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Conserved domains on  [gi|1020738751|ref|NP_001310294|]
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type 2 lactosamine alpha-2,3-sialyltransferase isoform 1 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 5.08e-151

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467712  Cd Length: 206  Bit Score: 422.62  E-value: 5.08e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 114 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 193
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 194 LRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHE 273
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738751 274 VHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 319
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 5.08e-151

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 422.62  E-value: 5.08e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 114 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 193
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 194 LRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHE 273
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738751 274 VHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 319
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 63-324 4.07e-71

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 221.33  E-value: 4.07e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751  63 FLCAADFRKIASLYGSdKFDLPYgmRTSAEYFRLALSKLqscdlfdEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVI 142
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPF--TVTEELLELLPKVS-------PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 143 IRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHN-------DPNTTVILTAFKPHDLRWLLELLMGDKINT----NGF 211
Cdd:pfam00777  71 IRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNlgfshprDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 212 WKKPALNLiyKPYQIRILDPFIIRTAAYELLHFPKVfpknqKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLH 291
Cdd:pfam00777 151 LKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHH 223

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1020738751 292 YYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNL 324
Cdd:pfam00777 224 YYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 5.08e-151

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 422.62  E-value: 5.08e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 114 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 193
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 194 LRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHE 273
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738751 274 VHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 319
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 114-319 6.54e-116

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 333.49  E-value: 6.54e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 114 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 193
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 194 LRWLLELLMGDKINTN-GFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFpkNQKPKHPTTGIIAITLAFYICH 272
Cdd:cd23967    81 LLWLQAVIKGKKPNGKgGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG--KQGKNVPTTGIIAIVMALHYCD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1020738751 273 EVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 319
Cdd:cd23967   159 EVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 114-317 8.07e-82

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 246.88  E-value: 8.07e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 114 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDP-IHNDPNTTVILTAFKPH 192
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgIENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 193 DLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKvfpKNQKPKHPTTGIIAITLAFYICH 272
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPG---QRKKKQKPTTGLLAITLALHLCD 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738751 273 EVHLAGFKY-NFSDLKSPLHYYGNATMSLMnKNAYHNVTAEQLFLK 317
Cdd:cd23982   158 EVHIAGFGYpDNGNSNQPIHYYNQITLKSM-ANSGHNLNAEAQAIQ 202
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 63-324 4.07e-71

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 221.33  E-value: 4.07e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751  63 FLCAADFRKIASLYGSdKFDLPYgmRTSAEYFRLALSKLqscdlfdEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVI 142
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPF--TVTEELLELLPKVS-------PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 143 IRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHN-------DPNTTVILTAFKPHDLRWLLELLMGDKINT----NGF 211
Cdd:pfam00777  71 IRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNlgfshprDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 212 WKKPALNLiyKPYQIRILDPFIIRTAAYELLHFPKVfpknqKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLH 291
Cdd:pfam00777 151 LKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHH 223

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1020738751 292 YYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNL 324
Cdd:pfam00777 224 YYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 114-317 2.07e-67

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 210.37  E-value: 2.07e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 114 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 193
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 194 LRWLLELLMGDKI---NTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKvfPKN----QKPKHPTTGIIAITL 266
Cdd:cd23983    81 FAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPE--PQSrlwgWDKNVPTLGVTAVVL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1020738751 267 AFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLK 317
Cdd:cd23983   159 ATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLK 209
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 115-319 1.95e-61

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 194.76  E-value: 1.95e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 115 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDL 194
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 195 RWLLELLMGDKIN-TNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHE 273
Cdd:cd23981    82 KWLKYIVYKEKVSaSDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738751 274 VHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 319
Cdd:cd23981   162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 118-319 4.04e-37

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 131.72  E-value: 4.04e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 118 CVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV---------FSDPIHNDPNTTVILTA 188
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAgfylrgprcGCHPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 189 FKPHDLRWLLELlmgdkintngFWKKPALNLIYKPYQIRILDPFIirtAAYELLHFPKVFPKNqkpkHPTTGIIAITLAF 268
Cdd:cd19952    81 AAAADFKRLKRR----------KKRHDNAVLLLTDPAPDLLSYVR---KRLEKLGLKSFFGGN----APSSGLLAVLLAL 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1020738751 269 YICHEVHLAGF-KYNFSDLKSPLHYYGNATMSLMNKnaYHNVTAEQLFLKDI 319
Cdd:cd19952   144 QLCDSVDLYGFgVDSGHAPKVPYHYYDLVEAEEGTA--VHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 114-312 1.60e-33

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 125.06  E-value: 1.60e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 114 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVF-SDPIH--NDPNTTVILTAFK 190
Cdd:cd23964    81 RCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHnSLLKHvpQDKDTKYLFIPFK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 191 PHDLRWLLELLMGDKINT---NGFWKKPALNLIYKPYQIRILDPFIIRtaayellHFPKVFPKNQKPKHPTTGIIAITLA 267
Cdd:cd23964   161 IRDYDYLDAVLSGKPVPDgcdKGKRPPPLFGPKLNATNVRLLHPDFIR-------YLFNRWLNSSTSYRPTTGALMLLTA 233

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1020738751 268 FYICHEVHLAGFKYnfsDLKSPLHYYGNATMSLMNKNAYHNVTAE 312
Cdd:cd23964   234 LHTCDQVSVYGFGY---DPRFSLHYYDKTFVKFTVFYANHDFTNE 275
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 105-322 6.13e-31

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 117.77  E-value: 6.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 105 DLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVfsdpIHNDPNTTV 184
Cdd:cd23966    67 NPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA----VDLDPGVHL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 185 ILTAFKPHDLRWLLELLmgdkinTNGfwkkpalNLIYKPYQIRildPFI--IRTAAyELLH--FPKVFPKNQKPKH---P 257
Cdd:cd23966   143 VLVPFKVLDLQWLISAL------TTG-------EITRTYTPVK---RFIkaDKDKV-LVINpaFIKYVHDNWTEHHgryP 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1020738751 258 TTGIIAITLAFYICHEVHLAGF---KYNFSDlksplHYY-GNATMSLMNKNAYHNVTAEQlflkDIIEK 322
Cdd:cd23966   206 STGFLALIFALHICDEVSVFGFgadSKGNWH-----HYWeKNRSAGAFRKTGVHDADFES----DIIKK 265
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 92-318 2.30e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 102.72  E-value: 2.30e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751  92 EYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV 171
Cdd:cd23963    40 KTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSIL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 172 FSdpIHNDPNTTVILTAFKpHDLRWLLE-LLMGDKintngFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVF-- 248
Cdd:cd23963   120 KR--RYNSLKKNRDRDKFL-NRLKEYNGsILWYPK-----FSFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQkf 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1020738751 249 -PKNQKPKHPTTGIIAITLAFYICHEVHLAGFkYNFS-DLKS---PLHYYGNATMSLMNKNayHNVTAEQLFLKD 318
Cdd:cd23963   192 wKRRGLEKRPSTGLYLVSLALTFCDEIHLYGF-WPFPtDPNGrpvPYHYYDDLSPSTKNKV--HNMPEEFKLLRE 263
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 105-311 3.25e-25

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 102.27  E-value: 3.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 105 DLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSdpihNDPNTTV 184
Cdd:cd23980    71 DPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRE----LAQNVSM 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 185 ILTAFKPHDLRWLLELLMGDKINTNgFWKKPALNLIYKPyQIRILDPFIIRTaayellhfpkVFPK--NQKPKHPTTGII 262
Cdd:cd23980   147 ILVPFKTLDLEWVISATTTGTISHT-YVPVPRKIKVKKE-KILIYHPAFIKY----------VFDRwlQGHGRYPSTGIL 214

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1020738751 263 AITLAFYICHEVHLAGFKynfSDLKSPLHYY--GNATMSLMNKNAYH------NVTA 311
Cdd:cd23980   215 SVIFSLHVCDEVDLYGFG---ADSKGNWHHYweNNPSAGAFRKTGVHdgdfesNVTT 268
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 64-319 3.43e-25

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 101.96  E-value: 3.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751  64 LCAadFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLfdefdnipcKKCVVVGNGGVLKNKTLGEKIDSYDVII 143
Cdd:cd23968     5 LCR--LKKAAPFSTLRKTTSPFKDLLSLRYPFPESSLENTKRY---------NTCAVVSSSGALLGSKLGKEIDSHDAVL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 144 RMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNttviltafkphDLRWLLELLMGDKINTNG----FWKKPALNL 219
Cdd:cd23968    74 RFNDAPTKGFEKDVGSKTTLRLINSQILSKPEFNFLTD-----------PLYRNVTLLVWDPSSYNVnlekWYKKPDFDF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 220 I--YKPYQIR-------ILDP-FIIRtaAYELLHfpKVFPKNQKPKHPTTGIIAITLAFYICHEVHLagfkYNF--SDLK 287
Cdd:cd23968   143 FpnYIKYRRRhpeepfyLIDPrFLWR--LWDILQ--EYTPEKIKPNPPSSGFIGIVLMLHLCDWVDV----YEYvpSVRQ 214

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1020738751 288 SPL-HYYGNATMSLMNKNAYHNVTAEQLFLKDI 319
Cdd:cd23968   215 TDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 107-293 5.36e-21

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 90.70  E-value: 5.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 107 FDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPihndPNTTVIL 186
Cdd:cd23979    72 YRSWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLP----ANVSFVL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 187 TAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIrildpfiirtaaYELLHFPKVFPK--NQKPKHPTTGIIAI 264
Cdd:cd23979   148 VPFKTLDLLWITSALSTGQIRFTYAPVKQFLRVDKDKVQI------------YNPAFFKYIHDRwtEHHGRYPSTGMLVL 215

                         170       180
                  ....*....|....*....|....*....
gi 1020738751 265 TLAFYICHEVHLAGFKynfSDLKSPLHYY 293
Cdd:cd23979   216 FFALHVCDEVNVYGFG---ADSRGNWHHY 241
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 115-294 1.10e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 83.45  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 115 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLF-YP--ESVFSDPIHNDPN----TTVILt 187
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVsHSslPRLLRNAILLLAGtrapTVVVF- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 188 afkphdlrWLLEllmgDKINTNGFWKKPALNLIYKPYqiRILDPFIIRTAAYEllHFPKVFpKNQ--KPKHPT-----TG 260
Cdd:cd23965    80 --------WGPE----TKMNKDGAGKYNLLRSLSKKY--PDVEFYSLTPEKMD--YADELF-EKEtgKSRIKSgtwlsTG 142

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1020738751 261 IIAITLAFYICHEVHLAGF---KY--NFSDLKSPLHYYG 294
Cdd:cd23965   143 WFTMLLALDVCDEIKVYGMvpeNYcrEHPNSKVPYHYYE 181
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 116-319 2.34e-18

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 83.35  E-value: 2.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 116 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPEsVFSDPIHNDPNTT----VILTAFKP 191
Cdd:cd23986    50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ-ILTNPNHHFIDSSlykdVILVAWDP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 192 HDLrwllellmgdKINTNGFWKKPALNLI--YKPYQIRILD-PFIIRTAAYeLLHFPKVFPKNQK----PKHPTTGIIAI 264
Cdd:cd23986   129 APY----------SANLHKWYKKPDYNLFtpYVQYRKRNPNqPFYILHPKF-IWQLWDIIQENTQekiqPNPPSSGFIGI 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1020738751 265 TLAFYICHEVHLagFKYNFSDLKSPL-HYYGNATMSLMNKNAYHNVTAEQLFLKDI 319
Cdd:cd23986   198 LIMMSMCREVHV--YEYIPSVRQTDLcHYHERYYDAACTLGAYHPLLYEKLLIQRM 251
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 110-317 9.86e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 81.67  E-value: 9.86e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 110 FDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPeSVFsDPIHNDPNTTVILTAF 189
Cdd:cd23970    63 FQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-SIL-EKYYNNLLTIQDRNNF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 190 KpHDLRWLlellmGDKIntngFWkKPALNLIYKPYQIRILDPFIIrtaayELLHFPKV---FP-------------KNQK 253
Cdd:cd23970   141 F-LSLKKL-----DGAI----LW-IPAFFFHTSATVTRTLVDFFV-----EHRGQLKVqlaWPgnimqhvnrywktKHLS 204

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1020738751 254 PKHPTTGIIAITLAFYICHEVHLAGFkYNFSDLKS----PLHYYGN-ATMSLMNKNAYHNVTAEQLFLK 317
Cdd:cd23970   205 PKRLSTGILMYTLASAICEEIHLYGF-WPFGFDPTgtplPYHYYDKkGTKFTTKWQESHQLPAEFVLLY 272
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 115-293 4.79e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 80.18  E-value: 4.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 115 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSD------------PIHNDpnT 182
Cdd:cd23973    83 CIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSlmilqkrgfkniPQDKD--I 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 183 TVILTAFKPHDLRWLLELLMGDKINTNGFWK---KPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTT 259
Cdd:cd23973   161 KYILFPEGPRDYQWLEALLKNKTIPSGAYYGrrpRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTT 240

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1020738751 260 GIIAITLAFYICHEVHLAGFKYNfSDLKSPLHYY 293
Cdd:cd23973   241 GAFLLLTALHLCDTVSAYGFITE-DYRKYPDHYY 273
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 116-303 5.18e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 79.77  E-value: 5.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 116 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFypesvfsdpihndpNTTVILTAFK----P 191
Cdd:cd23969    65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTM--------------NPSVIPHAYGdlvnA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 192 HDLRWLLELL--MGDKIntngFWkKPALNLIYKPYQIRILDPFI------IRTA--AYELLHFPKVFPKNQK--PKHPTT 259
Cdd:cd23969   131 TDKEKFVERLrqLGDSI----LW-IPAFVSKGGEEHVQWTNEIIlkhklnVKTAypPLRLNHAIRGYWLTTKfrIKRPST 205

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1020738751 260 GIIAITLAFYICHEVHLAGFkYNFS-DLK-SPL--HYYGNATMSLMNK 303
Cdd:cd23969   206 GLLMYTLATRFCDEIHLYGF-YPFSeDGNgRAVkyHYYDNRKYLTTAR 252
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 114-330 1.34e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 78.21  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 114 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLF------YPESVF-SDPIHNDPnttvIL 186
Cdd:cd23985    44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLInsqlvtTEKHKFlKDSLYNEG----IL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 187 TAFKP---HDlrwllellmgdkiNTNGFWKKPALNlIYKPYQ-IRILDPfiirTAAYELLHfPKV-----------FPKN 251
Cdd:cd23985   120 IVWDPapyHS-------------DIPEWYKNPDYN-FFENYKtYRRLNP----NQPFYILH-PQMqwelwdiiqenSPEE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 252 QKPKHPTTGIIAITLAFYICHEVHLagfkYNF--SDLKSPL-HYYGNATMSLMNKNAYHNVtaeqLFlkdiiEKNLVINL 328
Cdd:cd23985   181 IQPNPPSSGMLGIILMMTLCDQVDV----YEFlpSKRKTDVcHYYQKFFDRACTMGAYHPL----LY-----EKNLVKHL 247


                  ..
gi 1020738751 329 TQ 330
Cdd:cd23985   248 NQ 249
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 110-295 7.83e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 70.36  E-value: 7.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 110 FDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPvLGHEEEVGRRTTF-------------RLFYPESVFSDPI 176
Cdd:cd23971    59 FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNLvtanpsilrekfhNLKKRRRPFVERM 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 177 HNDPNTTVILTAFKPHdlrwllellmgdkINTngfwkKPALNLIYkpyqirILDPFIIRTAAYeLLHfPK------VFPK 250
Cdd:cd23971   138 KVYGNALLLLPAFSYT-------------SNT-----EPSLRALY------TLEDFGSPQKVL-FFN-PEylrnlsRYWK 191

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1020738751 251 NQ--KPKHPTTGIIAITLAFYICHEVHLAGFkYNFS-DLKS---PLHYYGN 295
Cdd:cd23971   192 SKglKARRLSTGLMLVSAALELCENVHLYGF-WPFStDLDGnpiSHHYYDN 241
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 106-300 1.45e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 70.17  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 106 LFDEFD----NIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVF-------SD 174
Cdd:cd23974    71 MFDWWDrpngRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMnslrayaGV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 175 PIHNDPNTTVILTAFKP-HDLRWLL-----ELLMGDKINTNGfwKKPAL----NLiyKPYQIRILDPFIIRTAAYELLHF 244
Cdd:cd23974   151 GFNGPPQSKETRYIFLPdHDRDYLLvkaalTHTPIDRGRDKS--KRPSKyfgkDV--TAEKFKIYHPDFIRYLRNRFLWS 226

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1020738751 245 PKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGF------KYN---FSDLKSPLHYYGNATMSL 300
Cdd:cd23974   227 PILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpdygKYSdhyYDKTYHKVVFYANHDLRL 291
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 116-319 1.86e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 66.50  E-value: 1.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 116 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPesvfsdpihndpntTVILTAFKphDL- 194
Cdd:cd23987    65 KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP--------------SVVQRAFE--DLv 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 195 --RWLLELLMG-DKINTNGFWkKPALNLIYKPYQIRILDPFII------RTA--AYELLHFPKVFPKNQKP--KHPTTGI 261
Cdd:cd23987   129 neTWKEKFLQRlQSLNGSILW-IPAFMAKGGEERVEWVNDLILkhhinvRTAypSLRLLHAVRGYWLTNKVhiKRPTTGL 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020738751 262 IAITLAFYICHEVHLAGF-KYNFSDLKSPL--HYYGNATMSLMNKNAYHNVTAEQLFLKDI 319
Cdd:cd23987   208 LMYTLATRFCNRIHLYGFwPFPRDQNQNPVkyHYYDSLKYGYTSQASPHTMPLEFKALKNL 268
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 116-295 1.73e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 63.70  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 116 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLG-HEEEVGRRTTFRLFYPESV-------------FSDPIHNDPN 181
Cdd:cd23990    65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPSIIterfhklekwrrpFYEVLQVYEN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 182 TTVILTAFkpHDLRwllellmgdkiNTN-GFWKKPALNLIYKPYQIRILDP-FIIRTAAYELLhfpkvfpKNQKPKHPTT 259
Cdd:cd23990   145 ASVVLPAF--YNTR-----------NTDvSIRVKYVLDDFESQQAVYYFHPqYLLNVSRFWLR-------QGVRAKRISS 204

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1020738751 260 GIIAITLAFYICHEVHLAG---FKYNFSDLKSPLHYYGN 295
Cdd:cd23990   205 GLMLVTAALELCEEVHLYGfwaFPMNPSGIFITHHYYDN 243
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 116-314 3.96e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 62.66  E-value: 3.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 116 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYP------------ESVFSDPIH-----N 178
Cdd:cd23988    65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPsvvqrafggfrnESDREKFVHrlsmlN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 179 DpnTTVILTAF-----KPHdLRWLLELLMGDKINTNGFWkkPALNLIYKpyqIRildpfiirtaAYELlhfpkvfpKNQK 253
Cdd:cd23988   145 D--SVLWIPAFmvkggEKH-VEWVNALILKNKLKVRTAY--PSLRLIHA---VR----------GYWL--------TNKV 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 254 P-KHPTTGIIAITLAFYICHEVHLAGF------------KYN-FSDLKspLHYYGNAT---MSLMNK--NAYHNVTAEQL 314
Cdd:cd23988   199 NiKRPSTGLLMYTLATRFCDEIHLYGFwpfpkdangnpvKYHyYDDLK--YRYFSNAGphrMPLEFKtlNVLHNRGALKL 276
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 115-293 4.25e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 61.79  E-value: 4.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 115 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVF------SDPIHNDPNTTVIlta 188
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYrvlrrpQEFLNRTPETTLI--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 189 fkphdlrwllellmgdkintngFW------KKPALNLIYKPYQ-----IRILDPFIIrtAAYELLHFPKVFP----KNQK 253
Cdd:cd23978    78 ----------------------FWgppnkmQKDGKSNLFRIIQrasmtFPNMSAFVV--SPRRMRQFDDLFRgetgRDRK 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1020738751 254 PKHP--TTGIIAITLAFYICHEVHLAGF-KYNF-----SDLKSPLHYY 293
Cdd:cd23978   134 KSHSwlSTGWFTMVIAVELCDNVHVYGMvPPNYcskrpTPKKMPYHYY 181
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 84-300 4.34e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 62.92  E-value: 4.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751  84 PYGMR-TSAEYFRLALSKL---QSCDLFDEFDNIP-CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVG 158
Cdd:cd23972    46 PYGWKgLSHQVVASTLSLLndsANAKLFFPRDTPGkCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 159 RRTTFRLFYPESVFSDPI-------HNDPNTTVILTAFKPHDLR---WLLELLMGDKInTNGFWK--KPA--LNLIYKPY 224
Cdd:cd23972   126 TKTSFYGFTVNTMKNSLIsywnlgfTRTPQGQDLQYIFIPSDIRdyvMLRSAILGVPV-PEGLDKgdRPHkyFGPEASAK 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 225 QIRILDPFIIRtaaYELLHFPKVFPKNQKPKH---PTTGIIAITLAFYICHEVHLAGF---KYN-FSD-----LKSPLHY 292
Cdd:cd23972   205 KFKLLHPDFIS---YLTDRFLKSKLLNTHYGHlymPSTGALMLLTALHTCDQVSAYGFitsNYWkFSDhyyerKKKPLVF 281


                  ....*...
gi 1020738751 293 YGNATMSL 300
Cdd:cd23972   282 YANHDMLL 289
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 115-293 4.43e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 61.87  E-value: 4.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 115 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV---FSDPIH--NDPNTTVILTAF 189
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVpllLKNPDYffKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 190 KPHDLRwllelLMGDKINTNgFWKKPALNliYKPYQIRIldpfiirTAAYELLHFPKVFPKN------QKPKHPTTGIIA 263
Cdd:cd23975    81 PFRNMR-----KDGKGIVYN-MLKKAVES--YPQAKIYV-------TTEKRMSYCDTVFKKEtgkdrvQSGSYLSTGWFT 145

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1020738751 264 ITLAFYICHEVHLAGF---KYNFSD--LKSPLHYY 293
Cdd:cd23975   146 LILAMDACYGIHVYGMindTYCKTEgyRKVPYHYY 180
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 115-171 3.65e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 59.10  E-value: 3.65e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1020738751 115 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV 171
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSV 57
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 113-316 6.28e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 52.91  E-value: 6.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 113 IPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVL-GHEEEVGRRTTFRLFYPeSVFSDPIHN-DPNTTVILTAFK 190
Cdd:cd23989    61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQLVTANP-SIIDKRFQNlLWSRKSFVESMK 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738751 191 PHDLRWLLELLMGDKINTN-GFWKKPALNLIYKPYQIRILDPFIIRTAAyellhfpkVFPKNQ--KPKHPTTGIIAITLA 267
Cdd:cd23989   140 VYGRSYIYMPAFSMKTGTDpSLRVYYTLADVGANQTVLFANPNFLRNVG--------KFWKSKgvHAKRLSTGLFLVSAA 211

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1020738751 268 FYICHEVHLAGFkYNFS-DL-KSPL--HYYGNatmsLMNKNAYHNVTAEQLFL 316
Cdd:cd23989   212 LGLCEEVTIYGF-WPFSvDLdERTIshHYYDN----VLPDSGFHAMPEEFLQL 259
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 110-161 1.81e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 51.68  E-value: 1.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1020738751 110 FDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHE-EEVGRRT 161
Cdd:cd23991    59 FRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNIsKDVGSKT 111
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 115-171 1.33e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 48.71  E-value: 1.33e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1020738751 115 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV 171
Cdd:cd23976    15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSI 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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