NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1018191453|ref|NP_001309783|]
View 

NIPA-like protein 3 isoform a [Homo sapiens]

Protein Classification

DMT family transporter( domain architecture ID 581036)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0005215|GO:0005886
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
EamA super family cl23754
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
32-326 2.13e-70

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


The actual alignment was detected with superfamily member pfam05653:

Pssm-ID: 474045  Cd Length: 295  Bit Score: 223.49  E-value: 2.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453  32 ENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRA------YFKTKTWWLGLFLMLLGELGVFASYAFAPLSLIVPL 105
Cdd:pfam05653   2 DFYIGVGLAISSSIFIGSSFIIKKKGLLRLARKGHPRAgaggygYLKEWLWWAGLLTMGVGEAANFAAYAFAPATLVTPL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 106 SAVSVIASAIIGIIFIKEKWKPKDFLrryvlsfvGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYMLVEII 185
Cdd:pfam05653  82 GALSVIISAVLASFFLKEKLNLSGKL--------GCVLCILGSTVIVIHAPKEQEIESLREVWHLLTDPGFLVYVILVVG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 186 L-FCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQAS 264
Cdd:pfam05653 154 VvLALILYFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPIAWILLLVMITCCVTQINYLNKAL 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1018191453 265 QMYDSSLIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKK 326
Cdd:pfam05653 234 DIFNTSIVTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLHAFRDK 295
 
Name Accession Description Interval E-value
Mg_trans_NIPA pfam05653
Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family ...
32-326 2.13e-70

Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.


Pssm-ID: 398984  Cd Length: 295  Bit Score: 223.49  E-value: 2.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453  32 ENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRA------YFKTKTWWLGLFLMLLGELGVFASYAFAPLSLIVPL 105
Cdd:pfam05653   2 DFYIGVGLAISSSIFIGSSFIIKKKGLLRLARKGHPRAgaggygYLKEWLWWAGLLTMGVGEAANFAAYAFAPATLVTPL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 106 SAVSVIASAIIGIIFIKEKWKPKDFLrryvlsfvGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYMLVEII 185
Cdd:pfam05653  82 GALSVIISAVLASFFLKEKLNLSGKL--------GCVLCILGSTVIVIHAPKEQEIESLREVWHLLTDPGFLVYVILVVG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 186 L-FCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQAS 264
Cdd:pfam05653 154 VvLALILYFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPIAWILLLVMITCCVTQINYLNKAL 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1018191453 265 QMYDSSLIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKK 326
Cdd:pfam05653 234 DIFNTSIVTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLHAFRDK 295
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
76-326 3.86e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 42.14  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453  76 WWLGLFLMLLGELGVFASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLrryvlsfvGCGLAVVGTYLLVtfa 155
Cdd:COG0697    69 LLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWL--------GLLLGFAGVLLIV--- 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 156 pnshekmtGENVTRHLVSWPFLLYMLVEIILFCLLLYFYKeknannivvilLLVALLGSMTVVTVKAVAG---MLVLSIQ 232
Cdd:COG0697   138 --------GPGGGGGGGSLLGDLLALLAALSWALYTVLTR-----------RLSRRLDPLTLTFWQMLVGallLLPLALL 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 233 GNLQLDYP---IFYVMFVCMVATAVYQAAFLsQASQMYDSSLIASVGYiLSTTIAITAGAIFYldfiGEdVLHIcMFALG 309
Cdd:COG0697   199 TGLPLPLSaaaWLALLYLGLFGTALAYLLWF-RALRRLGASRAAPLTY-LEPVFAVLLGWLLL----GE-PLTP-LQLLG 270
                         250
                  ....*....|....*..
gi 1018191453 310 CLIAFLGVFLITRNRKK 326
Cdd:COG0697   271 AALILAGVLLAALRERR 287
 
Name Accession Description Interval E-value
Mg_trans_NIPA pfam05653
Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family ...
32-326 2.13e-70

Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.


Pssm-ID: 398984  Cd Length: 295  Bit Score: 223.49  E-value: 2.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453  32 ENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRA------YFKTKTWWLGLFLMLLGELGVFASYAFAPLSLIVPL 105
Cdd:pfam05653   2 DFYIGVGLAISSSIFIGSSFIIKKKGLLRLARKGHPRAgaggygYLKEWLWWAGLLTMGVGEAANFAAYAFAPATLVTPL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 106 SAVSVIASAIIGIIFIKEKWKPKDFLrryvlsfvGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYMLVEII 185
Cdd:pfam05653  82 GALSVIISAVLASFFLKEKLNLSGKL--------GCVLCILGSTVIVIHAPKEQEIESLREVWHLLTDPGFLVYVILVVG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 186 L-FCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQAS 264
Cdd:pfam05653 154 VvLALILYFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPIAWILLLVMITCCVTQINYLNKAL 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1018191453 265 QMYDSSLIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKK 326
Cdd:pfam05653 234 DIFNTSIVTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLHAFRDK 295
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
76-326 3.86e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 42.14  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453  76 WWLGLFLMLLGELGVFASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLrryvlsfvGCGLAVVGTYLLVtfa 155
Cdd:COG0697    69 LLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWL--------GLLLGFAGVLLIV--- 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 156 pnshekmtGENVTRHLVSWPFLLYMLVEIILFCLLLYFYKeknannivvilLLVALLGSMTVVTVKAVAG---MLVLSIQ 232
Cdd:COG0697   138 --------GPGGGGGGGSLLGDLLALLAALSWALYTVLTR-----------RLSRRLDPLTLTFWQMLVGallLLPLALL 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453 233 GNLQLDYP---IFYVMFVCMVATAVYQAAFLsQASQMYDSSLIASVGYiLSTTIAITAGAIFYldfiGEdVLHIcMFALG 309
Cdd:COG0697   199 TGLPLPLSaaaWLALLYLGLFGTALAYLLWF-RALRRLGASRAAPLTY-LEPVFAVLLGWLLL----GE-PLTP-LQLLG 270
                         250
                  ....*....|....*..
gi 1018191453 310 CLIAFLGVFLITRNRKK 326
Cdd:COG0697   271 AALILAGVLLAALRERR 287
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
74-152 7.43e-03

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 36.70  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191453  74 KTWWLGL---FLMLLGELGVFASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLrryvlsfvGCGLAVVGTYL 150
Cdd:COG2510    63 KSWLFLLlsgLATGLSWLFYFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQII--------GILLIVAGVIL 134

                  ..
gi 1018191453 151 LV 152
Cdd:COG2510   135 LS 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH