kelch-like protein 32 isoform n [Homo sapiens]
kelch-like protein 32( domain architecture ID 20003498)
kelch-like protein 32 (KLHL32) may be ssociated with Tourette syndrome and obsessive-compulsive disorder in humans
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
BACK_KLHL32_BKLHD5 | cd18471 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ... |
75-172 | 5.63e-65 | |||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry. : Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 206.68 E-value: 5.63e-65
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BTB_POZ super family | cl38908 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ... |
5-82 | 3.90e-51 | |||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain. The actual alignment was detected with superfamily member cd18261: Pssm-ID: 453885 [Multi-domain] Cd Length: 133 Bit Score: 171.69 E-value: 3.90e-51
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NanM | COG3055 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
260-531 | 2.36e-39 | |||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; : Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 144.91 E-value: 2.36e-39
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Kelch | smart00612 | Kelch domain; |
227-282 | 1.15e-05 | |||||
Kelch domain; : Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 42.55 E-value: 1.15e-05
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Name | Accession | Description | Interval | E-value | ||||||||
BACK_KLHL32_BKLHD5 | cd18471 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ... |
75-172 | 5.63e-65 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry. Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 206.68 E-value: 5.63e-65
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BTB_POZ_KLHL32 | cd18261 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-82 | 3.90e-51 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 171.69 E-value: 3.90e-51
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NanM | COG3055 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
260-531 | 2.36e-39 | ||||||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 144.91 E-value: 2.36e-39
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PHA03098 | PHA03098 | kelch-like protein; Provisional |
29-526 | 2.74e-32 | ||||||||
kelch-like protein; Provisional Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 130.66 E-value: 2.74e-32
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BACK | smart00875 | BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ... |
80-180 | 8.41e-25 | ||||||||
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 98.57 E-value: 8.41e-25
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BACK | pfam07707 | BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ... |
81-180 | 2.52e-19 | ||||||||
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation). Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 82.98 E-value: 2.52e-19
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Kelch_6 | pfam13964 | Kelch motif; |
272-324 | 7.05e-07 | ||||||||
Kelch motif; Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 46.17 E-value: 7.05e-07
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Kelch | smart00612 | Kelch domain; |
227-282 | 1.15e-05 | ||||||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 42.55 E-value: 1.15e-05
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BTB | pfam00651 | BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ... |
5-73 | 1.38e-04 | ||||||||
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN. Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 41.47 E-value: 1.38e-04
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Kelch | smart00612 | Kelch domain; |
431-483 | 1.45e-04 | ||||||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 39.46 E-value: 1.45e-04
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BTB | smart00225 | Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ... |
4-75 | 1.80e-04 | ||||||||
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures. Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 40.75 E-value: 1.80e-04
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Name | Accession | Description | Interval | E-value | ||||||||
BACK_KLHL32_BKLHD5 | cd18471 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ... |
75-172 | 5.63e-65 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry. Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 206.68 E-value: 5.63e-65
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BTB_POZ_KLHL32 | cd18261 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-82 | 3.90e-51 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 171.69 E-value: 3.90e-51
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NanM | COG3055 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
260-531 | 2.36e-39 | ||||||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 144.91 E-value: 2.36e-39
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PHA03098 | PHA03098 | kelch-like protein; Provisional |
29-526 | 2.74e-32 | ||||||||
kelch-like protein; Provisional Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 130.66 E-value: 2.74e-32
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NanM | COG3055 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
225-437 | 1.99e-26 | ||||||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 108.70 E-value: 1.99e-26
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BACK | smart00875 | BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ... |
80-180 | 8.41e-25 | ||||||||
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 98.57 E-value: 8.41e-25
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BACK | pfam07707 | BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ... |
81-180 | 2.52e-19 | ||||||||
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation). Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 82.98 E-value: 2.52e-19
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NanM | COG3055 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
223-404 | 1.31e-16 | ||||||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 80.20 E-value: 1.31e-16
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BTB_POZ_KLHL26 | cd18255 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-76 | 2.55e-14 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 69.35 E-value: 2.55e-14
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BACK_KBTBD3 | cd18480 | BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ... |
75-154 | 8.14e-12 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear. Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 61.19 E-value: 8.14e-12
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BACK_KLHL12 | cd18452 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ... |
75-204 | 3.03e-11 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 61.26 E-value: 3.03e-11
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BACK_KLHL3 | cd18513 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ... |
75-204 | 3.13e-11 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 60.85 E-value: 3.13e-11
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BACK_KLHL9_13 | cd18449 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ... |
79-169 | 2.62e-10 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 57.43 E-value: 2.62e-10
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BACK_KLHL34 | cd18473 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ... |
86-177 | 1.17e-09 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy. Pssm-ID: 350548 Cd Length: 106 Bit Score: 55.90 E-value: 1.17e-09
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BACK_KLHL2_like | cd18445 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ... |
79-172 | 1.18e-09 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 56.09 E-value: 1.18e-09
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BTB_POZ_ZBTB_KLHL-like | cd18186 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
4-57 | 1.32e-09 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 54.87 E-value: 1.32e-09
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BTB_POZ_KLHL9_13 | cd18239 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
4-75 | 1.46e-09 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 55.97 E-value: 1.46e-09
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BACK_KLHL2_Mayven | cd18512 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ... |
75-204 | 3.68e-09 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 55.04 E-value: 3.68e-09
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BACK_KLHL7 | cd18447 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ... |
74-171 | 9.83e-09 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa. Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 52.75 E-value: 9.83e-09
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BACK_KLHL18 | cd18457 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ... |
75-172 | 1.52e-08 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 52.70 E-value: 1.52e-08
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BACK_KLHL6 | cd18446 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ... |
75-173 | 2.06e-08 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 52.47 E-value: 2.06e-08
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BACK | cd14733 | BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ... |
79-132 | 2.32e-08 | ||||||||
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates. Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 50.35 E-value: 2.32e-08
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BACK_KLHL22 | cd18461 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ... |
79-173 | 1.32e-07 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Pssm-ID: 350536 Cd Length: 104 Bit Score: 49.76 E-value: 1.32e-07
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BTB_POZ_KLHL18 | cd18247 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-73 | 1.34e-07 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 50.36 E-value: 1.34e-07
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BTB_POZ_KLHL7 | cd18237 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-81 | 1.43e-07 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 50.56 E-value: 1.43e-07
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BTB_POZ_KLHL36 | cd18266 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
4-87 | 2.19e-07 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 50.28 E-value: 2.19e-07
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BACK_KEL_like | cd18508 | BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ... |
79-154 | 2.81e-07 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 48.17 E-value: 2.81e-07
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BACK_KLHL26 | cd18465 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ... |
81-172 | 2.88e-07 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats. Pssm-ID: 350540 Cd Length: 97 Bit Score: 48.75 E-value: 2.88e-07
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BACK_KLHL33 | cd18472 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ... |
75-151 | 3.60e-07 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk. Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 47.77 E-value: 3.60e-07
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BTB_POZ_KLHL34 | cd18264 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-75 | 5.56e-07 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 49.02 E-value: 5.56e-07
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PLN02193 | PLN02193 | nitrile-specifier protein |
384-492 | 5.68e-07 | ||||||||
nitrile-specifier protein Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 52.27 E-value: 5.68e-07
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Kelch_6 | pfam13964 | Kelch motif; |
272-324 | 7.05e-07 | ||||||||
Kelch motif; Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 46.17 E-value: 7.05e-07
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BACK_KLHL21 | cd18460 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ... |
79-168 | 1.06e-06 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 47.10 E-value: 1.06e-06
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PLN02153 | PLN02153 | epithiospecifier protein |
269-492 | 1.16e-06 | ||||||||
epithiospecifier protein Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 50.76 E-value: 1.16e-06
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BACK_KLHL5 | cd18511 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ... |
74-172 | 1.39e-06 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus. Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 46.98 E-value: 1.39e-06
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Kelch_1 | pfam01344 | Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ... |
419-465 | 3.89e-06 | ||||||||
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415. Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 43.75 E-value: 3.89e-06
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BTB_POZ_KLHL12_C3IP1_DKIR | cd18242 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-79 | 5.17e-06 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 45.90 E-value: 5.17e-06
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BACK_calicin | cd18503 | BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ... |
75-154 | 5.30e-06 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 44.65 E-value: 5.30e-06
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BACK_KBTBD2 | cd18479 | BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ... |
75-168 | 7.13e-06 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 44.66 E-value: 7.13e-06
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BACK_KLHL19_KEAP1 | cd18458 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ... |
95-164 | 7.21e-06 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 44.59 E-value: 7.21e-06
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BTB_POZ_KLHL31_KBTBD1 | cd18260 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
17-82 | 1.06e-05 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 44.80 E-value: 1.06e-05
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BTB_POZ_KLHL1-like | cd18234 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-81 | 1.12e-05 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 44.28 E-value: 1.12e-05
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Kelch | smart00612 | Kelch domain; |
227-282 | 1.15e-05 | ||||||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 42.55 E-value: 1.15e-05
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Kelch_1 | pfam01344 | Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ... |
324-367 | 1.68e-05 | ||||||||
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415. Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 42.21 E-value: 1.68e-05
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BTB_POZ_KLHL4 | cd18336 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-81 | 1.79e-05 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 44.27 E-value: 1.79e-05
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BTB_POZ_KLHL27_IPP | cd18256 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
4-79 | 2.13e-05 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 43.93 E-value: 2.13e-05
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BACK_KLHL10 | cd18450 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ... |
75-154 | 2.61e-05 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 42.60 E-value: 2.61e-05
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BTB_POZ_KLHL17_actinfilin | cd18246 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-76 | 2.81e-05 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 44.25 E-value: 2.81e-05
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BACK_KLHL16_gigaxonin | cd18455 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ... |
87-154 | 2.99e-05 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 43.07 E-value: 2.99e-05
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BACK_BTBD9 | cd14822 | BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ... |
75-177 | 3.26e-05 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 42.99 E-value: 3.26e-05
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Kelch_1 | pfam01344 | Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ... |
272-321 | 3.34e-05 | ||||||||
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415. Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 41.44 E-value: 3.34e-05
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BTB_POZ_KLHL21 | cd18250 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-79 | 3.62e-05 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 43.60 E-value: 3.62e-05
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BACK_KLHL4 | cd18510 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ... |
74-172 | 4.25e-05 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 42.98 E-value: 4.25e-05
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BACK_KLHL8 | cd18448 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ... |
79-169 | 5.26e-05 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN. Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 42.29 E-value: 5.26e-05
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BTB_POZ_KBTBD6_7 | cd18273 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
4-85 | 6.62e-05 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 43.27 E-value: 6.62e-05
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BACK_KLHL20 | cd18459 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ... |
116-172 | 8.75e-05 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 41.65 E-value: 8.75e-05
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BACK_KLHL38 | cd18476 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ... |
75-168 | 9.04e-05 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation. Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 41.65 E-value: 9.04e-05
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BTB_POZ_KLHL8 | cd18238 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-56 | 9.89e-05 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 41.89 E-value: 9.89e-05
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PHA02713 | PHA02713 | hypothetical protein; Provisional |
316-459 | 1.15e-04 | ||||||||
hypothetical protein; Provisional Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 45.00 E-value: 1.15e-04
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BTB | pfam00651 | BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ... |
5-73 | 1.38e-04 | ||||||||
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN. Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 41.47 E-value: 1.38e-04
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BACK_KLHL15 | cd18454 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ... |
79-172 | 1.42e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Pssm-ID: 350529 Cd Length: 108 Bit Score: 41.42 E-value: 1.42e-04
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Kelch | smart00612 | Kelch domain; |
431-483 | 1.45e-04 | ||||||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 39.46 E-value: 1.45e-04
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BACK_KLHL17 | cd18456 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ... |
75-175 | 1.49e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function. Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 41.14 E-value: 1.49e-04
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PRK14131 | PRK14131 | N-acetylneuraminate epimerase; |
425-492 | 1.67e-04 | ||||||||
N-acetylneuraminate epimerase; Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 44.24 E-value: 1.67e-04
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BTB | smart00225 | Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ... |
4-75 | 1.80e-04 | ||||||||
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures. Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 40.75 E-value: 1.80e-04
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BTB_POZ_KLHL38 | cd18268 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-83 | 1.82e-04 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 41.69 E-value: 1.82e-04
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BACK_KLHL29_KBTBD9 | cd18468 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ... |
79-169 | 2.01e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers. Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 40.86 E-value: 2.01e-04
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Kelch | smart00612 | Kelch domain; |
336-367 | 2.21e-04 | ||||||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 39.08 E-value: 2.21e-04
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BTB_POZ_KBTBD8 | cd18274 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-79 | 2.54e-04 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 41.13 E-value: 2.54e-04
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BTB_POZ_KLHL30 | cd18259 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-81 | 3.05e-04 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 40.97 E-value: 3.05e-04
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BACK_KLHL35 | cd18474 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ... |
79-153 | 3.10e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm. Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 39.41 E-value: 3.10e-04
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BACK_KBTBD6_7 | cd18482 | BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ... |
81-169 | 3.24e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 40.18 E-value: 3.24e-04
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BACK_ABTB1_BPOZ | cd18497 | BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ... |
75-113 | 3.73e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. Pssm-ID: 350572 Cd Length: 72 Bit Score: 39.07 E-value: 3.73e-04
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BACK_KLHL1 | cd18509 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ... |
75-172 | 3.88e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 40.00 E-value: 3.88e-04
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BACK_KLHL11 | cd18451 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ... |
75-154 | 4.26e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 39.56 E-value: 4.26e-04
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BTB_POZ_KLHL1 | cd18335 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-83 | 4.36e-04 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 40.41 E-value: 4.36e-04
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BACK_KLHL31_KBTBD1 | cd18470 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ... |
86-170 | 4.56e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). Pssm-ID: 350545 Cd Length: 98 Bit Score: 39.47 E-value: 4.56e-04
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BACK_KLHL37_ENC1 | cd18515 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ... |
113-172 | 5.60e-04 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 39.57 E-value: 5.60e-04
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BTB2_POZ_RhoBTB | cd18300 | second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ... |
5-75 | 7.67e-04 | ||||||||
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 39.14 E-value: 7.67e-04
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BTB_POZ_KLHL42 | cd18319 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-56 | 8.94e-04 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349628 [Multi-domain] Cd Length: 93 Bit Score: 38.70 E-value: 8.94e-04
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Kelch | smart00612 | Kelch domain; |
383-429 | 9.97e-04 | ||||||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 37.15 E-value: 9.97e-04
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BTB_POZ_KLHL28_BTBD5 | cd18257 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
4-76 | 1.06e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 39.06 E-value: 1.06e-03
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BTB_POZ_KLHL16_gigaxonin | cd18245 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
3-71 | 1.08e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 38.86 E-value: 1.08e-03
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BTB_POZ_KLHL15 | cd18244 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
6-75 | 1.15e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 39.55 E-value: 1.15e-03
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BACK_BTBD17 | cd18493 | BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ... |
84-151 | 1.43e-03 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression. Pssm-ID: 350568 Cd Length: 74 Bit Score: 37.56 E-value: 1.43e-03
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BACK_KBTBD12 | cd18485 | BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ... |
102-174 | 1.82e-03 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear. Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 37.78 E-value: 1.82e-03
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BTB_POZ | cd01165 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ... |
4-56 | 2.08e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain. Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 37.26 E-value: 2.08e-03
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Kelch | smart00612 | Kelch domain; |
284-327 | 2.64e-03 | ||||||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 36.00 E-value: 2.64e-03
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BTB_POZ_KLHL19_KEAP1 | cd18248 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-75 | 2.71e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 38.13 E-value: 2.71e-03
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Kelch_3 | pfam13415 | Galactose oxidase, central domain; |
381-428 | 3.83e-03 | ||||||||
Galactose oxidase, central domain; Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 35.73 E-value: 3.83e-03
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BACK_KLHL1_like | cd18444 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ... |
79-172 | 4.81e-03 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 36.93 E-value: 4.81e-03
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BACK_KLHL40_KBTBD5 | cd18516 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ... |
79-172 | 4.95e-03 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 36.66 E-value: 4.95e-03
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BTB_POZ_trishanku-like | cd18314 | BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ... |
5-56 | 5.09e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 36.55 E-value: 5.09e-03
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BTB_POZ_KBTBD2_BKLHD1 | cd18270 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-79 | 5.11e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 37.29 E-value: 5.11e-03
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BTB_POZ_ZBTB44 | cd18228 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
19-71 | 6.20e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 37.15 E-value: 6.20e-03
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Kelch_4 | pfam13418 | Galactose oxidase, central domain; |
419-464 | 6.24e-03 | ||||||||
Galactose oxidase, central domain; Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 34.90 E-value: 6.24e-03
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BACK_NS1BP_IVNS1ABP | cd18502 | BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ... |
75-166 | 6.27e-03 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. Pssm-ID: 350577 Cd Length: 99 Bit Score: 36.44 E-value: 6.27e-03
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BTB_POZ_ZBTB47_ZNF651 | cd18231 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
18-56 | 6.47e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 36.82 E-value: 6.47e-03
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BACK_KLHL42_KLHDC5 | cd18478 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ... |
79-131 | 6.66e-03 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis. Pssm-ID: 350553 Cd Length: 103 Bit Score: 36.29 E-value: 6.66e-03
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Kelch_6 | pfam13964 | Kelch motif; |
420-465 | 6.88e-03 | ||||||||
Kelch motif; Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 35.00 E-value: 6.88e-03
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Kelch_6 | pfam13964 | Kelch motif; |
379-420 | 7.44e-03 | ||||||||
Kelch motif; Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 34.62 E-value: 7.44e-03
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BACK_KLHL36 | cd18475 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ... |
79-172 | 7.75e-03 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Pssm-ID: 350550 Cd Length: 100 Bit Score: 36.36 E-value: 7.75e-03
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BACK_KLHL28_BTBD5 | cd18467 | BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ... |
75-172 | 8.17e-03 | ||||||||
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear. Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 36.08 E-value: 8.17e-03
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BTB_POZ_KLHL20_KLEIP | cd18249 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
5-81 | 8.34e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 36.66 E-value: 8.34e-03
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BTB_POZ_KLHL37_ENC1 | cd18267 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ... |
4-83 | 9.75e-03 | ||||||||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 36.89 E-value: 9.75e-03
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