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Conserved domains on  [gi|1016080585|ref|NP_001309190|]
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G1/S-specific cyclin-E1 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 194-307 1.71e-80

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410284  Cd Length: 114  Bit Score: 241.22  E-value: 1.71e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 194 PLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWC 273
Cdd:cd20581     1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1016080585 274 DIENCVKWMVPFAMVIRETGSSKLKHFRGVADED 307
Cdd:cd20581    81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 103-190 4.29e-51

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20579:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 137  Bit Score: 166.98  E-value: 4.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 103 SPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM----------------------------- 153
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMevcevyklhretfylaqdffdrfmatqen 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1016080585 154 --------------------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20579    81 vvktrlqligisslfiaaklEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
 
Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 194-307 1.71e-80

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 241.22  E-value: 1.71e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 194 PLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWC 273
Cdd:cd20581     1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1016080585 274 DIENCVKWMVPFAMVIRETGSSKLKHFRGVADED 307
Cdd:cd20581    81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 103-190 4.29e-51

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 166.98  E-value: 4.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 103 SPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM----------------------------- 153
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMevcevyklhretfylaqdffdrfmatqen 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1016080585 154 --------------------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20579    81 vvktrlqligisslfiaaklEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 115-193 6.90e-22

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 89.88  E-value: 6.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 115 EVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM----------------------------------------- 153
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVevhekfkllpetlylavnyldrflskksvpknklqlvgvtc 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1016080585 154 -------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLS 193
Cdd:pfam00134  81 lfiaakyEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 196-314 3.24e-13

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 65.72  E-value: 3.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 196 TIVSWLNVYMQVA-YLNDLHEVLLPQYpqqifiqiaeLLDLCVLDVDCLEFPYGILAASALYHFSS-------SELMQKV 267
Cdd:pfam02984   2 TPLSFLRRFSKAAdYLHDLELRTLAKY----------LLELTLLDYDFLKYPPSLIAAAAVYLARKtlnspewTETLEHY 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1016080585 268 SGYQWCDIENCVKWMVPFamVIRETGSSKLKHFRGVADEDAHNIQTH 314
Cdd:pfam02984  72 TGYSEEDLKPCVKLLLEL--LLNAPSSKLQAVRRKYSSSKFMKVSTL 116
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
114-193 7.59e-08

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 53.63  E-value: 7.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 114 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWL----------------------------------------- 152
Cdd:COG5024   182 SDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLvevhgkfgllpetlflainiidrflssrvvslekyqlvgis 261

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1016080585 153 -------MEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLS 193
Cdd:COG5024   262 alfiaskYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309
 
Name Accession Description Interval E-value
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 194-307 1.71e-80

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 241.22  E-value: 1.71e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 194 PLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWC 273
Cdd:cd20581     1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1016080585 274 DIENCVKWMVPFAMVIRETGSSKLKHFRGVADED 307
Cdd:cd20581    81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 103-190 4.29e-51

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 166.98  E-value: 4.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 103 SPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM----------------------------- 153
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMevcevyklhretfylaqdffdrfmatqen 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1016080585 154 --------------------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20579    81 vvktrlqligisslfiaaklEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 109-190 2.50e-43

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 146.30  E-value: 2.50e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 109 SWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM----------------------------------- 153
Cdd:cd20519     1 SWADSEEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMevcevyrlhretfylavdfvdrylstqtnvpktql 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1016080585 154 --------------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20519    81 qligitclfiaaklEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 194-292 2.95e-42

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 142.81  E-value: 2.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 194 PLTIVSWLNVYMQVAYLNDLH-----EVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYH-FSSSELMQKV 267
Cdd:cd20520     1 PPTPNSWLNLYLQLAQLNPPPkendsAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYLvSPDDEAIEQV 80

                          90       100
                  ....*....|....*....|....*
gi 1016080585 268 SGYQWCDIENCVKWMVPFAMVIRET 292
Cdd:cd20520    81 TGYSWEQLAPCVEWMTPFAEVLEEE 105
CYCLIN_CCNE2_rpt2 cd20582
second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 194-292 5.39e-42

second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410285  Cd Length: 99  Bit Score: 141.83  E-value: 5.39e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 194 PLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWC 273
Cdd:cd20582     1 PVTIISWLNLYLQVDSLKDHPNVLLPQYSQETFIQIAQLLDLCILDINSLDFQYRVLAAAALCHFTSFEVVKKASGLEWD 80

                          90
                  ....*....|....*....
gi 1016080585 274 DIENCVKWMVPFAMVIRET 292
Cdd:cd20582    81 CISECVNWMVPFVRTVREC 99
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 103-190 1.03e-37

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 132.28  E-value: 1.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 103 SPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM----------------------------- 153
Cdd:cd20580     1 SPLPELSWGNSKDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLevcevytlhretfylaqdffdrfmltqkn 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1016080585 154 --------------------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20580    81 inksmlqligitslfiasklEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 115-193 6.90e-22

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 89.88  E-value: 6.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 115 EVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM----------------------------------------- 153
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVevhekfkllpetlylavnyldrflskksvpknklqlvgvtc 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1016080585 154 -------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLS 193
Cdd:pfam00134  81 lfiaakyEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 115-189 2.96e-17

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 77.18  E-value: 2.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 115 EVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM----------------------------------------- 153
Cdd:cd20507     7 DIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVevhlkfkllpetlyltvniidrylskkqvprkklqlvgvta 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1016080585 154 -------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALK 189
Cdd:cd20507    87 lliaskyEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 196-314 3.24e-13

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 65.72  E-value: 3.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 196 TIVSWLNVYMQVA-YLNDLHEVLLPQYpqqifiqiaeLLDLCVLDVDCLEFPYGILAASALYHFSS-------SELMQKV 267
Cdd:pfam02984   2 TPLSFLRRFSKAAdYLHDLELRTLAKY----------LLELTLLDYDFLKYPPSLIAAAAVYLARKtlnspewTETLEHY 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1016080585 268 SGYQWCDIENCVKWMVPFamVIRETGSSKLKHFRGVADEDAHNIQTH 314
Cdd:pfam02984  72 TGYSEEDLKPCVKLLLEL--LLNAPSSKLQAVRRKYSSSKFMKVSTL 116
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 114-189 1.91e-09

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 54.95  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 114 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM---------------------------------------- 153
Cdd:cd20504     4 DDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVevaeeyklvpetlylavnyidrflsqmsvlrsklqlvgta 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1016080585 154 --------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALK 189
Cdd:cd20504    84 cmfiaakyEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 104-190 2.76e-09

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 54.99  E-value: 2.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 104 PLPVLSWANreEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLM------------------------------ 153
Cdd:cd20568     2 PLMVAEYVP--EIFEYLRELELKTLPNPNYMDDQKELRWKMRGILVDWLVevhekfrllpetlflavniidrflskrvvs 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1016080585 154 ------------------EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20568    80 lnklqlvgisalfiaskyEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
114-193 7.59e-08

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 53.63  E-value: 7.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 114 EEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWL----------------------------------------- 152
Cdd:COG5024   182 SDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLvevhgkfgllpetlflainiidrflssrvvslekyqlvgis 261

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1016080585 153 -------MEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLS 193
Cdd:COG5024   262 alfiaskYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 100-189 3.11e-07

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 49.17  E-value: 3.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 100 SRGSPLPVLSWANreEVWKIMLNKEKTYLRDQhFLEQHPLLQPKMRAILLDWLME------------------------- 154
Cdd:cd20508     6 NSDDPFQVSEYAK--DIFDYMKEREEKFVVPD-YLEKQTELTPSMRAILVDWLVEvqenfelnhetlylavklvdlylsk 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1016080585 155 -----------------------EIYPPKLHQFAYVTDGACSGDEILTMELMIMKALK 189
Cdd:cd20508    83 kvvkkeklqllgatailiaskfdERCPPCVDDFLYICDDAYTREELLKMEREILKTLD 140
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 121-190 5.42e-07

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 48.13  E-value: 5.42e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1016080585 121 LNKEKTYLRDQH---FLEQHPLLQPKMR-----AILLDWLMEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20561    53 LQNETLHLAVNYidrFLSSMSVLRGKLQlvgtaAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 133-190 1.15e-05

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 44.48  E-value: 1.15e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1016080585 133 FLEQHPLLQPKMR-----AILLDWLMEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20565    67 FLQNNPVPKKMLQlvgvtAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 133-190 1.20e-05

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 44.47  E-value: 1.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1016080585 133 FLEQHPLLQPKMR-----AILLDWLMEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20566    71 FLQVQPVSRKKLQlvgvtALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 154-188 1.33e-05

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 43.08  E-value: 1.33e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080585 154 EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKAL 188
Cdd:cd20536    59 EEIYPPEVKDLLALCCGAYTREQICNLECIILTKL 93
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 133-190 1.40e-05

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 44.64  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080585 133 FLEQHPLLQPKMRAILLDWLM------------------------------------------------EEIYPPKLHQF 164
Cdd:cd20567    42 YMSQQPDINEKMRAILIDWLIevhlkfelmpetlyltvnlidrflsvkqvprkelqlvgvtamliaskyEEIWAPEVNDF 121

                          90       100
                  ....*....|....*....|....*.
gi 1016080585 165 AYVTDGACSGDEILTMELMIMKALKW 190
Cdd:cd20567   122 VYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 146-188 8.15e-05

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 42.52  E-value: 8.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1016080585 146 AILLDWLMEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKAL 188
Cdd:cd20560   118 AILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 154-191 1.00e-04

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 41.63  E-value: 1.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1016080585 154 EEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR 191
Cdd:cd20562    99 EEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 153-192 1.46e-04

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 40.38  E-value: 1.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1016080585 153 MEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRL 192
Cdd:cd20542    57 FEERFPPEVATLCYLTDDSYSKKQVLRMERRVLRRLRFDL 96
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 232-280 2.05e-04

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 39.98  E-value: 2.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1016080585 232 LLDLCVLDVDCLEFPYGILAASALY--------HFSSSELMQKVSGYQWCDIENCVK 280
Cdd:cd20537    27 LLELSLLDYEFLKYRPSLIAAAALYlarkilgePPPSPQLLQLVTGYSENDLQECAK 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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