NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1012282647|ref|NP_001308642|]
View 

nuclear receptor coactivator 2 isoform c [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 577-662 4.41e-38

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


:

Pssm-ID: 465083  Cd Length: 87  Bit Score: 137.24  E-value: 4.41e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  577 KQEPVSPKKKE-NALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEI 655
Cdd:pfam16279    1 KQEQLSPKKKKnNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSKSEKEESKIKTEPPDELSLDNLDAI 80


                   ....*..
gi 1012282647  656 LDDLQNS 662
Cdd:pfam16279   81 LGDLRNS 87
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 309-433 3.78e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


:

Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 135.63  E-value: 3.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  309 YALKMNSPSQSSPGMNPGQPTSMLSPRHRmspgvaGSPRIPPSQFSPAGSLHSPVGV----CSSTGNSHSYTNSSLNALQ 384
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHR------GSPKMPANQFSPGMGLHSPMGSvssgGSGGGGSRTYSSSSLNALQ 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1012282647  385 ALSEGHGVSLGSSLASPDLKMGNLQnspvNMNPPPLSKMGSLDSKDCFG 433
Cdd:pfam16665   75 AISEGVGNSLGSSLTSPVPKQDSSP----NINSTQQKKEGSSDSKSPSS 119
PAS_11 super family cl37882
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 114-224 1.63e-27

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


The actual alignment was detected with superfamily member pfam14598:

Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 107.77  E-value: 1.63e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  114 ESFTTRQDLQGKITSLDTstmRAAMKPGWED--LVRRCIQKFHAQHEgesVSYAKRHHHEVL-RQGLAFSQIYRFSLSDG 190
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD---LRTAKSHLREIIqTRGRATSPSYRLRLRDG 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1012282647  191 TLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQN 224
Cdd:pfam14598   76 DFLSVHTKSKLFLNQNSNQQPFIMCTHTILREEN 109
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 482-555 2.27e-26

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


:

Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 104.01  E-value: 2.27e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  482 KGQTKLLQLLTTKSDQMEPSPLAS-SLSDTN-KDSTG-----------SLPGSGSTHGTSLKEKHKILHRLLQDSSSPVD 548
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGPSPLRShADADTDcKDSLAgvtspssgvssSSGSSCPSHHSSLQEKHKILHRLLQNGNSPDD 80


                   ....*..
gi 1012282647  549 LAKLTAE 555
Cdd:pfam08832   81 VAKLTAE 87
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1127-1184 1.57e-20

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


:

Pssm-ID: 462174  Cd Length: 58  Bit Score: 86.36  E-value: 1.57e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1012282647 1127 GMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMM 1184
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 917-961 4.23e-18

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


:

Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 78.99  E-value: 4.23e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1012282647  917 ESPSDEGALLDQLYLALRNFD--GLEEIDRALGIPELVSQSQAVDPE 961
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDetGLEEIDRALGIPELVGQGQGLDPD 47
 
Name Accession Description Interval E-value
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 577-662 4.41e-38

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 137.24  E-value: 4.41e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  577 KQEPVSPKKKE-NALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEI 655
Cdd:pfam16279    1 KQEQLSPKKKKnNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSKSEKEESKIKTEPPDELSLDNLDAI 80


                   ....*..
gi 1012282647  656 LDDLQNS 662
Cdd:pfam16279   81 LGDLRNS 87
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 309-433 3.78e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 135.63  E-value: 3.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  309 YALKMNSPSQSSPGMNPGQPTSMLSPRHRmspgvaGSPRIPPSQFSPAGSLHSPVGV----CSSTGNSHSYTNSSLNALQ 384
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHR------GSPKMPANQFSPGMGLHSPMGSvssgGSGGGGSRTYSSSSLNALQ 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1012282647  385 ALSEGHGVSLGSSLASPDLKMGNLQnspvNMNPPPLSKMGSLDSKDCFG 433
Cdd:pfam16665   75 AISEGVGNSLGSSLTSPVPKQDSSP----NINSTQQKKEGSSDSKSPSS 119
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 114-224 1.63e-27

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 107.77  E-value: 1.63e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  114 ESFTTRQDLQGKITSLDTstmRAAMKPGWED--LVRRCIQKFHAQHEgesVSYAKRHHHEVL-RQGLAFSQIYRFSLSDG 190
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD---LRTAKSHLREIIqTRGRATSPSYRLRLRDG 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1012282647  191 TLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQN 224
Cdd:pfam14598   76 DFLSVHTKSKLFLNQNSNQQPFIMCTHTILREEN 109
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 482-555 2.27e-26

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 104.01  E-value: 2.27e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  482 KGQTKLLQLLTTKSDQMEPSPLAS-SLSDTN-KDSTG-----------SLPGSGSTHGTSLKEKHKILHRLLQDSSSPVD 548
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGPSPLRShADADTDcKDSLAgvtspssgvssSSGSSCPSHHSSLQEKHKILHRLLQNGNSPDD 80


                   ....*..
gi 1012282647  549 LAKLTAE 555
Cdd:pfam08832   81 VAKLTAE 87
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1127-1184 1.57e-20

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 86.36  E-value: 1.57e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1012282647 1127 GMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMM 1184
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 917-961 4.23e-18

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 78.99  E-value: 4.23e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1012282647  917 ESPSDEGALLDQLYLALRNFD--GLEEIDRALGIPELVSQSQAVDPE 961
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDetGLEEIDRALGIPELVGQGQGLDPD 47
 
Name Accession Description Interval E-value
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 577-662 4.41e-38

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 137.24  E-value: 4.41e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  577 KQEPVSPKKKE-NALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEI 655
Cdd:pfam16279    1 KQEQLSPKKKKnNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSKSEKEESKIKTEPPDELSLDNLDAI 80


                   ....*..
gi 1012282647  656 LDDLQNS 662
Cdd:pfam16279   81 LGDLRNS 87
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 309-433 3.78e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 135.63  E-value: 3.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  309 YALKMNSPSQSSPGMNPGQPTSMLSPRHRmspgvaGSPRIPPSQFSPAGSLHSPVGV----CSSTGNSHSYTNSSLNALQ 384
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHR------GSPKMPANQFSPGMGLHSPMGSvssgGSGGGGSRTYSSSSLNALQ 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1012282647  385 ALSEGHGVSLGSSLASPDLKMGNLQnspvNMNPPPLSKMGSLDSKDCFG 433
Cdd:pfam16665   75 AISEGVGNSLGSSLTSPVPKQDSSP----NINSTQQKKEGSSDSKSPSS 119
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 114-224 1.63e-27

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 107.77  E-value: 1.63e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  114 ESFTTRQDLQGKITSLDTstmRAAMKPGWED--LVRRCIQKFHAQHEgesVSYAKRHHHEVL-RQGLAFSQIYRFSLSDG 190
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD---LRTAKSHLREIIqTRGRATSPSYRLRLRDG 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1012282647  191 TLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQN 224
Cdd:pfam14598   76 DFLSVHTKSKLFLNQNSNQQPFIMCTHTILREEN 109
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 482-555 2.27e-26

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 104.01  E-value: 2.27e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282647  482 KGQTKLLQLLTTKSDQMEPSPLAS-SLSDTN-KDSTG-----------SLPGSGSTHGTSLKEKHKILHRLLQDSSSPVD 548
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGPSPLRShADADTDcKDSLAgvtspssgvssSSGSSCPSHHSSLQEKHKILHRLLQNGNSPDD 80


                   ....*..
gi 1012282647  549 LAKLTAE 555
Cdd:pfam08832   81 VAKLTAE 87
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1127-1184 1.57e-20

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 86.36  E-value: 1.57e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1012282647 1127 GMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMM 1184
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 917-961 4.23e-18

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 78.99  E-value: 4.23e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1012282647  917 ESPSDEGALLDQLYLALRNFD--GLEEIDRALGIPELVSQSQAVDPE 961
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDetGLEEIDRALGIPELVGQGQGLDPD 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH