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Conserved domains on  [gi|1015809784|ref|NP_001309113|]
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L-dopachrome tautomerase isoform 3 [Homo sapiens]

Protein Classification

tyrosinase family protein( domain architecture ID 1166)

tyrosinase family protein such as tyrosinase, a metal-containing oxidase that catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine; may be partial

Gene Ontology:  GO:0046872|GO:0016491
PubMed:  29473882|11412044

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tyrosinase super family cl02830
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 13-98 3.55e-13

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


The actual alignment was detected with superfamily member pfam00264:

Pssm-ID: 470683  Cd Length: 209  Bit Score: 65.57  E-value: 3.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809784  13 DIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGTLdsqvmsLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIF 92
Cdd:pfam00264 130 LKQQLNTLDVVDDLLTYQPDYTSFSNTLEGDGGNEEGL------PHNGVHVWVGGDMGDVFTAPNDPIFFLHHANIDRLW 203


                  ....*.
gi 1015809784  93 DEWMKR 98
Cdd:pfam00264 204 AIWQRL 209
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 13-98 3.55e-13

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 65.57  E-value: 3.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809784  13 DIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGTLdsqvmsLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIF 92
Cdd:pfam00264 130 LKQQLNTLDVVDDLLTYQPDYTSFSNTLEGDGGNEEGL------PHNGVHVWVGGDMGDVFTAPNDPIFFLHHANIDRLW 203


                  ....*.
gi 1015809784  93 DEWMKR 98
Cdd:pfam00264 204 AIWQRL 209
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 13-98 3.55e-13

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 65.57  E-value: 3.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809784  13 DIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGTLdsqvmsLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIF 92
Cdd:pfam00264 130 LKQQLNTLDVVDDLLTYQPDYTSFSNTLEGDGGNEEGL------PHNGVHVWVGGDMGDVFTAPNDPIFFLHHANIDRLW 203


                  ....*.
gi 1015809784  93 DEWMKR 98
Cdd:pfam00264 204 AIWQRL 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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