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Conserved domains on  [gi|1008806484|ref|NP_001308236|]
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protein NPAT isoform 1 [Homo sapiens]

Protein Classification

LisH domain-containing protein( domain architecture ID 12174358)

LisH domain-containing protein; LisH domain-containing protein similar to Homo sapiens single-stranded DNA-binding protein 2 (SSBP2), a tumor suppressor implicated in multiple cancer forms

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPAT_C pfam15712
NPAT C terminus;
758-1434 0e+00

NPAT C terminus;


:

Pssm-ID: 434876 [Multi-domain]  Cd Length: 680  Bit Score: 1049.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  758 SAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAE-VGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFS 836
Cdd:pfam15712    1 SAVSSISGENLPTIILSSPAKSPAKNAELVKCLSSEETAGAVVSAErVGDSASVEQSLLVLKPEDSAANNTQNEECTAFS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  837 ANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQL-QTPPRSNSV 915
Cdd:pfam15712   81 ANGTPCVSKDGGFIQLMPATSTTFGNSNNILIATCVTDPTALGTTVTQSNVVVLPGNSAPMASQPPPPQQlQTPPRSNSV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  916 FAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQ 995
Cdd:pfam15712  161 FTVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNAFSAPSQQVLHMPLAAPVCNRSIPKLPIPPKSQKAQ 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  996 GLRNKPCIGKQVNNLVDSSGHSVGCHAQnfvlfcfRTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKP--CHRRVLCF 1073
Cdd:pfam15712  241 GLRNKPCTGKQVNSLTDSSSHPVGSHAQ-------RTEVSDKNMATDLGKKLEETTVPFSTESTVPSSKPfeSHRRVLCF 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1074 D-STTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLkPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQ 1152
Cdd:pfam15712  314 DsSTTSPVANTQGSNHKMTSQNKERNEISFSTLDSPGASSAL-LPSNNSSKREREKPPLPKILSKSEVASSRHTAVKETQ 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1153 SEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNvlSVGT 1232
Cdd:pfam15712  393 SEKKVSPTELVLESFHKATANKENELCSDVERQKNQETSKLSVGQQNGGLRNEKAIASLQELTKKQGTSSNSKN--SVGT 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1233 AVKDLKQEQTKSASSL---------ITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFS 1303
Cdd:pfam15712  471 PSKDPKQEQTKSASERmsltsplakQATEMLHDIQWQSPASKLPDSGDLPVPRTPGSGAGDKHKEEPSDGIKTPSSRRYS 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1304 EDSSTSKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRaSSRSTTKKRKIEELD 1383
Cdd:pfam15712  551 EDGSTPKVMVPPATPDLPACSPASETGSENSVNMAAHTLMILSRAAIARTTSTTPLKDNTQQFR-SSRSTTKKRKLEELD 629

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1008806484 1384 ERERNSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE 1434
Cdd:pfam15712  630 ECERNSRPSKKDLQNSSVPMKKKKIKKKKLPDSFPAGMDVDKFLLSLHYDE 680
 
Name Accession Description Interval E-value
NPAT_C pfam15712
NPAT C terminus;
758-1434 0e+00

NPAT C terminus;


Pssm-ID: 434876 [Multi-domain]  Cd Length: 680  Bit Score: 1049.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  758 SAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAE-VGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFS 836
Cdd:pfam15712    1 SAVSSISGENLPTIILSSPAKSPAKNAELVKCLSSEETAGAVVSAErVGDSASVEQSLLVLKPEDSAANNTQNEECTAFS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  837 ANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQL-QTPPRSNSV 915
Cdd:pfam15712   81 ANGTPCVSKDGGFIQLMPATSTTFGNSNNILIATCVTDPTALGTTVTQSNVVVLPGNSAPMASQPPPPQQlQTPPRSNSV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  916 FAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQ 995
Cdd:pfam15712  161 FTVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNAFSAPSQQVLHMPLAAPVCNRSIPKLPIPPKSQKAQ 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  996 GLRNKPCIGKQVNNLVDSSGHSVGCHAQnfvlfcfRTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKP--CHRRVLCF 1073
Cdd:pfam15712  241 GLRNKPCTGKQVNSLTDSSSHPVGSHAQ-------RTEVSDKNMATDLGKKLEETTVPFSTESTVPSSKPfeSHRRVLCF 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1074 D-STTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLkPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQ 1152
Cdd:pfam15712  314 DsSTTSPVANTQGSNHKMTSQNKERNEISFSTLDSPGASSAL-LPSNNSSKREREKPPLPKILSKSEVASSRHTAVKETQ 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1153 SEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNvlSVGT 1232
Cdd:pfam15712  393 SEKKVSPTELVLESFHKATANKENELCSDVERQKNQETSKLSVGQQNGGLRNEKAIASLQELTKKQGTSSNSKN--SVGT 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1233 AVKDLKQEQTKSASSL---------ITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFS 1303
Cdd:pfam15712  471 PSKDPKQEQTKSASERmsltsplakQATEMLHDIQWQSPASKLPDSGDLPVPRTPGSGAGDKHKEEPSDGIKTPSSRRYS 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1304 EDSSTSKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRaSSRSTTKKRKIEELD 1383
Cdd:pfam15712  551 EDGSTPKVMVPPATPDLPACSPASETGSENSVNMAAHTLMILSRAAIARTTSTTPLKDNTQQFR-SSRSTTKKRKLEELD 629

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1008806484 1384 ERERNSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE 1434
Cdd:pfam15712  630 ECERNSRPSKKDLQNSSVPMKKKKIKKKKLPDSFPAGMDVDKFLLSLHYDE 680
 
Name Accession Description Interval E-value
NPAT_C pfam15712
NPAT C terminus;
758-1434 0e+00

NPAT C terminus;


Pssm-ID: 434876 [Multi-domain]  Cd Length: 680  Bit Score: 1049.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  758 SAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAE-VGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFS 836
Cdd:pfam15712    1 SAVSSISGENLPTIILSSPAKSPAKNAELVKCLSSEETAGAVVSAErVGDSASVEQSLLVLKPEDSAANNTQNEECTAFS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  837 ANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQL-QTPPRSNSV 915
Cdd:pfam15712   81 ANGTPCVSKDGGFIQLMPATSTTFGNSNNILIATCVTDPTALGTTVTQSNVVVLPGNSAPMASQPPPPQQlQTPPRSNSV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  916 FAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQ 995
Cdd:pfam15712  161 FTVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNAFSAPSQQVLHMPLAAPVCNRSIPKLPIPPKSQKAQ 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484  996 GLRNKPCIGKQVNNLVDSSGHSVGCHAQnfvlfcfRTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKP--CHRRVLCF 1073
Cdd:pfam15712  241 GLRNKPCTGKQVNSLTDSSSHPVGSHAQ-------RTEVSDKNMATDLGKKLEETTVPFSTESTVPSSKPfeSHRRVLCF 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1074 D-STTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLkPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQ 1152
Cdd:pfam15712  314 DsSTTSPVANTQGSNHKMTSQNKERNEISFSTLDSPGASSAL-LPSNNSSKREREKPPLPKILSKSEVASSRHTAVKETQ 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1153 SEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNvlSVGT 1232
Cdd:pfam15712  393 SEKKVSPTELVLESFHKATANKENELCSDVERQKNQETSKLSVGQQNGGLRNEKAIASLQELTKKQGTSSNSKN--SVGT 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1233 AVKDLKQEQTKSASSL---------ITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFS 1303
Cdd:pfam15712  471 PSKDPKQEQTKSASERmsltsplakQATEMLHDIQWQSPASKLPDSGDLPVPRTPGSGAGDKHKEEPSDGIKTPSSRRYS 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806484 1304 EDSSTSKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRaSSRSTTKKRKIEELD 1383
Cdd:pfam15712  551 EDGSTPKVMVPPATPDLPACSPASETGSENSVNMAAHTLMILSRAAIARTTSTTPLKDNTQQFR-SSRSTTKKRKLEELD 629

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1008806484 1384 ERERNSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE 1434
Cdd:pfam15712  630 ECERNSRPSKKDLQNSSVPMKKKKIKKKKLPDSFPAGMDVDKFLLSLHYDE 680
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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