NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1008909340|ref|NP_001308316|]
View 

pleiotrophin isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTN_MK_N super family cl02505
PTN/MK heparin-binding protein family, N-terminal domain;
47-131 1.38e-39

PTN/MK heparin-binding protein family, N-terminal domain;


The actual alignment was detected with superfamily member smart00193:

Pssm-ID: 470593  Cd Length: 80  Bit Score: 128.84  E-value: 1.38e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008909340   47 CGEWQWSVCVPTSGDCGLGTREGTrtgaeCKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRAL 126
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGT-----CGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKAL 75


                   ....*
gi 1008909340  127 HNAEC 131
Cdd:smart00193  76 YNADC 80
 
Name Accession Description Interval E-value
PTN smart00193
Pleiotrophin / midkine family; Heparin-binding domain family.
 47-131 1.38e-39

Pleiotrophin / midkine family; Heparin-binding domain family.


Pssm-ID: 128490  Cd Length: 80  Bit Score: 128.84  E-value: 1.38e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008909340   47 CGEWQWSVCVPTSGDCGLGTREGTrtgaeCKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRAL 126
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGT-----CGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKAL 75


                   ....*
gi 1008909340  127 HNAEC 131
Cdd:smart00193  76 YNADC 80
PTN_MK_N pfam05196
PTN/MK heparin-binding protein family, N-terminal domain;
45-95 8.94e-21

PTN/MK heparin-binding protein family, N-terminal domain;


Pssm-ID: 461582  Cd Length: 57  Bit Score: 80.19  E-value: 8.94e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1008909340  45 SDCGEWQWSVCVPTSGDCGLGTREGTrtgaeCKQTMKTQRCKIPCNWKKQF 95
Cdd:pfam05196  12 SDCAEWQWGKCVPNSGDCGLGFREGT-----CKEQTKKIKCKIPCNWKKEF 57
 
Name Accession Description Interval E-value
PTN smart00193
Pleiotrophin / midkine family; Heparin-binding domain family.
 47-131 1.38e-39

Pleiotrophin / midkine family; Heparin-binding domain family.


Pssm-ID: 128490  Cd Length: 80  Bit Score: 128.84  E-value: 1.38e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008909340   47 CGEWQWSVCVPTSGDCGLGTREGTrtgaeCKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRAL 126
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGT-----CGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKAL 75


                   ....*
gi 1008909340  127 HNAEC 131
Cdd:smart00193  76 YNADC 80
PTN_MK_N pfam05196
PTN/MK heparin-binding protein family, N-terminal domain;
45-95 8.94e-21

PTN/MK heparin-binding protein family, N-terminal domain;


Pssm-ID: 461582  Cd Length: 57  Bit Score: 80.19  E-value: 8.94e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1008909340  45 SDCGEWQWSVCVPTSGDCGLGTREGTrtgaeCKQTMKTQRCKIPCNWKKQF 95
Cdd:pfam05196  12 SDCAEWQWGKCVPNSGDCGLGFREGT-----CKEQTKKIKCKIPCNWKKEF 57
PTN_MK_C pfam01091
PTN/MK heparin-binding protein family, C-terminal domain;
96-145 5.68e-20

PTN/MK heparin-binding protein family, C-terminal domain;


Pssm-ID: 460059  Cd Length: 65  Bit Score: 78.65  E-value: 5.68e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1008909340  96 GAECKYQFQAWGECDLNTALKTRTGSLKRALHNAECQKTVTISKPCGKLT 145
Cdd:pfam01091   1 GADCKYKFGAWGECDPATGTKTRTGTLKKALFNAECQQTVSVTKPCKPKT 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH