYLDQQQYQSALFWADKVASLSREPQDIYW-LAQCLYLTAQYHRAAHAL-RSRKLDKLYEACRYLAARCH 79
Cdd:COG2956   109 DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCeLAELYLEQGDYDEAIEALeKALKLDPDCARALLLLAELY 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  80 YAAKEHQQALDVLdmeepinKRLFEkylkdesgfKDPSSdwemsqssikSSICLLRGKIYDALDNRTLATYSYKEALKLD 159
Cdd:COG2956   189 LEQGDYEEAIAAL-------ERALE---------QDPDY----------LPALPRLAELYEKLGDPEEALELLRKALELD 242
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
313-430 2.81e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 313 HKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAayftaaqlmkgchlpmlyigleygltnnsklaerfFSQ 392
Cdd:COG3063     6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-----------------------------------LEK 50

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1052798154 393 ALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEK 430
Cdd:COG3063    51 ALKLDPNNAEALLNLAELLLELGDYDEALAYLERALEL 88
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 273-362 3.42e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 273 TLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQA 352
Cdd:COG4783    47 ILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE-ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125

                          90
                  ....*....|
gi 1052798154 353 MAAYFTAAQL 362
Cdd:COG4783   126 IAALEKALEL 135
TPR_7 pfam13176
Tetratricopeptide repeat;
446-473 4.82e-03

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 35.21  E-value: 4.82e-03
                          10        20
                  ....*....|....*....|....*...
gi 1052798154 446 LLNNLGHVCRKLKKYAEALDYHRQALVL 473
Cdd:pfam13176   1 ALLNLGRIYRKLGDYDEAISLYEQALAL 28
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
13-93 5.56e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154  13 YLDQQQYQSALFWADKVASLSREPQDIY-WLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDV 91
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALnNLGLLLLEQGRYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81


                  ..
gi 1052798154  92 LD 93
Cdd:COG3063    82 LE 83
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 384-475 5.96e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 39.12  E-value: 5.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052798154 384 KLAErffsQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALekikAIGNEVTVDKWepllnnLGHVCRKLKKYAEA 463
Cdd:COG3071   245 KRAE----KWLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAAL----ALRPSAEAYAE------LARLLEQLGDPEEA 310

                          90
                  ....*....|..
gi 1052798154 464 LDYHRQALVLIP 475
Cdd:COG3071   311 AEHYRKALALAL 322
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 460-507 7.60e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 37.73  E-value: 7.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1052798154 460 YAEALDYHRQALVLiPQNASTYSAI----GYIHSLMGNFENAVDYFHTALGL 507
Cdd:PRK02603   51 YAEALENYEEALKL-EEDPNDRSYIlynmGIIYASNGEHDKALEYYHQALEL 101
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 478-511 9.28e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.34  E-value: 9.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1052798154  478 ASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDD 511
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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