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BLOC-3 complex member HPS1 isoform e [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
Fuz_longin_3 | pfam19038 | Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ... |
216-371 | 2.02e-19 | |||
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia. : Pssm-ID: 465955 Cd Length: 103 Bit Score: 82.30 E-value: 2.02e-19
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Fuzzy super family | cl40581 | protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector ... |
28-81 | 1.33e-05 | |||
protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector that controls multiple cellular processes during development. PCP signalling is an evolutionarily conserved pathway by which directional information regarding polarized cell movement is provided to cells. The PCP signalling axis involves PCP core and PCP effector genes, which are activated consecutively to govern orientated cell migration and the establishment of cytoskeletal structures. Dishevelled (Dvl in mammals or Dsh in Drosophila) and Fuz (or fuzzy in Drosophila) are two representative PCP core and effector genes, respectively. PCP regulates mammalian nervous system development; Fuz-null mutant mice display neural tube defects due to failure of directional cell motility and cell fusion. The actual alignment was detected with superfamily member pfam19037: Pssm-ID: 477403 Cd Length: 98 Bit Score: 43.37 E-value: 1.33e-05
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Name | Accession | Description | Interval | E-value | |||
Fuz_longin_3 | pfam19038 | Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ... |
216-371 | 2.02e-19 | |||
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia. Pssm-ID: 465955 Cd Length: 103 Bit Score: 82.30 E-value: 2.02e-19
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Fuz_longin_2 | pfam19037 | Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ... |
28-81 | 1.33e-05 | |||
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia. Pssm-ID: 465954 Cd Length: 98 Bit Score: 43.37 E-value: 1.33e-05
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Name | Accession | Description | Interval | E-value | |||
Fuz_longin_3 | pfam19038 | Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ... |
216-371 | 2.02e-19 | |||
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia. Pssm-ID: 465955 Cd Length: 103 Bit Score: 82.30 E-value: 2.02e-19
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Fuz_longin_2 | pfam19037 | Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ... |
28-81 | 1.33e-05 | |||
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia. Pssm-ID: 465954 Cd Length: 98 Bit Score: 43.37 E-value: 1.33e-05
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