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Conserved domains on  [gi|995970200|ref|NP_001307156|]
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60S ribosomal export protein NMD3 isoform 1 [Homo sapiens]

Protein Classification

60S ribosomal export protein NMD3( domain architecture ID 10523188)

60S ribosomal export protein NMD3 acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NMD3 pfam04981
NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal ...
17-246 4.94e-102

NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.


:

Pssm-ID: 461505  Cd Length: 242  Bit Score: 306.91  E-value: 4.94e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970200   17 CCECGVPISPNPANICVACLRSKVDISQGIPKqVSISFCKQCQRYFqPPGTWIQCaLESRELLALCLKKI---------K 87
Cdd:pfam04981   1 CCRCGRPIEPPINGLCVDCYRKEVDITEGIPK-ITVTFCRGCGRYL-PGGRWVRA-LESRELLAECLKKLvskglnvheD 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970200   88 APLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEV--MNGAILQQVFVVDYVVQSQMCGDCHRVEAKdFWKAVIQVRQK--- 162
Cdd:pfam04981  78 VEDVKVELVDAEFIWTEPHSKRIKVKLTVQGEVrgLVGTILQQEFVVEVVVRRQQCPDCSRIAGG-YWEAIVQVRQKrel 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970200  163 --TLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPCRYKASQRLISQDIHSNTYNYKS 240
Cdd:pfam04981 157 teVEHKRTFLYLEQLILKHDAHAFISKIKEVKDGLDFYFGSRNHARKIVDFLSSVVPGKVKESKKLVSHDKDSGKYNYRF 236

                  ....*.
gi 995970200  241 TFSVEI 246
Cdd:pfam04981 237 TYSVRI 242
 
Name Accession Description Interval E-value
NMD3 pfam04981
NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal ...
17-246 4.94e-102

NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.


Pssm-ID: 461505  Cd Length: 242  Bit Score: 306.91  E-value: 4.94e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970200   17 CCECGVPISPNPANICVACLRSKVDISQGIPKqVSISFCKQCQRYFqPPGTWIQCaLESRELLALCLKKI---------K 87
Cdd:pfam04981   1 CCRCGRPIEPPINGLCVDCYRKEVDITEGIPK-ITVTFCRGCGRYL-PGGRWVRA-LESRELLAECLKKLvskglnvheD 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970200   88 APLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEV--MNGAILQQVFVVDYVVQSQMCGDCHRVEAKdFWKAVIQVRQK--- 162
Cdd:pfam04981  78 VEDVKVELVDAEFIWTEPHSKRIKVKLTVQGEVrgLVGTILQQEFVVEVVVRRQQCPDCSRIAGG-YWEAIVQVRQKrel 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970200  163 --TLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPCRYKASQRLISQDIHSNTYNYKS 240
Cdd:pfam04981 157 teVEHKRTFLYLEQLILKHDAHAFISKIKEVKDGLDFYFGSRNHARKIVDFLSSVVPGKVKESKKLVSHDKDSGKYNYRF 236

                  ....*.
gi 995970200  241 TFSVEI 246
Cdd:pfam04981 237 TYSVRI 242
 
Name Accession Description Interval E-value
NMD3 pfam04981
NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal ...
17-246 4.94e-102

NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.


Pssm-ID: 461505  Cd Length: 242  Bit Score: 306.91  E-value: 4.94e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970200   17 CCECGVPISPNPANICVACLRSKVDISQGIPKqVSISFCKQCQRYFqPPGTWIQCaLESRELLALCLKKI---------K 87
Cdd:pfam04981   1 CCRCGRPIEPPINGLCVDCYRKEVDITEGIPK-ITVTFCRGCGRYL-PGGRWVRA-LESRELLAECLKKLvskglnvheD 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970200   88 APLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEV--MNGAILQQVFVVDYVVQSQMCGDCHRVEAKdFWKAVIQVRQK--- 162
Cdd:pfam04981  78 VEDVKVELVDAEFIWTEPHSKRIKVKLTVQGEVrgLVGTILQQEFVVEVVVRRQQCPDCSRIAGG-YWEAIVQVRQKrel 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970200  163 --TLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPCRYKASQRLISQDIHSNTYNYKS 240
Cdd:pfam04981 157 teVEHKRTFLYLEQLILKHDAHAFISKIKEVKDGLDFYFGSRNHARKIVDFLSSVVPGKVKESKKLVSHDKDSGKYNYRF 236

                  ....*.
gi 995970200  241 TFSVEI 246
Cdd:pfam04981 237 TYSVRI 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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