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Conserved domains on  [gi|1003088806|ref|NP_001307701|]
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WD repeat domain phosphoinositide-interacting protein 1 isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-180 1.77e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 1.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806   6 FKKGTEICNYSY---SSNILSIRLNRQRLLVC---LEESIYIHNIKDMKLLKTLLDIPAnptGLCALSINHSNSYLAypG 79
Cdd:cd00200    78 WDLETGECVRTLtghTSYVSSVAFSPDGRILSsssRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVA--S 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  80 SLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEFrRGMKRYVTisSLVFS 159
Cdd:cd00200   153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL-RGHENGVN--SVAFS 228

                         170       180
                  ....*....|....*....|.
gi 1003088806 160 MDSQFLCASSNTETVHIFKLE 180
Cdd:cd00200   229 PDGYLLASGSEDGTIRVWDLR 249
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-180 1.77e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 1.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806   6 FKKGTEICNYSY---SSNILSIRLNRQRLLVC---LEESIYIHNIKDMKLLKTLLDIPAnptGLCALSINHSNSYLAypG 79
Cdd:cd00200    78 WDLETGECVRTLtghTSYVSSVAFSPDGRILSsssRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVA--S 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  80 SLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEFrRGMKRYVTisSLVFS 159
Cdd:cd00200   153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL-RGHENGVN--SVAFS 228

                         170       180
                  ....*....|....*....|.
gi 1003088806 160 MDSQFLCASSNTETVHIFKLE 180
Cdd:cd00200   229 PDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
38-180 3.21e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 3.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  38 SIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGS 117
Cdd:COG2319   185 TVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR 259

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1003088806 118 KLASASEKGTViRVFSVPDGQKLYEFRRGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLE 180
Cdd:COG2319   260 LLASGSADGTV-RLWDLATGELLRTLTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLA 318
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-180 1.77e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 1.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806   6 FKKGTEICNYSY---SSNILSIRLNRQRLLVC---LEESIYIHNIKDMKLLKTLLDIPAnptGLCALSINHSNSYLAypG 79
Cdd:cd00200    78 WDLETGECVRTLtghTSYVSSVAFSPDGRILSsssRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVA--S 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  80 SLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEFrRGMKRYVTisSLVFS 159
Cdd:cd00200   153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL-RGHENGVN--SVAFS 228

                         170       180
                  ....*....|....*....|.
gi 1003088806 160 MDSQFLCASSNTETVHIFKLE 180
Cdd:cd00200   229 PDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
38-180 3.21e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 3.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  38 SIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGS 117
Cdd:COG2319   185 TVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR 259

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1003088806 118 KLASASEKGTViRVFSVPDGQKLYEFRRGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLE 180
Cdd:COG2319   260 LLASGSADGTV-RLWDLATGELLRTLTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
38-180 2.87e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 2.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  38 SIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGS 117
Cdd:COG2319   269 TVRLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLAS-GS-DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1003088806 118 KLASASEKGTViRVFSVPDGQKLYEFrRGMKRYVTisSLVFSMDSQFLCASSNTETVHIFKLE 180
Cdd:COG2319   344 TLASGSDDGTV-RLWDLATGELLRTL-TGHTGAVT--SVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
65-275 3.67e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 3.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  65 ALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTViRVFSVPDGQKLYEFR 144
Cdd:COG2319   125 SVAFSPDGKTLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLT 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806 145 RGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLEqvtnsRPEEPSTWSGymgkmfmaatnylptqvsdmmHQDRAFAT 224
Cdd:COG2319   202 GHTGA---VRSVAFSPDGKLLASGSADGTVRLWDLA-----TGKLLRTLTG---------------------HSGSVRSV 252

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1003088806 225 ArlnFS--GQrnictlstiqklpRLLVASSSGHLYMYNLdpqDGGECVLIKTH 275
Cdd:COG2319   253 A---FSpdGR-------------LLASGSADGTVRLWDL---ATGELLRTLTG 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-180 1.95e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  81 LTSGE---IVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEFrRGMKRYVTisSLV 157
Cdd:cd00200    67 ASGSSdktIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTL-RGHTDWVN--SVA 142

                          90       100
                  ....*....|....*....|...
gi 1003088806 158 FSMDSQFLCASSNTETVHIFKLE 180
Cdd:cd00200   143 FSPDGTFVASSSQDGTIKLWDLR 165
WD40 COG2319
WD40 repeat [General function prediction only];
84-180 5.43e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 5.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  84 GEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTViRVFSVPDGQKLYEFrRGMKRYVTisSLVFSMDSQ 163
Cdd:COG2319   100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV-RLWDLATGKLLRTL-TGHSGAVT--SVAFSPDGK 175

                          90
                  ....*....|....*..
gi 1003088806 164 FLCASSNTETVHIFKLE 180
Cdd:COG2319   176 LLASGSDDGTVRLWDLA 192
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-270 1.24e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  62 GLCALSINHSNSYLAyPGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLY 141
Cdd:cd00200    11 GVTCVAFSPDGKLLA-TGS-GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806 142 EFrRGMKRYVtiSSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRpeepsTWSGymgkmFMAATNYLPTQVSDMM----H 217
Cdd:cd00200    88 TL-TGHTSYV--SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-----TLRG-----HTDWVNSVAFSPDGTFvassS 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1003088806 218 QDRafaTARL----------NFSG-QRNICTLSTIQKLPRLLVASSSGHLYMYNLdpqDGGECV 270
Cdd:cd00200   155 QDG---TIKLwdlrtgkcvaTLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL---STGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-133 1.18e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  18 SSNILSIRL--NRQRLLVC-LEESIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAypGSLTSGEIVLYDGNSL 94
Cdd:cd00200   177 TGEVNSVAFspDGEKLLSSsSDGTIKLWDLSTGKCLGTL---RGHENGVNSVAFSPDGYLLA--SGSEDGTIRVWDLRTG 251

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1003088806  95 KTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFS 133
Cdd:cd00200   252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT-IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
38-136 1.90e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  38 SIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAYPGSltSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGS 117
Cdd:COG2319   311 TVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKTLASGSD--DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR 385

                          90
                  ....*....|....*....
gi 1003088806 118 KLASASEKGTvIRVFSVPD 136
Cdd:COG2319   386 TLASGSADGT-VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-195 8.89e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 8.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  97 VCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLyefRRGMKRYVTISSLVFSMDSQFLCASSNTETVHI 176
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELL---RTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90
                  ....*....|....*....
gi 1003088806 177 FKLEQvtnsrPEEPSTWSG 195
Cdd:cd00200    78 WDLET-----GECVRTLTG 91
WD40 COG2319
WD40 repeat [General function prediction only];
80-181 1.70e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003088806  80 SLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTViRVFSVPDGQKLYEFrRGMKRYVTisSLVFS 159
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RLWDLATGLLLRTL-TGHTGAVR--SVAFS 129

                          90       100
                  ....*....|....*....|..
gi 1003088806 160 MDSQFLCASSNTETVHIFKLEQ 181
Cdd:COG2319   130 PDGKTLASGSADGTVRLWDLAT 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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