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Conserved domains on  [gi|1026191061|ref|NP_001311397|]
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elongator complex protein 2 isoform 10 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12202454)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
125-547 1.76e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 125 TLETVLAGHENWVNAVHWQPVfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDG 204
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 205 SMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 284
Cdd:COG2319   133 KTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 285 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKA 359
Cdd:COG2319   200 LTGHTGAVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGS 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 360 VFqgDIASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 434
Cdd:COG2319   249 VR--SVAFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 435 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnk 514
Cdd:COG2319   305 SGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG---- 370

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1026191061 515 itsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 547
Cdd:COG2319   371 ----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
446-673 2.02e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 2.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 446 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 525
Cdd:COG2319    59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 526 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 604
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1026191061 605 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 673
Cdd:COG2319   191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 47-88 3.03e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1026191061   47 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 88
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
125-547 1.76e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 125 TLETVLAGHENWVNAVHWQPVfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDG 204
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 205 SMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 284
Cdd:COG2319   133 KTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 285 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKA 359
Cdd:COG2319   200 LTGHTGAVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGS 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 360 VFqgDIASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 434
Cdd:COG2319   249 VR--SVAFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 435 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnk 514
Cdd:COG2319   305 SGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG---- 370

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1026191061 515 itsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 547
Cdd:COG2319   371 ----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-267 2.60e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 2.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061  16 LCLSFLPNTdvPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyiksts 95
Cdd:cd00200    97 SSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGT--FVASSSQDGTIKLW-------- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061  96 letqDDDNIRLKentftienesvkiafavtleTVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKTMILWapDEE 175
Cdd:cd00200   163 ----DLRTGKCV--------------------ATLTGHTGEVNSVAFSP----DGE-----KLLSSSSDGTIKLW--DLS 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 176 SGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFII 255
Cdd:cd00200   208 TGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVW-----DLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                         250
                  ....*....|..
gi 1026191061 256 TVGTDQTTRLFA 267
Cdd:cd00200   278 SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
446-673 2.02e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 2.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 446 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 525
Cdd:COG2319    59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 526 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 604
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1026191061 605 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 673
Cdd:COG2319   191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 519-547 9.43e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 9.43e-06
                           10        20
                   ....*....|....*....|....*....
gi 1026191061  519 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 547
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
519-547 1.36e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.36e-05
                          10        20
                  ....*....|....*....|....*....
gi 1026191061 519 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 547
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 47-88 3.03e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1026191061   47 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 88
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
48-87 3.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 3.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1026191061  48 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 87
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 519-674 4.39e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 519 HSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecD-STDDCIEHNIGPCSSVLDVggavtavsvcpVLHPSQRYVVAVGLEc 597
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DlETGELLRTLKGHTGPVRDV-----------AASADGTYLASGSSD- 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1026191061 598 GKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqkeaegaewlhFASCGEDHTVKIHRVNK 674
Cdd:cd00200    73 KTIRLWDLETGECVRTL------------TGHTSYVSSVAFSP-DGRI------------LSSSSRDKTIKVWDVET 124
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
125-547 1.76e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 125 TLETVLAGHENWVNAVHWQPVfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDG 204
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 205 SMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 284
Cdd:COG2319   133 KTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 285 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKA 359
Cdd:COG2319   200 LTGHTGAVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGS 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 360 VFqgDIASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 434
Cdd:COG2319   249 VR--SVAFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 435 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnk 514
Cdd:COG2319   305 SGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG---- 370

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1026191061 515 itsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 547
Cdd:COG2319   371 ----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-267 2.60e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 2.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061  16 LCLSFLPNTdvPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyiksts 95
Cdd:cd00200    97 SSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGT--FVASSSQDGTIKLW-------- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061  96 letqDDDNIRLKentftienesvkiafavtleTVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKTMILWapDEE 175
Cdd:cd00200   163 ----DLRTGKCV--------------------ATLTGHTGEVNSVAFSP----DGE-----KLLSSSSDGTIKLW--DLS 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 176 SGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFII 255
Cdd:cd00200   208 TGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVW-----DLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                         250
                  ....*....|..
gi 1026191061 256 TVGTDQTTRLFA 267
Cdd:cd00200   278 SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-492 7.82e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 7.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061  25 DVPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddni 104
Cdd:COG2319    89 DGRLLASASADGTVRLWDLATGLLLRTLT--GHTGAVRSVAFSPDGK--TLASGSADGTVRLW-------DLATG----- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 105 rlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEQVR 184
Cdd:COG2319   153 --------------------KLLRTLTGHSGAVTSVAFSP----DGK-----LLASGSDDGTVRLW--DLATGKLLRTLT 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 185 vgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTR 264
Cdd:COG2319   202 -----GHTGAVRSVAFSPDGKLLASGSADGTVRLW-----DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 265 LfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----QFVSGADEKVLRVFSAPrnfvenfcaiTGQslnhvlcn 339
Cdd:COG2319   272 L---WDLA-----TGELLRTLTGHSGGVNSVA----FspdgkLLASGSDDGTVRLWDLA----------TGK-------- 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 340 qdsdlpegatvpalglsnkavfqgdiasqpsdeeelltstgfeyqqvafqpsiltepptedhllqntlwpEVQKLYGHGY 419
Cdd:COG2319   322 ----------------------------------------------------------------------LLRTLTGHTG 331

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1026191061 420 EIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLW 492
Cdd:COG2319   332 AVRSVAFSPDGKTLASGS-----DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
2-318 1.28e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 1.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061   2 CLQTLNFGNGFALALclSFLPNTDvpILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQD 81
Cdd:COG2319   154 LLRTLTGHSGAVTSV--AFSPDGK--LLASGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPDGK--LLASGSAD 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061  82 CLIRIWklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSA 161
Cdd:COG2319   226 GTVRLW-------DLATG-------------------------KLLRTLTGHSGSVRSVAFSP----DG-----RLLASG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 162 SMDKTMILWAPDEESGVWLEQVRVGEVggntlgfYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDG 241
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHSGGV-------NSVAFSPDGKLLASGSDDGTVRLW-----DLATGKLLRTLTGHTGA 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 242 VQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----QFVSGADEKVLRVFS 316
Cdd:COG2319   333 VRSVAFSPDGKTLASGSDDGTVRL---WDLA-----TGELLRTLTGHTGAVTSVA----FspdgrTLASGSADGTVRLWD 400


                  ..
gi 1026191061 317 AP 318
Cdd:COG2319   401 LA 402
WD40 COG2319
WD40 repeat [General function prediction only];
17-317 9.03e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 9.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061  17 CLSFLPNTDvpILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSL 96
Cdd:COG2319   125 SVAFSPDGK--TLASGSADGTVRLWDLATGKLLRTLT--GHSGAVTSVAFSPDGK--LLASGSDDGTVRLW-------DL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061  97 ETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGvlqQpvRLLSASMDKTMILWapDEES 176
Cdd:COG2319   192 ATG-------------------------KLLRTLTGHTGAVRSVAFSP----DG---K--LLASGSADGTVRLW--DLAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 177 GVwleqvRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIIT 256
Cdd:COG2319   236 GK-----LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-----DLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1026191061 257 VGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----QFVSGADEKVLRVFSA 317
Cdd:COG2319   306 GSDDGTVRL---WDLA-----TGKLLRTLTGHTGAVRSVA----FspdgkTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-547 1.05e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 1.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061  56 GHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQDddnirlkentftienesvkiafavtLETVLAGHEN 135
Cdd:cd00200     7 GHTGGVTCVAFSPDGK--LLATGSGDGTIKVW-------DLETGE-------------------------LLRTLKGHTG 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 136 WVNAVHWQPVFYKdgvlqqpvrLLSASMDKTMILWapDEESGVwleqvRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGA 215
Cdd:cd00200    53 PVRDVAASADGTY---------LASGSSDKTIRLW--DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 216 LHLWKQNTVnprewTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapwkrkdqsqvtwheiarpqihgYDLKCL 295
Cdd:cd00200   117 IKVWDVETG-----KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL------------------------WDLRTG 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 296 aminrfqfvsgadeKVLRVFSAPRNFVeNFCAITGQSLNHVLCNQDSDlpegatvpalglsnkavfqgdiasqpsdeeel 375
Cdd:cd00200   168 --------------KCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDGT-------------------------------- 200

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 376 ltstgfeyqqvafqpsiltepptedhllqntlwpevqklyghgyeifcvtcnssktllasackaakkehaaIILWNTTSW 455
Cdd:cd00200   201 -----------------------------------------------------------------------IKLWDLSTG 209

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 456 KQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRT---WSLWKKqdtispefEPVFSLFAftnkitsvHSRIIWSCDWSPDS 532
Cdd:cd00200   210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTirvWDLRTG--------ECVQTLSG--------HTNSVTSLAWSPDG 273

                         490
                  ....*....|....*
gi 1026191061 533 KYFFTGSRDKKVVVW 547
Cdd:cd00200   274 KRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
410-669 1.41e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 1.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 410 EVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 489
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 490 SLWKKQDTispefEPVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLD 569
Cdd:COG2319   187 RLWDLATG-----KLLRTL--------TGHTGAVRSVAFSPDGKLLASGSADGTVRLW---DLAT-------GKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 570 V-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWkncS--GKTe 646
Cdd:COG2319   244 GhSGSVRSVAF----SPDGRLLASGSAD-GTVRLWDLATGELLRTL------------TGHSGGVNSVAF---SpdGKL- 302

                         250       260
                  ....*....|....*....|...
gi 1026191061 647 qkeaegaewlhFASCGEDHTVKI 669
Cdd:COG2319   303 -----------LASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
150-547 2.08e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 2.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 150 GVLQQPVRLLSASMDKTMILWAPDEESGVWLE--QVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTvnpr 227
Cdd:COG2319    34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAaaGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT---- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 228 eWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----Q 302
Cdd:COG2319   110 -GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL---WDLA-----TGKLLRTLTGHSGAVTSVA----FspdgkL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 303 FVSGADEKVLRVFSAPrnfvenfcaiTGQslnhvlcnqdsdlpegatvpalglsnkavfqgdiasqpsdeeelltstgfe 382
Cdd:COG2319   177 LASGSDDGTVRLWDLA----------TGK--------------------------------------------------- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 383 yqqvafqpsiltepptedhllqntlwpEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLV 462
Cdd:COG2319   196 ---------------------------LLRTLTGHTGAVRSVAFSPDGKLLASGS-----ADGTVRLWDLATGKLLRTLT 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 463 FHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFslfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDK 542
Cdd:COG2319   244 GHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLATGELLRTL----------TGHSGGVNSVAFSPDGKLLASGSDDG 310


                  ....*
gi 1026191061 543 KVVVW 547
Cdd:COG2319   311 TVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
407-669 2.38e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 2.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 407 LW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 481
Cdd:COG2319   146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 482 AVSRDRTWSLWkkqDTISPEfePVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 561
Cdd:COG2319   221 SGSADGTVRLW---DLATGK--LLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLAT------- 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 562 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWKN 640
Cdd:COG2319   278 GELLRTLTGhSGGVNSVAF----SPDGKLLASGSDD-GTVRLWDLATGKLLRTLTG------------HTGAVRSVAFSP 340

                         250       260
                  ....*....|....*....|....*....
gi 1026191061 641 cSGKTeqkeaegaewlhFASCGEDHTVKI 669
Cdd:COG2319   341 -DGKT------------LASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 410-669 1.62e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 1.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 410 EVQKLYGHGYEIFCVTCNSSKTLLASAckaakKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 489
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 490 SLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVLD 569
Cdd:cd00200   160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLR 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 570 V-GGAVTAVSVCPvlhpsQRYVVAVGLECGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqk 648
Cdd:cd00200   217 GhENGVNSVAFSP-----DGYLLASGSEDGTIRVWDLRTGECVQTL------------SGHTNSVTSLAWSP-DGKR--- 275

                         250       260
                  ....*....|....*....|.
gi 1026191061 649 eaegaewlhFASCGEDHTVKI 669
Cdd:cd00200   276 ---------LASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 410-669 2.62e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 2.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 410 EVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 489
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-----IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 490 SLWKKQDTispefEPVFSLFAFTNKitsvhsriIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVL- 568
Cdd:cd00200    76 RLWDLETG-----ECVRTLTGHTSY--------VSSVAFSPDGRILSSSSRDKTIKVW----------DVETGKCLTTLr 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 569 DVGGAVTAVSVcpvlHPSQRYVVAVGLECgkiCLYTWkktdqvpEINDWtHCVETsqSQSHTLAIRKLCWkncSGKTEqk 648
Cdd:cd00200   133 GHTDWVNSVAF----SPDGTFVASSSQDG---TIKLW-------DLRTG-KCVAT--LTGHTGEVNSVAF---SPDGE-- 190

                         250       260
                  ....*....|....*....|.
gi 1026191061 649 eaegaewlHFASCGEDHTVKI 669
Cdd:cd00200   191 --------KLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
402-673 6.40e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 6.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 402 LLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 481
Cdd:COG2319    62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 482 AVSRDRTWSLWkkqDTISPEFEPVFslfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 561
Cdd:COG2319   137 SGSADGTVRLW---DLATGKLLRTL----------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLAT------- 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 562 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkn 640
Cdd:COG2319   194 GKLLRTLTGhTGAVRSVAF----SPDGKLLASGSAD-GTVRLWDLATGKLLRTLTG------------HSGSVRSVAF-- 254

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1026191061 641 cS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 673
Cdd:COG2319   255 -SpdGRL------------LASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 234-567 1.27e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 234 VISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKDQSQVTwheiaRPQIH-GYDLKCLAMINRFQFVSGADEKVL 312
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKV---WDLETGELLR-----TLKGHtGPVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 313 RVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKAVFQGDIasqpSDEEELLTSTGFeyqqvafqpsi 392
Cdd:cd00200    76 RLW---------------------------DLETGECVRTLTGHTSYVSSVAF----SPDGRILSSSSR----------- 113

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 393 ltepptedhllQNTLW-------PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHS 465
Cdd:cd00200   114 -----------DKTIKvwdvetgKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT-----IKLWDLRTGKCVATLTGHT 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 466 LTVTQMAFSPNEKFLLAVSRDRTWSLWKKQdtispEFEPVFSLFAftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVV 545
Cdd:cd00200   178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-----TGKCLGTLRG--------HENGVNSVAFSPDGYLLASGSEDGTIR 244

                         330       340
                  ....*....|....*....|....*.
gi 1026191061 546 VW----GECDSTddCIEHNiGPCSSV 567
Cdd:cd00200   245 VWdlrtGECVQT--LSGHT-NSVTSL 267
WD40 COG2319
WD40 repeat [General function prediction only];
446-673 2.02e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 2.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 446 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 525
Cdd:COG2319    59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 526 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 604
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1026191061 605 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 673
Cdd:COG2319   191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 519-547 9.43e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 9.43e-06
                           10        20
                   ....*....|....*....|....*....
gi 1026191061  519 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 547
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
519-547 1.36e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.36e-05
                          10        20
                  ....*....|....*....|....*....
gi 1026191061 519 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 547
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-493 1.24e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1026191061  454 SWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWK 493
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 47-88 3.03e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1026191061   47 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 88
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
48-87 3.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 3.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1026191061  48 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 87
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 519-674 4.39e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026191061 519 HSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecD-STDDCIEHNIGPCSSVLDVggavtavsvcpVLHPSQRYVVAVGLEc 597
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DlETGELLRTLKGHTGPVRDV-----------AASADGTYLASGSSD- 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1026191061 598 GKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqkeaegaewlhFASCGEDHTVKIHRVNK 674
Cdd:cd00200    73 KTIRLWDLETGECVRTL------------TGHTSYVSSVAFSP-DGRI------------LSSSSRDKTIKVWDVET 124
WD40 pfam00400
WD domain, G-beta repeat;
455-492 7.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1026191061 455 WKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLW 492
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
229-266 8.32e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 8.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1026191061 229 WTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLF 266
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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