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Conserved domains on  [gi|1043631233|ref|NP_001316447|]
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zinc finger protein 420 isoform d [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-506 2.58e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233  94 KPYECKQCGKAFSRDSQLSLHQRLHTGEKPYAC--KECGKAFTQSSQLILHHRIHTGEKPYKCEecgKAFIRSSQLTRHQ 171
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 172 KV----HTGEKPYECKECGKAFTQNSQLTLHQRLHTgekLYECKECRKVFTQLSQLILHKRIHtGEKPYECKeCGKAFIC 247
Cdd:COG5048   109 SLssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 248 GSQLSQHQKIHNGEKPYECKECGRAFIRGSLLmQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGK 327
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 328 MFSHGSQLTQHQRIHTGE-------KPYQCKECGKAFNRGSLLTRHQR--IHTGE--KPYECKE--CGKTFSRGSELTQH 394
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 395 ERIHTGEKPYECKEC-------GKSFIRGSQLTQHQRIHTGEKPYEC--KECRMAFTQSSHLSQHQRLHTGEKPYVCN-- 463
Cdd:COG5048   343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1043631233 464 ECGKAFARGLLLIQHQRIHTGEKPYQCkeCGKAFIRGSQLTQH 506
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.50e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 1043631233 558 HLSRHQRIHTGEKPYQCKECGKAFTR 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-527 7.87e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.87e-04
                          10        20
                  ....*....|....*....|....*
gi 1043631233 503 LTQHQRIHTGEKPYECKECGKAFSH 527
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-555 5.72e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 531 LTLHQRIHTGEKPYECRECRKAFTQ 555
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-506 2.58e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233  94 KPYECKQCGKAFSRDSQLSLHQRLHTGEKPYAC--KECGKAFTQSSQLILHHRIHTGEKPYKCEecgKAFIRSSQLTRHQ 171
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 172 KV----HTGEKPYECKECGKAFTQNSQLTLHQRLHTgekLYECKECRKVFTQLSQLILHKRIHtGEKPYECKeCGKAFIC 247
Cdd:COG5048   109 SLssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 248 GSQLSQHQKIHNGEKPYECKECGRAFIRGSLLmQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGK 327
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 328 MFSHGSQLTQHQRIHTGE-------KPYQCKECGKAFNRGSLLTRHQR--IHTGE--KPYECKE--CGKTFSRGSELTQH 394
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 395 ERIHTGEKPYECKEC-------GKSFIRGSQLTQHQRIHTGEKPYEC--KECRMAFTQSSHLSQHQRLHTGEKPYVCN-- 463
Cdd:COG5048   343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1043631233 464 ECGKAFARGLLLIQHQRIHTGEKPYQCkeCGKAFIRGSQLTQH 506
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 1043631233 558 HLSRHQRIHTGEKPYQCKECGKAFTR 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-303 3.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.59e-04
                          10        20
                  ....*....|....*....|....*
gi 1043631233 279 LMQHQRIHTGEKPYKCEECGKAFIR 303
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-527 7.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.87e-04
                          10        20
                  ....*....|....*....|....*
gi 1043631233 503 LTQHQRIHTGEKPYECKECGKAFSH 527
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-555 5.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 531 LTLHQRIHTGEKPYECRECRKAFTQ 555
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-506 2.58e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233  94 KPYECKQCGKAFSRDSQLSLHQRLHTGEKPYAC--KECGKAFTQSSQLILHHRIHTGEKPYKCEecgKAFIRSSQLTRHQ 171
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 172 KV----HTGEKPYECKECGKAFTQNSQLTLHQRLHTgekLYECKECRKVFTQLSQLILHKRIHtGEKPYECKeCGKAFIC 247
Cdd:COG5048   109 SLssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 248 GSQLSQHQKIHNGEKPYECKECGRAFIRGSLLmQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGK 327
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 328 MFSHGSQLTQHQRIHTGE-------KPYQCKECGKAFNRGSLLTRHQR--IHTGE--KPYECKE--CGKTFSRGSELTQH 394
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 395 ERIHTGEKPYECKEC-------GKSFIRGSQLTQHQRIHTGEKPYEC--KECRMAFTQSSHLSQHQRLHTGEKPYVCN-- 463
Cdd:COG5048   343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1043631233 464 ECGKAFARGLLLIQHQRIHTGEKPYQCkeCGKAFIRGSQLTQH 506
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-590 1.37e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 1.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 178 KPYECKECGKAFTQNSQLTLHQRLHTGEKLYEC--KECRKVFTQLSQLILHKRIHTGEKpyeckecgkaficgSQLSQHQ 255
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP--------------SDLNSKS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 256 KIHNGEKPYECKE--CGRAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEK-------PYECKECG 326
Cdd:COG5048    98 LPLSNSKASSSSLssSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 327 KMFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYEC 406
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 407 KECGKSF--IRGSQLTQHQRIHTGE-----KPYECKECRMAFTQSSHLSQHQR--LHTGE--KPYVCNE--CGKAFARGL 473
Cdd:COG5048   258 SESPRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 474 LLIQHQRIHTGEKPYQCKEC-------GKAFIRGSQLTQHQRIHTGEKPYEC--KECGKAFSHGSQLTLHQRIHTGEKPY 544
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1043631233 545 ECR--ECRKAFTQSSHLSRHQRIHTGEKPYQCkeCGKAFTRGSQLTQH 590
Cdd:COG5048   418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-602 4.93e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 4.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 206 KLYECKECRKVFTQLSQLILHKRIHTGEKPYEC--KECGKAFICGSQLSQHQKIHNGEKPYEC--KECGRAFIRGSLLMQ 281
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 282 HQrIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKMFSHGSQ--LTQHQRIHTgekpyqcKECGKAFNR 359
Cdd:COG5048   112 SS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnSLHPPLPAN-------SLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 360 GSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTgEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRM 439
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 440 AFTQSSHLSQHQRLHTGE-------KPYVCNECGKAFARGLLLIQHQR--IHTGE--KPYQCKE--CGKAFIRGSQLTQH 506
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 507 QRIHTGEKPYECK--ECGKAFSHGS-----QLTLHQRIHTGEKPYEC--RECRKAFTQSSHLSRHQRIHTGEKPYQCK-- 575
Cdd:COG5048   343 ILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420
                  ....*....|....*....|....*..
gi 1043631233 576 ECGKAFTRGSQLTQHQRIHISEKSFEY 602
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-603 4.61e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 249 SQLSQHQKIHNGEKPYECKECGRAFIRGSLLMQHQRIHTGEKPYKC--EECGKAFIRGSQLTQHQRIHTNEKPYECkecg 326
Cdd:COG5048    19 TPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN---- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 327 kmfSHGSQLTQHQRIHTGE--------KPYQCKECGKAFNRGSLLTRHQRIHTgeKPYECKECGKTFSRGSELTQHERIH 398
Cdd:COG5048    95 ---SKSLPLSNSKASSSSLsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHP 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 399 TGEKPYECKECGKSFIRGSqltqHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQH 478
Cdd:COG5048   170 PLPANSLSKDPSSNLSLLI----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 479 QRIHTGEKPYQCKECGKAF--IRGSQLTQHQRIHTGekpyeckecgkafSHGSQLTLHQrihtgekpyeCRECRKAFTQS 556
Cdd:COG5048   246 SSLSSSDSSSSASESPRSSlpTASSQSSSPNESDSS-------------SEKGFSLPIK----------SKQCNISFSRS 302

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1043631233 557 SHLSRHQR--IHTGE--KPYQCKE--CGKAFTRGSQLTQHQRIHISEKSFEYK 603
Cdd:COG5048   303 SPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
58-366 6.54e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 6.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233  58 HSRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSS 137
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 138 QLILHHRIHTGE-------KPYKCEECGKAFIRSSQLTRHQ--KVHTGE--KPYECKE--CGKAFTQNSQLTLHQRLHTG 204
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 205 EKLYECK--ECRKVFTQLSqlilhkrihtgekpyeckecgkaFICGSQLSQHQKIHNGEKPYEC--KECGRAFIRGSLLM 280
Cdd:COG5048   349 ISPAKEKllNSSSKFSPLL-----------------------NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLS 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233 281 QHQRIHTGEKPYKCEecgkafirgsqltqhqrihtnekpyeCKECGKMFSHGSQLTQHQRIHTGEKPYQCkECGKAFNRG 360
Cdd:COG5048   406 LHIITHLSFRPYNCK--------------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRD 458


                  ....*.
gi 1043631233 361 SLLTRH 366
Cdd:COG5048   459 LDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 1043631233 558 HLSRHQRIHTGEKPYQCKECGKAFTR 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-303 3.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.59e-04
                          10        20
                  ....*....|....*....|....*
gi 1043631233 279 LMQHQRIHTGEKPYKCEECGKAFIR 303
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
46-182 4.41e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 4.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233  46 MSIFNQHTYLSQHSRC--HSTE--KPYKCKE--CGKAFRRASHLTQHQSIHTGEKPYECK--QCGKAFS-----RDSQLS 112
Cdd:COG5048   296 NISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnEPPQSL 375

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1043631233 113 LHQRLHTGEKPYAC--KECGKAFTQSSQLILHHRIHTGEKP--YKCEECGKAFIRSSQLTRHQKVHTGEKPYEC 182
Cdd:COG5048   376 QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-387 5.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|....*
gi 1043631233 363 LTRHQRIHTGEKPYECKECGKTFSR 387
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
390-415 7.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1043631233 390 ELTQHERIHTGEKPYECKECGKSFIR 415
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-359 7.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.35e-04
                          10        20
                  ....*....|....*....|....*
gi 1043631233 335 LTQHQRIHTGEKPYQCKECGKAFNR 359
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-527 7.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.87e-04
                          10        20
                  ....*....|....*....|....*
gi 1043631233 503 LTQHQRIHTGEKPYECKECGKAFSH 527
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 87-198 1.01e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043631233  87 QSIHTGEKPYECKQCGKAFSRDSQLSLH---QRLHT-GEKPYACK--ECGKAFTQSSQLiLHHRIHTGEKPYKCEECGKa 160
Cdd:COG5189   309 EMIDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP- 386

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1043631233 161 firssqlTRHQKVHTGEKPYECKECGKAFTQNSQLTLH 198
Cdd:COG5189   387 -------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
167-191 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 167 LTRHQKVHTGEKPYECKECGKAFTQ 191
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
475-499 1.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.58e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 475 LIQHQRIHTGEKPYQCKECGKAFIR 499
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-471 2.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1043631233 446 HLSQHQRLHTGEKPYVCNECGKAFAR 471
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-331 2.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.44e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 307 LTQHQRIHTNEKPYECKECGKMFSH 331
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-443 3.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.57e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 419 LTQHQRIHTGEKPYECKECRMAFTQ 443
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-247 3.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.64e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 223 LILHKRIHTGEKPYECKECGKAFIC 247
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
82-107 4.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1043631233  82 HLTQHQSIHTGEKPYECKQCGKAFSR 107
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-555 5.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 531 LTLHQRIHTGEKPYECRECRKAFTQ 555
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 152-174 7.50e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.50e-03
                          10        20
                  ....*....|....*....|...
gi 1043631233 152 YKCEECGKAFIRSSQLTRHQKVH 174
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
111-135 8.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.48e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 111 LSLHQRLHTGEKPYACKECGKAFTQ 135
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
139-163 9.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.00e-03
                          10        20
                  ....*....|....*....|....*
gi 1043631233 139 LILHHRIHTGEKPYKCEECGKAFIR 163
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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