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Conserved domains on  [gi|1024249284|ref|NP_001311265|]
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leucine-rich repeat protein SHOC-2 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 1.30e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 1.30e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 114 ILPSSIKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886    87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 194 LTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 274 LDLPDtIGNLSSLSRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886   241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886   319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                         330
                  ....*....|....*
gi 1024249284 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886   399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 3.30e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 3.30e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886    58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886   132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                         170
                  ....*....|....
gi 1024249284 547 SIENCPLSHLPPQI 560
Cdd:COG4886   211 DLSGNQLTDLPEPL 224
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 1.30e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 1.30e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 114 ILPSSIKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886    87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 194 LTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 274 LDLPDtIGNLSSLSRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886   241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886   319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                         330
                  ....*....|....*
gi 1024249284 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886   399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 3.30e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 3.30e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886    58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886   132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                         170
                  ....*....|....
gi 1024249284 547 SIENCPLSHLPPQI 560
Cdd:COG4886   211 DLSGNQLTDLPEPL 224
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-483 1.73e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 105.32  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 115 LPSSIKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLTSlpdsldnlkklrmldlrhnklrEIPSVVYRLDS 193
Cdd:PLN00113  252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQN 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 194 LTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQH 270
Cdd:PLN00113  310 LEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFS 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 271 NELLD-LPDTIGNLSSLSRLGLRYNRLSA-IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFqlypV 348
Cdd:PLN00113  390 NSLEGeIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----F 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 349 GGPSQFS---TIYSLNMEHNRINK-IP--FGIFSRakvLSKLNMKDNQLTS-LPLDFGTWTSMVELNLATNQLT-KIPED 420
Cdd:PLN00113  466 GGLPDSFgskRLENLDLSRNQFSGaVPrkLGSLSE---LMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPAS 542

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1024249284 421 VSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113  543 FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGNIDL 607
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-528 3.09e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 3.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 360 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 439
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 440 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLTTLpRGIGHLTNLTHLGLGENLLTHLPE- 511
Cdd:cd21340    83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                         170
                  ....*....|....*....
gi 1024249284 512 --EIGTLENLEELYLNDNP 528
Cdd:cd21340   161 ldLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-562 1.52e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 1.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 353 QFSTIYSLNMEHNRIN-KIPFGIFSRAKVLSKLNMKDNQLTSlPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVL 430
Cdd:PLN00113   91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 431 ILSNN-LLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:PLN00113  170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLT 249

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1024249284 508 -HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Cdd:PLN00113  250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305
LRR_8 pfam13855
Leucine rich repeat;
123-181 5.38e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 5.38e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1024249284 123 TQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 383-528 4.08e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 4.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK----IPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLR-KLRE 452
Cdd:cd00116    62 ETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEK 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 453 LDLEENKL-----ESLPNEIAYLKDLQKLVLTNNQL-----TTLPRGIGHLTNLTHLGLGENLLTH-----LPEEIGTLE 517
Cdd:cd00116   142 LVLGRNRLegascEALAKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLK 221

                         170
                  ....*....|.
gi 1024249284 518 NLEELYLNDNP 528
Cdd:cd00116   222 SLEVLNLGDNN 232
LRR_8 pfam13855
Leucine rich repeat;
426-483 1.75e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.75e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 426 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 483
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 1.30e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 1.30e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 114 ILPSSIKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886    87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 194 LTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 274 LDLPDtIGNLSSLSRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886   241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886   319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                         330
                  ....*....|....*
gi 1024249284 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886   399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-498 6.73e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.05  E-value: 6.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284  81 TRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 161 LPDSLDNLKKLRMLDLRHNKLreipsvVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNL 240
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 241 ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
Cdd:COG4886   162 KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 321 TLPEslLSSLVKLNSLTLARNcfQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400
Cdd:COG4886   242 DLPE--LGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 401 WTsMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN 480
Cdd:COG4886   318 LL-LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396

                         410
                  ....*....|....*...
gi 1024249284 481 NQLTTLPRGIGHLTNLTH 498
Cdd:COG4886   397 TAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
144-539 7.69e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.88  E-value: 7.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 144 CLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 224 ENKIKQLPAEIGELCNLITLDVAHNqlehlpKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSL 303
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 304 AKCSAleelnlennnistlpesllsslvklnsltlarncfqlypvggpsqfstiyslnmehnrinkipfgifsrakvLSK 383
Cdd:COG4886   156 GNLTN------------------------------------------------------------------------LKS 163

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL 463
Cdd:COG4886   164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1024249284 464 PnEIAYLKDLQKLVLTNNQLTTLPrGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELAL 539
Cdd:COG4886   244 P-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
319-557 1.46e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.11  E-value: 1.46e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 319 ISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDF 398
Cdd:COG4886     7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 399 GTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVL 478
Cdd:COG4886    87 LGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1024249284 479 TNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIMSIENCPLSHLP 557
Cdd:COG4886   167 SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 3.30e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 3.30e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886    58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886   132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                         170
                  ....*....|....
gi 1024249284 547 SIENCPLSHLPPQI 560
Cdd:COG4886   211 DLSGNQLTDLPEPL 224
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-483 1.73e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 105.32  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 115 LPSSIKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLTSlpdsldnlkklrmldlrhnklrEIPSVVYRLDS 193
Cdd:PLN00113  252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQN 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 194 LTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQH 270
Cdd:PLN00113  310 LEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFS 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 271 NELLD-LPDTIGNLSSLSRLGLRYNRLSA-IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFqlypV 348
Cdd:PLN00113  390 NSLEGeIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----F 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 349 GGPSQFS---TIYSLNMEHNRINK-IP--FGIFSRakvLSKLNMKDNQLTS-LPLDFGTWTSMVELNLATNQLT-KIPED 420
Cdd:PLN00113  466 GGLPDSFgskRLENLDLSRNQFSGaVPrkLGSLSE---LMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPAS 542

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1024249284 421 VSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113  543 FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGNIDL 607
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-543 2.81e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 104.93  E-value: 2.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 101 NSMR---LDLSKRSIH-ILPSSIKELTQLTELYLYSNKLQ-SLPAEVGCLV-NLMTLALSENSLTSlPDSLDNLKKLRML 174
Cdd:PLN00113   67 NSSRvvsIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTG-SIPRGSIPNLETL 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 175 DLRHNKLR-EIPSVVYRLDSLTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENK-IKQLPAEIGELCNLITLDVAHNQLE 251
Cdd:PLN00113  146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLS 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 252 -HLPKEIGNCTQITNLDLQHNELL-DLPDTIGNLSSLSRLGLRYNRLSA-IPRSLAkcsaleelnlennnistlpeslls 328
Cdd:PLN00113  226 gEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIF------------------------ 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 329 SLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRIN-KIPFGIFSRAKvLSKLNMKDNQLT-SLPLDFGTWTSMVE 406
Cdd:PLN00113  282 SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPR-LQVLQLWSNKFSgEIPKNLGKHNNLTV 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 407 LNLATNQLT-KIPEDVSGLVSLEVLIL-SNNLLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113  361 LDLSTNNLTgEIPEGLCSSGNLFKLILfSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 484 T-------------------------TLPRGIGHlTNLTHLGLGENLLTH-LPEEIGTLENLEELYLNDNPNLHSLPFEL 537
Cdd:PLN00113  441 QgrinsrkwdmpslqmlslarnkffgGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDEL 519


                  ....*.
gi 1024249284 538 ALCSKL 543
Cdd:PLN00113  520 SSCKKL 525
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
78-326 4.07e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 94.76  E-value: 4.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284  78 APgTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKEltQLTELYLYSNKLQSLPAEVGClvNLMTLALSENS 157
Cdd:PRK15370  157 AP-AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQ 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 158 LTSLPDSLDNlkKLRMLDLRHNKLREIPSvvyRLDS-LTTLYLRFNRITTVEKDIKNlsKLSMLSIRENKIKQLPAE--- 233
Cdd:PRK15370  232 LTSIPATLPD--TIQEMELSINRITELPE---RLPSaLQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHlps 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 234 -IGEL---------------CNLITLDVAHNQLEHLPKEIGncTQITNLDLQHNELLDLPDTIGnlSSLSRLGLRYNRLS 297
Cdd:PRK15370  305 gITHLnvqsnsltalpetlpPGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALT 380

                         250       260
                  ....*....|....*....|....*....
gi 1024249284 298 AIPRSLAkcSALEELNLENNNISTLPESL 326
Cdd:PRK15370  381 NLPENLP--AALQIMQASRNNLVRLPESL 407
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
262-554 4.19e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 88.22  E-value: 4.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 262 QITNLDLQHNELLDLPDTI-GNLSSLSrlgLRYNRLSAIPrslakcsaleelnlennniSTLPESLlsslvklNSLTLAR 340
Cdd:PRK15370  200 QITTLILDNNELKSLPENLqGNIKTLY---ANSNQLTSIP-------------------ATLPDTI-------QEMELSI 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 341 NCFQLYPVGGPSqfsTIYSLNMEHNRINKIPFGIfsrAKVLSKLNMKDNQLTSLPLDFGTwtSMVELNLATNQLTKIPED 420
Cdd:PRK15370  251 NRITELPERLPS---ALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPET 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 421 VSglVSLEVLILSNNLLKKLPhglgnlrklreldleenklESLPNEiaylkdLQKLVLTNNQLTTLPRGIGhlTNLTHLG 500
Cdd:PRK15370  323 LP--PGLKTLEAGENALTSLP-------------------ASLPPE------LQVLDVSKNQITVLPETLP--PTITTLD 373

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1024249284 501 LGENLLTHLPEEI-GTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Cdd:PRK15370  374 VSRNALTNLPENLpAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-528 3.09e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 3.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 360 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 439
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 440 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLTTLpRGIGHLTNLTHLGLGENLLTHLPE- 511
Cdd:cd21340    83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                         170
                  ....*....|....*....
gi 1024249284 512 --EIGTLENLEELYLNDNP 528
Cdd:cd21340   161 ldLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-414 4.93e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.90  E-value: 4.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 115 LPSSIKELTQLTELYL-YSNKLQSLPAEVGCLVNLMTLALSENSLT-SLPDSLDNLKKLRMLDLRHNKLR-EIPSVVYRL 191
Cdd:PLN00113  228 IPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQL 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 192 DSLTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE------------------ 251
Cdd:PLN00113  308 QNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklil 387

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 252 -------HLPKEIGNCTQITNLDLQHN----------------------------------------ELLDL-------- 276
Cdd:PLN00113  388 fsnslegEIPKSLGACRSLRRVRLQDNsfsgelpseftklplvyfldisnnnlqgrinsrkwdmpslQMLSLarnkffgg 467

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 277 -PDTIGNlSSLSRLGLRYNRLS-AIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLnsltlarncfqlypvggpsqf 354
Cdd:PLN00113  468 lPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKL--------------------- 525

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1024249284 355 stiYSLNMEHNRIN-KIPFGiFSRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQL 414
Cdd:PLN00113  526 ---VSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-562 1.52e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 1.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 353 QFSTIYSLNMEHNRIN-KIPFGIFSRAKVLSKLNMKDNQLTSlPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVL 430
Cdd:PLN00113   91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 431 ILSNN-LLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:PLN00113  170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLT 249

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1024249284 508 -HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Cdd:PLN00113  250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-301 8.29e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.67  E-value: 8.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 122 LTQLTELYLYSNKLQSLPAEVGCLvNLMTLALSENSLTSLPDsLDNLKKLRMLDLRHNKLREIPSVVyRLDSLTTLYLRF 201
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 202 NRITTVEkDIKNLSKLSMLSI------RENKIKQLPAEIGELCN-LITLDVAHNQLEHLpKEIGNCTQITNLDLQHNELL 274
Cdd:cd21340    78 NRISVVE-GLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155

                         170       180       190
                  ....*....|....*....|....*....|
gi 1024249284 275 DLPD---TIGNLSSLSRLGLRYNRLSAIPR 301
Cdd:cd21340   156 DLEElldLLSSWPSLRELDLTGNPVCKKPK 185
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
73-460 1.18e-12

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 70.96  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284  73 KRPNPAPGTRKKssnAEVIKELNKCREENSMRLDLSKRSIHILPSSIKelTQLTELYLYSNKLQSLPAevgCLVNLMTLA 152
Cdd:PRK15387  177 RRAAPAEESRGR---AAVVQKMRACLNNGNAVLNVGESGLTTLPDCLP--AHITTLVIPDNNLTSLPA---LPPELRTLE 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 153 LSENSLTSLPDSLDNLKKLRMLDlrhNKLREIPSVVyrlDSLTTLYLRFNRITTVEKDIKNLSKLSmlsIRENKIKQLPA 232
Cdd:PRK15387  249 VSGNQLTSLPVLPPGLLELSIFS---NPLTHLPALP---SGLCKLWIFGNQLTSLPVLPPGLQELS---VSDNQLASLPA 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 233 EIGELCNLITLDvahNQLEHLPKeignctqitnldlqhnelldLPdtignlSSLSRLGLRYNRLSAIPrslakcsaleel 312
Cdd:PRK15387  320 LPSELCKLWAYN---NQLTSLPT--------------------LP------SGLQELSVSDNQLASLP------------ 358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 313 nlennnisTLPesllsslvklnsltlarncfqlypvggpsqfSTIYSLNMEHNRINKIPfgifSRAKVLSKLNMKDNQLT 392
Cdd:PRK15387  359 --------TLP-------------------------------SELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLT 395

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1024249284 393 SLPLdfgTWTSMVELNLATNQLTKIPEDVSGLVSLEVLilsNNLLKKLPHGLGNLRKLRELDLEENKL 460
Cdd:PRK15387  396 SLPV---LPSELKELMVSGNRLTSLPMLPSGLLSLSVY---RNQLTRLPESLIHLSSETTVNLEGNPL 457
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 322-554 1.18e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.95  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 322 LPESLLSSLVKLNSLTLARNCFQLYPVGGpsQFSTIYSLNMEHNRIN-KIP--FGIFSRAKVLsklNMKDNQLTS-LPLD 397
Cdd:PLN00113  109 IPDDIFTTSSSLRYLNLSNNNFTGSIPRG--SIPNLETLDLSNNMLSgEIPndIGSFSSLKVL---DLGGNVLVGkIPNS 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 398 FGTWTSMVELNLATNQLT-------------------------KIPEDVSGLVSLEVL-ILSNNLLKKLPHGLGNLRKLR 451
Cdd:PLN00113  184 LTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIPYEIGGLTSLNHLdLVYNNLTGPIPSSLGNLKNLQ 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 452 ELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT-HLPEEIGTLENLEELYLNDNP 528
Cdd:PLN00113  264 YLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNK 343

                         250       260
                  ....*....|....*....|....*.
gi 1024249284 529 NLHSLPFELALCSKLSIMSIENCPLS 554
Cdd:PLN00113  344 FSGEIPKNLGKHNNLTVLDLSTNNLT 369
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-560 4.22e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 4.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN 458
Cdd:COG4886     4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 459 KLESLPNEIAYLKDLQKLVLTNNQlttlprGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELA 538
Cdd:COG4886    84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN-QLTDLPEPLG 156

                         170       180
                  ....*....|....*....|..
gi 1024249284 539 LCSKLSIMSIENCPLSHLPPQI 560
Cdd:COG4886   157 NLTNLKSLDLSNNQLTDLPEEL 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
215-522 4.37e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 65.95  E-value: 4.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 215 SKLSMLSIRENKIKQLPAEIGELcnlITLDVAHNQLEHLPKEIGNctqITNLDLQHNELLDLPDTIGNLSSLSRLGLRYN 294
Cdd:PRK15387  222 AHITTLVIPDNNLTSLPALPPEL---RTLEVSGNQLTSLPVLPPG---LLELSIFSNPLTHLPALPSGLCKLWIFGNQLT 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 295 RLSAIPRSLAKCSaleelnlennnistLPESLLSSLVKLnsltlarncfqlypvggPSQFSTIYSLNMEHNRINKIPFGi 374
Cdd:PRK15387  296 SLPVLPPGLQELS--------------VSDNQLASLPAL-----------------PSELCKLWAYNNQLTSLPTLPSG- 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 375 fsrakvLSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPEDVSGLvslEVLILSNNLLKKLPHGLGnlrKLRELD 454
Cdd:PRK15387  344 ------LQELSVSDNQLASLPT---LPSELYKLWAYNNRLTSLPALPSGL---KELIVSGNRLTSLPVLPS---ELKELM 408

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1024249284 455 LEENKLESLPneiAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLpeeigTLENLEEL 522
Cdd:PRK15387  409 VSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSER-----TLQALREI 468
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
105-296 1.25e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.33  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 105 LDLSKRSIHILPSSIKelTQLTELYLYSNKLQSLPAEVGclVNLMTLALSENSLTSLPDSLDnlKKLRMLDLRHNKLREI 184
Cdd:PRK15370  288 LSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVL 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 185 PSVVyrLDSLTTLYLRFNRITTVEKDIKnlSKLSMLSIRENKIKQLPaeigelcnlitldvahnqlEHLPKEIGNCTQIT 264
Cdd:PRK15370  362 PETL--PPTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLP-------------------ESLPHFRGEGPQPT 418

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1024249284 265 NLDLQHNELLDlpDTIGNLSSL-SRLGLRYNRL 296
Cdd:PRK15370  419 RIIVEYNPFSE--RTIQNMQRLmSSVGYQGPRV 449
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
243-528 4.02e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 62.87  E-value: 4.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 243 LDVAHNQLEHLPkeigNC--TQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSaleELNLENNNIS 320
Cdd:PRK15387  206 LNVGESGLTTLP----DClpAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELS---IFSNPLTHLP 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 321 TLPESLLSSLVKLNSLTLarncfqlYPVGGPSqfstIYSLNMEHNRINKIPfgifSRAKVLSKLNMKDNQLTSLPLdfgT 400
Cdd:PRK15387  279 ALPSGLCKLWIFGNQLTS-------LPVLPPG----LQELSVSDNQLASLP----ALPSELCKLWAYNNQLTSLPT---L 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLgnlrklRELDLEENKLESLPneiAYLKDLQKLVLTN 480
Cdd:PRK15387  341 PSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGL------KELIVSGNRLTSLP---VLPSELKELMVSG 411

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1024249284 481 NQLTTLPRgigHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
Cdd:PRK15387  412 NRLTSLPM---LPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNP 456
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
381-557 4.05e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.41  E-value: 4.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 381 LSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPEDVSGLVSLevLILSNNL--LKKLPHGlgnlrkLRELDLEEN 458
Cdd:PRK15387  244 LRTLEVSGNQLTSLPV---LPPGLLELSIFSNPLTHLPALPSGLCKL--WIFGNQLtsLPVLPPG------LQELSVSDN 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 459 KLESLPneiAYLKDLQKLVLTNNQLTTLPRgigHLTNLTHLGLGENLLTHLPeeigTL-ENLEELYLNDNpNLHSLPfel 537
Cdd:PRK15387  313 QLASLP---ALPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLP----TLpSELYKLWAYNN-RLTSLP--- 378

                         170       180
                  ....*....|....*....|
gi 1024249284 538 ALCSKLSIMSIENCPLSHLP 557
Cdd:PRK15387  379 ALPSGLKELIVSGNRLTSLP 398
LRR_8 pfam13855
Leucine rich repeat;
123-181 5.38e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 5.38e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1024249284 123 TQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
147-204 2.27e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.27e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 147 NLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVV-YRLDSLTTLYLRFNRI 204
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 383-528 4.08e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 4.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK----IPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLR-KLRE 452
Cdd:cd00116    62 ETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEK 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 453 LDLEENKL-----ESLPNEIAYLKDLQKLVLTNNQL-----TTLPRGIGHLTNLTHLGLGENLLTH-----LPEEIGTLE 517
Cdd:cd00116   142 LVLGRNRLegascEALAKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLK 221

                         170
                  ....*....|.
gi 1024249284 518 NLEELYLNDNP 528
Cdd:cd00116   222 SLEVLNLGDNN 232
PLN03150 PLN03150
hypothetical protein; Provisional
 229-303 9.00e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 9.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1024249284 229 QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQHNELL-DLPDTIGNLSSLSRLGLRYNRLSA-IPRSL 303
Cdd:PLN03150  433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPAAL 510
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 115-289 9.54e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 52.18  E-value: 9.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284  115 LPSSIKELTQLTELYL-YSNKLQSLPAEV-----------GCL---------VNLMTLALSENSLTSLPDS--LDNLKKL 171
Cdd:PLN03210   673 LPSSIQYLNKLEDLDMsRCENLEILPTGInlkslyrlnlsGCSrlksfpdisTNISWLDLDETAIEEFPSNlrLENLDEL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284  172 RMLDLRHNKLRE-----IPSVVYRLDSLTTLYLRFN-RITTVEKDIKNLSKLSMLSIRENK-IKQLPAEIgELCNLITLD 244
Cdd:PLN03210   753 ILCEMKSEKLWErvqplTPLMTMLSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCInLETLPTGI-NLESLESLD 831

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1024249284  245 VAH-NQLEHLPkEIGncTQITNLDLQHNELLDLPDTIGNLSSLSRL 289
Cdd:PLN03210   832 LSGcSRLRTFP-DIS--TNISDLNLSRTGIEEVPWWIEKFSNLSFL 874
LRR_8 pfam13855
Leucine rich repeat;
426-483 1.75e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.75e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 426 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 483
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 377-560 3.39e-06

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 50.26  E-value: 3.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284  377 RAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL-ATNQLTKIPeDVSGLVSLEVLILSN-NLLKKLPHGLGNLRKLRELD 454
Cdd:PLN03210   609 RPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIP-DLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLD 687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284  455 LEE-NKLESLPNEI-------------AYLK-------DLQKLVLTNNQLTTLPRGIgHLTNLTHLGLGENLLTHLPEEI 513
Cdd:PLN03210   688 MSRcENLEILPTGInlkslyrlnlsgcSRLKsfpdistNISWLDLDETAIEEFPSNL-RLENLDELILCEMKSEKLWERV 766

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1024249284  514 GTL--------ENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCP-LSHLPPQI 560
Cdd:PLN03210   767 QPLtplmtmlsPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCInLETLPTGI 822
LRR_8 pfam13855
Leucine rich repeat;
473-528 1.37e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1024249284 473 LQKLVLTNNQLTTLPRGI-GHLTNLTHLGLGENLLTHL-PEEIGTLENLEELYLNDNP 528
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
402-460 1.54e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.54e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1024249284 402 TSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLKKL-PHGLGNLRKLRELDLEENKL 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 214-458 1.63e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 214 LSKLSMLSIRENKIKQLPaEIGELCNLITLDVAHNQLEHLPKeIGNCTQITNLDLQHNELLDLPDtIGNLSSLSRLGLRY 293
Cdd:cd21340     1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 294 NRLSAIprslakcsaleelnlennnistlpeSLLSSLVKLNSLTLARncfQLYPVGGPSQFStiyslnmehnrinkiPFG 373
Cdd:cd21340    78 NRISVV-------------------------EGLENLTNLEELHIEN---QRLPPGEKLTFD---------------PRS 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 374 IFSRAKVLSKLNMKDNQLTSLpldfgtwtsmvelnlatnqltkipEDVSGLVSLEVLILSNNLL---KKLPHGLGNLRKL 450
Cdd:cd21340   115 LAALSNSLRVLNISGNNIDSL------------------------EPLAPLRNLEQLDASNNQIsdlEELLDLLSSWPSL 170


                  ....*...
gi 1024249284 451 RELDLEEN 458
Cdd:cd21340   171 RELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 417-491 1.65e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.65e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1024249284 417 IPEDVSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIG 491
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 453-527 1.89e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 1.89e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1024249284 453 LDLEENKLES-LPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT-HLPEEIGTLENLEELYLNDN 527
Cdd:PLN03150  423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
448-506 2.70e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1024249284 448 RKLRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTL-PRGIGHLTNLTHLGLGENLL 506
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 115-188 6.59e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 6.59e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1024249284 115 LPSSIKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLT-SLPDSLDNLKKLRMLDLRHNKLR-EIPSVV 188
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 260-507 7.52e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 7.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 260 CTQITNLD---LQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSaleelnlennnistlpeSLLSSLVKLNSL 336
Cdd:cd00116    24 CLQVLRLEgntLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLL-----------------QGLTKGCGLQEL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 337 TLARNCFQLYPVGGPSQFSTIYSL---NMEHNRINKIPF-----GIFSRAKVLSKLNMKDNQLTS-----LPLDFGTWTS 403
Cdd:cd00116    87 DLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLrllakGLKDLPPALEKLVLGRNRLEGasceaLAKALRANRD 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 404 MVELNLATNQL-----TKIPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLRKLRELDLEENKLESLPneIAYLKD- 472
Cdd:cd00116   167 LKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAG--AAALASa 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1024249284 473 -------LQKLVLTNNQLT-----TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:cd00116   245 llspnisLLTLSLSCNDITddgakDLAEVLAEKESLLELDLRGNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
193-250 1.06e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 193 SLTTLYLRFNRITTVEKDI-KNLSKLSMLSIRENKIKQL-PAEIGELCNLITLDVAHNQL 250
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 376-445 2.20e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 2.20e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1024249284 376 SRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVLILSNNLLK-KLPHGLG 445
Cdd:PLN03150  439 SKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
170-227 5.69e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 5.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 170 KLRMLDLRHNKLREI-PSVVYRLDSLTTLYLRFNRITTVEKD-IKNLSKLSMLSIRENKI 227
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
111-224 9.47e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 9.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024249284 111 SIHILPSSIKELT--------------QLTELYLYSNKLQSLPAEVGCLVNLMtlaLSENSLTSLPDSLDNLKKLRMLDL 176
Cdd:PRK15387  336 SLPTLPSGLQELSvsdnqlaslptlpsELYKLWAYNNRLTSLPALPSGLKELI---VSGNRLTSLPVLPSELKELMVSGN 412

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1024249284 177 RHNKLREIPS-----VVYR--LDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
Cdd:PRK15387  413 RLTSLPMLPSgllslSVYRnqLTRLPESLIHLSSETTVNLEGNPLSERTLQALRE 467
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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