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Conserved domains on  [gi|1003088765|ref|NP_001307752|]
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WD repeat-containing protein 54 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
127-297 3.57e-07

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 127 SGDASPVQAVfarGIAASGHFICVGTWSGRVLVFDIPAKgpniVLSEELAGHQMPITDIATEPaQGQDcvadMVTADDSG 206
Cdd:COG2319   243 TGHSGSVRSV---AFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSP-DGKL----LASGSDDG 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 207 LLCVWrSGPEFTLLTRIPGFGVPCPSVQL--WQGIIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLASEVGKLLS 284
Cdd:COG2319   311 TVRLW-DLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         170
                  ....*....|...
gi 1003088765 285 AGEDTFVHIWKLS 297
Cdd:COG2319   390 GSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
127-297 3.57e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 127 SGDASPVQAVfarGIAASGHFICVGTWSGRVLVFDIPAKgpniVLSEELAGHQMPITDIATEPaQGQDcvadMVTADDSG 206
Cdd:COG2319   243 TGHSGSVRSV---AFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSP-DGKL----LASGSDDG 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 207 LLCVWrSGPEFTLLTRIPGFGVPCPSVQL--WQGIIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLASEVGKLLS 284
Cdd:COG2319   311 TVRLW-DLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         170
                  ....*....|...
gi 1003088765 285 AGEDTFVHIWKLS 297
Cdd:COG2319   390 GSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-295 1.10e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 144 SGHFICVGTWSGRVLVFDIPakgpNIVLSEELAGHQMPITDIATEPAQGQdcvadMVTADDSGLLCVWRSgPEFTLLTRI 223
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVAFSPDGEK-----LLSSSSDGTIKLWDL-STGKCLGTL 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1003088765 224 PGFGVPCPSVQL--WQGIIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLASEVGKLLSAGEDTFVHIWK 295
Cdd:cd00200   216 RGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
127-297 3.57e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 127 SGDASPVQAVfarGIAASGHFICVGTWSGRVLVFDIPAKgpniVLSEELAGHQMPITDIATEPaQGQDcvadMVTADDSG 206
Cdd:COG2319   243 TGHSGSVRSV---AFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSP-DGKL----LASGSDDG 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 207 LLCVWrSGPEFTLLTRIPGFGVPCPSVQL--WQGIIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLASEVGKLLS 284
Cdd:COG2319   311 TVRLW-DLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         170
                  ....*....|...
gi 1003088765 285 AGEDTFVHIWKLS 297
Cdd:COG2319   390 GSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-295 1.10e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 144 SGHFICVGTWSGRVLVFDIPakgpNIVLSEELAGHQMPITDIATEPAQGQdcvadMVTADDSGLLCVWRSgPEFTLLTRI 223
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVAFSPDGEK-----LLSSSSDGTIKLWDL-STGKCLGTL 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1003088765 224 PGFGVPCPSVQL--WQGIIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLASEVGKLLSAGEDTFVHIWK 295
Cdd:cd00200   216 RGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
124-297 1.16e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 124 ALDSGDASPVQAVfarGIAASGHFICVGTWSGRVLVFDIpAKGPNIvlsEELAGHQMPITDIATEPaQGQDcvadMVTAD 203
Cdd:COG2319   114 RTLTGHTGAVRSV---AFSPDGKTLASGSADGTVRLWDL-ATGKLL---RTLTGHSGAVTSVAFSP-DGKL----LASGS 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 204 DSGLLCVWRSgPEFTLLTRIPGFGVPCPSVQLWQG--IIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLaSEVGK 281
Cdd:COG2319   182 DDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF-SPDGR 259

                         170
                  ....*....|....*..
gi 1003088765 282 LL-SAGEDTFVHIWKLS 297
Cdd:COG2319   260 LLaSGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
135-301 2.60e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 135 AVFARGIAASGHFICVGTWSGRVLVFDIPAKGPNIVLSeelaGHQMPITDIATEPaQGQDcvadMVTADDSGLLCVW--R 212
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT----GHTGAVRSVAFSP-DGKT----LASGSADGTVRLWdlA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 213 SGpefTLLTRIPGFGVPCPSVQLWQG--IIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLASEvGKLL-SAGEDT 289
Cdd:COG2319   151 TG---KLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLaSGSADG 226

                         170
                  ....*....|..
gi 1003088765 290 FVHIWKLSRNPE 301
Cdd:COG2319   227 TVRLWDLATGKL 238
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 141-297 3.08e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.86  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 141 IAASGHFICVGTWSGRVLVFDIPakgpNIVLSEELAGHQMPITDIAtepaqgqdCVAD---MVTADDSGLLCVWRSGpEF 217
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLE----TGELLRTLKGHTGPVRDVA--------ASADgtyLASGSSDKTIRLWDLE-TG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088765 218 TLLTRIPGF--GVPCPSVQLWQGIIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLaSEVGKLLSAG-EDTFVHIW 294
Cdd:cd00200    84 ECVRTLTGHtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSsQDGTIKLW 162


                  ...
gi 1003088765 295 KLS 297
Cdd:cd00200   163 DLR 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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