NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1028630645|ref|NP_001313340|]
View 

phosphatidylserine decarboxylase proenzyme, mitochondrial isoform a [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PS_Dcarbxylase super family cl03656
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 81-407 1.86e-86

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


The actual alignment was detected with superfamily member PLN02938:

Pssm-ID: 470849  Cd Length: 428  Bit Score: 269.38  E-value: 1.86e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645  81 RQYEKYRERELEKLGLEipPKLAGHWEVALYKSVPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEdLH 160
Cdd:PLN02938   63 RLYEDKKVEEAREKGIE--PEFSPDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LE 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 161 HYRNLSEFFRRKLKPQARPV-CGLHSVISPSDGRILNFGQVK--NCEVEQVKGVTYSLESFLG----PRMCTE-----DL 228
Cdd:PLN02938  140 EYASLREFFVRSLKEGARPIdPDPNCLVSPVDGIVLRFGELKgpGTMIEQVKGFSYSVSALLGanslLPMTAEgkeekEE 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 229 PFPPAASCDSF----------KNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKEL 298
Cdd:PLN02938  220 ETLKDKSSKSWlrvslaspklRDPVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNL 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 299 FCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRhsKGSYNDF---SFVTHTNREGVPMRKGEHLGEFN 375
Cdd:PLN02938  300 YVENERVVLEGEWQEGFMAMAAVGATNIGSIELFIEPELRTNRPK--KKIFNSEppeERVYEPEGCGLCLKKGDEVAVFN 377

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1028630645 376 LGSTIVLIFEAP--------------KDFNFQLKTGQKIRFGEALG 407
Cdd:PLN02938  378 LGSTVVLVFEAPveveplfkvldqssSDFRFCVRKGDRIRVGQALG 423
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 81-407 1.86e-86

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 269.38  E-value: 1.86e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645  81 RQYEKYRERELEKLGLEipPKLAGHWEVALYKSVPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEdLH 160
Cdd:PLN02938   63 RLYEDKKVEEAREKGIE--PEFSPDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LE 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 161 HYRNLSEFFRRKLKPQARPV-CGLHSVISPSDGRILNFGQVK--NCEVEQVKGVTYSLESFLG----PRMCTE-----DL 228
Cdd:PLN02938  140 EYASLREFFVRSLKEGARPIdPDPNCLVSPVDGIVLRFGELKgpGTMIEQVKGFSYSVSALLGanslLPMTAEgkeekEE 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 229 PFPPAASCDSF----------KNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKEL 298
Cdd:PLN02938  220 ETLKDKSSKSWlrvslaspklRDPVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNL 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 299 FCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRhsKGSYNDF---SFVTHTNREGVPMRKGEHLGEFN 375
Cdd:PLN02938  300 YVENERVVLEGEWQEGFMAMAAVGATNIGSIELFIEPELRTNRPK--KKIFNSEppeERVYEPEGCGLCLKKGDEVAVFN 377

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1028630645 376 LGSTIVLIFEAP--------------KDFNFQLKTGQKIRFGEALG 407
Cdd:PLN02938  378 LGSTVVLVFEAPveveplfkvldqssSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 165-407 9.18e-74

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 228.70  E-value: 9.18e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 165 LSEFFRRKLKPQARPVC-GLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMctedlpfppaascdsfknql 243
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 244 vTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 323
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 324 TNVGSIRIYFdrdlhtnsprhskgsyndfsfvthtnREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFG 403
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 1028630645 404 EALG 407
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 151-407 3.04e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 228.95  E-value: 3.04e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 151 MKEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGprmctEDLP 229
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 230 FPPaascdSFKNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 309
Cdd:TIGR00163  76 LSP-----YFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 310 DWKHGFFSLTAVGATNVGSIRIYFDRDLHTNsPRHskgsyNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEA-PK 388
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTN-PRH-----EFTQTWTYNALGPVKLLKGEEMGYFELGSTVILLFEAdAF 216

                         250
                  ....*....|....*....
gi 1028630645 389 DFNFQLKTGQKIRFGEALG 407
Cdd:TIGR00163 217 QLSAHLAVGQEVKIGELLA 235
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 115-409 1.16e-55

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 183.52  E-value: 1.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 115 PTRLLSRAWGRLNQVELPHWlrRPVYSLYIWTFGVNMKEAAVEdlhHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGR 193
Cdd:COG0688     1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 194 ILNFGQVKNCEVEQVKGVTYSLESFLGPrmctedlpfppAASCDSFKN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 272
Cdd:COG0688    76 VSQIGEIEEDRLLQAKGHPYSLEELLGD-----------SELAEKFEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 273 TVSHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDrdlhtnsprhskgsyndf 352
Cdd:COG0688   135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYVK------------------ 194

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1028630645 353 sfvthtnrEGVPMRKGEHLGEFNLGSTIVLIFEaPKDFNFQLKTGQKIRFGEALGSL 409
Cdd:COG0688   195 --------EGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 81-407 1.86e-86

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 269.38  E-value: 1.86e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645  81 RQYEKYRERELEKLGLEipPKLAGHWEVALYKSVPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEdLH 160
Cdd:PLN02938   63 RLYEDKKVEEAREKGIE--PEFSPDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LE 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 161 HYRNLSEFFRRKLKPQARPV-CGLHSVISPSDGRILNFGQVK--NCEVEQVKGVTYSLESFLG----PRMCTE-----DL 228
Cdd:PLN02938  140 EYASLREFFVRSLKEGARPIdPDPNCLVSPVDGIVLRFGELKgpGTMIEQVKGFSYSVSALLGanslLPMTAEgkeekEE 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 229 PFPPAASCDSF----------KNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKEL 298
Cdd:PLN02938  220 ETLKDKSSKSWlrvslaspklRDPVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNL 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 299 FCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRhsKGSYNDF---SFVTHTNREGVPMRKGEHLGEFN 375
Cdd:PLN02938  300 YVENERVVLEGEWQEGFMAMAAVGATNIGSIELFIEPELRTNRPK--KKIFNSEppeERVYEPEGCGLCLKKGDEVAVFN 377

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1028630645 376 LGSTIVLIFEAP--------------KDFNFQLKTGQKIRFGEALG 407
Cdd:PLN02938  378 LGSTVVLVFEAPveveplfkvldqssSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 165-407 9.18e-74

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 228.70  E-value: 9.18e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 165 LSEFFRRKLKPQARPVC-GLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMctedlpfppaascdsfknql 243
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 244 vTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 323
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 324 TNVGSIRIYFdrdlhtnsprhskgsyndfsfvthtnREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFG 403
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 1028630645 404 EALG 407
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 151-407 3.04e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 228.95  E-value: 3.04e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 151 MKEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGprmctEDLP 229
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 230 FPPaascdSFKNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 309
Cdd:TIGR00163  76 LSP-----YFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 310 DWKHGFFSLTAVGATNVGSIRIYFDRDLHTNsPRHskgsyNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEA-PK 388
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTN-PRH-----EFTQTWTYNALGPVKLLKGEEMGYFELGSTVILLFEAdAF 216

                         250
                  ....*....|....*....
gi 1028630645 389 DFNFQLKTGQKIRFGEALG 407
Cdd:TIGR00163 217 QLSAHLAVGQEVKIGELLA 235
PTZ00403 PTZ00403
phosphatidylserine decarboxylase; Provisional
 116-407 8.33e-63

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 173594  Cd Length: 353  Bit Score: 205.86  E-value: 8.33e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 116 TRLL-----SRAWGRLNQVELPHWLRRPVYSLYIWTFGVNmKEAAVEDLHHYRNLSEFFRRKLKPQARPV--CGLHSVIS 188
Cdd:PTZ00403   57 ARLLfgrtrSRITGSIFNIEIPNTYRLPIYNFLIKYMGIN-KEEIKYPIESYKSIGDFFSRYIREETRPIgdVSDYSIVS 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 189 PSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMctedlpfppaascdsfknQLVTREG-NELYHCVIYLAPGDYHCFH 267
Cdd:PTZ00403  136 PCDSELTDYGELSSEYLENVKGVKFNVNTFLGSDM------------------QKKYNDGsTKFFYAIFYLSPKKYHHFH 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 268 SPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRHSKg 347
Cdd:PTZ00403  198 APFNFKYKIRRHISGELFPVFQGMFKIINNLFNINERVILSGEWKGGNVYYAAISAYNVGNIKIINDEELVTNNLRTQL- 276

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 348 SYNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFGEALG 407
Cdd:PTZ00403  277 SYMGGDINTKIYDSYKSVEVGDEVGEFRMGSSIVVIFENKKNFSWNVKPNQTVSVGQRLG 336
PRK03934 PRK03934
phosphatidylserine decarboxylase; Provisional
 115-409 1.51e-61

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 235177 [Multi-domain]  Cd Length: 265  Bit Score: 199.79  E-value: 1.51e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 115 PTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEaaVEDLHHYRNLSEFFRRKLKPQaRPV-CGLHSVISPSDGR 193
Cdd:PRK03934    3 LSNALSRIFGKFAGYKFPKFIQKFINASYVKIFKIDMSE--FKPPENYKSLNALFTRSLKKP-REFdEDPNIFISPCDSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 194 ILNFGQVKNCEVEQVKGVTYSLESFLGPRMCTEDLPFppaascdSFKNqlvtregnelyhcvIYLAPGDYHCFHSPTDWT 273
Cdd:PRK03934   80 ITECGSLEEDKALQIKGMEYSIEELLGESNSELVNGF-------DYIN--------------FYLSPKDYHRYHAPCDLE 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 274 VSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHG-FFSLTAVGATNVGSIRIYFDRDLHTNSprhskgsynDF 352
Cdd:PRK03934  139 ILEARYIPGKLYPVNLPSLEKNKNLFVKNERVVLKCKDKKGkRLYFVFVGALNVGKMRFNFDERIQTNA---------KA 209

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1028630645 353 SFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEaPKDFNFQLKTGQKIRFGEALGSL 409
Cdd:PRK03934  210 RFIQTYEYENLKLKKGEELGNFEMGSTIVLFSQ-KGSLEFNLKAGKSVKFGESIGEI 265
psd PRK00044
phosphatidylserine decarboxylase; Reviewed
 108-407 7.99e-59

phosphatidylserine decarboxylase; Reviewed


Pssm-ID: 234591  Cd Length: 288  Bit Score: 193.50  E-value: 7.99e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 108 VALYKSVPTRLLSRAWGRLNQVELPhWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHSV 186
Cdd:PRK00044    7 ILLQYLLPKHLLTRLAGWLASSRAG-WLTTAVIRLFIKKYKVDMSEAQKPDPAAYKTFNDFFTRALKDGARPIDeDPNAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 187 ISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGprmCTEDLpfppaasCDSFKN-QLVTregnelyhcvIYLAPGDYHC 265
Cdd:PRK00044   86 VSPADGAISQLGPIEDGQIFQAKGHSYSLEALLG---GDAAL-------ADPFRNgSFAT----------IYLSPRDYHR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 266 FHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIriyfdrdlHT------ 339
Cdd:PRK00044  146 VHMPCDGTLREMIYVPGDLFSVNPLTARNVPNLFARNERVVCLFDTEFGPMAQVLVGATIVGSI--------ETvwagtv 217

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1028630645 340 NSPRHSKGSYNDFSfvtHTNREGVPMRKGEHLGEFNLGSTIVLIFEAPK-DFNFQLKTGQKIRFGEALG 407
Cdd:PRK00044  218 TPPREGIIKRWDYP---EAGDGAITLKKGAEMGRFKLGSTVINLFPPGKvQLAEQLQAGSVVRMGQPLA 283
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 115-409 1.16e-55

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 183.52  E-value: 1.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 115 PTRLLSRAWGRLNQVELPHWlrRPVYSLYIWTFGVNMKEAAVEdlhHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGR 193
Cdd:COG0688     1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 194 ILNFGQVKNCEVEQVKGVTYSLESFLGPrmctedlpfppAASCDSFKN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 272
Cdd:COG0688    76 VSQIGEIEEDRLLQAKGHPYSLEELLGD-----------SELAEKFEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 273 TVSHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDrdlhtnsprhskgsyndf 352
Cdd:COG0688   135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYVK------------------ 194

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1028630645 353 sfvthtnrEGVPMRKGEHLGEFNLGSTIVLIFEaPKDFNFQLKTGQKIRFGEALGSL 409
Cdd:COG0688   195 --------EGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
PRK00723 PRK00723
phosphatidylserine decarboxylase; Provisional
 116-407 5.64e-34

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179097 [Multi-domain]  Cd Length: 297  Bit Score: 128.11  E-value: 5.64e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 116 TRLLSRAWGRLNQVElphWLRRPVYSlYIWTFGVNMKEAAvEDLHHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGRI 194
Cdd:PRK00723   42 KKIFSKIYGWYCDSR---LSRKKIKP-FVNDFNIDMSESE-KPLSDFKSFNDFFTRKLKPEARPIDqGENILISPGDGRL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 195 LNFGQVKNCEVEQVKGVTYSLESFLGprmctedlpfppaascdsfKNQLVtregnELYH---CVIY-LAPGDYHCFHSPT 270
Cdd:PRK00723  117 LAYENIDLNSLFQVKGKTYSLKELLG-------------------DPELA-----KKYAggtCLILrLCPTDYHRFHFPD 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 271 DWTVSHRRHFPGSLMSVNPGMARWIKELFCHNER--VVLTGDwKHGFFSLTAVGATNVGSIriyfdrdLHTNSPrhskgs 348
Cdd:PRK00723  173 SGICEETRKIKGHYYSVNPIALKKIFELFCENKRewSIFKSE-NFGDILYVEVGATCVGSI-------IQTYKP------ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1028630645 349 yndfsfvthtnreGVPMRKGEHLGEFNL-GSTIVLIFEAPK-----DFNFQLKTG--QKIRFGEALG 407
Cdd:PRK00723  239 -------------NKKVKKGDEKGYFKFgGSTVILFFEKNKikidaDILEQSKLGyeTKVLMGESIG 292
PRK03140 PRK03140
phosphatidylserine decarboxylase; Provisional
 135-409 3.39e-32

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179544 [Multi-domain]  Cd Length: 259  Bit Score: 122.40  E-value: 3.39e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 135 LRRPVYSLYIWTFGVNMKEAAvEDLHHYRNLSEFFRRKLKPQARPV-CGLHSVISPSDGRILNFGQVKNCEVEQVKGVTY 213
Cdd:PRK03140   30 LSSILIPSYAKVYQINQDEME-KGLKEYRTLHELFTRKLKEGKRPIdTDASSIVSPVDGVFADVGPIEDDKTFDVKGKRY 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 214 SLESFLGprmctedlpfppaascdsfkNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSH-----RRHFPgslmsVN 288
Cdd:PRK03140  109 SIAEMLG--------------------NEERAQRYAGGTYMVLYLSPSHYHRIHSPISGTVTEqfvlgRKSYP-----VN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 289 PGMARWIKELFCHNERVV--LTGDWKHgfFSLTAVGATNVGSIRIyfdrdlhtnsprhskgsyndfsfvTHTNREgvpMR 366
Cdd:PRK03140  164 ALGLEYGKRPLSKNYRSVteVNSDGEH--MALVKVGAMFVNSIEL------------------------THERDT---VQ 214

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1028630645 367 KGEHLGEFNLGSTIVLIFEapKD---FNFQLKTGQKIRFGEALGSL 409
Cdd:PRK03140  215 KGEEMAYFSFGSTVVLLFE--KDmiePDQELKSGQEVRLGEKIGTR 258
PRK09629 PRK09629
bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional
 114-407 8.09e-31

bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional


Pssm-ID: 104071 [Multi-domain]  Cd Length: 610  Bit Score: 124.46  E-value: 8.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 114 VPTRLLSRAWGRLNQVELpHWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPV-CGLHSVISPSDG 192
Cdd:PRK09629  336 LPHHLLSRLAGCVAECRV-RWFKNAFTAWFARRYQVDMSQALVEDLTSYEHFNAFFTRALKADARPLdTTPGAILSPADG 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 193 RILNFGQVKNCEVEQVKGVTYSLESFLG--PRMCTedlPFppaascdsfknqlvtrEGNELyhCVIYLAPGDYHCFHSPT 270
Cdd:PRK09629  415 AISQLGPIDHGRIFQAKGHSFSVLELLGgdPKLSA---PF----------------MGGEF--ATVYLSPKDYHRVHMPL 473

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 271 DWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFdRDLHTNSPRHSKgsyn 350
Cdd:PRK09629  474 AGTLREMVYVPGRIFSVNQTTAENVPELFARNERVVCLFDTERGPMAVVLVGAMIVASVETVW-AGLVTPPKRELK---- 548

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1028630645 351 DFSFvTHTNREGVPMRKGEHLGEFNLGSTIVLIFeAPKDFNF--QLKTGQKIRFGEALG 407
Cdd:PRK09629  549 TFSY-DEAARAPIHLEKGAEMGRFKLGSTAIVLF-GPNQVKWaeQLTAGSKVQMGQALA 605
PLN02964 PLN02964
phosphatidylserine decarboxylase
 149-386 1.64e-20

phosphatidylserine decarboxylase


Pssm-ID: 215520 [Multi-domain]  Cd Length: 644  Bit Score: 93.77  E-value: 1.64e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 149 VNMKEAAvEDLHHYRNLSEFFRRKLKPQARPV-CGLHS--VISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMCT 225
Cdd:PLN02964  401 INMDEVK-YPLEHFKTFNEFFIRELKPGARPIaCMDNDdvAVCAADCRLMAFQSVDDSTRFWIKGRKFSIKGLLGKKVHS 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 226 EDLPFPPAAscdsfknqlvtregnelyhcVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPgMARWIK--ELFCHNE 303
Cdd:PLN02964  480 DAFLDGSLV--------------------IFRLAPQDYHRFHVPVSGVIEKFVDVPGSLYTVNP-IAVNSKycNVFTENK 538

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028630645 304 RVV-LTGDWKHGFFSLTAVGATNVGSIriyfdrdlhtnsprhskgsyndfsfvTHTNREGVPMRKGEHLGEFNLG-STIV 381
Cdd:PLN02964  539 RAVcIISTAEFGKVAFVAIGATMVGSI--------------------------TFVKKEGDHVKKGDELGYFSFGgSTVI 592


                  ....*
gi 1028630645 382 LIFEA 386
Cdd:PLN02964  593 CVFEK 597
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH