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Conserved domains on  [gi|1028630697|ref|NP_001313342|]
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phosphatidylserine decarboxylase proenzyme, mitochondrial isoform c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PS_Dcarbxylase super family cl03656
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 93-386 4.33e-84

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


The actual alignment was detected with superfamily member PLN02938:

Pssm-ID: 470849  Cd Length: 428  Bit Score: 262.45  E-value: 4.33e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  93 VPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEdLHHYRNLSEFFRRKLKPQARPV-CGLHSVISPSDG 171
Cdd:PLN02938   94 LPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPDPNCLVSPVDG 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 172 RILNFGQVK--NCEVEQVKGVTYSLESFLG----PRMCTE-----DLPFPPAASCDSF----------KNQLVTREGNEL 230
Cdd:PLN02938  173 IVLRFGELKgpGTMIEQVKGFSYSVSALLGanslLPMTAEgkeekEEETLKDKSSKSWlrvslaspklRDPVSASPMKGL 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 231 YHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRI 310
Cdd:PLN02938  253 FYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAVGATNIGSIEL 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 311 YFDRDLHTNSPRhsKGSYND---FSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAP--------------KDFNFQL 373
Cdd:PLN02938  333 FIEPELRTNRPK--KKIFNSeppEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvldqssSDFRFCV 410

                         330
                  ....*....|...
gi 1028630697 374 KTGQKIRFGEALG 386
Cdd:PLN02938  411 RKGDRIRVGQALG 423
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 93-386 4.33e-84

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 262.45  E-value: 4.33e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  93 VPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEdLHHYRNLSEFFRRKLKPQARPV-CGLHSVISPSDG 171
Cdd:PLN02938   94 LPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPDPNCLVSPVDG 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 172 RILNFGQVK--NCEVEQVKGVTYSLESFLG----PRMCTE-----DLPFPPAASCDSF----------KNQLVTREGNEL 230
Cdd:PLN02938  173 IVLRFGELKgpGTMIEQVKGFSYSVSALLGanslLPMTAEgkeekEEETLKDKSSKSWlrvslaspklRDPVSASPMKGL 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 231 YHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRI 310
Cdd:PLN02938  253 FYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAVGATNIGSIEL 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 311 YFDRDLHTNSPRhsKGSYND---FSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAP--------------KDFNFQL 373
Cdd:PLN02938  333 FIEPELRTNRPK--KKIFNSeppEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvldqssSDFRFCV 410

                         330
                  ....*....|...
gi 1028630697 374 KTGQKIRFGEALG 386
Cdd:PLN02938  411 RKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 144-386 2.94e-74

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 229.47  E-value: 2.94e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 144 LSEFFRRKLKPQARPVC-GLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMctedlpfppaascdsfknql 222
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 223 vTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 302
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 303 TNVGSIRIYFdrdlhtnsprhskgsyndfsfvthtnREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFG 382
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 1028630697 383 EALG 386
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 130-386 1.38e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 228.95  E-value: 1.38e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 130 MKEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGprmctEDLP 208
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 209 FPPaascdSFKNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 288
Cdd:TIGR00163  76 LSP-----YFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 289 DWKHGFFSLTAVGATNVGSIRIYFDRDLHTNsPRHskgsyNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEA-PK 367
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTN-PRH-----EFTQTWTYNALGPVKLLKGEEMGYFELGSTVILLFEAdAF 216

                         250
                  ....*....|....*....
gi 1028630697 368 DFNFQLKTGQKIRFGEALG 386
Cdd:TIGR00163 217 QLSAHLAVGQEVKIGELLA 235
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 94-388 6.77e-56

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 183.52  E-value: 6.77e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  94 PTRLLSRAWGRLNQVELPHWlrRPVYSLYIWTFGVNMKEAAVEdlhHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGR 172
Cdd:COG0688     1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 173 ILNFGQVKNCEVEQVKGVTYSLESFLGPrmctedlpfppAASCDSFKN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 251
Cdd:COG0688    76 VSQIGEIEEDRLLQAKGHPYSLEELLGD-----------SELAEKFEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 252 TVSHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDrdlhtnsprhskgsyndf 331
Cdd:COG0688   135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYVK------------------ 194

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1028630697 332 sfvthtnrEGVPMRKGEHLGEFNLGSTIVLIFEaPKDFNFQLKTGQKIRFGEALGSL 388
Cdd:COG0688   195 --------EGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 93-386 4.33e-84

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 262.45  E-value: 4.33e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  93 VPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEdLHHYRNLSEFFRRKLKPQARPV-CGLHSVISPSDG 171
Cdd:PLN02938   94 LPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPDPNCLVSPVDG 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 172 RILNFGQVK--NCEVEQVKGVTYSLESFLG----PRMCTE-----DLPFPPAASCDSF----------KNQLVTREGNEL 230
Cdd:PLN02938  173 IVLRFGELKgpGTMIEQVKGFSYSVSALLGanslLPMTAEgkeekEEETLKDKSSKSWlrvslaspklRDPVSASPMKGL 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 231 YHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRI 310
Cdd:PLN02938  253 FYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAVGATNIGSIEL 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 311 YFDRDLHTNSPRhsKGSYND---FSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAP--------------KDFNFQL 373
Cdd:PLN02938  333 FIEPELRTNRPK--KKIFNSeppEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvldqssSDFRFCV 410

                         330
                  ....*....|...
gi 1028630697 374 KTGQKIRFGEALG 386
Cdd:PLN02938  411 RKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 144-386 2.94e-74

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 229.47  E-value: 2.94e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 144 LSEFFRRKLKPQARPVC-GLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMctedlpfppaascdsfknql 222
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 223 vTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 302
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 303 TNVGSIRIYFdrdlhtnsprhskgsyndfsfvthtnREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFG 382
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 1028630697 383 EALG 386
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 130-386 1.38e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 228.95  E-value: 1.38e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 130 MKEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGprmctEDLP 208
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 209 FPPaascdSFKNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 288
Cdd:TIGR00163  76 LSP-----YFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 289 DWKHGFFSLTAVGATNVGSIRIYFDRDLHTNsPRHskgsyNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEA-PK 367
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTN-PRH-----EFTQTWTYNALGPVKLLKGEEMGYFELGSTVILLFEAdAF 216

                         250
                  ....*....|....*....
gi 1028630697 368 DFNFQLKTGQKIRFGEALG 386
Cdd:TIGR00163 217 QLSAHLAVGQEVKIGELLA 235
PTZ00403 PTZ00403
phosphatidylserine decarboxylase; Provisional
 95-386 6.27e-63

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 173594  Cd Length: 353  Bit Score: 205.47  E-value: 6.27e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  95 TRLL-----SRAWGRLNQVELPHWLRRPVYSLYIWTFGVNmKEAAVEDLHHYRNLSEFFRRKLKPQARPV--CGLHSVIS 167
Cdd:PTZ00403   57 ARLLfgrtrSRITGSIFNIEIPNTYRLPIYNFLIKYMGIN-KEEIKYPIESYKSIGDFFSRYIREETRPIgdVSDYSIVS 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 168 PSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMctedlpfppaascdsfknQLVTREG-NELYHCVIYLAPGDYHCFH 246
Cdd:PTZ00403  136 PCDSELTDYGELSSEYLENVKGVKFNVNTFLGSDM------------------QKKYNDGsTKFFYAIFYLSPKKYHHFH 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 247 SPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRHSKg 326
Cdd:PTZ00403  198 APFNFKYKIRRHISGELFPVFQGMFKIINNLFNINERVILSGEWKGGNVYYAAISAYNVGNIKIINDEELVTNNLRTQL- 276

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 327 SYNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFGEALG 386
Cdd:PTZ00403  277 SYMGGDINTKIYDSYKSVEVGDEVGEFRMGSSIVVIFENKKNFSWNVKPNQTVSVGQRLG 336
PRK03934 PRK03934
phosphatidylserine decarboxylase; Provisional
 94-388 4.81e-62

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 235177 [Multi-domain]  Cd Length: 265  Bit Score: 200.17  E-value: 4.81e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  94 PTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEaaVEDLHHYRNLSEFFRRKLKPQaRPV-CGLHSVISPSDGR 172
Cdd:PRK03934    3 LSNALSRIFGKFAGYKFPKFIQKFINASYVKIFKIDMSE--FKPPENYKSLNALFTRSLKKP-REFdEDPNIFISPCDSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 173 ILNFGQVKNCEVEQVKGVTYSLESFLGPRMCTEDLPFppaascdSFKNqlvtregnelyhcvIYLAPGDYHCFHSPTDWT 252
Cdd:PRK03934   80 ITECGSLEEDKALQIKGMEYSIEELLGESNSELVNGF-------DYIN--------------FYLSPKDYHRYHAPCDLE 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 253 VSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHG-FFSLTAVGATNVGSIRIYFDRDLHTNSprhskgsynDF 331
Cdd:PRK03934  139 ILEARYIPGKLYPVNLPSLEKNKNLFVKNERVVLKCKDKKGkRLYFVFVGALNVGKMRFNFDERIQTNA---------KA 209

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1028630697 332 SFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEaPKDFNFQLKTGQKIRFGEALGSL 388
Cdd:PRK03934  210 RFIQTYEYENLKLKKGEELGNFEMGSTIVLFSQ-KGSLEFNLKAGKSVKFGESIGEI 265
psd PRK00044
phosphatidylserine decarboxylase; Reviewed
 87-386 3.24e-59

phosphatidylserine decarboxylase; Reviewed


Pssm-ID: 234591  Cd Length: 288  Bit Score: 193.89  E-value: 3.24e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  87 VALYKSVPTRLLSRAWGRLNQVELPhWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHSV 165
Cdd:PRK00044    7 ILLQYLLPKHLLTRLAGWLASSRAG-WLTTAVIRLFIKKYKVDMSEAQKPDPAAYKTFNDFFTRALKDGARPIDeDPNAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 166 ISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGprmCTEDLpfppaasCDSFKN-QLVTregnelyhcvIYLAPGDYHC 244
Cdd:PRK00044   86 VSPADGAISQLGPIEDGQIFQAKGHSYSLEALLG---GDAAL-------ADPFRNgSFAT----------IYLSPRDYHR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 245 FHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRiyfdrdlhT------ 318
Cdd:PRK00044  146 VHMPCDGTLREMIYVPGDLFSVNPLTARNVPNLFARNERVVCLFDTEFGPMAQVLVGATIVGSIE--------Tvwagtv 217

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1028630697 319 NSPRHSKGSYNDFSfvtHTNREGVPMRKGEHLGEFNLGSTIVLIFEAPK-DFNFQLKTGQKIRFGEALG 386
Cdd:PRK00044  218 TPPREGIIKRWDYP---EAGDGAITLKKGAEMGRFKLGSTVINLFPPGKvQLAEQLQAGSVVRMGQPLA 283
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 94-388 6.77e-56

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 183.52  E-value: 6.77e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  94 PTRLLSRAWGRLNQVELPHWlrRPVYSLYIWTFGVNMKEAAVEdlhHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGR 172
Cdd:COG0688     1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 173 ILNFGQVKNCEVEQVKGVTYSLESFLGPrmctedlpfppAASCDSFKN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 251
Cdd:COG0688    76 VSQIGEIEEDRLLQAKGHPYSLEELLGD-----------SELAEKFEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 252 TVSHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDrdlhtnsprhskgsyndf 331
Cdd:COG0688   135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYVK------------------ 194

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1028630697 332 sfvthtnrEGVPMRKGEHLGEFNLGSTIVLIFEaPKDFNFQLKTGQKIRFGEALGSL 388
Cdd:COG0688   195 --------EGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
PRK00723 PRK00723
phosphatidylserine decarboxylase; Provisional
 83-386 2.01e-34

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179097 [Multi-domain]  Cd Length: 297  Bit Score: 128.88  E-value: 2.01e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  83 PVSRVALYKSVPTRLLSRAWGRLNQVElphWLRRPVYSlYIWTFGVNMKEAAvEDLHHYRNLSEFFRRKLKPQARPVC-G 161
Cdd:PRK00723   30 PIGKNLLELLIKKKIFSKIYGWYCDSR---LSRKKIKP-FVNDFNIDMSESE-KPLSDFKSFNDFFTRKLKPEARPIDqG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 162 LHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGprmctedlpfppaascdsfKNQLVtregnELYH---CVIY-L 237
Cdd:PRK00723  105 ENILISPGDGRLLAYENIDLNSLFQVKGKTYSLKELLG-------------------DPELA-----KKYAggtCLILrL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 238 APGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNER--VVLTGDwKHGFFSLTAVGATNVGSIriyfdrd 315
Cdd:PRK00723  161 CPTDYHRFHFPDSGICEETRKIKGHYYSVNPIALKKIFELFCENKRewSIFKSE-NFGDILYVEVGATCVGSI------- 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1028630697 316 LHTNSPrhskgsyndfsfvthtnreGVPMRKGEHLGEFNL-GSTIVLIFEAPK-----DFNFQLKTG--QKIRFGEALG 386
Cdd:PRK00723  233 IQTYKP-------------------NKKVKKGDEKGYFKFgGSTVILFFEKNKikidaDILEQSKLGyeTKVLMGESIG 292
PRK03140 PRK03140
phosphatidylserine decarboxylase; Provisional
 114-388 1.54e-32

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179544 [Multi-domain]  Cd Length: 259  Bit Score: 122.79  E-value: 1.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 114 LRRPVYSLYIWTFGVNMKEAAvEDLHHYRNLSEFFRRKLKPQARPV-CGLHSVISPSDGRILNFGQVKNCEVEQVKGVTY 192
Cdd:PRK03140   30 LSSILIPSYAKVYQINQDEME-KGLKEYRTLHELFTRKLKEGKRPIdTDASSIVSPVDGVFADVGPIEDDKTFDVKGKRY 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 193 SLESFLGprmctedlpfppaascdsfkNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSH-----RRHFPgslmsVN 267
Cdd:PRK03140  109 SIAEMLG--------------------NEERAQRYAGGTYMVLYLSPSHYHRIHSPISGTVTEqfvlgRKSYP-----VN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 268 PGMARWIKELFCHNERVV--LTGDWKHgfFSLTAVGATNVGSIRIyfdrdlhtnsprhskgsyndfsfvTHTNREgvpMR 345
Cdd:PRK03140  164 ALGLEYGKRPLSKNYRSVteVNSDGEH--MALVKVGAMFVNSIEL------------------------THERDT---VQ 214

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1028630697 346 KGEHLGEFNLGSTIVLIFEapKD---FNFQLKTGQKIRFGEALGSL 388
Cdd:PRK03140  215 KGEEMAYFSFGSTVVLLFE--KDmiePDQELKSGQEVRLGEKIGTR 258
PRK09629 PRK09629
bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional
 93-386 4.91e-31

bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional


Pssm-ID: 104071 [Multi-domain]  Cd Length: 610  Bit Score: 124.46  E-value: 4.91e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697  93 VPTRLLSRAWGRLNQVELpHWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPV-CGLHSVISPSDG 171
Cdd:PRK09629  336 LPHHLLSRLAGCVAECRV-RWFKNAFTAWFARRYQVDMSQALVEDLTSYEHFNAFFTRALKADARPLdTTPGAILSPADG 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 172 RILNFGQVKNCEVEQVKGVTYSLESFLG--PRMCTedlPFppaascdsfknqlvtrEGNELyhCVIYLAPGDYHCFHSPT 249
Cdd:PRK09629  415 AISQLGPIDHGRIFQAKGHSFSVLELLGgdPKLSA---PF----------------MGGEF--ATVYLSPKDYHRVHMPL 473

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 250 DWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFdRDLHTNSPRHSKgsyn 329
Cdd:PRK09629  474 AGTLREMVYVPGRIFSVNQTTAENVPELFARNERVVCLFDTERGPMAVVLVGAMIVASVETVW-AGLVTPPKRELK---- 548

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1028630697 330 DFSFvTHTNREGVPMRKGEHLGEFNLGSTIVLIFeAPKDFNF--QLKTGQKIRFGEALG 386
Cdd:PRK09629  549 TFSY-DEAARAPIHLEKGAEMGRFKLGSTAIVLF-GPNQVKWaeQLTAGSKVQMGQALA 605
PLN02964 PLN02964
phosphatidylserine decarboxylase
 128-365 1.25e-20

phosphatidylserine decarboxylase


Pssm-ID: 215520 [Multi-domain]  Cd Length: 644  Bit Score: 93.77  E-value: 1.25e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 128 VNMKEAAvEDLHHYRNLSEFFRRKLKPQARPV-CGLHS--VISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMCT 204
Cdd:PLN02964  401 INMDEVK-YPLEHFKTFNEFFIRELKPGARPIaCMDNDdvAVCAADCRLMAFQSVDDSTRFWIKGRKFSIKGLLGKKVHS 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 205 EDLPFPPAAscdsfknqlvtregnelyhcVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPgMARWIK--ELFCHNE 282
Cdd:PLN02964  480 DAFLDGSLV--------------------IFRLAPQDYHRFHVPVSGVIEKFVDVPGSLYTVNP-IAVNSKycNVFTENK 538

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630697 283 RVV-LTGDWKHGFFSLTAVGATNVGSIriyfdrdlhtnsprhskgsyndfsfvTHTNREGVPMRKGEHLGEFNLG-STIV 360
Cdd:PLN02964  539 RAVcIISTAEFGKVAFVAIGATMVGSI--------------------------TFVKKEGDHVKKGDELGYFSFGgSTVI 592


                  ....*
gi 1028630697 361 LIFEA 365
Cdd:PLN02964  593 CVFEK 597
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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