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Conserved domains on  [gi|1019366746|ref|NP_001310189|]
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kelch-like protein 32 isoform l [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 20871882)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
SCOP:  3000448

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
101-372 3.74e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 143.76  E-value: 3.74e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 101 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 179
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 180 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 256
Cdd:COG3055    76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 257 MLQRRVYHSMAAV-QRKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCNfNLLTGQNESGVAVHNGRIYLVGGYSIW 335
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1019366746 336 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 372
Cdd:COG3055   219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
Kelch smart00612
Kelch domain;
68-123 1.90e-05

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 1.90e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1019366746   68 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 123
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
101-372 3.74e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 143.76  E-value: 3.74e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 101 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 179
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 180 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 256
Cdd:COG3055    76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 257 MLQRRVYHSMAAV-QRKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCNfNLLTGQNESGVAVHNGRIYLVGGYSIW 335
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1019366746 336 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 372
Cdd:COG3055   219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
PHA03098 PHA03098
kelch-like protein; Provisional
66-304 2.12e-23

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 101.77  E-value: 2.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746  66 DTLYIIGGKKREVCKVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEvehasGRTCAVRTA 145
Cdd:PHA03098  295 NVIYFIGGMNKNNLSVNSVVSYDTKTKS---------WNKVPELIYPRKNPGVTVFNNRIYVIGGI-----YNSISLNTV 360
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 146 CRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLL 225
Cdd:PHA03098  361 ESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKI 440
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 226 WISGGVTNTAQYQ--NRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDrilvrHIDSYNIDTDQW 303
Cdd:PHA03098  441 YVIGGISYIDNIKvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYIN-----EIEVYDDKTNTW 515

                  .
gi 1019366746 304 T 304
Cdd:PHA03098  516 T 516
Kelch_6 pfam13964
Kelch motif;
113-165 1.17e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.02  E-value: 1.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1019366746 113 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 165
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
68-123 1.90e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 1.90e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1019366746   68 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 123
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
272-324 2.40e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.31  E-value: 2.40e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1019366746  272 KLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCNfNLLTGQNESGVAVHNG 324
Cdd:smart00612   1 KIYVVGG----FDGGQRL-KSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
101-372 3.74e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 143.76  E-value: 3.74e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 101 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 179
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 180 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 256
Cdd:COG3055    76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 257 MLQRRVYHSMAAV-QRKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCNfNLLTGQNESGVAVHNGRIYLVGGYSIW 335
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1019366746 336 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 372
Cdd:COG3055   219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
66-278 8.29e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 107.93  E-value: 8.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746  66 DTLYIIGGkkrevckvkeLRYFNPVDQENALIAAIANWSELAPMP-VGRSHHCVAVMGDFLFVAGGEVEHASGRTcAVRT 144
Cdd:COG3055    23 GKVYVAGG----------LSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTGANPSST-PLND 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 145 ACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVlPTVERYCPKKNKWTFVQSFDRSLSCHAGYVA-DG 223
Cdd:COG3055    92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNV-AWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDG 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 224 LLWISGGVTNTAQYQ---------------------NRLMV-------------YEPNQNKWISRSPMLQRRVYHSMAAV 269
Cdd:COG3055   171 KILVIGGRNGSGFSNtwttlaplptaraghaaavlgGKILVfggesgfsdeveaYDPATNTWTALGELPTPRHGHAAVLT 250

                  ....*....
gi 1019366746 270 QRKLYVLGG 278
Cdd:COG3055   251 DGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
66-304 2.12e-23

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 101.77  E-value: 2.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746  66 DTLYIIGGKKREVCKVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEvehasGRTCAVRTA 145
Cdd:PHA03098  295 NVIYFIGGMNKNNLSVNSVVSYDTKTKS---------WNKVPELIYPRKNPGVTVFNNRIYVIGGI-----YNSISLNTV 360
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 146 CRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLL 225
Cdd:PHA03098  361 ESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKI 440
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 226 WISGGVTNTAQYQ--NRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDrilvrHIDSYNIDTDQW 303
Cdd:PHA03098  441 YVIGGISYIDNIKvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYIN-----EIEVYDDKTNTW 515

                  .
gi 1019366746 304 T 304
Cdd:PHA03098  516 T 516
PHA03098 PHA03098
kelch-like protein; Provisional
117-367 6.79e-22

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 97.53  E-value: 6.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 117 CVAVMGDFLFVAGGEVEhasgRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRnELRQVLPTVERY 196
Cdd:PHA03098  289 GSVVLNNVIYFIGGMNK----NNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI-YNSISLNTVESW 363
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 197 CPKKNKWTFVQS--FDRSLSCHAGYvaDGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLY 274
Cdd:PHA03098  364 KPGESKWREEPPliFPRYNPCVVNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIY 441
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 275 VLGGndLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNgRIYLVGGYSI--WTNEplacIQVLDVsrEG 352
Cdd:PHA03098  442 VIGG--ISYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNN-KIYVVGGDKYeyYINE----IEVYDD--KT 512
                         250
                  ....*....|....*
gi 1019366746 353 KEEVFYGPTLPFASN 367
Cdd:PHA03098  513 NTWTLFCKFPKVIGS 527
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
64-245 1.17e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.43  E-value: 1.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746  64 QSDTLYIIGGKKREVCKVKELR---YFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHAsgrtc 140
Cdd:COG3055    69 QDGKLYVFGGFTGANPSSTPLNdvyVYDPATNT---------WTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG----- 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 141 AVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEE-YLYAVGGRNE---------------------------------- 185
Cdd:COG3055   135 NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGGRNGsgfsntwttlaplptaraghaaavlggkilvfgg 214
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 186 LRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYE 245
Cdd:COG3055   215 ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTSAE 274
PLN02193 PLN02193
nitrile-specifier protein
225-333 3.19e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 52.27  E-value: 3.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 225 LWISGGVTNTAQYqNRLMVYEPNQNKWISRSPMLQ---RRVYHSMAAVQRKLYVLGGndldyNNDRILVRHIDSYNIDTD 301
Cdd:PLN02193  231 LYVFGGRDASRQY-NGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGG-----VSATARLKTLDSYNIVDK 304
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1019366746 302 QWTRCN--FNLLTGQNESGVAVHNGRIYLVGGYS 333
Cdd:PLN02193  305 KWFHCStpGDSFSIRGGAGLEVVQGKVWVVYGFN 338
PLN02153 PLN02153
epithiospecifier protein
110-333 6.81e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 50.76  E-value: 6.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 110 PVGRSHHCVAVMGDFLFVAGGEV---EHASgrtcavRTACRYDPRSNSWAEIAPMKNCREHFVLG----AMEEYLYAVGG 182
Cdd:PLN02153   20 PGPRCSHGIAVVGDKLYSFGGELkpnEHID------KDLYVFDFNTHTWSIAPANGDVPRISCLGvrmvAVGTKLYIFGG 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 183 RNELRQvLPTVERYCPKKNKWTFVQSFDrslschagyvadgllwISGGvtntaqyqnrlmvyePnqnkwisrspmlQRRV 262
Cdd:PLN02153   94 RDEKRE-FSDFYSYDTVKNEWTFLTKLD----------------EEGG---------------P------------EART 129
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1019366746 263 YHSMAAVQRKLYVLGG---NDLDYNNDRIlvRHIDSYNIDTDQWTRC-----NFNLLTGqneSGVAVHNGRIYLVGGYS 333
Cdd:PLN02153  130 FHSMASDENHVYVFGGvskGGLMKTPERF--RTIEAYNIADGKWVQLpdpgeNFEKRGG---AGFAVVQGKIWVVYGFA 203
Kelch_6 pfam13964
Kelch motif;
113-165 1.17e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.02  E-value: 1.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1019366746 113 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 165
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
260-306 6.45e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.98  E-value: 6.45e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1019366746 260 RRVYHSMAAVQRKLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRC 306
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG----FDGNQSL-NSVEVYDPETNTWSKL 42
Kelch smart00612
Kelch domain;
68-123 1.90e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 1.90e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1019366746   68 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 123
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
165-208 2.40e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 2.40e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1019366746 165 REHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 208
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPS 44
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
113-162 4.83e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 4.83e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1019366746 113 RSHHCVAVMGDFLFVAGGevehaSGRTCAVRTACRYDPRSNSWAEIAPMK 162
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG-----FDGNQSLNSVEVYDPETNTWSKLPSMP 46
PHA02713 PHA02713
hypothetical protein; Provisional
157-300 5.89e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.00  E-value: 5.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 157 EIAPMKNCREHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQ 236
Cdd:PHA02713  334 ELPPMIKNRCRFSLAVIDDTIYAIGGQNG-TNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHID 412
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 237 Y-----------------QNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLggndLDYNNDRILVRHIDSYNID 299
Cdd:PHA02713  413 YtsvhhmnsidmeedthsSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV----CDIKDEKNVKTCIFRYNTN 488

                  .
gi 1019366746 300 T 300
Cdd:PHA02713  489 T 489
PRK14131 PRK14131
N-acetylneuraminate epimerase;
266-333 1.01e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 1.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1019366746 266 MAAVQRKLYVLGGNDlDYNNDR--ILVRHIDSYNIDTDQWTRCNFNL---LTGQneSGVAVHNGRIYLVGGYS 333
Cdd:PRK14131   80 AAFIDGKLYVFGGIG-KTNSEGspQVFDDVYKYDPKTNSWQKLDTRSpvgLAGH--VAVSLHNGKAYITGGVN 149
Kelch smart00612
Kelch domain;
272-324 2.40e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.31  E-value: 2.40e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1019366746  272 KLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCNfNLLTGQNESGVAVHNG 324
Cdd:smart00612   1 KIYVVGG----FDGGQRL-KSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
177-208 3.07e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.31  E-value: 3.07e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1019366746  177 LYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 208
Cdd:smart00612   2 IYVVGGFDG-GQRLKSVEVYDPETNKWTPLPS 32
Kelch smart00612
Kelch domain;
224-270 1.39e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.38  E-value: 1.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1019366746  224 LLWISGGvTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQ 270
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
152-278 1.59e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.38  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 152 SNSWAEIAPMKNC-REHFVLGAMEEYLYAVGG---RNE--LRQVLPTVERYCPKKNKWTFVQSFD-RSLSCHAGYVADG- 223
Cdd:PRK14131   61 SKGWTKIAAFPGGpREQAVAAFIDGKLYVFGGigkTNSegSPQVFDDVYKYDPKTNSWQKLDTRSpVGLAGHVAVSLHNg 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 224 LLWISGGV-----------TNTA----------------------QYQNRLMVYEPNQNKWIS--RSPMLQrRVYHSMAA 268
Cdd:PRK14131  141 KAYITGGVnknifdgyfedLAAAgkdktpkdkindayfdkkpedyFFNKEVLSYDPSTNQWKNagESPFLG-TAGSAVVI 219
                         170
                  ....*....|
gi 1019366746 269 VQRKLYVLGG 278
Cdd:PRK14131  220 KGNKLWLING 229
PHA03098 PHA03098
kelch-like protein; Provisional
199-334 2.37e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.14  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 199 KKNKWTFVQSfDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGG 278
Cdd:PHA03098  272 PLSEINTIID-IHYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG 350
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1019366746 279 NDLDynndrILVRHIDSYNIDTDQWTRcNFNLLTGQNESGVAVHNGRIYLVGGYSI 334
Cdd:PHA03098  351 IYNS-----ISLNTVESWKPGESKWRE-EPPLIFPRYNPCVVNVNNLIYVIGGISK 400
Kelch_3 pfam13415
Galactose oxidase, central domain;
222-269 3.81e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 3.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1019366746 222 DGLLWISGG-VTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 269
Cdd:pfam13415   1 GDKLYIFGGlGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
125-168 3.90e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 3.90e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1019366746  125 LFVAGGeveHASGRTCavRTACRYDPRSNSWAEIAPMKNCREHF 168
Cdd:smart00612   2 IYVVGG---FDGGQRL--KSVEVYDPETNKWTPLPSMPTPRSGH 40
Kelch_4 pfam13418
Galactose oxidase, central domain;
260-305 4.43e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 4.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1019366746 260 RRVYHSMAAVQR-KLYVLGGndldYNNDRILVRHIDSYNIDTDQWTR 305
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGG----EGEDGTLLSDLWVFDLSTNEWTR 43
Kelch_4 pfam13418
Galactose oxidase, central domain;
112-161 8.59e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 8.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1019366746 112 GRSHH-CVAVMGDFLFVAGGEVEhaSGRTCAvrTACRYDPRSNSWAEIAPM 161
Cdd:pfam13418   1 PRAYHtSTSIPDDTIYLFGGEGE--DGTLLS--DLWVFDLSTNEWTRLGSL 47
Kelch_6 pfam13964
Kelch motif;
220-261 9.00e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 9.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1019366746 220 VADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRR 261
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_6 pfam13964
Kelch motif;
261-306 9.09e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 9.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1019366746 261 RVYHSMAAVQRKLYVLGGndldYNNDRILVRHIDSYNIDTDQWTRC 306
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEEL 43
PHA02713 PHA02713
hypothetical protein; Provisional
105-185 9.23e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 38.07  E-value: 9.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019366746 105 ELAPMPVGRSHHCVAVMGDFLFVAGGEvehasGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRN 184
Cdd:PHA02713  334 ELPPMIKNRCRFSLAVIDDTIYAIGGQ-----NGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRT 408

                  .
gi 1019366746 185 E 185
Cdd:PHA02713  409 E 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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