NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1015172271|ref|NP_001309007|]
View 

zinc finger and SCAN domain-containing protein 5A isoform e [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13416207)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-349 1.30e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.30e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015172271 324 SLKEHQRIHSGEKPYKCSKCPRAFSR 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-293 2.38e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.38e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015172271 268 SLQFHQRTHTGERPYTCDVCQKQFTQ 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-321 2.06e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.06e-04
                          10        20
                  ....*....|....*....|..
gi 1015172271 300 HKRSHTGEKPFECKDCKKVFTY 321
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
209-362 6.06e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271 209 ASPVSHPDGQEAKALPPFACDVCEKRFTCNSKLVIHKRS--HTGERL--FQC--NLCGKRFMQLISLQFHQRTHTGERPY 282
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271 283 TC--DVCQKQFTQKSYLK-----CHKRSHTGEKPFEC--KDCKKVFTYRGSLKEH--QRIHSGEKPYKCSKCPRAFSRLK 351
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHY 432

                         170
                  ....*....|.
gi 1015172271 352 LLRRHQKTHPE 362
Cdd:COG5048   433 NLIPHKKIHTN 443
Treacle super family cl25490
Treacher Collins syndrome protein Treacle;
5-225 4.67e-03

Treacher Collins syndrome protein Treacle;


The actual alignment was detected with superfamily member pfam03546:

Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 38.90  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271   5 PPQPRETDSDIEMAEAPSsvRDDLKDVSSQRASSVNQMRPGEGQAHRELQILPRVPALSRRQGEDFLL-HKSIDVTGDPK 83
Cdd:pfam03546 147 PAPPGKAGSAAPLVQVGK--KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGAAPAPpQKAGPVATQVK 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271  84 SLRPKQTLE--KDLKENREENPGLTSP---EPQLPKSPTDLVRAKEGKDPPKIASVENVDADTPSACVVEREASTHSgnr 158
Cdd:pfam03546 225 AERSKEDSEssEESSDSEEEAPAAATPaqaKPALKTPQTKASPRKGTPITPTSAKVPPVRVGTPAPWKAGTVTSPAC--- 301

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015172271 159 gdalnLSSP------KRSKPDASSISQEEPQGEATPVGNReSPGQAGMNSIHSPGPASPVSHPDGQEAKALPP 225
Cdd:pfam03546 302 -----ASSPavargaQRPEEDSSSSEESESEEETAPAAAV-GQAKSVGKGLQGKAASAPTKGPSGQGTAPVPP 368
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-349 1.30e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.30e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015172271 324 SLKEHQRIHSGEKPYKCSKCPRAFSR 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-293 2.38e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.38e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015172271 268 SLQFHQRTHTGERPYTCDVCQKQFTQ 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-321 2.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.06e-04
                          10        20
                  ....*....|....*....|..
gi 1015172271 300 HKRSHTGEKPFECKDCKKVFTY 321
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-362 6.06e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271 209 ASPVSHPDGQEAKALPPFACDVCEKRFTCNSKLVIHKRS--HTGERL--FQC--NLCGKRFMQLISLQFHQRTHTGERPY 282
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271 283 TC--DVCQKQFTQKSYLK-----CHKRSHTGEKPFEC--KDCKKVFTYRGSLKEH--QRIHSGEKPYKCSKCPRAFSRLK 351
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHY 432

                         170
                  ....*....|.
gi 1015172271 352 LLRRHQKTHPE 362
Cdd:COG5048   433 NLIPHKKIHTN 443
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-263 3.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.58e-03
                          10        20
                  ....*....|....*....|...
gi 1015172271 241 LVIHKRSHTGERLFQCNLCGKRF 263
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
5-225 4.67e-03

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 38.90  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271   5 PPQPRETDSDIEMAEAPSsvRDDLKDVSSQRASSVNQMRPGEGQAHRELQILPRVPALSRRQGEDFLL-HKSIDVTGDPK 83
Cdd:pfam03546 147 PAPPGKAGSAAPLVQVGK--KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGAAPAPpQKAGPVATQVK 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271  84 SLRPKQTLE--KDLKENREENPGLTSP---EPQLPKSPTDLVRAKEGKDPPKIASVENVDADTPSACVVEREASTHSgnr 158
Cdd:pfam03546 225 AERSKEDSEssEESSDSEEEAPAAATPaqaKPALKTPQTKASPRKGTPITPTSAKVPPVRVGTPAPWKAGTVTSPAC--- 301

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015172271 159 gdalnLSSP------KRSKPDASSISQEEPQGEATPVGNReSPGQAGMNSIHSPGPASPVSHPDGQEAKALPP 225
Cdd:pfam03546 302 -----ASSPavargaQRPEEDSSSSEESESEEETAPAAAV-GQAKSVGKGLQGKAASAPTKGPSGQGTAPVPP 368
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-349 1.30e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.30e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015172271 324 SLKEHQRIHSGEKPYKCSKCPRAFSR 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-293 2.38e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.38e-05
                          10        20
                  ....*....|....*....|....*.
gi 1015172271 268 SLQFHQRTHTGERPYTCDVCQKQFTQ 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 338-360 1.32e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.32e-04
                          10        20
                  ....*....|....*....|...
gi 1015172271 338 YKCSKCPRAFSRLKLLRRHQKTH 360
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-321 2.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.06e-04
                          10        20
                  ....*....|....*....|..
gi 1015172271 300 HKRSHTGEKPFECKDCKKVFTY 321
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 310-332 2.38e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|...
gi 1015172271 310 FECKDCKKVFTYRGSLKEHQRIH 332
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-362 6.06e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271 209 ASPVSHPDGQEAKALPPFACDVCEKRFTCNSKLVIHKRS--HTGERL--FQC--NLCGKRFMQLISLQFHQRTHTGERPY 282
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271 283 TC--DVCQKQFTQKSYLK-----CHKRSHTGEKPFEC--KDCKKVFTYRGSLKEH--QRIHSGEKPYKCSKCPRAFSRLK 351
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHY 432

                         170
                  ....*....|.
gi 1015172271 352 LLRRHQKTHPE 362
Cdd:COG5048   433 NLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-343 9.57e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 9.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015172271 280 RPYTCDVCQKQFTQKSYLKCHKRSHTGEKPFECKD--CKKVFTYRGSLKEHQRIHSGEKPYKCSKC 343
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 194-358 2.29e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271 194 SPGQAGMNSIHSP--GPASPVSHPDGQEAKALPPFACDVCEK--RFTCNSKLVIHKRSHTGERlfqcNLCGKRFMQLIsl 269
Cdd:COG5189   271 SPSQGSAELFEESslGFDYEFIHKSVGNKEIRGGISTGEMIDvrKLPCTNSSSNGKLAHGGER----NIDTPSRMLKV-- 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271 270 qfhqrthTGERPYTCDV--CQKQFTQKSYLKCHKR-SHTGEKPFECKDCKKvftyrgslkeHQRIHSGEKPYKCSKCPRA 346
Cdd:COG5189   345 -------KDGKPYKCPVegCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKR 407

                         170
                  ....*....|..
gi 1015172271 347 FSRLKLLRRHQK 358
Cdd:COG5189   408 YKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-263 3.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.58e-03
                          10        20
                  ....*....|....*....|...
gi 1015172271 241 LVIHKRSHTGERLFQCNLCGKRF 263
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
5-225 4.67e-03

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 38.90  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271   5 PPQPRETDSDIEMAEAPSsvRDDLKDVSSQRASSVNQMRPGEGQAHRELQILPRVPALSRRQGEDFLL-HKSIDVTGDPK 83
Cdd:pfam03546 147 PAPPGKAGSAAPLVQVGK--KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGAAPAPpQKAGPVATQVK 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015172271  84 SLRPKQTLE--KDLKENREENPGLTSP---EPQLPKSPTDLVRAKEGKDPPKIASVENVDADTPSACVVEREASTHSgnr 158
Cdd:pfam03546 225 AERSKEDSEssEESSDSEEEAPAAATPaqaKPALKTPQTKASPRKGTPITPTSAKVPPVRVGTPAPWKAGTVTSPAC--- 301

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015172271 159 gdalnLSSP------KRSKPDASSISQEEPQGEATPVGNReSPGQAGMNSIHSPGPASPVSHPDGQEAKALPP 225
Cdd:pfam03546 302 -----ASSPavargaQRPEEDSSSSEESESEEETAPAAAV-GQAKSVGKGLQGKAASAPTKGPSGQGTAPVPP 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH