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Conserved domains on  [gi|1450319434|ref|NP_001310847|]
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jmjC domain-containing protein 8 isoform 2 precursor [Homo sapiens]

Protein Classification

cupin domain-containing protein( domain architecture ID 1562428)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cupin_8 super family cl46322
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 54-240 2.19e-08

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


The actual alignment was detected with superfamily member pfam13621:

Pssm-ID: 463936  Cd Length: 251  Bit Score: 53.53  E-value: 2.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450319434  54 AEFVQQYAFV-RPVILQGLTDN----SRFRALCSRDRLLASFGDRVVRLS-TANTY-------------SYHKVDLPFQE 114
Cdd:pfam13621   2 AEFFREYVAKnKPVVIRGAVKDwpavQKWTDSSLLDYLKDKYGDVEVTVEvTPDGRadrlfynddftfvNPKEERMPFGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450319434 115 YVEQLlhpQDPTSLGNDTLYFFGDNNFTEWASLFRHYSPPPF--GLLGTAP-AYSFGIAGAGSGVPFHW-HGPGYSEVIY 190
Cdd:pfam13621  82 FLDRL---EAGEDTDTAPYAYLQSDNLRSEFPELLEDNDLPFatEAFGGEPdAVNLWMGNGRSVTSLHYdHYENLYCVVR 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1450319434 191 GRKRWFLYPPEKTP-------EFHPNKTTLAWL------RDTYPALPPSARPLECTIRAGAVL 240
Cdd:pfam13621 159 GRKRFTLFPPSDVPnlypgplEPTPEGQVFSLVdplapdFERFPRFRDAARPLVVTLNPGDVL 221
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 54-240 2.19e-08

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 53.53  E-value: 2.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450319434  54 AEFVQQYAFV-RPVILQGLTDN----SRFRALCSRDRLLASFGDRVVRLS-TANTY-------------SYHKVDLPFQE 114
Cdd:pfam13621   2 AEFFREYVAKnKPVVIRGAVKDwpavQKWTDSSLLDYLKDKYGDVEVTVEvTPDGRadrlfynddftfvNPKEERMPFGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450319434 115 YVEQLlhpQDPTSLGNDTLYFFGDNNFTEWASLFRHYSPPPF--GLLGTAP-AYSFGIAGAGSGVPFHW-HGPGYSEVIY 190
Cdd:pfam13621  82 FLDRL---EAGEDTDTAPYAYLQSDNLRSEFPELLEDNDLPFatEAFGGEPdAVNLWMGNGRSVTSLHYdHYENLYCVVR 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1450319434 191 GRKRWFLYPPEKTP-------EFHPNKTTLAWL------RDTYPALPPSARPLECTIRAGAVL 240
Cdd:pfam13621 159 GRKRFTLFPPSDVPnlypgplEPTPEGQVFSLVdplapdFERFPRFRDAARPLVVTLNPGDVL 221
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 54-240 2.19e-08

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 53.53  E-value: 2.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450319434  54 AEFVQQYAFV-RPVILQGLTDN----SRFRALCSRDRLLASFGDRVVRLS-TANTY-------------SYHKVDLPFQE 114
Cdd:pfam13621   2 AEFFREYVAKnKPVVIRGAVKDwpavQKWTDSSLLDYLKDKYGDVEVTVEvTPDGRadrlfynddftfvNPKEERMPFGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450319434 115 YVEQLlhpQDPTSLGNDTLYFFGDNNFTEWASLFRHYSPPPF--GLLGTAP-AYSFGIAGAGSGVPFHW-HGPGYSEVIY 190
Cdd:pfam13621  82 FLDRL---EAGEDTDTAPYAYLQSDNLRSEFPELLEDNDLPFatEAFGGEPdAVNLWMGNGRSVTSLHYdHYENLYCVVR 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1450319434 191 GRKRWFLYPPEKTP-------EFHPNKTTLAWL------RDTYPALPPSARPLECTIRAGAVL 240
Cdd:pfam13621 159 GRKRFTLFPPSDVPnlypgplEPTPEGQVFSLVdplapdFERFPRFRDAARPLVVTLNPGDVL 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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