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Conserved domains on  [gi|1009035472|ref|NP_001308367|]
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protein lifeguard 3 isoform 2 [Homo sapiens]

Protein Classification

protein lifeguard( domain architecture ID 10179627)

protein lifeguard similar to human protein lifeguard 2, an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 13-197 2.28e-79

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 235.90  E-value: 2.28e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  13 EPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSI 92
Cdd:cd10428    37 DPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILLGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  93 SVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGivtsIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPE 172
Cdd:cd10428   117 GLTLFAFQTKYDFTSCGGVLFVLSIVLLIFG----IVAIFFYVKWLHIVYASLGALLFSLYLAVDTQLLMGGRKYELSPE 192

                         170       180
                  ....*....|....*....|....*
gi 1009035472 173 DYITGALQIYTDIIYIFTFVLQLMG 197
Cdd:cd10428   193 EYIFAALNIYVDIVNIFLYILQLIG 217
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 13-197 2.28e-79

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 235.90  E-value: 2.28e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  13 EPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSI 92
Cdd:cd10428    37 DPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILLGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  93 SVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGivtsIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPE 172
Cdd:cd10428   117 GLTLFAFQTKYDFTSCGGVLFVLSIVLLIFG----IVAIFFYVKWLHIVYASLGALLFSLYLAVDTQLLMGGRKYELSPE 192

                         170       180
                  ....*....|....*....|....*
gi 1009035472 173 DYITGALQIYTDIIYIFTFVLQLMG 197
Cdd:cd10428   193 EYIFAALNIYVDIVNIFLYILQLIG 217
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 14-196 5.31e-20

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 83.38  E-value: 5.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  14 PVSAFVRRNVAVYYVSY-AVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSI 92
Cdd:pfam01027  29 PALLFPSLHPPLFWVLIiAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLMGLTLGPLLLVYTGAIIATAFLGTAAIFG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  93 SVTIFCFQTKVDFTSCTGLFCVLGIVLlvtgIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISpE 172
Cdd:pfam01027 109 GLSLYALTTKRDLSFLGGFLFAGLIGL----IVASLVNIFLPSSALSLAISYLGVLLFSGFILYDTQRIIKRYGEYGD-Y 183

                         170       180
                  ....*....|....*....|....
gi 1009035472 173 DYITGALQIYTDIIYIFTFVLQLM 196
Cdd:pfam01027 184 DAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 47-200 6.74e-17

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 75.60  E-value: 6.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  47 RRRFPWNIILLTLFTFAMGFMTGTISSMYQTKA----VIIAMIITAVVSISVTIFCFQTKVDFTSCTGlFCVLGIVLLvt 122
Cdd:COG0670    81 RANSAAALALLFAYTALMGLTLSPILLVYTGLSgpasIAQAFGGTAATFGGLSLYGYTTKRDLSFLGS-FLFMGLIGL-- 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1009035472 123 gIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVlgnRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 200
Cdd:COG0670   158 -IIASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 13-197 2.28e-79

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 235.90  E-value: 2.28e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  13 EPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSI 92
Cdd:cd10428    37 DPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILLGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  93 SVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGivtsIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPE 172
Cdd:cd10428   117 GLTLFAFQTKYDFTSCGGVLFVLSIVLLIFG----IVAIFFYVKWLHIVYASLGALLFSLYLAVDTQLLMGGRKYELSPE 192

                         170       180
                  ....*....|....*....|....*
gi 1009035472 173 DYITGALQIYTDIIYIFTFVLQLMG 197
Cdd:cd10428   193 EYIFAALNIYVDIVNIFLYILQLIG 217
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 15-197 2.60e-31

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 112.89  E-value: 2.60e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  15 VSAFVRRNVAVYYVSYAVFVVT--YLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSI 92
Cdd:cd06181    24 ATAFTVCDPGWYWSPALMGLLTsmLALMATAAMIRAKMPVNLILLFGFTGLMGYVVGPLLFFYGPTILLRALGGTALVFF 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  93 SVTIFCFQTKVDFTSCTG-LFCVLGIVLLvtgivTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHtiSP 171
Cdd:cd06181   104 GLTVYALQARKDFLFLGGpLMAGLGFLLL-----SFLLNTFFYSPWLHLVAAAVGLVLFCGFLLYDTQLIIHKAEV--GP 176

                         170       180
                  ....*....|....*....|....*.
gi 1009035472 172 EDYITGALQIYTDIIYIFTFVLQLMG 197
Cdd:cd06181   177 EDYINACISLYLDIINIFIRLLTILA 202
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 1-200 2.65e-28

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 105.76  E-value: 2.65e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472   1 MTGKCDTLLSEREPVSAFVRRNVAVYYVSyavFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAV 80
Cdd:cd10429    44 ATTAVSALFYLSPSIKTFVQSHPWLFLIS---LIGSLILLIALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  81 IIAMIITAVVSISVTIFCFQTKVDFTSCTGLfcvLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQL 160
Cdd:cd10429   121 LQALILTLGVFVGLTAYTFQTKRDFSSFGAL---LFILLWALILLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQL 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1009035472 161 VLgnrkHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 200
Cdd:cd10429   198 IM----KRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 14-196 5.31e-20

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 83.38  E-value: 5.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  14 PVSAFVRRNVAVYYVSY-AVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSI 92
Cdd:pfam01027  29 PALLFPSLHPPLFWVLIiAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLMGLTLGPLLLVYTGAIIATAFLGTAAIFG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  93 SVTIFCFQTKVDFTSCTGLFCVLGIVLlvtgIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISpE 172
Cdd:pfam01027 109 GLSLYALTTKRDLSFLGGFLFAGLIGL----IVASLVNIFLPSSALSLAISYLGVLLFSGFILYDTQRIIKRYGEYGD-Y 183

                         170       180
                  ....*....|....*....|....
gi 1009035472 173 DYITGALQIYTDIIYIFTFVLQLM 196
Cdd:pfam01027 184 DAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 47-200 6.74e-17

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 75.60  E-value: 6.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  47 RRRFPWNIILLTLFTFAMGFMTGTISSMYQTKA----VIIAMIITAVVSISVTIFCFQTKVDFTSCTGlFCVLGIVLLvt 122
Cdd:COG0670    81 RANSAAALALLFAYTALMGLTLSPILLVYTGLSgpasIAQAFGGTAATFGGLSLYGYTTKRDLSFLGS-FLFMGLIGL-- 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1009035472 123 gIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVlgnRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 200
Cdd:COG0670   158 -IIASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 47-197 1.26e-14

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 69.13  E-value: 1.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  47 RRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTScTGLFCVLGIVLLvtgIVT 126
Cdd:cd10432    62 KMSVATALPLFFAFAALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSF-LGSFLFMGLIGL---IIA 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1009035472 127 SIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVL---GNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMG 197
Cdd:cd10432   138 SLVNIFLQSSALQFAISAIGVLIFSGLIAYDTQRIKrmyEAGGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 15-197 1.60e-08

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 52.20  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  15 VSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQT-----KAVIIAMIITAV 89
Cdd:cd10433    23 LGAGVSMAGGSPIMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTGFMGYTLGPILNMYLAlpnggQIIMTALGGTAA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472  90 VSISVTIFCFQTKVDFTSCTGlFCVLGIVLLVTGIVTSIvlyFQYVYWLHMLYAALGAICFTLFLAYDTQLVLgNRKHTi 169
Cdd:cd10433   103 IFFGLSAYALTTKKDFSFLGG-FLFVGAIVLLLAAVANI---FLQIPALSLAISAAFVLFSSGFILYDTSRII-HGGET- 176

                         170       180
                  ....*....|....*....|....*...
gi 1009035472 170 speDYITGALQIYTDIIYIFTFVLQLMG 197
Cdd:cd10433   177 ---NYIMATVSLYVSIYNLFVSLLNLLG 201
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 115-197 2.61e-03

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 37.75  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472 115 LGIVLLVTGIVTSIVLYFQYVYWlhmlyaalGAICFTLFLAYDTQLVLGNRK----HTISPEDYITGALQIYTDIIYIFT 190
Cdd:cd10431   180 LGSMFLPPTTALGAGLYSVSLYG--------GLVLFGGFLLYDTQKIIKRAEthplYGVRKYDPINASMSIYMDTINIFI 251


                  ....*..
gi 1009035472 191 FVLQLMG 197
Cdd:cd10431   252 RLVTILA 258
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 111-196 2.63e-03

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 37.20  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009035472 111 LFCVLGIVLLVtgivtSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHtiSPEDYITGALQIYTDIIYIFT 190
Cdd:cd10430   130 LSSALSILLLV-----SLANIFGGSKFLFQAELYLGLLVFCGFVLFDTQMIIEKAEN--GDRDYIWHALDLFVDFVALFR 202


                  ....*.
gi 1009035472 191 FVLQLM 196
Cdd:cd10430   203 RLLIIL 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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