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fumarylacetoacetate hydrolase domain-containing protein 2B isoform b [Homo sapiens]
fumarylacetoacetate hydrolase family protein( domain architecture ID 1000357)
fumarylacetoacetate (FAA) hydrolase family protein belongs to the FAA hydrolase family which includes a large variety of metabolic enzymes, such as those with hydrolase functions involved in the breakdown of aromatic compounds, oxaloacetate decarboxylase, and enzymes associated with other catabolic pathways including decarboxylation of substrates other than oxaloacetate, hydration, isomerization and hydroxylation reactions
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
FAA_hydrolase super family | cl46602 | Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ... |
100-154 | 7.91e-20 | ||
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase. The actual alignment was detected with superfamily member COG0179: Pssm-ID: 480942 Cd Length: 206 Bit Score: 82.04 E-value: 7.91e-20
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Name | Accession | Description | Interval | E-value | ||
YcgM | COG0179 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) ... |
100-154 | 7.91e-20 | ||
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 439949 Cd Length: 206 Bit Score: 82.04 E-value: 7.91e-20
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FAA_hydrolase | pfam01557 | Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ... |
109-154 | 1.19e-08 | ||
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase. Pssm-ID: 460252 Cd Length: 210 Bit Score: 52.29 E-value: 1.19e-08
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HpaG-C-term | TIGR02303 | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; ... |
83-150 | 4.20e-07 | ||
4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; This model represents one of two subunits/domains of the bifunctional isomerase/decarboxylase involved in 4-hydroxyphenylacetate degradation. In E. coli and some other species this enzyme is encoded by a single polypeptide containing both this domain and the closely related N-terminal domain (TIGR02305). In other species such as Pasteurella multocida these domains are found as two separate proteins (usually as tandem genes). Together, these domains carry out the decarboxylation of 5-oxopent-3-ene-1,2,5-tricarboxylic acid (OPET) to 2-hydroxy-2,4-diene-1,7-dioate (HHDD) and the subsequent isomerization to 2-oxohept-3-ene-1,7-dioate (OHED). Pssm-ID: 131356 [Multi-domain] Cd Length: 245 Bit Score: 48.27 E-value: 4.20e-07
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PRK10691 | PRK10691 | fumarylacetoacetate hydrolase family protein; |
107-135 | 1.67e-05 | ||
fumarylacetoacetate hydrolase family protein; Pssm-ID: 182650 Cd Length: 219 Bit Score: 43.54 E-value: 1.67e-05
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Name | Accession | Description | Interval | E-value | |||
YcgM | COG0179 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) ... |
100-154 | 7.91e-20 | |||
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 439949 Cd Length: 206 Bit Score: 82.04 E-value: 7.91e-20
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FAA_hydrolase | pfam01557 | Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ... |
109-154 | 1.19e-08 | |||
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase. Pssm-ID: 460252 Cd Length: 210 Bit Score: 52.29 E-value: 1.19e-08
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HpaG-C-term | TIGR02303 | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; ... |
83-150 | 4.20e-07 | |||
4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; This model represents one of two subunits/domains of the bifunctional isomerase/decarboxylase involved in 4-hydroxyphenylacetate degradation. In E. coli and some other species this enzyme is encoded by a single polypeptide containing both this domain and the closely related N-terminal domain (TIGR02305). In other species such as Pasteurella multocida these domains are found as two separate proteins (usually as tandem genes). Together, these domains carry out the decarboxylation of 5-oxopent-3-ene-1,2,5-tricarboxylic acid (OPET) to 2-hydroxy-2,4-diene-1,7-dioate (HHDD) and the subsequent isomerization to 2-oxohept-3-ene-1,7-dioate (OHED). Pssm-ID: 131356 [Multi-domain] Cd Length: 245 Bit Score: 48.27 E-value: 4.20e-07
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PRK10691 | PRK10691 | fumarylacetoacetate hydrolase family protein; |
107-135 | 1.67e-05 | |||
fumarylacetoacetate hydrolase family protein; Pssm-ID: 182650 Cd Length: 219 Bit Score: 43.54 E-value: 1.67e-05
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PRK15203 | PRK15203 | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional |
70-150 | 7.25e-04 | |||
4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional Pssm-ID: 185125 [Multi-domain] Cd Length: 429 Bit Score: 39.26 E-value: 7.25e-04
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Blast search parameters | ||||
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