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Conserved domains on  [gi|1039673927|ref|NP_001315549|]
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solute carrier family 2, facilitated glucose transporter member 5 isoform 3 [Homo sapiens]

Protein Classification

SLC2A family MFS transporter( domain architecture ID 13024547)

SLC2A (solute carrier family 2, facilitated glucose transporter) family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of hexoses such as glucose and fructose

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 8-427 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 637.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927   8 STPQHWTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIIS 87
Cdd:cd17432    33 ETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMIIVG 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  88 RLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLP 167
Cdd:cd17432   113 RFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVLGLRELLGNEEGWPLLLALTGVPALLQLLTLP 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 168 FFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLS 247
Cdd:cd17432   193 FFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKGVGTVSVLELFRDRSVRWQLISIIVLMAGQQLC 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 248 GVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSW 327
Cdd:cd17432   273 GINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSW 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 328 MPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLL 407
Cdd:cd17432   353 MPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSNFLVGLLFPFIQEGLGAYCFLVFAVICLL 432

                         410       420
                  ....*....|....*....|
gi 1039673927 408 TTIYIFLIVPETKAKTFIEI 427
Cdd:cd17432   433 TAIYIFFVLPETKGKTFLEI 452
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 8-427 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 637.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927   8 STPQHWTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIIS 87
Cdd:cd17432    33 ETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMIIVG 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  88 RLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLP 167
Cdd:cd17432   113 RFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVLGLRELLGNEEGWPLLLALTGVPALLQLLTLP 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 168 FFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLS 247
Cdd:cd17432   193 FFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKGVGTVSVLELFRDRSVRWQLISIIVLMAGQQLC 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 248 GVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSW 327
Cdd:cd17432   273 GINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSW 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 328 MPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLL 407
Cdd:cd17432   353 MPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSNFLVGLLFPFIQEGLGAYCFLVFAVICLL 432

                         410       420
                  ....*....|....*....|
gi 1039673927 408 TTIYIFLIVPETKAKTFIEI 427
Cdd:cd17432   433 TAIYIFFVLPETKGKTFLEI 452
Sugar_tr pfam00083
Sugar (and other) transporter;
22-431 1.96e-116

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 348.88  E-value: 1.96e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  22 PLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNV 101
Cdd:pfam00083  43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 102 VPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLR-NLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQk 180
Cdd:pfam00083 123 APMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGlNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEK- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 181 KDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIY 260
Cdd:pfam00083 202 GRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIF 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 261 LSAGVPEehVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTA-ALALQDTVSWMPYISIVCVISY 339
Cdd:pfam00083 282 ENLGLSD--SFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIvALLGVSKSDWAGIVAIVFIALF 359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 340 VIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLG-PYSFIVFAVICLLTTIYIFLIVPE 418
Cdd:pfam00083 360 IAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPE 439

                         410
                  ....*....|...
gi 1039673927 419 TKAKTFIEINQIF 431
Cdd:pfam00083 440 TKGRTLEEIDELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 24-427 2.13e-113

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 342.01  E-value: 2.13e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  24 TLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVP 103
Cdd:TIGR00879  70 SSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVP 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 104 MYLGELAPKNLRGALGVVPQLFITVGILVAQIFG-LRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQkKD 182
Cdd:TIGR00879 150 MYLSEIAPKALRGALTSLYQLAITFGILVAYGFGsGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGK-GR 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 183 EAAAKKALQTLRGWDSVDREVAEIRQEDEA----EKAAGFISVLKLFRM-RSLRWQLLSIIVLMGGQQLSGVNAIYYYAD 257
Cdd:TIGR00879 229 VEEARKSLARLRGTSGEDKELLDELELIDIkrsiEKRSVQPSWGSLFSStRRIRRRLFLGVVLQWFQQFTGINAIMYYSP 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 258 QIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDT--VSWMPYISIVC 335
Cdd:TIGR00879 309 TIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTgsSKSSGNVAIVF 388

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 336 VISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPY-SFIVFAVICLLTTIYIFL 414
Cdd:TIGR00879 389 ILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGgVFIFFGGLNVLGLIFVYF 468

                         410
                  ....*....|...
gi 1039673927 415 IVPETKAKTFIEI 427
Cdd:TIGR00879 469 FLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
 25-436 1.81e-30

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 122.88  E-value: 1.81e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  25 LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAI------LMGCSRVATSFELII---ISRLLVGICA 95
Cdd:PRK10077   55 SLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALgsawpeFGFTSIGPDNTGYVPefvIYRIIGGIGV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  96 GVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIF------GLRNLLANVDGWPILLGLTGVPAALQLLLLPFF 169
Cdd:PRK10077  135 GLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVnyfiarSGDASWLNTDGWRYMFASEAIPALLFLMLLYFV 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 170 PESPRYLLIQkKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGfisvLKLFRMRSLrwQLLSIIVLMGGQQLSGV 249
Cdd:PRK10077  215 PETPRYLMSR-GKQEQAEGILRKIMGNTLATQALQEIKHSLDHGRKTG----GKLLMFGVG--VIVIGVMLSVFQQFVGI 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 250 NAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLlgfsICLIACCVLTAALALQDTVSWMP 329
Cdd:PRK10077  288 NVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQI----IGALGMAIGMFSLGTAFYTQAPG 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 330 YISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGL-------GPYSFIVFA 402
Cdd:PRK10077  364 IVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSwlvahfhNGFSYWIYG 443

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1039673927 403 VICLLTTIYIFLIVPETKAKTFIEINQIFTKMNK 436
Cdd:PRK10077  444 CMGVLAALFMWKFVPETKGKTLEEMEALWEPETK 477
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 22-196 9.72e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 65.60  E-value: 9.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  22 PLTLLWSVTVSMFPFGgfIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNV 101
Cdd:COG0477    48 SAQLGWIVSAYLLGRA--IGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG---LAPSPELLIAARALQGIGAGGLMPG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 102 VPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLrnLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKK 181
Cdd:COG0477   123 ALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG--LLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLA 200

                         170
                  ....*....|....*
gi 1039673927 182 DEAAAKKALQTLRGW 196
Cdd:COG0477   201 LALAALLLAALALAL 215
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 8-427 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 637.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927   8 STPQHWTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIIS 87
Cdd:cd17432    33 ETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMIIVG 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  88 RLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLP 167
Cdd:cd17432   113 RFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVLGLRELLGNEEGWPLLLALTGVPALLQLLTLP 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 168 FFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLS 247
Cdd:cd17432   193 FFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKGVGTVSVLELFRDRSVRWQLISIIVLMAGQQLC 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 248 GVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSW 327
Cdd:cd17432   273 GINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSW 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 328 MPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLL 407
Cdd:cd17432   353 MPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSNFLVGLLFPFIQEGLGAYCFLVFAVICLL 432

                         410       420
                  ....*....|....*....|
gi 1039673927 408 TTIYIFLIVPETKAKTFIEI 427
Cdd:cd17432   433 TAIYIFFVLPETKGKTFLEI 452
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 11-422 2.88e-132

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 388.93  E-value: 2.88e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  11 QHWTGEF---MEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIIS 87
Cdd:cd17357    32 DTLVDRYglnLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLIFG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  88 RLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLP 167
Cdd:cd17357   112 RFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIPALLQLAALP 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 168 FFPESPRYLLIQKKDEAAAKKALQTLRGW-DSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQL 246
Cdd:cd17357   192 FFPESPKFLLISKGDEEEAEKSLKFLRGIeDDVDQELEEIKKESEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVSASQQF 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 247 SGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVS 326
Cdd:cd17357   272 SGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNS 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 327 WMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICL 406
Cdd:cd17357   352 WMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCA 431

                         410
                  ....*....|....*.
gi 1039673927 407 LTTIYIFLIVPETKAK 422
Cdd:cd17357   432 LFLLYLYRYLPETKGR 447
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 13-422 1.51e-125

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 372.05  E-value: 1.51e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  13 WTGEFMEDFP---LTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRL 89
Cdd:cd17431    35 LGDRYGEPISpetLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLILGRF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  90 LVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLPFF 169
Cdd:cd17431   115 IIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIFGLEFILGTEELWPLLLGFTIVPAILQLALLPFC 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 170 PESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGV 249
Cdd:cd17431   195 PESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMMREKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGI 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 250 NAIYYYADQIYLSAGVPEEhvQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMP 329
Cdd:cd17431   275 NAVFYYSTSIFEKAGVQQP--VYATIGAGVVNTIFTVVSLFLVERAGRRTLHLIGLGGMAICAILMTIALLLLEGYPWMS 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 330 YISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTT 409
Cdd:cd17431   353 YVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIVGMCFQYIANLCGPYVFIIFTVFLLTFF 432

                         410
                  ....*....|...
gi 1039673927 410 IYIFLIVPETKAK 422
Cdd:cd17431   433 IFTYFKVPETKGK 445
Sugar_tr pfam00083
Sugar (and other) transporter;
22-431 1.96e-116

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 348.88  E-value: 1.96e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  22 PLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNV 101
Cdd:pfam00083  43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 102 VPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLR-NLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQk 180
Cdd:pfam00083 123 APMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGlNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEK- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 181 KDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIY 260
Cdd:pfam00083 202 GRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIF 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 261 LSAGVPEehVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTA-ALALQDTVSWMPYISIVCVISY 339
Cdd:pfam00083 282 ENLGLSD--SFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIvALLGVSKSDWAGIVAIVFIALF 359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 340 VIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLG-PYSFIVFAVICLLTTIYIFLIVPE 418
Cdd:pfam00083 360 IAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPE 439

                         410
                  ....*....|...
gi 1039673927 419 TKAKTFIEINQIF 431
Cdd:pfam00083 440 TKGRTLEEIDELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 24-427 2.13e-113

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 342.01  E-value: 2.13e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  24 TLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVP 103
Cdd:TIGR00879  70 SSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVP 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 104 MYLGELAPKNLRGALGVVPQLFITVGILVAQIFG-LRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQkKD 182
Cdd:TIGR00879 150 MYLSEIAPKALRGALTSLYQLAITFGILVAYGFGsGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGK-GR 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 183 EAAAKKALQTLRGWDSVDREVAEIRQEDEA----EKAAGFISVLKLFRM-RSLRWQLLSIIVLMGGQQLSGVNAIYYYAD 257
Cdd:TIGR00879 229 VEEARKSLARLRGTSGEDKELLDELELIDIkrsiEKRSVQPSWGSLFSStRRIRRRLFLGVVLQWFQQFTGINAIMYYSP 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 258 QIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDT--VSWMPYISIVC 335
Cdd:TIGR00879 309 TIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTgsSKSSGNVAIVF 388

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 336 VISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPY-SFIVFAVICLLTTIYIFL 414
Cdd:TIGR00879 389 ILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGgVFIFFGGLNVLGLIFVYF 468

                         410
                  ....*....|...
gi 1039673927 415 IVPETKAKTFIEI 427
Cdd:TIGR00879 469 FLPETKGRTLEEI 481
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 20-426 7.29e-66

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 217.83  E-value: 7.29e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  20 DFPLTLL-WSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRvatSFELIIISRLLVGICAGVS 98
Cdd:cd17358    35 SLPLTVAqFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAK---DVWMLYLGRFLAGFGGGAA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  99 SNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGlrNLLAnvdgWPILLGLTGVPAALQLLLLPFFPESPRYLLi 178
Cdd:cd17358   112 SVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLG--SFLP----WRTLALIGAIPPVVFLILLFFIPESPRWLA- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 179 QKKDEAAAKKALQTLRGWD-SVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYAD 257
Cdd:cd17358   185 KKGREEEAEKSLQFLRGKDaDISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYAS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 258 QIYLSAGV---PEEhvqyVTAGTGAVNVVMTFCAVFVVELL---GRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYI 331
Cdd:cd17358   265 SIFDEAGSgldPNT----ATIIIGVVQVVGTLVATLLVDRLgrrPLLLVSAIGMGIGLLALGLYFYLQEHGALLSSVSWL 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 332 SIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGP-YSFIVFAVICLLTTI 410
Cdd:cd17358   341 PLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGAsGTFWIFAGICGLALV 420

                         410
                  ....*....|....*.
gi 1039673927 411 YIFLIVPETKAKTFIE 426
Cdd:cd17358   421 FVLLFVPETKGKSLEE 436
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 24-418 1.36e-62

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 207.04  E-value: 1.36e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  24 TLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVP 103
Cdd:cd17315    33 TSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA---LAPNVWVLIVGRFLLGLGVGLASVLVP 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 104 MYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRylliqkkde 183
Cdd:cd17315   110 LYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPESRA--------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 184 aaakkalqtlrgwdsvdrevaeirqedeaekaagfisvlklfrmrslrwqlLSIIVLMGG-QQLSGVNAIYYYADQIYLS 262
Cdd:cd17315   181 ---------------------------------------------------LLVGVGLQLlQQLTGINAVMYYAPTIFKS 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 263 AGvPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIG 342
Cdd:cd17315   210 AG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAA 288

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039673927 343 HALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLG-PYSFIVFAVICLLTTIYIFLIVPE 418
Cdd:cd17315   289 FAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGlAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 20-431 3.20e-47

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 167.43  E-value: 3.20e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  20 DFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSrvATSFELIIISRLLVGICAGVSS 99
Cdd:cd17356    40 YYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAA--IGKWYQLIVGRIIAGLGVGFAS 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 100 NVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQI--FGLRNLLANVDgWPILLGLTGVPAALQLLLLPFFPESPRYLl 177
Cdd:cd17356   118 VLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCinYGTHKLDGSAQ-WRIPLGLQIVWGLLLLIGMFFLPESPRWL- 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 178 iqkkdeaaakkalqtlrgwdsvdrevaeirqedeaekaagfisvlklfrmrslrWQLLSIIVLMGGQQLSGVNAIYYYAD 257
Cdd:cd17356   196 ------------------------------------------------------YRTILGIMLQLFQQLTGINYFFYYGT 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 258 QIYLSAGVpEEHVQYVTAG-TGAVNVVMTFCAVFVVELLGRRLLLLlgFSICLIACCVLTAAlALQDTVSWMPYIS---- 332
Cdd:cd17356   222 TIFQSTGL-TGSSPLLTSIiLYIVNFVSTIPGLFFVDKFGRRTCLL--IGAAGMSICLFIYA-AVGVRYLIPNPQSgtsn 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 333 -------IVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVIC 405
Cdd:cd17356   298 ksagngmIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIGFKYYYIFAGCN 377

                         410       420
                  ....*....|....*....|....*.
gi 1039673927 406 LLTTIYIFLIVPETKAKTFIEINQIF 431
Cdd:cd17356   378 LLAFIVVFFFVPETKGLTLEEIDELF 403
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 14-418 8.51e-44

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 157.73  E-value: 8.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  14 TGEFME-DFPLT-LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAIlmGCSrVATSFELIIISRLLV 91
Cdd:cd17359    23 ALPFLQtDFNLTpFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISAL--GSA-FSPNFTIFIIARIIG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  92 GICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIF------GLRNLLANVDGWPILLGLTGVPAALQLLL 165
Cdd:cd17359   100 GLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVnylianAGGADWLGAEGWRWMLGLEAIPAILFLLG 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 166 LPFFPESPRYLLiqkkdeaaakkalqtlrgwdsvdrevaeirqedEAEKAAGFISVLklfrmrslrwqlLSIIvlmggQQ 245
Cdd:cd17359   180 MLFIPESPRWLV---------------------------------SKGKPILIIGIG------------LAIF-----QQ 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 246 LSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTV 325
Cdd:cd17359   210 FVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFAPGS 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 326 SWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGP-YSFIVFAVI 404
Cdd:cd17359   290 QASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLaFTFLIFAVI 369

                         410
                  ....*....|....
gi 1039673927 405 CLLTTIYIFLIVPE 418
Cdd:cd17359   370 CVLAFLFVWKFVPE 383
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 18-418 2.78e-38

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 142.41  E-value: 2.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  18 MEDFPLTLLW-SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAG 96
Cdd:cd17360    27 LGEVVLSTGWqELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMA---AAPNKEVLIVGRVLVGLGVG 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  97 VSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANvDGWPILLGLTGVPAALQLLLLPFFPESPRYl 176
Cdd:cd17360   104 IASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLP-GGWRWMLGLAAVPAVLQFIGLLFLPESPRW- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 177 liqkkdeaaakkalqtlrgwdsvdrevaeirqedeaekaagfisvlklfrmRSLRWQLLSIIVLMGGQQLSGVNAIYYYA 256
Cdd:cd17360   182 ---------------------------------------------------PSTRRALIVGCGLQAFQQFSGINTVMYYS 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 257 DQIYLSAGVPEEH-VQYVTAGTGAVNVVMTFCAVFVVELLGRRLllllgfsICLIACCVLTAALALqdTVSWMPYISIvc 335
Cdd:cd17360   211 ATILQMAGFKDNQnAIWLSLIVAGTNFIFTIVGMYLIDKFGRRK-------LLLISLFGVIVALVV--LAVWLALVGL-- 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 336 vISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPY-SFIVFAVICLLTTIYIFL 414
Cdd:cd17360   280 -ILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYgTFLLFAGLAVLGLIFIYF 358


                  ....
gi 1039673927 415 IVPE 418
Cdd:cd17360   359 CVPE 362
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 31-427 6.17e-37

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 139.41  E-value: 6.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  31 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCsrvATSFELIIISRLLVGICAGVSSNVVPMYLGELA 110
Cdd:cd17362    45 VSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGL---APSYPVLLVGRLIYGVGIGLAMHAAPVYIAETS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 111 PKNLRGALGVVPQLFITVGILVAqiFGLRNLLANV-DGWPILLGLTGVPAALQLLLLPFFPESPRYlliqkkdeaaakka 189
Cdd:cd17362   122 PSHIRGLLVSLKELFIVLGILLG--YVSGYAFADVvGGWRYMYGLAAPPALLLGIGMWFLPPSPRW-------------- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 190 lqtlrgwdsvdrevaeirqedeaekaagfisvlklfrMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGV-PEE 268
Cdd:cd17362   186 -------------------------------------QGNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFsAAS 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 269 HVQYVTAGTGAVNVVMTFCAVFVVELL-----GRRLLLLLGFSICLIACCvltaALALQDTVSWMPYISIVCVISYVIGH 343
Cdd:cd17362   229 DATLVSVGLGVFKLLMTIVAVLLVDKLgrrplLLGGVSGMVVSLFLLAAY----NLFVQMGPAGLAWLSLVALLLYVGAY 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 344 ALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLG-PYSFIVFAVICLLTTIYIFLIVPETKAK 422
Cdd:cd17362   305 QISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGlPGTFLGFGVIGVLALLFIYFTVPETKGL 384


                  ....*
gi 1039673927 423 TFIEI 427
Cdd:cd17362   385 SLEEI 389
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 32-424 1.32e-30

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 122.29  E-value: 1.32e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  32 SMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVP-AILMGcsrvATSFELIIISRLLVGICAGVSSNVVPMYLGELA 110
Cdd:cd17433    48 SVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGfTVITA----AQNVWMLYVGRLLTGLASGVTSLVVPVYISEIA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 111 PKNLRGALGVVPQLFITVGILVAQIFGLrnllanVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQkKDEAAAKKAL 190
Cdd:cd17433   124 HPRVRGTLGSCVQLMVVIGIMGAYLAGL------VLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQ-HRRQEAMAAL 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 191 QTLRGWDsVDREvAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHV 270
Cdd:cd17433   197 RFLRGPD-QGWE-WECIGIEQSFHLEEQSFSLALLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSSV 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 271 QYVTagTGAVNVVMTFCAVFVVEllgrRLLLLLGFSICLIACCVLTAALAlqdtvsWMPYISIVCVISyviGHALGPSPI 350
Cdd:cd17433   275 ASVI--VAAIQVLFTAVAALIMD----RAGRKVLLVLSGVVMVFSTAAFG------WLAVGSMGFFIA---GFAVGWGPI 339

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039673927 351 PALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPY-SFIVFAVICLLTTIYIFLIVPETKAKTF 424
Cdd:cd17433   340 PWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLMEVLSSYgTFWLFSAFCAFSVLFTLFCVPETKGKTL 414
xylE PRK10077
D-xylose transporter XylE; Provisional
 25-436 1.81e-30

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 122.88  E-value: 1.81e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  25 LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAI------LMGCSRVATSFELII---ISRLLVGICA 95
Cdd:PRK10077   55 SLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALgsawpeFGFTSIGPDNTGYVPefvIYRIIGGIGV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  96 GVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIF------GLRNLLANVDGWPILLGLTGVPAALQLLLLPFF 169
Cdd:PRK10077  135 GLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVnyfiarSGDASWLNTDGWRYMFASEAIPALLFLMLLYFV 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 170 PESPRYLLIQkKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGfisvLKLFRMRSLrwQLLSIIVLMGGQQLSGV 249
Cdd:PRK10077  215 PETPRYLMSR-GKQEQAEGILRKIMGNTLATQALQEIKHSLDHGRKTG----GKLLMFGVG--VIVIGVMLSVFQQFVGI 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 250 NAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLlgfsICLIACCVLTAALALQDTVSWMP 329
Cdd:PRK10077  288 NVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQI----IGALGMAIGMFSLGTAFYTQAPG 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 330 YISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGL-------GPYSFIVFA 402
Cdd:PRK10077  364 IVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSwlvahfhNGFSYWIYG 443

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1039673927 403 VICLLTTIYIFLIVPETKAKTFIEINQIFTKMNK 436
Cdd:PRK10077  444 CMGVLAALFMWKFVPETKGKTLEEMEALWEPETK 477
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 25-418 2.65e-26

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 109.65  E-value: 2.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  25 LLWSVTVSMFpFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPM 104
Cdd:cd17361    52 LLQLFTSSLY-LAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNA---AAQNIAMLIVGRILLGFGVGFGNQAVPL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 105 YLGELAPKNLRGALGVVPQLFITVGILVAQI--FGLRNLLANvdGWPILLGLTGVPAALQLLLLPFFPESPRYLliqkkd 182
Cdd:cd17361   128 YLSEMAPAKLRGALNIGFQLAITIGILIANLinYGTSKIKPN--GWRLSLGLAAVPALILLLGSLFLPETPNSP------ 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 183 eaaakkalqtlrgwdsvdrevaeirqedeaekaagfisvlklfrmrslrwQLLSIIVLMGGQQLSGVNAIYYYADQIYLS 262
Cdd:cd17361   200 --------------------------------------------------QLVIAILIPFFQQLTGINVIMFYAPVLFQT 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 263 AGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVS-----WMPYISIVCVI 337
Cdd:cd17361   230 LGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLASQVAIGILLAVKFGDGgelpkAYAIAVVVLIC 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 338 SYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVP 417
Cdd:cd17361   310 LYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVNFLFTFVIAQAFLSMLCAMKFGIFLFFAGWVVVMSLFVYFLLP 389


                  .
gi 1039673927 418 E 418
Cdd:cd17361   390 E 390
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 40-427 2.55e-25

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 107.10  E-value: 2.55e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  40 IGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALG 119
Cdd:cd17437    47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMG---VAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLT 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 120 VVPQLFITVGILVAQI--FGLRNLLANVdGWPILLGLTGVPAALQLLLLPFFPESPRYlliqkkdeaaakkalqtlrgwd 197
Cdd:cd17437   124 SFPEIFINIGILLGYVsnYAFSGLPLHV-GWRLMLGVGAVPSLFLAIGVLAMPESPRW---------------------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 198 svdrevaeirqedeaekaagfisvlklfrMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQY-VTAG 276
Cdd:cd17437   181 -----------------------------TPAVRRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLlATVA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 277 TGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQD----TVSWMPYISIVCVISYVIGHALGPSPIPA 352
Cdd:cd17437   232 VGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALATSLTFIDrnggGLTWALVLAITAVCSFVAFFSIGAGPITW 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039673927 353 LLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLG-PYSFIVFAVICLLTTIYIFLIVPETKAKTFIEI 427
Cdd:cd17437   312 VYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITtGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 29-427 6.16e-24

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 102.95  E-value: 6.16e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  29 VTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSrvaTSFELIIISRLLVGICAGVSSNVVPMYLGE 108
Cdd:cd17435    40 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCS---VSYTVLIVGRIAIGVSISLSSIATCVYIAE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 109 LAPKNLRGALGVVPQLFITVGILVAqiFGLRNLLANV-DGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQkkdeaaak 187
Cdd:cd17435   117 IAPQHRRGLLVSLNELMIVIGILLA--YISNYAFANVsNGWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMK-------- 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 188 kalqtlrgwdsvdrevaeirqedeaekaagfisvlklfrmRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGV-P 266
Cdd:cd17435   187 ----------------------------------------DNMRARLLIGLTLVFFVQITGQPNILFYASTVLKSVGFqS 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 267 EEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLllgfsicliacCVLTAALALQdTVSWMPYISIVCVISYVIGHALG 346
Cdd:cd17435   227 NEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFL-----------CIGSSVMAVS-LVTMGLWLSLASLLVYVAAFSIG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 347 PSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLG-PYSFIVFAVICLLTTIYIFLIVPETKAKTFI 425
Cdd:cd17435   295 LGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTELIGlPWVCFIYTAMSLASLVFVIMFVPETKGCSLE 374


                  ..
gi 1039673927 426 EI 427
Cdd:cd17435   375 QI 376
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 32-423 1.88e-21

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 96.06  E-value: 1.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  32 SMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCsrvATSFELIIISRLLVGICAGVSSNVVPMYLGELAP 111
Cdd:cd17434    48 SVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGS---AQGIWMLLLGRFLTGFAGGITAASIPVYVSEISH 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 112 KNLRGALGVVPQLFITVGILVAQIFGLrnLLAnvdgWPILLGLTGVPAALQLLLLPFFPESPRYLLIQkKDEAAAKKALQ 191
Cdd:cd17434   125 PGVRGALGACPQIMAVFGSLALYALGL--LLP----WRWLAVAGEVPVVIMILLLCFMPNSPRFLISK-GKDEKALKALA 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 192 TLRGWDSvDREVAEIRQEDEAEKAAGFISVLKLfRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHvQ 271
Cdd:cd17434   198 WLRGPNT-DYMTEFEQIKDNIRKQSSRLSWAEL-KTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVILEP-K 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 272 YVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTaalalqdtvswmpYISIVCVISYVIGHALGPSPIP 351
Cdd:cd17434   275 YDAALVGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFAANLSMG-------------LIPLIAAMLFIMGYAMGWGPIT 341

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039673927 352 ALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYS-FIVFAVICLLTTIYIFLIVPETKAKT 423
Cdd:cd17434   342 WLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVpFLFFAAVCAVSIIFTACCVPETKGRT 414
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 24-413 4.63e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 82.47  E-value: 4.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  24 TLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVP 103
Cdd:cd06174    30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA---FAPSFWLLLLGRFLLGLGSGLIDPAVL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 104 MYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRylliqkkde 183
Cdd:cd06174   107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPP--------- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 184 aaakkalqtlrgwdsvdrevaeiRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSA 263
Cdd:cd06174   178 -----------------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 264 GVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALqdtvswmPYISIVCVISYVIGH 343
Cdd:cd06174   235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS-------LLLLLLLLLLLGFGL 307

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039673927 344 AlGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLG--PYSFIVFAVICLLTTIYIF 413
Cdd:cd06174   308 G-GLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFglTGAFLVLAVLLLLAAILLL 378
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 31-427 4.10e-14

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 73.68  E-value: 4.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  31 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELA 110
Cdd:cd17436    42 VSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILT---LAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 111 PKNLRGALGVVPQLFITVGILVAqiFGLRNLLANV-DGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQkkdeaaakka 189
Cdd:cd17436   119 TPHQRGLLVSLYEAGITVGILIS--YALNYFFSNVlTGWRYMFGLAIIPAAIQFASILLLPKKPEVLNIK---------- 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 190 lqtlrgwdsvdrevaeirqedeaekaagfisvlklfrmRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEH 269
Cdd:cd17436   187 --------------------------------------DNMRRRTLVGLGLVLFQQFTGQPNVLCYASTIFRSVGFQSNS 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 270 VQYV-TAGTGAVNVVMTFCAVFVVELLGRrlllllgfSICLIACCVLTAaLALQDTVSWmpyISIVCVISYVIGHALGPS 348
Cdd:cd17436   229 SAVLaSVGLGVVKVIATLLAMLFADRAGR--------RSLLIAGCSVMA-VSVSGIGLW---ITLLCLMAFVSAFSIGFG 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 349 PIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLG-PYSFIVFAVICLLTTIYIFLIVPETKAKTFIEI 427
Cdd:cd17436   297 PMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGlSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 22-196 9.72e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 65.60  E-value: 9.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  22 PLTLLWSVTVSMFPFGgfIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNV 101
Cdd:COG0477    48 SAQLGWIVSAYLLGRA--IGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG---LAPSPELLIAARALQGIGAGGLMPG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 102 VPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLrnLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKK 181
Cdd:COG0477   123 ALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG--LLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLA 200

                         170
                  ....*....|....*
gi 1039673927 182 DEAAAKKALQTLRGW 196
Cdd:COG0477   201 LALAALLLAALALAL 215
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
17-157 1.13e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.77  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  17 FMEDFPLTLLW-SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICA 95
Cdd:COG2814    36 IAADLGASPAQaGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA---LAPSLWLLLAARFLQGLGA 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039673927  96 GVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLrnLLANVDGWPILLGLTGV 157
Cdd:COG2814   113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG--LLADLFGWRWVFLVNAV 172
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 20-157 1.10e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 63.00  E-value: 1.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  20 DFPLTLLWSVTVSMFPF-GGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSrvaTSFELIIISRLLVGICAGVS 98
Cdd:cd17316    30 SLGLSLLQTGLLFAAGFlGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIGIGGE 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039673927  99 SNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQI--FGLRNLLANVDGWPILLGLTGV 157
Cdd:cd17316   107 YPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALvaSLLIPLLSGDWGWRILFLIGAL 167
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 30-157 1.11e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 56.79  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  30 TVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGEL 109
Cdd:cd17324    39 LVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA---LAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1039673927 110 APKNLRG-ALGVVpQLFITVGILVAQIFGlrNLLANVDGWPILLGLTGV 157
Cdd:cd17324   116 VPPEKRGrAIGLV-FSGLTLGLVLGRPLG--GLLGQLLGWRAAFLAIAV 161
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
28-422 1.89e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.04  E-value: 1.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  28 SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLG 107
Cdd:COG2223    43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA---LAVSYWLLLLLGLLLGIGGGGSFAVGIALVS 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 108 ELAPKNLRG-ALGVVpQLFITVGILVAQIFGlrNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYlliqkkdeaaa 186
Cdd:COG2223   120 KWFPPDRRGlALGLA-AGGGNLGAAVAAFLA--PLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA----------- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 187 kkalqtlrgwdsvdrevaeirqEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIylsaGVP 266
Cdd:COG2223   186 ----------------------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF----GLS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 267 EEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALAlqdtvswMPYISIVCVISYVIGHALG 346
Cdd:COG2223   240 AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG-------SLWLFLVLFLLLGLALGGG 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039673927 347 PSPIPAlLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYS--FIVFAVICLLTTIYIFLIVPETKAK 422
Cdd:COG2223   313 NGAVFA-LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTaaFLVFAVLALVALVLTLLLYRRPRRA 389
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 30-240 6.88e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 54.64  E-value: 6.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  30 TVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNnifSIVPAILMGCSRVATSFELIIISRLLVGI-CAGVSSNVVPMYLgE 108
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLS---TLVTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVLNT-E 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927 109 LAPKNLRGALGVVPQLFITVGILVAQIFGLRnllanVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQkkdeAAAKK 188
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSLGLVLLPLVAYF-----IPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQ----GRIEE 278

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039673927 189 ALQTLRGWDSVDR-----EVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVL 240
Cdd:TIGR00898 279 ALKILQRIAKINGkklpaEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMML 335
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 17-137 5.02e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.42  E-value: 5.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  17 FMEDFPLT-LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICA 95
Cdd:cd17325    22 YAESLGASvAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA---FATSYWQLLLARFLQGLAS 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1039673927  96 GVSSNVVPMYLGELAPKNLRG-ALGVVpQLFITVGILVAQIFG 137
Cdd:cd17325    99 AAVWPAAMALIADIAPPEERGrAMGIF-SSAIGLGFLIGPLLG 140
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
16-157 1.24e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.25  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  16 EFMEDFPLTLL-WSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGIC 94
Cdd:COG2271    35 PLQADLGLSAAqLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG---FATSFWQLLLLRFLLGLG 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039673927  95 AGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLrnLLANVDGWPILLGLTGV 157
Cdd:COG2271   112 EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG--WLLAAFGWRAAFLILGL 172
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 28-132 3.13e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 49.12  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  28 SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLG 107
Cdd:cd17317    28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSA---FSPSYELFLVLRFLVGVTSAGIFTVGFVLGM 104

                          90       100
                  ....*....|....*....|....*
gi 1039673927 108 ELAPKNLRGALGVVPQLFITVGILV 132
Cdd:cd17317   105 EIVGPKYRSFVGILFGLFWALGYML 129
MFS_1 pfam07690
Major Facilitator Superfamily;
31-157 1.04e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.41  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  31 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELA 110
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL---FASSLWLLLVLRVLQGLGAGALFPAALALIADWF 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1039673927 111 PKNLRGALGVVPQLFITVGILVAQIFGLrnLLANVDGWPILLGLTGV 157
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGG--LLASLFGWRAAFLILAI 159
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 28-152 1.78e-05

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 46.70  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  28 SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLG 107
Cdd:cd17377    42 SLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNA---LAPSYEFFAVSRFLVGVMNGGMSLVAFVLLN 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039673927 108 ELAPKNLRGALGVVPQLFITVGILVAQIFGL-----RNL--LANVDGWPILL 152
Cdd:cd17377   119 ECVGKSYWALAGSLGGLFFAVGIAQYALLGYfirswRTLavVVNLQGTLVFL 170
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 36-132 5.75e-05

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 45.03  E-value: 5.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  36 FGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLR 115
Cdd:cd17379    44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMA---FSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYR 120

                          90
                  ....*....|....*..
gi 1039673927 116 GALGVVPQLFITVGILV 132
Cdd:cd17379   121 RTVGIVYQMFFTLGLLI 137
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 15-133 7.38e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.99  E-value: 7.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  15 GEFMEDFPLTLLWS-VTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGI 93
Cdd:cd17371    23 PALIAEFGLDEAEAgLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG---FAQNYWQLLILRALAGL 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1039673927  94 CAGVSSNVVPMYLGELAPKNLRG-ALGVVpQLFITVGILVA 133
Cdd:cd17371   100 GFGGEWAAGAALMAEYVPARHRGkALGYV-QSGWAVGWLLA 139
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 4-148 9.56e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 44.54  E-value: 9.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927   4 TWLLSTPQHWTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILmgCSRvATSFEL 83
Cdd:cd06179    11 LFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV--AGT-AKSVNM 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039673927  84 IIISRLLVGICAGVSSNVVPMyLGELAPKNLR----GALGVVPQLFITVGILVAQIFglrnLLANVDGW 148
Cdd:cd06179    88 LIGGQALIGIGAGTQGLGAAV-ASELVPNKYRglvqGVVNLVASPGSALGPLIAGAL----VEANAAGW 151
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 24-136 1.03e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.47  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  24 TLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLfnnIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVP 103
Cdd:cd17477    30 TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFA---AGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039673927 104 MYLGELAPKNLRGALGVVPQLFITVGILVAQIF 136
Cdd:cd17477   107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLL 139
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 31-138 1.29e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.12  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  31 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELA 110
Cdd:cd17489    37 VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL---LATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113

                          90       100
                  ....*....|....*....|....*....
gi 1039673927 111 PKNLRG-ALGVVpQLFITVGILVAQIFGL 138
Cdd:cd17489   114 PPSRRGeGIGYY-GLATTLAMALGPALGL 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
32-130 1.45e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  32 SMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAP 111
Cdd:COG2814   250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLA---LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                          90
                  ....*....|....*....
gi 1039673927 112 KNLRGALGVVPQLFITVGI 130
Cdd:COG2814   327 PEARGRASGLYNSAFFLGG 345
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
31-138 1.46e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  31 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNnIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELA 110
Cdd:COG2271   222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA-IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300

                          90       100
                  ....*....|....*....|....*....
gi 1039673927 111 PKNLRG-ALGVVPQLFITVGILVAQIFGL 138
Cdd:COG2271   301 PKKARGtASGLVNTFGFLGGALGPLLVGY 329
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 40-157 2.11e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 43.44  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  40 IGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRV-----ATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNL 114
Cdd:cd17367    55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTyatigIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1039673927 115 RGALGVVPQLFITVGILVAQI--FGLRNLLANVD----GWPILLGLTGV 157
Cdd:cd17367   135 RGFYSSFQYVTLIGGQLLALGvlLVLQHTLGEDQmaawGWRIPFLLGGV 183
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
32-157 2.28e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.30  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  32 SMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAP 111
Cdd:COG0738    50 FAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA---LAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1039673927 112 KNLRGALGVVpQLFITVGILVAQIFGLRNLLANVD-GWPILLGLTGV 157
Cdd:COG0738   127 ETAASRLNLL-HAFFSLGALLGPLLGGLLILLGLSlSWHLPYLILAV 172
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 28-157 6.46e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 41.75  E-value: 6.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  28 SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILmgcSRVATSFELIIISRLLVGICAGVSSNVVPMYLg 107
Cdd:cd17372    37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL---SAFAPNYMWLIILRCLVGLGLGGGPQLASWYL- 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039673927 108 ELAPKNLRGALGVVPQLFITVGILVaqIFGLRNLLANVDGWPILLGLTGV 157
Cdd:cd17372   113 EFLPAKSRGTWMVLFSVFWTVGTIF--EASLAWLVMPRLGWRWLLAFSSV 160
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 26-157 6.47e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.83  E-value: 6.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  26 LWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLfnnIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMY 105
Cdd:cd06173   245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL---IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTL 321

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039673927 106 LGELAPKNLRGALGVVPQLFITVGILVAQIFGlrNLLANVDGWPILLGLTGV 157
Cdd:cd06173   322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLA--GLLADALGLSAVFLLAGA 371
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 36-157 7.10e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.80  E-value: 7.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  36 FGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIiisRLLVGICAGVSSNVVPMYLGELAPKNLR 115
Cdd:cd17365    45 FGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL---RFLTGLGLGAAMPNAITLVSEYAPARRR 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1039673927 116 GALGVVPQLFITVGILVAQIFGLrnLLANVDGWPILLGLTGV 157
Cdd:cd17365   122 SLAVTLMFCGYPLGAALGGFLAA--ALIPAFGWRSVFLLGGV 161
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 31-116 9.34e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.43  E-value: 9.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  31 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFeLIIISRLLVGICAGVSSNVVPMYLGELA 110
Cdd:cd17316   219 LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPT-LLLLLLFILSFFVGGVWGALYAYLAELF 297


                  ....*.
gi 1039673927 111 PKNLRG 116
Cdd:cd17316   298 PTEVRA 303
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 26-140 1.20e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 40.74  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  26 LWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLfnniFSIVPAILMG-CSRVATSFELIIISRLLVGIC-AGVSSNVVP 103
Cdd:cd17374    36 LKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILL----LSLLQLAIFGtCAAFAPTFPVYCVLRFLAGFAvSGISINTLI 111

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1039673927 104 MYLgELAPKNLRGALGVVPQLFITVG--ILVAQIFGLRN 140
Cdd:cd17374   112 LGT-EWTTPRHRALAITLTSCFFSIGqmLLAGLAYAIRD 149
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 36-157 1.88e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 40.42  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  36 FGGFIGSLLVGPLVNKFGRKGALLfnnIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLR 115
Cdd:TIGR00895  63 IGMAFGALFFGPLADRIGRRRVLL---WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFR 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1039673927 116 GALGVVPQLFITVGILVAQIFGlrNLLANVDGWPILLGLTGV 157
Cdd:TIGR00895 140 GTAVGLMFCGYPIGAAVGGFLA--GWLIPVFGWRSLFYVGGI 179
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 16-148 2.27e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 40.25  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  16 EFMEDFPLTL-LWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRvatSFELIIISRLLVGIC 94
Cdd:cd17323    24 QIAEDFHVSEeVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP---NIAMLIILRFLQGFF 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039673927  95 AGVSSNVVPMYLGELAPKNLRG-ALGVVpQLFITVGILVAQIFGlrNLLANVDGW 148
Cdd:cd17323   101 GSSPLAIGAGTIADLFTPEERGkAMGVY-SLGPLLGPALGPIIG--GFITQSLGW 152
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 28-133 2.55e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.85  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  28 SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMgcsrVATSFELIIISRLLVGICAGVSSNVVPMYLG 107
Cdd:cd17478   233 GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF----LLTPGIWSYILLVLAGFLLFASFPVTVVLAQ 308

                          90       100
                  ....*....|....*....|....*..
gi 1039673927 108 ELAPKNLRGALGVVPQL-FITVGILVA 133
Cdd:cd17478   309 ELLPGNVGLASGLMMGLsFGLGGIGAP 335
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 36-96 3.67e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 39.56  E-value: 3.67e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039673927  36 FGGFIGSL----------LVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRvatSFELIIISRLLVGICAG 96
Cdd:cd17389    65 FGGLIGSLfsllqflsspITGAASDVYGRKPVLLLTMIGLAISYALWAVSR---SFTIFLLSRIVGGISKG 132
MFS_1 pfam07690
Major Facilitator Superfamily;
24-133 4.55e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  24 TLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVP 103
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313

                          90       100       110
                  ....*....|....*....|....*....|
gi 1039673927 104 MYLGELAPKNLRGALGVVPQLFITVGILVA 133
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 40-97 6.82e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 6.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039673927  40 IGSLLVGPLVNKFGRKGALlfnnIFSIVPAILMGCSRV-ATSFELIIISRLLVGICAGV 97
Cdd:cd17473    50 LFAPLAGWLADRFGRKRLL----IAGLLLYGIGGVAGLfLDSLYALLASRALLGIGVAG 104
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 25-125 7.31e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.33  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  25 LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSnVVPM 104
Cdd:cd17330    34 YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG---LSRNLWLLFLARFLDGLTGGNVS-VAQA 109

                          90       100
                  ....*....|....*....|..
gi 1039673927 105 YLGEL-APKNLRGALGVVPQLF 125
Cdd:cd17330   110 YIADItDEEERAKAFGIISAAF 131
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 30-139 7.69e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 38.33  E-value: 7.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039673927  30 TVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVP-----M 104
Cdd:cd17320    39 TLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA---LASSIEQLLIARFLQGLGAAAGSVVARaivrdL 115

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1039673927 105 YLGELAPK---NLRGALGVVPQLFITVGILVAQIFGLR 139
Cdd:cd17320   116 YSGAELAKifsLLMMILAIAPALAPLLGGLLLLFFGWR 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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