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Conserved domains on  [gi|1050115305|ref|NP_001316857|]
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[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor [Homo sapiens]

Protein Classification

PP2C family serine/threonine-protein phosphatase( domain architecture ID 10065450)

PP2C family protein-serine/threonine phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates

CATH:  3.60.40.10
EC:  3.1.3.16
Gene Ontology:  GO:0004722|GO:0006470|GO:0046872
PubMed:  9192069|8819174
SCOP:  3000909

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
109-517 9.50e-62

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


:

Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 203.33  E-value: 9.50e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 109 FESNQLAANSPVEDRRGVASCLQ-TNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTlehmegamesmkpllpil 187
Cdd:cd00143     4 GVSDKGGDRKTNEDAVVIKPNLNnEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLT------------------ 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 188 hwlkhpgdsiykdvtsvhldhlrvywqelldlhmEMGLSIEEALMYSFQRLDSDISLEIQAPLEDevtrnlslqvAFSGA 267
Cdd:cd00143    66 ----------------------------------LSEEDIEEALRKAFLRADEEILEEAQDEPDD----------ARSGT 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 268 TACMAHVDGIHLHVANAGDCRAILGVQEDngmwsCLPLTRDHNAWNQAELSRLKREHPEsedrtiIMEDRLLGVLIPCRA 347
Cdd:cd00143   102 TAVVALIRGNKLYVANVGDSRAVLCRNGE-----AVQLTKDHKPVNEEERERIEKAGGR------VSNGRVPGVLAVTRA 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 348 FGDVQLKwskelqrsilergfntealniyqftpphyytpPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLV 427
Cdd:cd00143   171 LGDFDLK--------------------------------PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIV 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 428 VGHLAEADwhktdlaqrPanlglmqslllqrkasglheadQNAATRLIRHAIgnneygemeaerlaamltlpedlARMYR 507
Cdd:cd00143   219 RSELAKED---------L----------------------QEAAQELVDLAL-----------------------RRGSH 244
                         410
                  ....*....|
gi 1050115305 508 DDITVTVVYF 517
Cdd:cd00143   245 DNITVVVVRL 254
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
109-517 9.50e-62

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 203.33  E-value: 9.50e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 109 FESNQLAANSPVEDRRGVASCLQ-TNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTlehmegamesmkpllpil 187
Cdd:cd00143     4 GVSDKGGDRKTNEDAVVIKPNLNnEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLT------------------ 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 188 hwlkhpgdsiykdvtsvhldhlrvywqelldlhmEMGLSIEEALMYSFQRLDSDISLEIQAPLEDevtrnlslqvAFSGA 267
Cdd:cd00143    66 ----------------------------------LSEEDIEEALRKAFLRADEEILEEAQDEPDD----------ARSGT 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 268 TACMAHVDGIHLHVANAGDCRAILGVQEDngmwsCLPLTRDHNAWNQAELSRLKREHPEsedrtiIMEDRLLGVLIPCRA 347
Cdd:cd00143   102 TAVVALIRGNKLYVANVGDSRAVLCRNGE-----AVQLTKDHKPVNEEERERIEKAGGR------VSNGRVPGVLAVTRA 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 348 FGDVQLKwskelqrsilergfntealniyqftpphyytpPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLV 427
Cdd:cd00143   171 LGDFDLK--------------------------------PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIV 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 428 VGHLAEADwhktdlaqrPanlglmqslllqrkasglheadQNAATRLIRHAIgnneygemeaerlaamltlpedlARMYR 507
Cdd:cd00143   219 RSELAKED---------L----------------------QEAAQELVDLAL-----------------------RRGSH 244
                         410
                  ....*....|
gi 1050115305 508 DDITVTVVYF 517
Cdd:cd00143   245 DNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
111-515 3.54e-55

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 186.04  E-value: 3.54e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  111 SNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTLEHMegamesmkpllpilhwl 190
Cdd:smart00332  14 SSMQGVRKPMEDAHVITPDLSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEKDELED----------------- 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  191 khpgdsiykdvtsvhldhlrvywqelldlhmemglsIEEALMYSFQRLDSDISLEIQApledevtrnlslqvaFSGATAC 270
Cdd:smart00332  77 ------------------------------------VEEALRKAFLSTDEEILEELEA---------------LSGSTAV 105
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  271 MAHVDGIHLHVANAGDCRAILGVQEDNgmwscLPLTRDHNAWNQAELSRLKREHPesedrtIIMEDRLLGVLIPCRAFGD 350
Cdd:smart00332 106 VALISGNKLYVANVGDSRAVLCRNGKA-----VQLTEDHKPSNEDERARIEAAGG------FVINGRVNGVLALSRAIGD 174
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  351 VQLKwskelqrsilergfntealniyqftpphyytpPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGH 430
Cdd:smart00332 175 FFLK--------------------------------PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQEVVDIVRKH 222
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  431 laeadwhktdlaqrpanlglmqslllqrkasgLHEADQNAATRLIRHAIgnneygemeaerlaamltlpedlARMYRDDI 510
Cdd:smart00332 223 --------------------------------LSKDPKEAAKRLIDLAL-----------------------ARGSKDNI 247

                   ....*
gi 1050115305  511 TVTVV 515
Cdd:smart00332 248 TVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
251-479 6.60e-32

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 123.21  E-value: 6.60e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 251 EDEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDNGmwscLPLTRDHNAWNQAELSRLKREHPesedr 330
Cdd:pfam00481  84 TDEVLRSAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCRNGNAI----KRLTKDHKPSDEDERRRIRAAGG----- 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 331 TIIMEDRLLGVLIPCRAFGDVQLKwskelqrsilergfntealniyqftpphyYTPPYLTAEPEVTYHRLRPQDKFLVLA 410
Cdd:pfam00481 155 FVSRNGRVNGVLAVSRAFGDFELK-----------------------------PGEQAVSAEPDITSHTITEDDEFLILA 205
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1050115305 411 SDGLWDMLSNEDVVrlvvghlaeadwhktDLAQRpaNLGLMQSLllqrkasglheadQNAATRLIRHAI 479
Cdd:pfam00481 206 CDGLWDVLSDQEVV---------------DLVRS--ELSDGGSP-------------MEAAEELRDEAI 244
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
208-433 3.53e-11

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 64.94  E-value: 3.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 208 HLRVYWQELLDLHMEmglsIEEALMYSFqrldsdisLEIQAPLEDEVTRNLSLQvafSGATACMAHVDGIHLHVANAGDC 287
Cdd:PLN03145  124 HLPRFIVEDEDFPRE----IEKVVSSAF--------LQTDTAFAEACSLDASLA---SGTTALAALVVGRSLVVANAGDC 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 288 RAILGVQEdngmwSCLPLTRDHNAWNQAELSRLKrehpesEDRTIIMEDRLLGVLIPCRAFGDvqlkwskelqrsilerg 367
Cdd:PLN03145  189 RAVLCRRG-----KAIEMSRDHKPMCSKERKRIE------ASGGYVYDGYLNGQLNVARALGD----------------- 240
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1050115305 368 FNTEALNIYQFTPphyytppyLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAE 433
Cdd:PLN03145  241 WHMEGMKGSDGGP--------LSAEPELMTTQLTEEDEFLIIGCDGIWDVFRSQNAVDFARRRLQE 298
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
266-427 2.39e-06

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 49.05  E-value: 2.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 266 GATACMAHVDGIHLHVANAGDCRA-ILgvqeDNGmwSCLPLTRDHNAWNQA-ELSRLKRE----HPesedrtiimedrll 339
Cdd:COG0631    98 GTTLVAALIAGGRLYIAHVGDSRAyLL----RDG--ELEQLTRDHSLVQELvDAGRITPEeartHP-------------- 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 340 gvlipcrafgdvqlkwskelQRSILergfnTEALNIYQftpphyytppylTAEPEVTYHRLRPQDKFLvLASDGLWDMLS 419
Cdd:COG0631   158 --------------------QRNVL-----TRALGTDD------------DVEPDISPLELEPGDRLL-LCSDGLTDMVS 199

                  ....*...
gi 1050115305 420 NEDVVRLV 427
Cdd:COG0631   200 DEEIAEIL 207
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
109-517 9.50e-62

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 203.33  E-value: 9.50e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 109 FESNQLAANSPVEDRRGVASCLQ-TNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTlehmegamesmkpllpil 187
Cdd:cd00143     4 GVSDKGGDRKTNEDAVVIKPNLNnEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLT------------------ 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 188 hwlkhpgdsiykdvtsvhldhlrvywqelldlhmEMGLSIEEALMYSFQRLDSDISLEIQAPLEDevtrnlslqvAFSGA 267
Cdd:cd00143    66 ----------------------------------LSEEDIEEALRKAFLRADEEILEEAQDEPDD----------ARSGT 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 268 TACMAHVDGIHLHVANAGDCRAILGVQEDngmwsCLPLTRDHNAWNQAELSRLKREHPEsedrtiIMEDRLLGVLIPCRA 347
Cdd:cd00143   102 TAVVALIRGNKLYVANVGDSRAVLCRNGE-----AVQLTKDHKPVNEEERERIEKAGGR------VSNGRVPGVLAVTRA 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 348 FGDVQLKwskelqrsilergfntealniyqftpphyytpPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLV 427
Cdd:cd00143   171 LGDFDLK--------------------------------PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIV 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 428 VGHLAEADwhktdlaqrPanlglmqslllqrkasglheadQNAATRLIRHAIgnneygemeaerlaamltlpedlARMYR 507
Cdd:cd00143   219 RSELAKED---------L----------------------QEAAQELVDLAL-----------------------RRGSH 244
                         410
                  ....*....|
gi 1050115305 508 DDITVTVVYF 517
Cdd:cd00143   245 DNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
111-515 3.54e-55

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 186.04  E-value: 3.54e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  111 SNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTLEHMegamesmkpllpilhwl 190
Cdd:smart00332  14 SSMQGVRKPMEDAHVITPDLSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEKDELED----------------- 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  191 khpgdsiykdvtsvhldhlrvywqelldlhmemglsIEEALMYSFQRLDSDISLEIQApledevtrnlslqvaFSGATAC 270
Cdd:smart00332  77 ------------------------------------VEEALRKAFLSTDEEILEELEA---------------LSGSTAV 105
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  271 MAHVDGIHLHVANAGDCRAILGVQEDNgmwscLPLTRDHNAWNQAELSRLKREHPesedrtIIMEDRLLGVLIPCRAFGD 350
Cdd:smart00332 106 VALISGNKLYVANVGDSRAVLCRNGKA-----VQLTEDHKPSNEDERARIEAAGG------FVINGRVNGVLALSRAIGD 174
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  351 VQLKwskelqrsilergfntealniyqftpphyytpPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGH 430
Cdd:smart00332 175 FFLK--------------------------------PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQEVVDIVRKH 222
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305  431 laeadwhktdlaqrpanlglmqslllqrkasgLHEADQNAATRLIRHAIgnneygemeaerlaamltlpedlARMYRDDI 510
Cdd:smart00332 223 --------------------------------LSKDPKEAAKRLIDLAL-----------------------ARGSKDNI 247

                   ....*
gi 1050115305  511 TVTVV 515
Cdd:smart00332 248 TVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
251-479 6.60e-32

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 123.21  E-value: 6.60e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 251 EDEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDNGmwscLPLTRDHNAWNQAELSRLKREHPesedr 330
Cdd:pfam00481  84 TDEVLRSAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCRNGNAI----KRLTKDHKPSDEDERRRIRAAGG----- 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 331 TIIMEDRLLGVLIPCRAFGDVQLKwskelqrsilergfntealniyqftpphyYTPPYLTAEPEVTYHRLRPQDKFLVLA 410
Cdd:pfam00481 155 FVSRNGRVNGVLAVSRAFGDFELK-----------------------------PGEQAVSAEPDITSHTITEDDEFLILA 205
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1050115305 411 SDGLWDMLSNEDVVrlvvghlaeadwhktDLAQRpaNLGLMQSLllqrkasglheadQNAATRLIRHAI 479
Cdd:pfam00481 206 CDGLWDVLSDQEVV---------------DLVRS--ELSDGGSP-------------MEAAEELRDEAI 244
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
208-433 3.53e-11

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 64.94  E-value: 3.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 208 HLRVYWQELLDLHMEmglsIEEALMYSFqrldsdisLEIQAPLEDEVTRNLSLQvafSGATACMAHVDGIHLHVANAGDC 287
Cdd:PLN03145  124 HLPRFIVEDEDFPRE----IEKVVSSAF--------LQTDTAFAEACSLDASLA---SGTTALAALVVGRSLVVANAGDC 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 288 RAILGVQEdngmwSCLPLTRDHNAWNQAELSRLKrehpesEDRTIIMEDRLLGVLIPCRAFGDvqlkwskelqrsilerg 367
Cdd:PLN03145  189 RAVLCRRG-----KAIEMSRDHKPMCSKERKRIE------ASGGYVYDGYLNGQLNVARALGD----------------- 240
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1050115305 368 FNTEALNIYQFTPphyytppyLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAE 433
Cdd:PLN03145  241 WHMEGMKGSDGGP--------LSAEPELMTTQLTEEDEFLIIGCDGIWDVFRSQNAVDFARRRLQE 298
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
249-442 3.46e-08

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 55.55  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 249 PLEDEVTRNLSLQV--AF--------SGATACMAHVDgIHLHVANAGDCRAILGVqedNGmwSCLPLTRDHNAWNQAELS 318
Cdd:PTZ00224   80 PMTDERMEELCLEIdeEWmdsgreggSTGTFCVIMKD-VHLQVGNVGDSRVLVCR---DG--KLVFATEDHKPNNPGERQ 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 319 RLKrehpesEDRTIIMEDRLLGVLIPCRAFGDvqlkwskelqRSilergfntealniYQFTPPHYYTPPYLTAEPEVTYH 398
Cdd:PTZ00224  154 RIE------ACGGRVVSNRVDGDLAVSRAFGD----------RS-------------FKVKGTGDYLEQKVIAVPDVTHL 204
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1050115305 399 RLRPQDkFLVLASDGLWD-MLSNEDVVRLVVGHLAEADwhktDLA 442
Cdd:PTZ00224  205 TCQSND-FIILACDGVFEgNFSNEEVVAFVKEQLETCD----DLA 244
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
266-427 2.39e-06

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 49.05  E-value: 2.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 266 GATACMAHVDGIHLHVANAGDCRA-ILgvqeDNGmwSCLPLTRDHNAWNQA-ELSRLKRE----HPesedrtiimedrll 339
Cdd:COG0631    98 GTTLVAALIAGGRLYIAHVGDSRAyLL----RDG--ELEQLTRDHSLVQELvDAGRITPEeartHP-------------- 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050115305 340 gvlipcrafgdvqlkwskelQRSILergfnTEALNIYQftpphyytppylTAEPEVTYHRLRPQDKFLvLASDGLWDMLS 419
Cdd:COG0631   158 --------------------QRNVL-----TRALGTDD------------DVEPDISPLELEPGDRLL-LCSDGLTDMVS 199

                  ....*...
gi 1050115305 420 NEDVVRLV 427
Cdd:COG0631   200 DEEIAEIL 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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