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Conserved domains on  [gi|1017029509|ref|NP_001309416|]
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BLOC-3 complex member HPS1 isoform e [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 216-371 2.02e-19

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465955  Cd Length: 103  Bit Score: 82.30  E-value: 2.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029509 216 GLVHFIYVDRTTGQMVAPSLncsqktssELGKGPLAAFVKTKVWSLIQLARRYLQ--KGYTTLLFQEGDfYCSYFLWFEN 293
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSL--------PTDPPYTTEQRRRRLRSFYQLLHSTLHspSGPLKLLYKVSD-YESLLAWFTD 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029509 294 dmgyklqmievpvlsddsvpigmlggdyyrkllryysknrpteavrCYELLALHLSVIPTDLLVQQAGQLARRLWEAS 371
Cdd:pfam19038  72 ----------------------------------------------CFELYVLFSPLVPKHALRSSANKLLKWIKKEE 103
Fuzzy super family cl40581
protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector ...
 28-81 1.33e-05

protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector that controls multiple cellular processes during development. PCP signalling is an evolutionarily conserved pathway by which directional information regarding polarized cell movement is provided to cells. The PCP signalling axis involves PCP core and PCP effector genes, which are activated consecutively to govern orientated cell migration and the establishment of cytoskeletal structures. Dishevelled (Dvl in mammals or Dsh in Drosophila) and Fuz (or fuzzy in Drosophila) are two representative PCP core and effector genes, respectively. PCP regulates mammalian nervous system development; Fuz-null mutant mice display neural tube defects due to failure of directional cell motility and cell fusion.


The actual alignment was detected with superfamily member pfam19037:

Pssm-ID: 477403  Cd Length: 98  Bit Score: 43.37  E-value: 1.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1017029509  28 FLDANVKESYCPLVPHTMYCLPLWQG-INLVLLTRSPSAPlALVLSQLMDGFSML 81
Cdd:pfam19037  45 SLELWIPICLPKFNPGVLHRYISFLGdINLCLLLLSGDKP-AFFELSLLDDRFWL 98
 
Name Accession Description Interval E-value
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 216-371 2.02e-19

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 82.30  E-value: 2.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029509 216 GLVHFIYVDRTTGQMVAPSLncsqktssELGKGPLAAFVKTKVWSLIQLARRYLQ--KGYTTLLFQEGDfYCSYFLWFEN 293
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSL--------PTDPPYTTEQRRRRLRSFYQLLHSTLHspSGPLKLLYKVSD-YESLLAWFTD 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029509 294 dmgyklqmievpvlsddsvpigmlggdyyrkllryysknrpteavrCYELLALHLSVIPTDLLVQQAGQLARRLWEAS 371
Cdd:pfam19038  72 ----------------------------------------------CFELYVLFSPLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 28-81 1.33e-05

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 43.37  E-value: 1.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1017029509  28 FLDANVKESYCPLVPHTMYCLPLWQG-INLVLLTRSPSAPlALVLSQLMDGFSML 81
Cdd:pfam19037  45 SLELWIPICLPKFNPGVLHRYISFLGdINLCLLLLSGDKP-AFFELSLLDDRFWL 98
 
Name Accession Description Interval E-value
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 216-371 2.02e-19

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 82.30  E-value: 2.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029509 216 GLVHFIYVDRTTGQMVAPSLncsqktssELGKGPLAAFVKTKVWSLIQLARRYLQ--KGYTTLLFQEGDfYCSYFLWFEN 293
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSL--------PTDPPYTTEQRRRRLRSFYQLLHSTLHspSGPLKLLYKVSD-YESLLAWFTD 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017029509 294 dmgyklqmievpvlsddsvpigmlggdyyrkllryysknrpteavrCYELLALHLSVIPTDLLVQQAGQLARRLWEAS 371
Cdd:pfam19038  72 ----------------------------------------------CFELYVLFSPLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 28-81 1.33e-05

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 43.37  E-value: 1.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1017029509  28 FLDANVKESYCPLVPHTMYCLPLWQG-INLVLLTRSPSAPlALVLSQLMDGFSML 81
Cdd:pfam19037  45 SLELWIPICLPKFNPGVLHRYISFLGdINLCLLLLSGDKP-AFFELSLLDDRFWL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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